Bioengineering 3D Tissues for In Vitro Disease Modeling and Pulmonary Applications

Timeslot: Wednesday, April 3, 2019 - 1:00pm to 3:00pm
Track: Tissue Engineering and Regenerative Medicine
Room: Chelan 2

About

An understanding of the cellular and molecular mechanisms of human disease leading to the development of innovative therapies is a primary research goal. A barrier to understanding the disease microenvironment is the lack of a realistic tissue model for the long-term study of disease mechanisms. Two-dimensional culture systems are a widely used model for the studies on disease progression and preclinical drug assessments., however, they fail to reproduce the in-vivo disease microenvironment and the data produced are not always predictive. Advances in 3D printing and new biomaterial design may offer the potential to create in vitro tissue models that mimic the in vivo disease microenvironment. Such disease models can be used to investigate mechanisms of disease progression, for drug development and toxicology testing, and can eliminate the need for animal experimentation. The focus of this symposium will be on 3D printing technologies, biomaterial and bioink development and the opportunities and challenges leading to the development of models for cancer as well as orthopedic, vascular, and pulmonary diseases.

Abstracts

  • 1:00:00 PM 49. 3D Printing of Cell Spheroids Within Self-healing Hydrogels, A. Daly*, M. Davidson, K.H. Song, J. Burdick; University of Pennsylvania, Philadelphia, PA, USA

  • 1:15:00 PM 50. An Osteocyte 3D Culture System to Study Osteochondral Strains and Fluid Flow in an ex vivo Model, R. Wilmoth*, A. Aziz, A. Uzcategui, V. Ferguson, S. Bryant; University of Colorado Boulder, Boulder, CO, USA

  • 1:30:00 PM 51. Multiscale Modeling of Vascular Pathophysiology Using 3D Bioprinting, K. Gold*, A. Gaharwar, A. Jain, R. Dedas, T. Snell, N. Pandian; Texas A&M University, College Station, TX, USA

  • 1:45:00 PM 52. 3D Printing Unmodified Hydrogels Using Rail-Based Open Microfluidics, J. Day*(1), U. Lee(1), A. Haack(1), W. Lu(1), A. Theberge(1,2), E. Berthier(1,2,3,4); (1)University of Washington, Seattle, WA, USA, (2)Stacks to the Future, LLC, Madison, WI, USA, (3)Tasso, Inc., Seattle, WA, USA, (4)Salus Discovery, LLC, Madison, WI, US

  • 2:00:00 PM 53. Engineering an in vitro Model of Ductal Carcinoma In Situ Using FRESH 3D Bioprinting, J. Tashman*(1), T. Hinton(1), D. Brown(2), D. Shiwarski(1), A. Lee(1), A. Hudson(1), A. Lee(2), A. Feinberg(1); (1)Carnegie Mellon University, Pittsburgh, PA, USA, (2)University of Pittsburgh, Pittsburgh, PA, USA

  • 2:15:00 PM 54. Lung Extracellular Matrix Hydrogels for Mesenchymal Stem Cells 3D Bioprinting, J. Otero*(1,2), B. Falcones(1), E. Marhuenda(1,2,3), I. Almendros(1,2,4), D. Navajas(1,2,3), R. Farre(1,2,4); (1)Universitat de Barcelona, Barcelona, Spain, (2)CIBER for Respiratory Diseases, Madrid, Spain, (3)Institute for Bioengineering of Catalonia, Ba

  • 2:30:00 PM 55. The Role of ECM Composition in Bioengineered Lung Barrier Formation, R. Heise*(1), B. Young(1), K. Shankar(1), R. Pouliot(2), D. Weiss(2); (1)Virginia Commonwealth University, Richmond, VA, USA, (2)University of Vermont, Burlington, VT, USA

  • 2:45:00 PM 56. Bottom-up Strategies for Engineering Distal Lung Structure in vitro, N. Darling*(1), T. D'ovidio(1), C. Magin(1,2); (1)University of Colorado at Anschutz Medical Campus, Aurora, CO, USA, (2)University of Colorado at Denver, Aurora, CO, USA

Cardiovascular Biomaterials and Blood Compatibility

Timeslot: Wednesday, April 3, 2019 - 1:00pm to 3:00pm
Track: Cardiovascular Biomaterials
Room: Yakima 2

