Advanced Antimicrobial Materials 2

10:30 a.m. 399. Assessment of Bacteriophage Activity in Poly(Ethylene Glycol) Hydrogels, M. E. Daz Ortiz*(1), C. T. Johnson(2), A. J. Garca(1), M. A. Prieto(3), N. Dinjaski(3), (1)Georgia Institute of Technology, Atlanta, GA, (2)Georgia Institute of Technology & Emory University, Atlanta, GA, (3)Consejo Superior de Investigaciones Cientificas (CSIC), Madrid, Spain

10:45 a.m. 400. Characterization of In-vitro Release of Gentamicin from Biodegradable Polymer Thin Films Microstructure-Function Relationship by Confocal Raman Microscopy, A. Pandey*(1), D. Armbruster*(1), L. Hughes(1), S. Nielsen(2), A. Mantz(2), (1)DePuy Synthes, West Chester, PA, (2)Janssen Pharmaceuticals, Spring House, PA

11:00 a.m. 401. Testing Leading to a "de novo" (i.e., No Predicate) FDA Cleared Antimicrobial Wound Dressing, C. Batich*(1), G. Schultz(1), W. Toreki(2), J. Olderman(2), B. Mast(1), D. Moore(2), D. Mozingo(1), B. Liesenfeld(2), (1)U Florida, Gainesville, FL, (2)Quick Med Technologies, Inc., Gainesville, FL

11:15 a.m. 402. Silver Nanoparticle-Embedded Polymersome Nanocarriers for the Treatment of Antibiotic-Resistant Infections, B. M. Geilich*, A. L. van de Ven, G. L. Singleton, S. Sridhar, T. J. Webster, Northeastern University, Boston, MA

11:30 a.m. 403. Introduction of Antibacterial Function into Biomedical TiNi Shape Memory Alloy by the Addition of Element Ag, Y.F. Zheng*, Peking University, Beijing, China

11:45 a.m. 404. Examining the Amount and Form of Silver Release from Antimicrobial Medical Devices, E. M. Sussman*, P. Jayanti, B. J. Casey, B. J. Dair, U.S. Food and Drug Administration, Silver Spring, MD

12:00 p.m. 405. Mitigation of MRSA Infection in vivo by Dual Local Controlled Delivery of Anti-Infective Agents, T. Briggs*(1), S. Bhattacharyya(1), H. Qu(1), N. Sheth(1), C. Knabe(2), P. Ducheyne(1), (1)University of Pennsylvania, Philadelphia, PA, (2)Philipps University, Marburg, Germany

12:15 p.m. 406. Antimicrobial Nanotextured Dental Implant Surfaces Against Porphyromonas Gingivalis A. Au(1), S. Patel(2), W. Li(1), C. Wu(1), C. Sukotjo(1),(1)University of Illinois at Chicago, Chicago, IL, (2)Michigan Technological University, Houghton, MI

Biomaterials for Regenerative Engineering 2

10:30 a.m. 407. Invited Speaker: Cato Laurencin, Institute for Regenerative Engineering, University of Connecticut

11:00 a.m. 408. Improved Cellular Recruitment and Mass Transport for Large Bone Defect Regeneration, S. M. Tabbaa*(1), A. Mlynarczyk(1), K. J. L. Burg(2), (1)Clemson University, Clemson, SC, (2)Kansas State University, Manhattan, KS

11:15 a.m. 409. Accelerated Bone Regeneration of BMP-2 Loaded Hydroxyapatite Microspheres for Bone Filler Applications, J. Baek*, H. Jung, T. Jang, S. W. Kim, M. Kang, J. Song, H. Kim, Seoul National University, Seoul, Republic of Korea

11:30 a.m. 410. Optimization of Mesenchymal Stem Cells Performance on Biomimetic Ligament Scaffolds for ACL Regeneration, X. Yu*, P. Mengsteab, L. S. Nair, C. T. Laurencin, University of Connecticut Health Center, Farmington, CT

11:45 a.m. 411. Anisotropic Network Formation of Neurons and Endothelial Cells in Engineered Muscle Tissue Construct, H. Takahashi*, T. Shimizu, M. Nakayama, M. Yamato, T. Okano, Tokyo Women's Medical University, Tokyo, Japan

12:00 p.m. 412. VEGF-Functionalized Integrin-Specific Hydrogels for Increased Stem Cell Proliferation, Vascularization and Regeneration of Critically-sized Bone Defects, J. R. Garcia*, A. J. Garcia, Georgia Institute of Technology, Atlanta, GA

12:15 p.m. 413. Human Plasma Based Composite Muscle ECM Directs Adipose Derived Stem Cells to Vasculogenic and Myogenic Lineage, A. Aurora*, R. J. Christy, T. J. Walters, S. Natesan, United States Army Institute of Surgical Research, JBSA Ft Sam Houston, TX

