About

Design, Fabrication and Characterization of Multiscale and Multifunctional Biomaterials: The ability to engineer biomaterials at the molecular, micro and macro scales provides new opportunities to design and fabricate multiscale systems that can interact with cells and tissues by integrating physical, mechanical and chemical mechanisms. This session welcomes submissions focused on new design strategies for these types of biomaterials, novel fabrication approaches from the nano to micro to macro scales, and methods used to characterize cell and tissue response.

Abstracts

3:45 p.m. 363. Invited Speaker: Michael McAlpine, PhD
4:15 p.m. 365. Use of a Hierarchical Electrospun Scaffold to Mimic Ligament Structural Properties and Promote Collagen Deposition, H. M. Pauly*(1), K. C. Popat(1), D. J. Kelly(2), T. L. Haut Donahue(1), (1)Colorado State University, Fort Collins, CO, (2)Trinity College Dublin, Dublin, Ireland
4:30 p.m. 366. Synthesis and Characterization of Elastin-Like Polypeptide-Polyethyleneimine Block Copolymers for use in Coatings, J. Cobb*, A. V. Janorkar, University of Mississippi Medical Center, Jackson, MS
4:45 p.m. 367. Hydrophobic and Antimicrobial Peptide-coated Dentin for Long-lasting Dental Restorations, D. G. Moussa*, A. S. Fok, C. Aparicio, School of Dentistry, University of Minnesota, Minneapolis, MN
5:00 p.m. 368. Novel Fibrin Poly-Dopamine Composite Hydrogels for Marine Applications, A. Tyo*, H. Fisher, K. Hubbard, B. Lee, R. Rajachar, Michigan Technological University, Houghton, MI
5:15 p.m. 369. New Bio-inspired Oxime Crosslinked Hydrogels for Anti-postsurgical Cardiac Adhesions, M. Fujita*, H. T. Lam, R. L. Braden, M. M. Madani, K. L. Christman, University of California, San Diego, La Jolla, CA
5:30 p.m. 370. Chitosan-based Hydrogel containing Liposome-loaded Ricinoleic acid for Topical Applications, A. A. A. Nada*(1), J. Monsika(2), Z. Kronekova(2), R. James(3), S. Kumbar(3), (1)National Research Center, Cairo, Egypt, (2)Slovak Academy of Sciences, Bratislava, Slovakia, (3)University of Connecticut Health Center, Farmington, CT

Invited Speaker(s)

Michael McAlpine, PhD

Panel Discussion: Ethical Challenges and Issues in Biomaterials Research, Development and Practice

Invited Speaker(s)

Frederick J. Schoen, MD, PhD
Nicholas Ziats, PhD
Jack Lemons, PhD
Peter Edelman, PhD
Stuart Goodman, MD, PhD

*BTI* Commercialization of Biomaterials and Medical Products

About

Commercialization of Biomaterials and Medical Products: The presentations in this symposium highlight recent advances and challenges in commercialization of biomaterials and medical devices from innovation to protection of intellectual property, fund raising mechanisms for product research and development, regulatory process for technical and clinical evaluation of biomaterials, and business models for commercialization of biomedical devices. This symposium covers fundamental concepts in commercialization of medical devices as well as the development and commercialization of novel biomaterials for tissue engineering and drug delivery.

Abstracts

3:45 p.m. 323. Invited Speaker: Anthony Ratcliffe, PhD
4:15 p.m. 325. Invited Speaker: Flagg Flanagan, PhD
4:30 p.m. 326. ,
4:45 p.m. 327. Development of a Sprayable Biopolymer Hydrogel for the Prevention of Postoperative Adhesions, L. Costella(1), M. Patterson(1), B. Janet(1), P. Cottler(2), C. Tison*(1), (1)Luna Innovations Incorporated, Charlottesville, VA, (2)University of Virginia, Charlottesville, VA
5:00 p.m. 328. Comparative Osteoinductive Characteristics of Silicon Nitride, Alumina, and Titanium, G. Pezzotti(1), A. Rondinella(1), E. Marin(1), W. Zhu(1), T. Adachi(2), R. M. Bock(3), B. J. McEntire*(3), B. S. Bal(4), (1)Kyoto institute of Technology, Kyoto, Japan, (2)Kyoto Prefectural University, Kyoto, Japan, (3)Amedica Corporation, Salt Lake City,
5:15 p.m. 329. Dynamic, Reversible 3D Cell Culture Matrices, K. Stipe*, M. Serban, B. Serban, University of Montana, Missoula, MT
5:30 p.m. 330. Exploitation of Biomarkers for Triggered Delivery of Therapeutics from Infection-Responsive Coating Technology, N. J. Irwin*, C. P. McCoy, S. P. Gorman, D. S. Jones, Queen's University Belfast, Belfast, United Kingdom