About

Thrombosis is often a major concern with cardiovascular medical devices such as stents, vascular grafts, heart valves, pacemakers, defibrillators, ventricular assist devices, cardiopulmonary bypass, and artificial heart. Although significant progress has been made in developing and using a wide variety of metallic, polymeric, ceramic, and natural biomaterials for making cardiovascular medical devices, still the blood compatibility of these devices remains an issue. This general session will focus on (i) recent developments in cardiovascular biomaterials for improving blood compatibility; (ii) the development of novel biomaterials for applications in cardiovascular medical devices; (iii) novel coatings and surface modification technologies for improving blood compatibility; (iv) in vitro and in vivo evaluation of blood compatibility of biomaterials; (v) clinical evaluation of cardiovascular medical devices; (vi) novel approaches to improve endothelialization of cardiovascular implants and devices; (vii) interactions of vascular cells with biomaterials

Abstracts

  • 1:00:00 PM 29. Prevention of Acute Venous Stent-induced Thrombosis Using Inhibition of FXII, M. Hinds*(1), K. Nguyen(1), M. Wallisch(1,2), J. Johnson(1), A. Gruber(1,2); (1)Oregon Health & Science University, Portland, OR, USA, (1)Oregon Health & Science Unversity, Portland, OR, USA, (2)Aronora, Inc., Portland, OR, USA

  • 1:15:00 PM 30. In vitro Dynamic Thrombogenicity Testing of Biomaterials: Impact of Test Sample Length and Flow Loop Configuration, M. Jamiolkowski*, M. Golding, R. Malinauskas, Q. Lu; US Food and Drug Administration, Silver Spring, MD, USA

  • 1:30:00 PM 31. Inorganic Polymerization for Crosslinking Porcine Pericardium as Bioprosthetic Heart Valves with Improved Extracellular Matrix Stability and Biocompatibility, G. Guo*, L. Jin, W. Jin, Y. Lei, Y. Wang; National Engineering Research Center for Biomaterials, Chengdu, China

  • 1:45:00 PM 32. Correlating Thrombus Constituents of Surface-Modified Vascular Graft Materials to Luminal Volume Using MicroCT to Better Quantify Clinical Functionality, D. Anderson*, A. Gupta, M. Hinds; Oregon Health & Science University, Portland, OR, USA

  • 2:00:00 PM 33. Enhanced Biocompatibility of Stents via CD47 Surface Functionalization, V. Inamdar*, E. Fitzpatrick, I. Alferiev, C. Nagaswami, R. Levy, I. Fishbein, S. Stachelek; Children's Hospital of Philadelphia, Philadelphia, PA, USA

  • 2:15:00 PM 34. Biodegradable, Elastic Polyurethane with Enhanced Anti-Thrombogenicity as Blood-Contacting Biomaterials, C. Xu*(1,2), A.E. Kuriakose(1,2), D. Truong(1,2), P. Punnakitikashem(1,2), K.T. Nguyen(1,2), Y. Hong(1,2); (1)University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA, (2)University of Texas at Arlington, Arlington, Arlington, TX, USA

  • 2:30:00 PM 35. Engineering Ubx-based Materials to Promote and Guide Neovascularization, G. Geraldo Mendes*, D. Howell, S.-P. Tsai, K. Bayless, S. Bondos; Texas A&M Health Science Center, College Station, TX, USA

  • 2:45:00 PM 36. Sustained Release of Synthetic Glycopolymers for Enhanced Endothelialization of Electrospun Scaffolds, S. Jiang*, J. Wu, Y. Hang, Q. Liu, D. Li, H. Chen; State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, Suzhou, China

Engineered Biomaterials for Neural Applications 1

Timeslot: Wednesday, April 3, 2019 - 1:00pm to 3:00pm
Track: Sensory Biomaterials and Tissues
Room: Chelan 4

About

Researchers are constantly developing and applying new biomaterials to challenging problems of the peripheral and central nervous systems. Engineered biomaterials are uniquely positioned for use in creating, testing, and regenerating neural tissue for better in vitro models of injury and disease, therapeutic treatments, understanding neural development, and mapping the brain. This session will focus on cutting edge research in neural biomaterials including fundamental material development through pre-clinical studies. These include big questions surrounding diseases and injuries spanning neurons, astrocytes, oligodendrocytes, microglia, and Schwann cells. Presentations will be highly interdisciplinary at the interfaces of biology, chemistry, materials science, engineering, and neuroscience. Target applications of these materials include neural injury, neurodegenerative diseases, stroke, diagnostics, brain-machine interfaces, and brain cancer.

