Biomaterials for Cardiovascular Regeneration

Timeslot: Thursday, April 4, 2019 - 10:30am to 12:30pm
Track: Cardiovascular Biomaterials
Room: Yakima 2

About

To develop new treatment strategies for cardiovascular diseases, some of the challenges include vascularization of synthetic tissues, renewable cell sources, biomaterials that have similar features to the native cardiovascular tissues, and efficacy in preclinical models. In this session, we will cover topics ranging from emerging biomaterials, injectable hydrogels, strategies of vascularization of engineered constructs, and advances in cardiovascular tissue engineering that have shown progress into clinical translation. Topics of interest include vascular grafts, valves, cardiac patches, and stem cell therapeutics.

Abstracts

  • 10:30:00 AM 197. Invited Speaker: Robert Tranquillo, University of Minnesota

  • 11:00:00 AM 199. Integrating Revascularization Therapy with Cardiac Tissue Engineering for Treating Myocardial Infarction, F. Munarin*(1), R. Kant(1), C. Rupert(1), A. Khoo(1), K. Coulombe(1); (1)Brown University, Providence, RI, USA

  • 11:15:00 AM 200. Correction of Heart Defects with a Polyurethane-Reinforced Hydrogel Patch in a Rat Model, Z.-W. Tao*(1), E. Beck(1), D. Jarrell(1), E. Vanderslice(1), M. Lennon(1), D. Pool(1), S. Wu(2), E. Cosgriff-Hernandez(2), J. Jacot(1); (1)University of Colorado Denver/Anschutz Medical Campus, Aurora, CO, USA, (2)University of Texas at Austin, Austin, TX

  • 11:30:00 AM 201. A Soluble Extracellular Matrix Hydrogel Therapy for Intravascular Infusion, M. Spang*, G. Sandoval, T. Lazerson, C. Luo, K. Osborn, P. Cabrales, F. Contijoch, R. Reeves, A. DeMaria, K. Christman; University of California, San Diego, La Jolla, CA, USA

  • 11:45:00 AM 202. A Bio-Hybrid Cardiac Patch Combining Poly(ester carbonate urethane)urea and Porcine Cardiac Extracellular Matrix Digest Induces Improved Ventricular Remodeling in a Model of Chronic Ischemia, L. Silveira Filho*(1,2), G. Coyan(1), A. D'Amore(1), S. Luketich(1), G. Menallo(1), A. Adamo(1), N. Kashiyama(1), Y. Matsumura(1), W. Wagner(1); (1)McGowan Institute for Regenerative Medicine University of Pittsburgh, Pittsburgh, PA, USA, (2)State Univers

  • 12:00:00 PM 203. HiPSC Encapsulation Geometry Impacts Engineered Cardiac Tissue Development and Function, M. Ellis*, B. Harris, E. Lipke; Auburn University, Auburn, AL, USA

  • 12:15:00 PM 204. Adventitial Extracellular Matrix Hydrogel Improves Sprouting of Human Thoracic Aortic Aneurysm-Derived Pericytes, B. Fisher*(1), J. Hill(1), M. Billaud(1,2,3), T. Richards(1), T. Gleason(1,2,3), J. Phillippi(1,2,3); (1)University of Pittsburgh Medical Center, Pittsburgh, PA, USA, (2)McGowan Institute of Regenerative Medicine, Pittsburgh, PA, USA, (3)University of Pittsburgh, Pittsburgh, PA, USA

Invited Speaker(s)

From Bench-to-Bedside: Translating Biomaterials Research *BTI* 2

Timeslot: Thursday, April 4, 2019 - 10:30am to 12:30pm
Track: Industry
Room: Yakima 1

About

The session will provide a podium for industry researchers developing a variety of innovative biomaterials-based technologies to give the audience perspective on the development process through specific examples. Talks will cover the entire R&D and translation from conception through licensing, preclinical development, clinical trials and commercialization.

