Con-current Oral Abstract Presentations Session 3

Enhanced Coated Hydrogel Device for Controlled Release of Drugs for Cataract Surgery

drug delivery/release; ophthalmic; sustained release

F. B. Karp, University of Washington, Seattle, WA

N. Geisler, University of Washington, Seattle, Washington

S. Garty, University of Washington, Seattle, Washington

T. T. Shen, University of Washington, Seattle, Washington

B. D. Ratner, University of Washington, Seattle, Washington

Sustained Release of Bevacizumab Using an Injectable, Degradable and Biocompatible Reverse Thermal Gel

angiogenesis/neovascularization; drug delivery/release; eye

B. M. Rauck, University of Pittsburgh, Pittsburgh, PA

C. Medina, University of Pittsburgh, Pittsburgh, Pennsylvania

T. R. Friberg, University of Pittsburgh, Pittsburgh, Pennsylvania

Y. Wang, University of Pittsburgh, Pittsburgh, Pennsylvania

Optimized Properties of Collagen Vitrigel Membranes for Ocular Repair and Regeneration Applications

collagen; eye; ocular

X. Caldron-Colon, The Johns Hopkins University Applied Physics Laboratory, Laurel, MD

Z. Xia, The Johns Hopkins University Applied Physics Laboratory, Laurel, Maryland

J. L. Breidenich, The Johns Hopkins University Applied Physics Laboratory, Laurel, Maryland

D. Mulreany, The Whitaker Biomedical Engineering Institute at Johns Hopkins University School of Medicine, Baltimore, Maryland

Q. Guo, The Whitaker Biomedical Engineering Institute at Johns Hopkins University School of Medicine, Baltimore, Maryland

M. Uy, The Johns Hopkins University Applied Physics Laboratory, Laurel, Maryland

J. Tiffany, The Johns Hopkins University Applied Physics Laboratory, Laurel, Maryland

D. E. Freund, The Johns Hopkins University Applied Physics Laboratory, Laurel, Maryland

R. L. McCally, The Johns Hopkins University Applied Physics Laboratory, Laurel, Maryland

O. Schein, The Wilmer Eye Institute Johns Hopkins Hospital, Baltimore, Maryland

J. H. Elisseeff, The Whitaker Biomedical Engineering Institute at Johns Hopkins University School of Medicine, Baltimore, Maryland

M. M. Trexler, The Johns Hopkins University Applied Physics Laboratory, Laurel, Maryland

The Monthly Eye Drop: Development of a Long-term, Noninvasive Glaucoma Treatment System

drug delivery/release; glaucoma

M. V. Fedorchak, University of Pittsburgh, Pittsburgh, PA

A. Cugini, University of Pittsburgh, Pittsburgh, Pennsylvania

J. S. Schuman, Unversity of Pittsburgh, Pittsburgh, Pennsylvania

S. R. Little, University of Pittsburgh, Pittsburgh, Pennsylvania

Extended Ocular Drug Delivery using Hyaluronic Acid-containing model Silicone Hydrogel Materials

contact lens; drug delivery/release; glaucoma

M. Korogiannaki, McMaster University, Hamilton, ON, Canada

Evaluating the Relationship Between Transparent Hydrogel Chemistry and Dexamethasone Delivery

contact lens; drug delivery/release; hydrogel

G. Guidi, McMaster University, Hamilton, ON, Canada

Nanogels for Sustained Ocular Delivery of Brimonidine for Treatment of Glaucoma

drug delivery/release

D. R. Janagam, University of Tennessee Health Science Center, memphis, TN

L. Wu, University of Tennessee Health Science Center, Memphis, Tennessee

J. Zhang, Henan Eye Institute, Zhengzhou, China

T. Lowe, University of Tennessee Health Science Center, Memphis, Tennessee

Hyaluronic Acid-Based Hydrogels as Scaffolds for Stem Cells to Differentiate Into Neuronal Cells

hydrogel; scaffolds; tissue engineering

K. Compton, University of Tennessee Health Science Center, Memphis, TN

L. Wu, University of Tennessee Health Science Center, Memphis, Tennessee

T. Lowe, University of Tennessee Health Science Center, Memphis, Tennessee

A New Green Route to Prepare Stimuli-responsive Hydrogel Particles: Integrating Epoxy Chemistry with Thermal Induced Phase Separation