Abstracts

  • 1:00:00 PM 41. Invited Speaker

  • 1:30:00 PM 43. Nanoparticle Delivery Precision Based on Sex-dependent Opening of the Blood-brain Barrier after Brain Injury, V. Bharadwaj*(1), C. Copeland(1), T. Anderson(2), J. Lifshitz(2,3), V. Kodibagkar(1), S. Stabenfeldt(1); (1)Arizona State University, Tempe, AZ, USA, (2)University of Arizona, College of Medicine-Phoenix, Phoenix, AZ, USA, (3)Barrow Neurological Institute

  • 1:45:00 PM 44. Effect of HA Scaffolds on Transplantation of V2a Interneurons and Neural Progenitors after Spinal Cord Injury, S. Sakiyama-Elbert*(1), R. Thompson(1,2), L. Zholudeva(3), M. Lane(3); (1)The University of Texas at Austin, Austin, TX, USA, (2)Washington University, St. Louis, MO, USA, (3)Drexel University, Philadelphia, PA, USA

  • 2:00:00 PM 45. Rapidly Assembling Pentapeptides for Injectable Delivery (RAPID) Hydrogels as Cytocompatible Cell Carriers, J. Tang*, K. Lampe; University of Virginia, Charlottesville, VA, USA

  • 2:15:00 PM 46. An Anti-Inflammatory Nanoscaffold for Enhanced Stem Cell Transplantation and Neuronal Differentiation Post-Spinal Cord Injury, L. Yang*(1), S. Cerqueira(2), J. Lee(2), K.-B. Lee(1); (1)Rutgers, the State University of New Jersey, Piscataway, NJ, USA, (2)The Miami Project to Cure Paralysis, University of Miami, Miami, FL, USA

  • 2:30:00 PM 47. 3D Graphene Oxide Scaffolds as Pro-Regenerative Biomaterials in the Rat Injured Spinal Cord, M. Serrano*(1), A. Domínguez-Bajo(1), A. González-Mayorga(2), E. López-Dolado(2,3); (1)Instituto de Ciencia de Materiales de Madrid, Consejo Superior de Investigaciones Científicas, Madrid, Spain, (2)Hospital Nacional de Parapléjicos, Servicio de Salud de

  • 2:45:00 PM 48. Particle Hydrogels Lead to Decrease in Gliosis and Promote Axon and Vessel Formation After Stroke, E. Sideris*(1), S. Carmichael(1), T. Segura(2); (1)University of California, Los Angeles, Los Angeles, CA, USA, (2)Duke, Durham, NC, USA

Invited Speaker(s)

From Bench-to-Bedside: Translating Biomaterials Research *BTI* 1

Timeslot: Wednesday, April 3, 2019 - 1:00pm to 3:00pm
Track: Industry
Room: Yakima 1

About

The session will provide a podium for industry researchers developing innovative biomaterials-based technologies to give the audience perspective on the development process through specific examples. Special emphasis will be placed on the emerging field of Intracochlear Drug and Cell Delivery including an invited presentation that will provide an overview of the physio local barriers to such therapies.

Abstracts

  • 1:00:00 PM 21. Invited Speaker: Recent Advances in Overcoming the Barriers to Intracochlear Drug and Cell Delivery Technologies, Verena Scheper, DVM, PhD, Hannover Medical School

  • 1:30:00 PM 23. Lab-on-a-Printer™ - 3D Bioprinting Technology Enabling Functional Human Tissues on Demand, T. Mohamed, C. Dickman, V. Russo, K. Thain, S. Pan, M.K. Khan, E. Käpylä*, S. Beyer, S. Wadsworth; Aspect Biosystems, Vancouver, BC, Canada

  • 1:45:00 PM 24. Translational Focus Design for New Tissue Adhesive Technologies, G. Munoz Taboada*(1), N. Artzi(2,3); (1)BioDevek Inc., Cambridge, MA, USA, (2)Brigham and Women’s Hospital, Cambridge, MA, USA, (3)Massachusetts Institute of Technology, Cambridge, MA, USA

  • 2:00:00 PM 25. Distribution and retention of neurotrophin-3 in cochlea, Q.-Y. Hu*(1), R. Richardson(2), A. Wise(2), R. Stewart(3), J. Lee(1), F. Shi(1); (1)Decibel Therapeutics, Boston, MA, USA, (2)Bionics Institute, Melbourne, Australia, (3)InviCro, Boston, MA, USA