Abstracts

  • 10:30:00 AM 189. Invited Speaker - Vincent Ling, Takeda,

  • 10:45:00 AM 190. Use of Nanomaterials to Develop Next Generation of Medical Device, M. Phaneuf*(1), S. Pathan(1), M. Contreras(2), N. Long(1), R. Kassab(1), B. Martino(1), A. Martin(1), G. Wong(1), M. Bide(3), T. Phaneuf(1); (1)BioSurfaces, Inc., Ashland, MA, USA, (2)BI Deaconess Medical Center, Boston, MA, USA, (3)University of Rhode Is

  • 11:00:00 AM 191. From Bench-to-Bedside: Licensing and Development of a Mineral-Organic Bone Adhesive for Bone Repair, M. Brown*(1), G. Kay(1), D. Cochran(2), J. Fiorellini(3), B. Hess(1); (1)LaunchPad Medical, LLC, Lowell, MA, USA, (2)University of Texas, San Antonio, TX, USA, (3)Penn State University, Philadelphia, PA, USA

  • 11:15:00 AM 192. Bringing Restorative Heart Valves Towards Clinical Practice, M. Cox*; Xeltis, Eindhoven, Netherlands

  • 11:30:00 AM 193. The Impact of Regenerative Therapies in the Clinic with Supporting Evidence from the Lab, R. Audet*(1), R. Diller(1), D. Dominguez(1), R. Kellar(1,2); (1)Axolotl Biologix Inc, Phoenix, AZ, USA, (2)Northern Arizona University, Flagstaff, AZ, USA

  • 11:45:00 AM 194. 3D-Painted Biomaterials: Hyperelastic Bone™, 3D-Graphene, Fluffy-X™, Tissue Papers, and More for Tissue Repair, Regeneration, and Biofabrication, A. Jakus*; Dimension Inx, LLC, Chicago, IL, USA

  • 12:00:00 PM 195. ABC103 from Bench to Bedside: Development of a Drug-Eluting Polymer Implant Which Prevents Post-Surgical Lung Cancer Recurrence, J. Schwartz*; AcuityBio Corporation, Newton, MA, USA

  • 12:15:00 PM 196. Sprayable Biopolymer Hydrogel for the Prevention of Postoperative Adhesions, L. Costella*(1), R. Villani(2), C. Tison(1); (1)Luna Innovations Incorporated, Charlottesville, VA, USA, (2)DaVINCI Biomedical Research Products, Lancaster, MA, USA

Invited Speaker(s)

Guided Tissue Regeneration

Timeslot: Thursday, April 4, 2019 - 10:30am to 12:30pm
Track: Tissue Engineering and Regenerative Medicine
Room: Chelan 2

About

Guided bone/guided tissue regeneration, GBR/GTR, strategies are widely used in dental/craniofacial repair/reconstruction to enhance bone healing/formation for implant therapies. GBR/GTR membranes work primarily by acting as a barrier to prevent invasion of soft tissue into regenerating bone grafted sites. While current membranes act primarily in a passive manner, new and developing membranes are providing adjunctive bioactive activities to stimulate healing, bone formation and or infection. Because of the success of GBR/GTR membranes in dental/craniofacial applications, they are being explored for use in large orthopedic defects, neuro-regeneration, and in other soft tissue repair strategies. Session will provide an overview of the clinical use and performance of GBR/GTR membranes in dental/craniofacial repair as well as focus on advances in GBR/GTR membrane strategies in tissue healing and regeneration.

Abstracts

  • 10:30:00 AM 229. Invited Speaker: Robert Horowitz, DDS

  • 11:00:00 AM 231. Chitosan Electrospun Membranes for Bone Regeneration – An in vivo Study in a Rat Calvarial Critical Sized Defect, F. Delbuque Guerra*(1), N. Ghadri(2), H. Su(1), J. Bumgardner(1); (1)University of Memphis, Memphis, TN, USA, (2)University of Tennessee Health Science Center, Memphis, TN, USA

  • 11:15:00 AM 232. Drug-loaded Elastin-like Polypeptide-Collagen Composites for Bone Tissue Engineering, P. Pal*, Q. Nguyen, A. Janorkar; University of Mississippi Medical Center, Jackson, MS, USA

  • 11:30:00 AM 233. Evaluation of Poly(?-caprolactone) Auxetic Knitted Scaffolds for Regeneration of Craniofacial Skeletal Muscle, M. Deshpande*(1), L. Katz(2), A. West(1), R. Shah(2), M. King(1); (1)North Carolina State University, Raleigh, NC, USA, (2)University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