degradation; nanomaterials/nanophase

W. He, University of Tennessee, Knoxville, Knoxville, TN

S. Tang, University of Tennessee, Knoxville, Knoxville, Tennessee

Z. Shi, University of Tennessee, Knoxville, Knoxville, Tennessee

Hydrogel-Nanoshell Composite Materials for Therapeutic Delivery

controlled release; drug delivery/release; nanotechnology

L. E. Strong, Duke University, Durham, NC

S. N. Dahotre, Duke University, Durham, North Carolina

J. L. West, Duke University, Durham, North Carolina

Preparation of Micrcogels Using Thiol-Ene “Click” Chemistry

controlled release; hydrogel; microspheres

A. K. Fraser, Indiana University Purdue University at Indianapolis, Indinapolis, IN

H. Shih, Indiana University Purdue University at Indianapolis, Indianapolis, Indiana

C. Lin, Indiana University Purdue University at Indianapolis, Indianapolis, Indiana

A Cell-targeted Photodynamic Nanomedicine Strategy for Head & Neck Cancers

block copolymer; drug delivery/release; nanotechnology

A. M. Master, Case Western Reserve University, Cleveland, OH

A. Malamas, Case Western Reserve University, Cleveland, Ohio

R. Solanki, Case Western Reserve University, Cleveland, Ohio

D. M. Clausen, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

J. L. Eiseman, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

A. Sen Gupta, Case Western Reserve University, Cleveland, Ohio

Study on the Novel Drug Vehicle for Encapsulation of Hydrophobic Agent and MR Imaging

drug delivery/release; hydrophobic; nanomedicine

H. Chen, National Yang-Ming University, Taipei, Taiwan

T. Liu, National Yang-Ming University, Taipei, Taiwan

Modulation of Polymer/DNA Release from Poly(lactic-co-glycolic acid) Microspheres through Poly(ethylenimine) Modification and Loading Concentration

controlled release; gene therapy/gene delivery; microspheres

C. J. Needham, Rice University, Houston, TX

S. Shah, Rice University, Houston, Texas

F. Kasper, Rice University, Houston, Texas

A. G. Mikos, Rice University, Houston, Texas

Array of Biodegradable Microelements for Isolation and Implantation of Living, Adherent Cells

biodegradation; microstructure; tumor

Y. Wang, University of North Carolina, Chapel Hill, Chapel Hill, NC

Preparation of Chitosan-Coated Magnetite Nanoparticles and Application for Immobilization of Laccase

enzyme(s); nanomodified surfaces

E. Aksoy, Middle East Technical University, Ankara, Turkey

S. Aksoy, Gazi University, Ankara, Turkey

N. Kalkan, Gazi University, Ankara, Turkey

N. Hasirci, Middle East Technical University, Ankara, Turkey

A Biomimetic Hydrogel System to Study Tumor Angiogenesis

angiogenesis/neovascularization; hydrogel; tumor

L. C. Roudsari, Duke University, Durham, NC

B. J. Gill, Rice University, Houston, Texas

D. L. Gibbons, The University of Texas MD Anderson Cancer Center, Houston, Texas

J. M. Kurie, The University of Texas MD Anderson Cancer Center, Houston, Texas

J. L. West, Duke University, Durham, North Carolina

Cancer-activated adipocytes and their role in extracellular matrix remodeling and angiogenesis

angiogenesis/neovascularization; extracellular matrix; tissue engineering

B. Seo, Cornell University, Ithaca, NY

J. Gonzalez, Cornell University, Ithaca, New York

S. Moore, Cornell University, Ithaca, New York

L. T. Vahdat, Weill Cornell Medical College, New York, New York

C. Fischbach, Cornell University, Ithaca, New York

Elucidating the Role of Microenvironmental Cues on Melanoma Drug Resistance

cell-material interactions; hydrogel

E. Y. Tokuda, The BioFrontiers Institute and the Howard Hughes Medical Institute, University of Colorado, Boulder, CO

J. L. Leight, The BioFrontiers Institute and the Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado

K. S. Anseth, The BioFrontiers Institute and the Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado

Engineering extracellular matrix constructs to modulate endothelial cell secretion and its ability to control cancer.

tumor

J. L. Dreyfuss, Massachusetts Institute of Technology, Cambridge, MA

Combination of Pathogen-mimicking Polymer Particles and an Injectable, Synthetic Immune-Priming Center (sIPC) Significantly Enhances Cellular and Protective Immunity in Murine Models of Cancer

gene therapy/gene delivery; hydrogel; nanomedicine

P. Pradhan, The University of Texas at Austin, Austin, TX

Engineered 3D matrices to study regulation of glioblastoma cell malignancy

biomimetic; cell-material interactions; tumor

S. Pedron, University of Illinois at Urbana-Champaign, Urbana, IL

E. Becka, University of Illinois at Urbana-Champaign, Urbana, Illinois

E. Roy, University of Illinois at Urbana-Champaign, Urbana, Illinois

B. Harley, University of Illinois at Urbana-Champaign, Urbana, Illinois

Extracellular matrix hydrogel as growth factor delivery system for prolonged release and enhanced effect of a novel engineered HGF mimic in a small animal model of myocardial infarction