  • 2:15:00 PM 26. Delivery of Bone-Binding Brain-Derived Neurotrophic Factor (BDNF) Analogue Ris-DHF Supports Hearing Recovery After Noise Damage in vivo, D. Jung*(1), J. Kempfle(1), C. Hamadani(1), K. Nguyen(2), B. Kashemirov(2), A. Zhang(1), C. McKenna(2); (1)Mass Eye and Ear, Boston, MA, USA, (2)USC, Los Angeles, CA, USA

  • 2:30:00 PM 27. Bioresorbable Poly(glycerol sebacate) Coated Polyglycolide Textile as a Regenerative Carotid Arterial Patch, R. Smalley*, S. Lu, A. Weber, A. Metzger, J. Harris, P. Gabriele; The Secant Group, LLC, Telford, PA, USA

  • 2:45:00 PM 28. Bench to Bedside: Quantum Dot Probes for Clinical Flow Cytometry, J. Winter*(1,2); (1)Core Quantum Technologies, Columbus, OH, USA, (2)The Ohio State University, Columbus, OH, USA

Invited Speaker(s)

Nanomaterials for Therapeutic Delivery

Timeslot: Wednesday, April 3, 2019 - 1:00pm to 3:00pm
Track: Therapeutic Delivery
Room: Skagit 3

About

Efficient delivery of therapeutics (including small or macromolecular drugs, biomolecules such as proteins or nucleotides, or engineered cells) is important to stimulate repair or regeneration of damaged or diseased tissues. Synthetic nanoengineered materials can be tailored for therapeutic delivery to cells and tissues for a range of biomedical applications. By modulating the physiochemical characteristics of nanomaterials, we can customize therapeutic efficacy, cellular internalization, biodistribution, and in vivo retention. This session will focus on emerging approaches to the design advanced nanomaterials for therapeutic delivery. These multidisciplinary approaches include modifications of synthetic and natural polymers with variety of chemistries, including click chemistry or supramolecular chemistries. Of special interest to this session are nanoscale engineered solutions for delivery of small and macro-molecule drugs, large therapeutic proteins and nucleotides for applications in regenerative medicine, stem cell engineering, immune modulation, antimicrobial, cardiovascular diseases and cancer therapeutics (in addition to the interactions of these nanoscale therapeutics in the body).

Abstracts

  • 1:00:00 PM 5. DNA Caged-Micelle Erasable Labels for Multiplexed Immunohistochemistry, J. Winter*(1,2), E. Jergens(1), Y. Cui(2); (1)Ohio State University, Columbus, OH, USA, (2)The Ohio State University, Columbus, OH, USA

  • 1:30:00 PM 7. Genetically Encoded Photocleavable Linkers for Protein Release from Biomaterials, J. Shadish*, A. Strange, C. DeForest; University of Washington, Seattle, WA, USA

  • 1:45:00 PM 8. Using Click Chemistry to Target and Refill Drug-Eluting Depots, Y. Brudno*; University of North Carolina - Chapel Hill and North Carolina State University - Raleigh, Raleigh, NC, USA

  • 2:00:00 PM 9. Designer Excipients Enable Oral Delivery of Poorly Soluble Drugs, J. Ting*(1), F. Bates(2), T. Reineke(2); (1)University of Chicago, Chicago, IL, USA, (2)University of Minnesota, Minneapolis, MN, USA

  • 2:15:00 PM 10. IR820-Loaded PLGA Nanoparticles for Photothermal Therapy of Triple-Negative Breast Cancer, E. Day*, D. Valcourt, M. Dang; University of Delaware, Newark, DE, USA

  • 2:30:00 PM 11. Effects of Nanometal Incorporation on Platelet-like Particle Properties and Antimicrobial Activity, E. Chee*(1), S. Nandi(1,2), E. Sproul(1,2), A. Brown(1,2); (1)Joint Department of Biomedical Engineering of University of North Carolina-Chapel Hill and North Carolina State University, Raleigh, NC, USA, (2)Comparative Medicine Institute, Raleigh, NC, USA

  • 2:45:00 PM 12. The Role of Activation in Macrophage Phagocytosis and Exocytosis of Oligonucleotide Nanoformulations, E. Wayne*, C. Long, A. Kabanov; University of North Carolina-Chapel Hill, Chapel Hill, NC, USA