Drug Delivery 2

10:30 a.m. 414. Local and Sustained Drug Delivery for the Treatment of Cavernous Nerves Post-Prostate Cancer Surgery, R. Goyal*(1), N. Patel(2), A. Salmasi(3), I. Kim(3), J. Kohn(1), (1)NJCBM, Piscataway, NJ, (2)CINJ, New Brunswick, NJ, (3)Cancer Institute of New Jersey, New Brunswick, NJ

10:45 a.m. 415. Prolonged Delivery of a P2X7R Antagonist using an Injectable Nanostructured Hydrogel Improves Bladder Function after SCI, I. K. Yazdi*, A. Munoz, N. Taghipour, T. B. Boone, E. Tasciotti, Houston Methodist Research Institute, Houston, TX

11:00 a.m. 416. Nanoparticle-engineered Adipose-derived Stem Cells Enhanced Migration towards Brain Tumors in vivo, X. Jiang*, C. Wang, F. Yang, Stanford University, Stanford, CA

11:15 a.m. 417. Click-Chemistry Customizable Polyhydroxyalkanoate Nanoparticles for Drug Delivery, R. A. Bader(1), P. M. Choiniere*(1), A. Levine(1), A. Pinto(2), C. T. Nomura(2), (1)Syracuse University, Syracuse, NY, (2)SUNY College of Environmental Science and Forestry, Syracuse, NY

11:30 a.m. 418. Avidity-Driven Targeting of a Novel Biohybrid Nanoscale Carrier Engineered for High Therapeutic Payload and Extended Release of Anticancer Drugs to Treat Small Cell Lung Cancer, R. J. Whitener*(1), K. A. Windham(1), J. Wower(1), M. E. Byrne(2), (1)Auburn University, Auburn, AL, (2)Rowan University, Glassboro, NJ

11:45 a.m. 419. Nanoparticle Delivery of a Highly Toxic Metal Chelator to Cancer Cells, Y. J. Kang*, C. Kuo, S. Majd, Penn State University, University Park, PA

12:00 p.m. 420. Implications Towards Targeted Delivery of Pentagalloyl Glucose for Regenerating Elastin in Emphysematous Lungs, V. Parasaram*, N. Nosoudi, N. Vyavahare, Clemson University, Clemson, SC

12:15 p.m. 421. Targeted Delivery of Antioxidant-loaded Biodegradable Nanoparticles for Neuroprotection, T. M. Brenza*(1), S. Ghaisas(1), J. Vela-Ramirez(1), B. Kalyanaraman(2), V. Anantharam(1), A. Kanthasamy(1), B. Narasimhan(1), (1)Iowa State University, Ames, IA, (2)Medical College of Wisconsin, Milwaukee, WI

Innate Immunity and Inflammation in Biomaterials Contexts

10:30 a.m. 422. Local IL-4 Delivery Increases Systemic Macrophage Trafficking and Prevents Bone-loss in a Mouse Model of Wear Particle Induced Osteolysis, J. Pajarinen*, T. Sato, T. Lin, F. Loi, R. Zhang, C. Fan, Z. Yao, S. Goodman, Department of Orthopaedic Surgery, Stanford University, Stanford, CA, USA, Stanford, CA

10:45 a.m.423. Degradation Kinetics Determine Intrinsic Immune Activity of Rapidly Degradable Polycations, J. I. Andorko*, C. M. Jewell, University of Maryland - College Park, College Park, MD

11:00 a.m. 424. Characterization of the Immune Response Associated with Bone Regeneration Induced by Fibrinogen Implants, D. M. Vasconcelos(1), C. R. Almeida*(1), R. M. Gonalves(1), I. Odila(1), M. I. Oliveira(1), N. Neves(1), A. M. Silva(1), A. C. Ribeiro(1), E. Seebach(2), K. L. Kynast(2), T. Niemietz(2), W. Richter(2), M. Lamghari(1), S. G. Santos(1), M. A. Barbosa(1), (1)INEB - Instituto de Engenharia Biomdica, Porto, Portugal, (2)Heidelberg University Hospital, Heidelberg, Germany

11:15 a.m. 425. Combining Human Monocytes in Co-culture with Vascular Smooth Muscle Cells Enhances Vascular Tissue Production under Biomechanical Stimulation, K. Battiston*(1), R. Labow(2), C. Simmons(1), P. Santerre(1), (1)University of Toronto, Toronto, ON, Canada, (2)University of Ottawa, Ottawa, ON, Canada

11:30 a.m. 426. PEEK Induces an Inflammatory Environment and Reduces Osteogenic Potential in Comparison to TiAlV, R. Olivares-Navarrete*(1), S. L. Hyzy(1), S. Ortman(2), P. J. Slosar(3), P. Ullrich, Jr.(4), Z. Schwartz(1), B. D. Boyan(1), (1)Virginia Commonwealth University, Richmond, VA, (2)Georgia Institute of Technology, Atlanta, GA, (3)SpineCare Medical Group, San Francisco Spine Institute, Daly City, CA, (4)TitanSpine, LLC, Mequon, WI