  • 11:45:00 AM 234. Hydrogels with Ultra-dynamic Network and Statically-tethered Ligands Enhance Mechanosensing-Dependent Activities of Encapsulated Stem Cells, L. Bian*, B. Yang, K. Wei; The Chinese University of Hong Kong, Hong Kong, Hong Kong

  • 12:00:00 PM 235. 3D Hydrogel System to Promote Distinct Arterial-venous Specification of Endothelial Progenitor Cells for Tissue-engineered Vasculature, B. Mahadik*(1), R. Frayman(2), J. Fisher(1); (1)University of Maryland, College Park, College Park, MD, USA, (2)Wake Forest University, Winston-Salem, NC, USA

  • 12:15:00 PM 236. Poly(Ethylene Glycol)-Crosslinked Gelatin Hydrogel Substrates with Conjugated Bioactive Peptides as a Basement Membrane Mimic for Endothelial Cell Culture, J. Su*(1,2), S. Satchell(3), J. Wertheim(1,2), R. Shah(1,4); (1)Northwestern University, Evanston, IL, USA, (2)Northwestern University Feinberg School of Medicine, Chicago, IL, USA, (3)University of Bristol, Bristol, United Kingdom, (4)University of Illinois at Chicago, Chicago, IL, USA

Invited Speaker(s)

Nanomaterials SIG

Timeslot: Thursday, April 4, 2019 - 10:30am to 12:30pm
Track: Functional Biomaterials and Surfaces
Room: Chelan 5

Abstracts

  • 10:30:00 AM 205. Nanofibrous Artificial Tissue Scaffold for Three Dimensional Epithelial Tissue Regeneration, Y.J. Son(1), W. Mao(1), J. Shin(1), J. Lee(1), K. N. Kim(2), S. Kim(2), H.S. Yoo*(1); (1)Kangwon National University, Chuncheon, Republic of Korea, (2)Korea Basic Science Institute Chuncheon Centor, Republic of Korea

  • 10:45:00 AM 206. Quantification of Lectin-Exosome Binding Affinity Using Lectin-conjugated Janus Nano particles for Detection of Pancreatic Cancer Exosome, U. Park*(1), Y. Choi(2), J. Choi(2), K. Kim(1); (1)Incheon National University, Incheon, Republic of Korea, (2)Chung-Ang University, Seoul, Republic of Korea

  • 11:00:00 AM 207. Real-Time and Long-Time in vivo Imaging in the Shortwave Infrared Window of Perforator Vessels for More Precise Evaluation of Flap Perfusion, J. CHEN*, Y. LI, S. Chen; Huashan Hospital, Fudan University, shanghai, China

  • 11:15:00 AM 208. Dual pH and Oxygen Luminescent Nanosensors for Extracellular Metabolism Monitoring, C. Yang*(1), T. Pan(1,2), M. Chen(2), Y. Tian(1); (1)Southern University of Science and Technology, Shenzhen, China, (2)University of Macau, Macau, China

  • 11:30:00 AM 209. Exosome-Polymer Hybrids, S. Yerneni*, S. Lathwal, J. Cuthbert, S. Das, K. Matyjaszewski, P. Campbell; Carnegie Mellon University, Pittsburgh, PA, USA

  • 11:45:00 AM 210. Determining Vaccination Status in the Developing World Using Microneedle-Delivered Fluorescent Microparticles, K. McHugh*(1), L. Jing(1,2), S. Severt(1), M. Cruz(1), H.S. Jayawardena(1), C. Perkinson(1), F. Larusson(3), S. Rose(1), R. Langer(1), A. Jaklenec(1); (1)Massachusetts Institute of Technology, Cambridge, MA, USA, (2)Chinese Academy of Sciences, Beijing, C

  • 12:00:00 PM 211. Differentially Branched Ester Amine Quadpolymers with Amphiphilic and pH Sensitive Properties for Efficient Nucleic Acid Delivery, D. Wilson*, Y. Rui, K. Siddiq, D. Routkevitch, J. Green; Johns Hopkins University, Baltimore, MD, USA

  • 12:15:00 PM 212. Development of Polymeric Nanogels for Tear Biomarker Detection, M. Wechsler*, J. Dang, S. Simmonds, N. Peppas; The University of Texas at Austin, Austin, TX, USA

Orthopedic Biomaterials SIG2

Timeslot: Thursday, April 4, 2019 - 10:30am to 12:30pm
Track: Musculoskeletal and Craniofacial Biomaterials
Room: Skagit 2

About

Advances in orthopedic biomaterials in the recent years will be presented. Topics will include bioglasses, bone grafts and substitutes, biomimetic scaffolds, drug delivery, advanced interfacial tissue repair, and in vitro and in vivo models for orthopedic biomaterial studies.