Orthopedic Biomaterials SIG 1

Timeslot: Wednesday, April 3, 2019 - 1:00pm to 3:00pm
Track: Musculoskeletal and Craniofacial Biomaterials
Room: Skagit 4/5

Abstracts

  • 1:00:00 PM 13. Invited Speaker: Malcolm Xing, PhD

  • 1:30:00 PM 15. Composite Hydrogels and Their Mechanisms to Inhibit Matrix Mineralization by Hypertrophic Chondrocytes, J. Chen*, A. Donius, J. Taboas; University of Pittsburgh, Pittsburgh, PA, USA

  • 1:45:00 PM 16. Compliant Interfaces and Fretting Corrosion in Modular Taper Junctions: The Micromechanics of Contact, S. Smith*, J. Gilbert; Clemson University, Charleston, SC, USA

  • 2:00:00 PM 17. Injectable Sulfonated Methylcellulose Hydrogels for Growth Factor Sequestration and Nucleus Pulposus Repair, N. Haq-Siddiqi*(1), K. Bunde(1), W. Nnadi(1), J. Iatridis(2), S. Nicoll(1); (1)City College of New York, New York, NY, USA, (2)Icahn School of Medicine at Mount Sinai, New York, NY, USA

  • 2:15:00 PM 18. Design Considerations for Piezocomposite Materials for Electrical Stimulation in Orthopedic Implants - Torsion, E. Krech*, E. Haas, G. Tideman, B. Reinsch, E. Friis; University of Kansas, Lawrence, KS, USA

  • 2:30:00 PM 19. Elastohydrodynamic Lubrication Model in 3D of Polycarbonate Polyurethane Acetabular Cups for Hip Implants, A. Ford*(1), S. Ferguson(2), L. Pruitt(1), L. Gao(3); (1)University of California Berkeley, Berkeley, CA, USA, (2)ETH Zurich, Zurich, Switzerland, (3)Imperial College London, London, United Kingdom

  • 2:45:00 PM 20. Strontium-Coated Clay Nanoparticles for Bone Regeneration, A. Elumulai*, Y. Luo, A. Humayun, D. Mills; Louisiana Tech University, Ruston, LA, USA

Invited Speaker(s)

Panel Discussion: Strategies for Effective and Engaged Teaching

Timeslot: Wednesday, April 3, 2019 - 1:00pm to 3:00pm
Track: Career Catalysis
Room: Chelan 5

About

Biomaterials educators bridge the gaps between theory and practice in biomaterials science. As science, technology, engineering and mathematics (STEM) education continues to evolve, innovative approaches for engaging all categories of student learners are widely sought. For faculty, the introduction of novel approaches in the classroom is often a missed opportunity for integration of their teaching and outreach with their traditional scholarship, and thus, missed opportunities for potential funding. This panel will include discussion of myriad academic development matters, including active learning activities, instructional laboratories, and conversion of educational innovations to scholarship. Topics will include project ideas for cooperative problem-based lab instruction, course innovations, academic-industry collaborative projects, outreach, and assessment methods. Experienced panelists in engineering education will outline education theories most commonly used and break down the stigma associated with theory. Panelists will also provide participants with a thorough introduction to active learning strategies and resources, overview best practices for incorporating active learning into biomaterials courses, and highlight success stories for integrating such educational activities with technical research and scholarship. This panel discussion will provide the framework for incorporation of innovative educational strategies into biomaterials curricula, outreach, and educational publications.

Abstracts

  • 1:00 PM 37. Karen Burg, PhD

  • 1:30 PM 38. Aileen Huang-Saad, PhD

  • 2:00 PM 39. Dale Feldman, PhD

  • 2:30 PM 40. Invited Speaker

Invited Speaker(s)

THOUGHT LEADER: Jennifer Elisseeff

Timeslot: Wednesday, April 3, 2019 - 1:00pm to 3:00pm
Track: Thought Leader
Room: Skagit 2

About

This symposium will explore the growing role of the immune system in promoting tissue regeneration and inhibiting the foreign body response to biomaterials. After introductory lectures, the panel of invited speakers will discuss the challenges of introducing cutting edge immunology techniques to biomaterials science and engineering. We will conclude with predictions of the future in biomaterials immunoengineering.

Abstracts

Invited Speaker(s)