Invited Speaker(s)

Flagg Flanagan, PhD
Anthony Ratcliffe, PhD

Thought Leader Symposium - Anna Belu, PhD & Nathan Lockwood, PhD: Industrial applications of biosurface modification and analysis

About

This session will provide a broad overview of coating and modification technologies currently being used in the medical device industry to control the surface of medical devices. It will also address the critical need to characterize and understand the materials properties at the surface of medical devices. The properties and the resulting performance of medical devices are largely controlled by the bulk of the material, however, it is the surfaces of medical device materials that dominate the interaction between the device and the body. The speakers, all from industry, will give examples of surface modification to enhance the performance of the devices, e.g. affect the biological response, prevent infection, enhance lubricity. The speakers will also address the safety and regulatory aspects of medical device surface modification, and tools required for nanoscale characterization of devices.

Abstracts

Susan Rea Peterson, Medtronic, “Coatings and Surface Modification Techniques for Medical Devices”
Nathan Lockwood, Surmodics, "Characterization of lubricious coatings for medical devices"
Lise Maloney, Sciessent, "Antimicrobial surfaces in medical devices"
Jeff Hendricks, Biotectix, "Conductive coatings and characterization"
Paul Gunning, Smith & Nephew, "Surface Imaging and Spectroscopy of Medical Devices"

Invited Speaker(s)

Susan Rea Peterson, PhD
Nathan Lockwood, PhD
Lise Maloney, PhD
Jeff Hendricks, PhD
Paul Gunning, PhD

Acellular Biomaterials for Myocardial Repair 2

About

Acellular biomaterials for myocardial repair: Using biomaterials without exogenous cells for myocardial repair has attracted great attention in the past several years largely due to their high translational potential. These biomaterials are designed to possess one or more of the following functions: provide mechanical support to the damaged hearts, prevent cardiac extracellular matrix from degradation by upregulated MMPs, recruit endogenous cells for regeneration, stimulate vascularization in the infarcted area, control inflammation to promote survival of cardiac cells, and decrease cardiac fibrosis. These biomaterials include injectable hydrogels, microspheres, nanoparticles, and 3D scaffolds. The injectable hydrogels, microspheres, and nanoparticles can be delivered to the infarcted hearts by localized injection after open chest surgery, catheter-based injection, or intravenous injection. Acellular 3D scaffolds can be patched on the infarcted heart surface. The biomaterials alone or in combination with drugs, genes, peptides, and growth factors have been used to promote cardiac repair. This symposium will allow presenters to share their current advances in using acellular biomaterials for cardiac repair.