Abstracts

  • 10:30:00 AM 181. Invited Speaker - Peter Yang, PhD

  • 11:00:00 AM 183. An in vitro Chondro-Osteo-Vascular Triphasic Model Of The Osteochondral Complex, R. Gottardi*(1,2), A. Pirosa(1,3), P. Alexander(1), P. Manner(4), D. Puppi(3), F. Chiellini(3), R. Tuan(1); (1)University of Pittsburgh, Pittsburgh, PA, USA, (2)Fodazione Ri.MED, Palermo, Italy, (3)Universita` degli Studi di Pisa, Pisa, Italy, (4)Universi

  • 11:15:00 AM 184. Rotator Cuff Enthesis Regeneration via Insulin-like Growth Factor-Mimic Delivery, A. Prabhath*(1,2,3), V. Vernekar(1,2), M. Badon(1,2), X. Tang(1,2), G. Dzidotor(1,2,4), J.-E. Avochinou(1,2), E. Weber(5), S. Kumbar(2,3), C. Laurencin(1,2,3,4); (1)Institute for Regenerative Engineering, UConn Health, Farmington, CT, USA, (2)Department o

  • 11:30:00 AM 185. Controlling Fiber Alignment Using Magnetically-Assisted Electrospinning for Interfacial Tissue Repair, R. Tindell*, J. Holloway; Arizona State University, Tempe, AZ, USA

  • 11:45:00 AM 186. Biomimetic Triphasic Scaffolds for Osteotendinous Junction Regeneration, R. Sun Han Chang*, C.-W. Lee, S. Rogers, B. Harley; University of Illinois at Urbana–Champaign, Urbana, IL, USA

  • 12:00:00 PM 187. Vertical Bone Augmentation Using Carbonate Apatite Bone Substitute, K. Ishikawa*, K. Hayashi, A. Tsuchiya, R. Kishida; Kyushu University, Fukuoka, Japan

  • 12:15:00 PM 188. Impact of Aging on Bioglass Foam Structure and Properties, C. Charbonneau*(1), P.F. Menci(2), A. Mari(2), L. De Nardo(2), F. Vanier(1), L.-P. Lefebvre(1); (1)National Research Council Canada, Boucherville, QC, Canada, (2)Politecnico di Milano, Milano, Italy

Invited Speaker(s)

Protein and Cells at Interfaces SIG

Timeslot: Thursday, April 4, 2019 - 10:30am to 12:30pm
Track: Engineered Microenvironments
Room: Chelan 4

Abstracts

  • 10:30:00 AM 221. Secreted Factors from Macrophages Reduce Valvular Interstitial Cell Myofibroblast Activation, J. Grim*(1,2), B. Aguado(1,2), K. Anseth(1,2); (1)University of Colorado-Boulder, Boulder, CO, USA, (2)BioFrontiers Institute, Boulder, CO, USA

  • 10:45:00 AM 222. Unfoldable Supramolecular Single Chain Nanogel-based Integrin Ligand Tether Regulates Mechanosensing of Stem Cells, X. CHEN*, D.S. Wang, K. Wei, L. Bian; The Chinese University of Hong Kong, Shatin, Hong Kong

  • 11:00:00 AM 223. High Throughput Screening of Random Heteropolymers that Stabilize Enzymes, S. kosuri*, M. Tamasi, A. Gormley; Rutgers University, Piscataway, NJ, USA

  • 11:15:00 AM 224. Cyclodextrin Polymer Coatings Resist Protein Adsorption and Mammalian Cell Adhesion in vitro, G. Learn*, E. Lai, H. von Recum; Case Western Reserve University, Cleveland, OH, USA