11:45 a.m. 427. Biomimetic Approaches for Tissue Healing and Restoration, E. Tasciotti*(1), F. Taraballi(1), B. Corradetti(1,2), S. Minardi(1,3), L. Pandolfi(1), F. J. Cabrera(1), C. Corbo(4), J. L. Van Eps(1,5), X. Wang(1), B. K. Weiner(5), (1)Houston Methodist Research Institute, Houston, TX, (2)Universit Politecnica delle Marche, houston, TX, (3)Department of Bioceramics and Bio-hybrid materials, National Research Council of Italy ISTEC, College of Materials Science and Optoelectronic technology, (4)IRCCS SDN-Foundation, houston, TX, (5)houston methodist Hospital, houston, TX

12:00 p.m. 428. Camouflaging PLGA microspheres in a 3D biomimetic collagen scaffold to escape macrophage internalization, S. Minardi*(1), B. Corradetti(2), F. Taraballi(2), S. Powell(2), M. Sandri(1), B. Weiner(2), A. Tampieri(1), E. Tasciotti(2), (1)National Research Council of Italy - ISTEC, Faenza, Italy, (2)Houston Methodist Research Institute, Houston, TX

12:15 p.m. 429. Extracellular Matrix Coatings Decrease the Foreign Body Response to Silicon Microelectrode Arrays Chronically Implanted in Rat Motor Cortex, R. S. Oakes*, M. D. Polei, J. L. Skousen, M. B. Christensen, P. A. Tresco, University of Utah, Salt Lake City, UT

Next Generation Biomaterial and Drug Delivery Technologies for Wound Healing

10:30 a.m. 430. Syndesome-Based Alginate Dressings for Enhanced Wound Healing in a Diabetic Mice Model, S. Das*(1), G. Singh(1), M. E. Martinez(1), A. K. Dunn(1), C. S. Wright(2), P. E. Martin(2), A. B. Baker(1), (1)University of Texas, Austin, Austin, TX, (2)Glasgow Caledonian University, Glasgow, United Kingdom

10:45 a.m. 431. Enzymatically-Responsive Delivery of Pro-Angiogenic Peptides for Therapeutic Vascularization, A. H. Van Hove*, D. S. W. Benoit, University of Rochester, Rochester, NY

11:00 a.m. 432. Intravenously-Administered Polymers for Modulating Clot Properties and Inducing Hemostasis, L. W. Chan*, X. Wang, H. Wei, L. D. Pozzo, N. J. White, S. H. Pun, University of Washington, Seattle, WA

11:15 a.m. 433. Microencapsulated Insulin-Producing Cells Accelerate Diabetic Wound Closure, A. Aijaz*, R. Faulknor, F. Berthiaume, R. Olabisi, A. Parekh, Rutgers University, Piscataway, NJ

11:30 a.m. 434. Chitosan Based Hydrogels for Delivering Oxygen and Sequestering Reactive Oxygen Species in Wound Healing, P. Patil*, N. D. Leipzig, N. Fountas-Davis, P. Joshi, H. Huang, L. Shriver, University of Akron, Akron, OH

11:45 a.m. 435. A Synergistic Polydiolcitrate-Copper Metal-Organic Framework Nanocomposite Improves Wound Healing, J. Xiao*, G. Ameer, Northwestern University, Evanston, IL

12:00 p.m. 436. MSC-Laden Anti-Inflammatory Hydrogel Improving Wound Healing of Diabetic Skin Ulcer, M. Xing*, U of Manitoba, Winnipeg, MB, Canada

12:15 p.m. 437. Mitigation of Hypertrophic Scar Contraction and Stiffening via an Elastomeric Biodegradable Scaffold, E. R. Lorden*(1), K. J. Miller(1), L. Bashirov(1), M. Ibrahim(1), E. Hammett(1), Y. Jung(2), M. A. Medina(1), A. Rastegarpour(1), M. A. Selim(1), K. W. Leong(3), H. Levinson(1), (1)Duke University, Durham, NC, (2)Korea Institute of Science and Technology, Seoul, Republic of Korea, (3)Columbia University, New York, NY

Panel Discussion: Progress and Challenges in Basic Science and Translation of Orthopaedic Biomaterial-Associated Infections

A Clinical Perspective on Infections Associated with Prosthesis-Related Infections , Rabih O. Darouiche

Tissue Engineering 2

10:30 a.m. 442. Hydrogel-Electrospun Mesh Composite for Prevention of Anastomosis Leakage, A. Kishan*(1), T. Touchet(1), C. Whitfield(2), N. Cohen(2), E. Cosgriff-Hernandez(3), (1)Texas A&M University, Houston, TX, (2)Texas A&M University College of Veterinary Medicine and Biomedical Sciences, College Station, TX, (3)Texas A&M University, College Station, TX