Abstracts

3:45 p.m. 331. Complex coacervate loaded with proteins for greater functional recovery post-MI, Y. Wang*, University of Pittsburgh, pittsburgh, PA
4:00 p.m. 332. Silk-ECM Composite Patches Ameliorate Left Ventricular Remodeling Following Myocardial Infarction, W. L. Stoppel*(1), K. E. Sullivan(2), J. M. Grasman(1), D. L. Kaplan(1), L. D. Black(1), (1)Tufts University, Medford, MA, (2)Amgen Inc, Cambridge, MA
4:15 p.m. 333. An Injectable and Thermosensitive Hydrogel Capable of Dual Delivering Matrix Metalloproteinase-2 Inhibitor and Basic Fibroblast Growth Factor to Preserve and Vascularize Cardiac ECM after Myocardial Infarction, Z. Fan, M. Fu, J. Guan*, The Ohio State University, Columbus, OH
4:30 p.m. 334. Targeting exosomes to myocardial infarction improves cardiac regeneration following ischemia/reperfusion injury, A. Vandergriff*(1,2), K. Huang(2), J. Tang(2), M. T. Hensley(2), J. A. Piedrahita(2), T. G. Caranasos(1), K. Cheng(2), (1)University of North Carolina at Chapel Hill, Raleigh, NC, (2)North Carolina State University, Raleigh, NC
4:45 p.m. 335. Myocardial Scaffold-Based Cardiac Tissue Engineering, J. Liao*(1), B. Wang(2), G. Zhang(3), (1)University of Texas at Arlington, Arlington, TX, (2)Alabama State University, Montgomery, AL, (3)University of Akron, Akron, OH
5:00 p.m. 336. Biodegradable polyurethane cardiac patch mechanically matching with native myocardium, C. Xu*, Y. Huang, J. Wu, J. Liao, L. Tang, Y. Hong, University of Texas at Arlington, Arlington, TX
5:15 p.m. 337. Decellularization of porcine carotid arteries for tissue engineering, A. M. Hassanbhai*, F. Wen, H. H. Lim, S. H. Teoh, Nanyang Technological University, Singapore
5:30 p.m. 338. Porous injectable bio-hybrid hydrogels facilitate cell infiltration and pro-M2 macrophage polarization, Y. Zhu*, H. Jiang, J. L. Dziki, S. T. LoPresti, L. Huleihel, G. F. Nogueira, L. C. Fuhrman, S. F. Badylak, W. R. Wagner, University of Pittsburgh, Pittsburgh, PA

Invited Speaker(s)

Yadong Wang, PhD

Advances in Antimicrobial Biomaterials

About

Advances in Antimicrobial Biomaterials: Antimicrobial resistance and lack in development of new classes of antimicrobial therapeutics have made it increasingly difficult to treat microbial infections. There is an immediate need to engineer advanced antimicrobial therapeutics, delivery systems, and materials that can rapidly and effectively treat infections, while helping to control the spread of resistance. This session will focus on the development and application of these advanced antimicrobial biomaterials targeting bacterial, fungal, viral, and biofilm-associated infections. Topics of interest include, but are not limited to: antimicrobial surfaces and device coatings, novel antimicrobial molecules and macromolecules, antimicrobial nano- and micro-particles, and triggered, targeted, and responsive antimicrobial delivery systems. Research in the design, synthesis, characterization, testing, and translation of these antimicrobial materials will be discussed.

Abstracts

3:45 p.m. 339. Dry powder inhalable bacteriophage-polymeric particles reduce lung cystic fibrosis bacterial infections, R. Agarwal*(1), C. T. Johnson(1), B. R. Imhoff(2), R. M. Donlan(3), N. A. McCarty(2), A. J. Garcia(1), (1)Georgia Institute of Technology, Atlanta, GA, (2)Emory University, Atlanta, GA, (3)Centers for Disease Control and Prevention, Atlanta, GA
4:00 p.m. 340. PEG Bottle Brush Copolymers for Lysis of Microbial Membrane Mimics by Entropic Templating, A. L. Garle*, B. M. Budhlall, University of Massachusetts, Lowell, MA
4:15 p.m. 341. Antimicrobial Smart Materials: From Responsive Hydrogels to Polymer-Drug Conjugates, A. Shukla*, Brown University, Providence, RI
4:30 p.m. 342. Effects of Quaternized Chitosan on Biofilm Eradication and Prevention, W. Lv*(1), Y. Sun(2), Y. Deng(1), (1)University of South Dakota, Sioux Falls, SD, (2)University of Massachusetts Lowell, Lowell, MA
4:45 p.m. 343. Lysostaphin and BMP-2 Co-delivery Reduces S. aureus Infection and Repairs Bone in a Mouse Model of Bone Repair, C. T. Johnson*, A. J. García, Georgia Institute of Technology, Atlanta, GA
5:00 p.m. 344. Nano-textured magnesium oxide microrods: the optimization of antimicrobial activity and the utilization in polymer-based implant coatings, N. Anicic*, M. Vukomanovic, D. Suvorov, Jozef Stefan Institute, Ljubljana, Slovenia
5:15 p.m. 345. Bacterial Adhesion on Dual Functionalized Biomaterial Surfaces with Texturing and Nitric Oxide Release, L.-C. Xu*(1), Y. Wo(2), M. E. Meyerhoff(2), C. A. Siedlecki(1), (1)The Pennsylvania State University, College of Medicine, Hershey, PA, (2)University of Michigan, Ann Arbor, MI
5:30 p.m. 346. Calcium fluoride coating with biocompatible and anti-bacterial effect on Ti by e-beam deposition for dental implant application, K. Cheon*(1), S. Kim(1), J. Song(2), S.-M. Kim(1), H.-E. Kim(1), (1)Seoul National University, Seoul, Republic of Korea, (2)Nanyang Technological University, Nanyang, Singapore