angiogenesis/neovascularization; cardiovascular; growth factor

S. Sonnenberg, University of California, San Diego, San Diego, CA

Sustained Release of SDF-1α Polypeptide Analogue from Hyaluronic Acid Hydrogels for Cardiac Repair

cytokines; drug delivery/release; regenerative medicine

B. P. Purcell, University of Pennsylvania, Philadelphia, PA

J. W. MacArthur, Jr., University of Pennsylvania, Philadelphia, Pennsylvania

J. Y. Woo, University of Pennsylvania, Philadelphia, Pennsylvania

J. A. Burdick, University of Pennsylvania, Philadelphia, Pennsylvania

Injectable Poly(Vinyl Alcohol) Hydrogels for Cardiovascular Applications

cardiovascular; hydrogel; phase separated polymer

G. J. Braithwaite, Cambridge Polymer Group, Boston, MA

T. Wilson-Hill, Cambridge Polymer Group, Boston, Massachusetts

J. Hung, Massachusetts General Hospital, Boston, Massachusetts

Examining the Influence of Injectable Hyaluronic Acid Hydrogels on Myocardial Infarct Repair using MRI

animal model; cardiovascular; hydrogel

S. M. Dorsey, University of Pennsylvania, Philadelphia, PA

E. Tous, University of Pennsylvania, Philadelphia, Pennsylvania

J. R. McGarvey, University of Pennsylvania, Glenolden, Pennsylvania

J. F. Wenk, University of Kentucky, Lexington, Kentucky

J. H. Gorman, III, University of Pennsylvania, Glenolden, Pennsylvania

R. C. Gorman, University of Pennsylvania, Glenolden, Pennsylvania

J. A. Burdick, University of Pennsylvania, Philadelphia, Pennsylvania

Integration of Cysteine-rich angiogenic inducer 61 (CYR61) into collagen biomaterial promotes the therapeutic potential of circulating angiogenic cells

angiogenesis/neovascularization; cell adhesion; cell therapy

B. McNeill, University of Ottawa Heart Institute, Ottawa, ON, Canada

B. Vulesevic, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

M. Ruel, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

E. J. Suuronen, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

Hydrogels Designed to Provide Sustained, Stimuli-Responsive Release of Pro-Angiogenic Peptides

angiogenesis/neovascularization; cardiovascular; hydrogel

A. H. Van Hove, University of Rochester, Rochester, NY

D. Benoit, University of Rochester, Rochester, New York

In Vivo Remodeling of 45S5 Bioactive Glass/Polyurethane Biocomposites with Initial Bone-like Mechanical Properties

bioactive glass; composite/hard tissue; in vivo

A. J. Harmata, Vanderbilt University, Nashville, TN

C. L. Ward, United States Army Institute of Surgical Research, Fort Sam Houston, Texas

K. J. Zienkiewicz, Vanderbilt University, Nashville, Tennessee

J. C. Wenke, United States Army Institute of Surgical Research, Fort Sam Houston, Texas

S. A. Guelcher, Vanderbilt University, Nashville, Tennessee

Polyvinyl alcohol-polyacrylic acid (PVA-PAA) hydrogels for osteochondral defect repair

cartilage; hydrogel

D. Bichara, Massachusetts General Hospital, Boston, MA

H. Bodugoz-Senturk, Massachusetts General Hospital, Boston, Massachusetts

D. Ling, Massachusetts General Hospital, Boston, Massachusetts

E. Malchau, Massachusetts General Hospital, Boston, Maryland

C. Bragdon, Massachusetts General Hospital, Boston, Massachusetts

O. Muratoglu, Massachusetts General Hospital, Boston, Massachusetts

One Year Evaluation of a PCL-TCP Putty in an Ovine Critical Sized Metaphyseal Defect Model.

biocompatibility/hard tissue; composite/hard tissue

S. Woods, DePuy Synthes, West Chester, PA

A. Petticoffer, DePuy Synthes, West Chester, Pennsylvania

P. Patel, DePuy Synthes, West Chester, Pennsylvania

D. Arens, AO Research Institute, Davos, Switzerland

Ultrasound As a Physical Force for Enhanced Scaffold-Based Bone Repair

bone; orthopedic; tissue engineering

J. Veronick, University of Connecticut, Farmington, CT

Y. Khan, University of Connecticut, Farmington, Connecticut

B. Huey, University of Connecticut, Storrs, Connecticut

Y. Kutes, Institute of Materials Science, Storrs, Connecticut

Rapid vascularization and anastomosis of a large vascularized construct of collagen/β-TCP scaffold fabricated by template-casting and electrochemical detachment technique