10:45 a.m. 443. A Biomaterial Strategy for Treatment of Ulcerative Colitis, T. J. Keane, Jr.*, S. F. Badylak, University of Pittsburgh, Pittsburgh, PA

11:00 a.m. 444. An Engineered Protein Hydrogel for Promoting Neurite Growth, K. J. Lampe*, C. M. Harris, University of Virginia, Charlottesville, VA

11:15 a.m. 445. 3D Printed Bone Scaffolds with Biomimetic Nanomaterials and Vascular Mimicking Microchannels, B. Holmes*, K. Bulusu, M. Plesniak, L. G. Zhang, The George Washington University, Washington, DC

11:30 a.m. 446. Isolating the Effect of Stiffness on Valvular Interstitial Cells and its Role in Phenotype Control, K. E. Coombs*, E. L. Hedberg-Dirk*, M. N. Rush, University of New Mexico, Albuquerque, NM

11:45 a.m. 447. A Bio-Inspired Hybrid Nanosack for Pancreatic Islet Transplantation in the Omentum, P. TJ Hwang*, D. Lim, S. Gilbert, L. Tian, A. Shalev, H. Jun, University of Alabama at Birmingham, Birmingham, AL

12:00 p.m. 448. Development of Surface Modified Polymeric Conduits for Nerve Regeneration, M. Uz*, A. D. Sharma, D. S. Sakaguchi, S. K. Mallapragada, Iowa State University, Ames, IA

12:15 p.m. 449. Engineering Tendons Using Adult Stem Cells Seeded in Mechanostimulated HUV, B. Engebretson, S. Bonhoure, Z. Mussett, V. Sikavitsas*, University of Oklahoma, Norman, OK

Vascular and Blood Cells Responses to Novel Cardiovascular Biomaterials

10:30 a.m. 450. Invited Speaker: Cationic Amphiphile-Modified Nano Surfaces Augment Regenerative ECM Repair by Vascular Smooth Muscle Cells, Anand Ramamurthi

11:00 a.m. 451. Surface Modified Poly(vinyl alcohol) Vascular Grafts Maintain Hemocompatibility, M. T. Hinds*(1), D. E. J. Anderson(1), M. F. A. Cutiongco(2), E. K. Yim(2), (1)Oregon Health & Science University, Portland, OR, (2)National University of Singapore, Singapore, Singapore

11:15 a.m. 452. Microgel-Based Materials for Augmentation of Hemostasis in Neonatal Cardiac Surgery Patients, A. C. Brown*(1), S. Saxena(1), K. Ahlstedt(1), B. Ahn(2), W. Lam(2), N. Guzzetta(2), T. H. Barker(1), A. Lyon(3), (1)Georgia Institute of Technology, Atlanta, GA, (2)Children's Healthcare of Atlanta/Emory University, Atlanta, GA, (3)Chapman University, Orange, CA

11:30 a.m. 453. Glypisomes: A Novel Construct for Enhancing Angiogenic Activity of Delivered Growth Factors, A. J. Monteforte*(1), B. Lam(1), S. Das(1), C. S. Wright(2), P. E. Martin(2), A. Dunn(1), A. B. Baker(1), (1)University of Texas at Austin, Austin, TX, (2)Glasgow Caledonian University, Glasgow, United Kingdom

11:45 a.m. 454. Interaction of Endothelial Cells and Smooth Muscle Cells with ePTFE and Electrospun PTFE, S. Lamichhane*(1), T. Remund(2), M. Larson(3), P. Kelly(4), G. Mani(5), (1)The University of South Dakota, Sioux Falls, SD, (2)Sanford Research, Sioux Falls, SD, (3)Augustana College, Sioux Falls, SD, (4)Sanford Vascular Associates, Sioux Falls, SD, (5)University of South Dakota, Sioux Falls, SD

12:00 p.m. 455. A Platelet-Inspired Nanomedicine Approach for Targeted Thrombolytic Therapy, C. Kos*(1), K. Ravichandran(2), W. Li(3), C. Modery-Pawlowski(1), A. Sen Gupta(1), (1)Case Western Reserve University, Cleveland, OH, (2)Hathaway Brown School, Westlake, OH, (3)The Cleveland Clinic Foundation, Cleveland, OH

12:15 p.m. 456. Contributions of Prekallikrein and High Molecular Weight Kininogen to the Intrinsic Pathway of Coagulation, Y. Yan*(1), A. Moyer(2), L. Xu(1), C. A. Siedlecki(1), (1)The Pennsylvania State University, College of Medicine, Hershey, PA, (2)Johns Hopkins University, Baltimore, MD