Biomaterials for Regenerative Engineering 2

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Biomaterials for Regenerative Engineering: Regenerative engineering aims to develop functional, bioactive, and instructive biomaterials for regeneration of damaged or injured tissues. Bioactivity can be engineered into biomaterials by functionalization with proteins, peptides, small molecules as well as by biophysical cues such as surface topography or alignment. This symposium will highlight recent trends in development of bioactive biomaterials that play active role in controlling cellular behaviors such as growth, alignment and differentiation. We will include different classes of biomaterials such as proteins, polysaccharides, synthetic polymers, fibers, metals, ceramics, and hydrogels for applications in regenerative tissue engineering. Translational strategies for taking these biomaterials from ‘Bench to Bedside’ will also be discussed during the symposium.

Abstracts

3:45 p.m. 347. A Bio-inspired Hybrid Nanosack to Enhance Islet Engraftment in the Omentum, P. Hwang*(1), D.-J. Lim(1), G. Alexander(1), A. Shalev(1), W. Cui(2), S. Gilbert(1), H.-W. Jun(1), (1)University of Alabama at Birmingham, Birmingham, AL, (2)Medstar Georgetown Hospital, Washington, DC
4:00 p.m. 348. Utility of VEGF mimetic QK Peptide in a Novel Library of Injectable Hydrogels to Promote Vascularization, M. Nikkhah*, A. Pal, S. Nagaraju, B. Vernon, Arizona State University, Tempe, AZ
4:15 p.m. 349. Chondrogenic Potential of Microspheres Encapsulating Decellularized Chondral Extracellular Matrix and their Incorporation in 3D Printed Scaffolds for the Treatment of Large Osteochondral Defects, P. Ghosh*(1), S. Gruber(2), C.-Y. J. Lin(2), P. W. Whitlock(1), (1)Cincinnati Children`s Hospital Medical Center, Cincinnati, OH, (2)University of Cincinnati, Cincinnati, Cincinnati, OH
4:30 p.m. 350. Bioactive Silk Biomaterials for Regenerative Engineering, M. Wöltje*(1), R. Brünler(1), S. Neuss(2), D. Aibibu(1), C. Cherif(1), (1)Technical University Dresden, Dresden, Germany, (2)RWTH Aachen University, Aachen, Germany
4:45 p.m. 351. Synthesis and Characterization of Interconnected Macroporous Fibrin/PEG-based Semi-Interpenetrating Polymer Networks for Dermal Tissue Engineering, O. Gsib*, Université de Technologie of Compiègne, Compiègne, France
5:00 p.m. 352. Promoting bioactive hydroxyapatite nucleation on modified polyurethane by adopting glycerol phosphate, E.-H. Song*, S.-H. Jeong, K.-I. Cho, H.-E. Kim, Seoul National University, Seoul, Republic of Korea
5:15 p.m. 353. ‘Easy Access cells’ for Intra-Operative Preparation of Cell-based Bone Regenerative Constructs, J. JJP. van den Beucken*(1), Y. Zhang(1), E.-C. Grosfeld(1), W. A. Camargo(1), H. Tang(1), A. MP. Magri(2), A. C. Renno(2), (1)Radboudumc, Nijmegen, Netherlands, (2)Federal University of São Paulo, Sao Paulo, Brazil
5:30 p.m. 354. Paper-Based Engineered Biomaterials, G. Camci-Unal*, University of Massachusetts Lowell, Lowell, MA