endothelialization

Y. Kang, Stanford University, Stanford, CA

N. Mochizuki, University of Tsukuba, Tsukuba, Ibaraki, Japan

L. Ren, Lanzhou University, Lanzhou,Gansu, China

A. Khademhosseini, Harvard Medical School, Cambridge, Massachusetts

J. Fukuda, University of Tsukuba, Ibaraki, Japan

Y. Yang, Stanford University, Stanford, California

Biomechanical Evaluation of an Injectable and Biodegradable Copolymer P(PF-co-CL) in a Cadaveric Vertebral Body Defect Model

biomechanics; bone graft; polymer

Z. Fang, Mayo Clinic, Rochester, MN

Novel Silk-Calcium Phosphate Ceramic Scaffolds for Bone Tissue Engineering

bone; calcium phosphate(s); ceramic

S. L. McNamara, Tufts University, Medford, MA

D. L. Kaplan, Tufts University, Medford, Massachusetts

T. J. Lo, Tufts University, Medford, Massachusetts

Investigation of Mesenchymal Stem Cell Phenotype and Function in an Allograft Cellular Bone Matrix

bone graft; orthopedic; stem/progenitor cells

L. S. Brown, Stryker, Corp., Malvern, PA

M. M. Darmoc, Stryker, Corp., Malvern, Pennsylvania

T. D. Clineff, Stryker, Corp., Malvern, Pennsylvania

Micro-contact Printing of Viable Tissues via Geometrically Patterned Shape-Shifting Supports

polymer; smart materials; tissue engineering

O. O. Akintewe, University Of South Florida, Tampa, FL

S. J. DuPont, University Of South Florida, Tampa, Florida

R. G. Toomey, University Of South Florida, Tampa, Florida

N. D. Gallant, University Of South Florida, Tampa, Florida

Integrating Mechanical Cues and Biomolecular Patterns in a Collagen-Glycosaminoglycan Scaffold for Tendon-Bone Junction Repair

biomechanics; cell-material interactions; scaffolds

L. Mozdzen, University of Illinois at Champaign-Urbana, Champaign, IL

Development and Characterization of a High-Throughput Screening Surface Combining Geometric and Nanotopographical Mechanical Cues to Investigate Cell-Surface Interactions

cell-material interactions; immunohistochemistry; nanotechnology

N. J. Steinmetz, University of Glasgow, Glasgow, United Kingdom (Great Britain)

M. J. Dalby, University of Glasgow, Glasgow, United Kingdom (Great Britain)

N. Gadegaard, University of Glasgow, Glasgow, United Kingdom (Great Britain)

Real-time Measurement of Intercellular Stresses in Cells Grown on Micropatterns

morphology; surface modification

K. Suffoletto, SUNY Buffalo, Buffalo, NY

Application of rapid prototyping to high throughput screening of 3D dynamic environments

bone; scaffolds; tissue engineering

P. F. Costa, University of Minho, Guimarães, Portugal

C. Vaquette, Queensland University of Technology, Brisbane, Australia

C. Theodoropoulos, Queensland University of Technology, Brisbane, Australia

M. E. Gomes, University of Minho, Guimarães, Portugal

R. L. Reis, University of Minho, Guimarães, Portugal

D. W. Hutmacher, Queensland University of Technology, Brisbane, Australia

A Novel Endothelial Cell Scaffold for Small-Diameter Vascular Engineering

cell-material interactions; endothelial cells; vascular graft

K. J. McHugh, Boston University; Schepens Eye Research Institute; The Charles Stark Draper Laboratory, Inc., Boston, MA

S. L. Tao, The Charles Stark Draper Laboratory, Inc.; CooperVision, Inc., Cambridge, Massachusetts

M. Saint-Geniez, Schepens Eye Research Institute; Harvard Medical School, Boston, Massachusetts

Effect of PGS-PCL Electrospun Fibers Orientation on Alignment and Proliferation of Human Umbilical Vein Endothelial Cells

cell-material interactions; endothelial cells; regenerative medicine

A. Gaharwar, Massachusetts Institute of Technology, Cambridge, MA

M. Nikkhah, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, Massachusetts

S. Sant, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, Massachusetts

A. Patel, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, Massachusetts

S. Mihaila, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, Massachusetts

A. Khademhosseini, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, Massachusetts

3D Patterned Microenvironments Created through Assembly of Discrete Collagen-Chitosan Tissue Modules

cell-cell interactions; microspheres; regenerative medicine

D. J. Caldwell, University of Michigan, Ann Arbor, MI

D. J. Caldwell, University of Michigan, Ann Arbor, Michigan

R. R. Rao, University of Michigan, Ann Arbor, Michigan

J. P. Stegemann, University of Michigan, Ann Arbor, Michigan