Biomaterials for Therapeutic Drug Delivery 3

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Biomaterials for Therapeutic Drug Delivery: Controlled release approaches have the potential to effectively treat a variety of medical conditions, while avoiding complications such as off-site toxicity and drug-resistance. Approaches can include localized, depot-based methods as well as targeted, systemic treatments. Controlled drug delivery can result from affinity interactions, bond cleavage, reservoir or diffusion-based control, and/or stimulus-responsive methodologies. This session will focus on the development of these drug delivery systems, which include nano and microparticles, hydrogels, scaffolds, and thin films, for applications including but not limited to regenerative medicine/tissue engineering, cancer treatments, microbial infections, autoimmune diseases, etc.

Abstracts

3:45 p.m. 355. Systemic Delivery of Gli-inhibitor via ROS-responsive and Bone-Targeted Polymeric Nanocarriers Blocks Tumor Invasion to Bone, J. Vanderburgh*, K. Kwakwa, A. Merkel, T. Werfel, C. Duvall, J. Sterling, S. Guelcher, Vanderbilt University, Nashville, TN
4:00 p.m. 356. Tracking siRNA-treated submandibular gland cell fate and function via co-delivery of 4-hydroxytamoxifen, J. J. Varghese*, M. E. Hansen, C. E. Ovitt, D. S. W. Benoit, University of Rochester, Rochester, NY
4:15 p.m. 357. Nitric Oxide Releasing Fibrin Degradation Products for Incorporation into Injectable PEG-Fibrinogen Hydrogels, B. M. Spalding*, A. Tyo, A. Francis, C. McCarthy, B. P. Lee, R. R. Rajachar, Michigan Technological University, Houghton, MI
4:30 p.m. 358. Nitric Oxide Releasing Nanomatrix for Dialysis Fistula Maturation Enhancement, P. Hwang*(1), G. Alexander(2), M. Somarathna(2), M. Collier(2), B. Brott(1), J. Pollock(2), T. Lee(2), H.-W. Jun(1), (1)Endomimetics, LLC, Birmingham, AL, (2)University of Alabama at Birmingham, Birmingham, AL
4:45 p.m. 359. Locally administered lovastatin-encapsulating poly(lactic-co-glycolic) acid nanoparticles protect against experimental autoimmune neuritis, K. A. Langert*(1), E. B. Stubbs(2), E. M. Brey(1), (1)Illinois Institute of Technology, Chicago, IL, (2)Edward Hines Jr. VA Hospital, Hines, IL
5:00 p.m. 360. Rolipram-loaded polymeric micelle reduces inflammatory response and apoptosis in rat spinal cord, C. Macks*(1), SJ. Gwak(2), M. Lynn(3), JS. Lee(2), (1)Clemson University, Clemson, SC, (2)Clemson University, Greenville, SC, (3)Greenville Hospital System, Greenville, SC
5:15 p.m. 361. Phospholipid Coatings Release Active Concentrations of Antibiotic and Biofilm Inhibitor, M. Harris*, L. Pace, J. A. Jennings, University of Memphis, Memphis, TN
5:30 p.m. 362. Controlled Release of Antibiotic from Synthetic Porous Scaffolds for Application in Gingival Tissue Engineering, M. E. E. Wright*, Y. Delaviz, J. P. Santerre, University of Toronto, Toronto, ON

Design, Fabrication and Characterization of Multiscale and Multifunctional Biomaterials 2

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Abstracts

Invited Speaker(s)

Panel Discussion: Ethical Challenges and Issues in Biomaterials Research, Development and Practice

Invited Speaker(s)

BTI Commercialization of Biomaterials and Medical Products

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Abstracts

Invited Speaker(s)

Thought Leader Symposium - Anna Belu, PhD & Nathan Lockwood, PhD: Industrial applications of biosurface modification and analysis

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Abstracts

Invited Speaker(s)

Acellular Biomaterials for Myocardial Repair 2

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Abstracts

Invited Speaker(s)

Advances in Antimicrobial Biomaterials

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Abstracts

Biomaterials for Regenerative Engineering 2

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Abstracts

Biomaterials for Therapeutic Drug Delivery 3

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Abstracts