  • 11:30:00 AM 225. The Effect of Varying Serum Concentrations on Cell Motility in Wicking Fiber Systems, K. Burg*, T. Ng, R. Marti; University of Georgia, Athens, GA, USA

  • 11:45:00 AM 226. The Molecular Mechanism of Mediation of Adsorbed Serum Proteins to Endothelial Cells Adhesion and Growth on Biomaterials, X. Lü*(1), D. Yang(1), Y. Hong(2), T. Xi(3), D. Zhang(4); (1)Southeast University, Nanjing, China, (2)Nanjing Drum Tower Hospital, Nanjing, China, (3)Shenzhen Research Institute, Peking University, Shenzhen, China, (4)R&D Center of Lifetech Scientific (Sh

  • 12:00:00 PM 227. Structures Related Adsorption Behavior of Mussel Adhesive Protein (Mefp-5) on Different Biomaterial Surfaces, Y. Wei*; National Taipei University of Technology, Taipei, Taiwan

  • 12:15:00 PM 228. Adsorption and Bioactivity of Bone Morphogenetic Protein-2 on Strontium-substituted Hydroxyapatite Surfaces, B. Huang*(1), Y. Lou(1), Y. Yuan(2), C. Liu(2); (1)Guangzhou University, Guangzhou, China, (2)East China University of Science and Technology, Shanghai, China

Targeted and Stimuli-Responsive Biomaterials

Timeslot: Thursday, April 4, 2019 - 10:30am to 12:30pm
Track: Functional Biomaterials and Surfaces
Room: Skagit 3

About

Targeted and stimuli-responsive biomaterials, or “smart” drug delivery systems, can be used to effectively treat a variety of medical conditions. These materials have the potential to act rapidly and effectively, while avoiding various complications (e.g., off-site toxicity). Common stimuli used to trigger a change in these materials include pH, temperature, ionic strength, chemical and/or mechanical microenvironment, redox potential, and light. This session will focus on the development and application of these targeted and/or stimuli-responsive biomaterials including, but not limited to, cancer therapy and diagnostics, infection, cardiovascular disease, autoimmune diseases, etc.

Abstracts

  • 10:30:00 AM 213. Protease-triggered Delivery of an Anti-Inflammatory Drug for Modulation of Macrophage Proliferation, D. Nguyen*, B. Soeranaya, T. Truong, T. Dang; Nanyang Technological University, Singapore, Singapore

  • 10:45:00 AM 214. Targeted Delivery of Peptide-based Matrix Metalloproteinase?2 (MMP-2) Inhibitor in Dual Sensitive Nanoparticles with Platelet Membrane Camouflage for Ischemic Limb Treatment, Y. Dang*(1), N. Gao(1), H. Niu(2), Y. Guan(1), J. Guan(1); (1)Washington University in St. Louis, St. Louis, MO, USA, (2)The Ohio State University, Columbus, OH, USA

  • 11:00:00 AM 215. A Novel Matrix for Endometrium Regeneration by the Recruitment and Selective Capture of Endogenous Mesenchymal Stem Cells, L. Ma*, X. Zheng, X. Wang, L. Xin, C. Gao; Zhejiang University, Hangzhou, China

  • 11:15:00 AM 216. Magnetoliposome-Integrated Hydrogels for Delayed and Triggered Deliveries, S.Z. M. Madani*, A. Reisch, E. Hughes, G. Bothun, S. Kennedy; University of Rhode Island, Kingston, RI, USA

  • 11:30:00 AM 217. Photo-Crosslinking of Recombinant Protein Vesicles via Incorporation of Unnatural Amino Acids, Y. Li*; Georgia Institute of Technology, Atlanta, GA, USA

  • 11:45:00 AM 218. Magnetic Nanostructure-loaded Bicontinuous Nanospheres for Magnetic Resonance Imaging and Drug Delivery, M. Modak*, V. Nandwana, V. Dravid, E. Scott; Northwestern University, Evanston, IL, USA

  • 12:00:00 PM 219. 'Smart' Hydrogel for the Radiosensitization and Sustained Delivery of Therapeutics Triggered by X-Ray Irradiation, M. Bouche?*, J. Hsu, D. Cormode; University of Pennsylvania, Philadelphia, PA, USA

  • 12:15:00 PM 220. Biological Characterization of Intelligent Nanogels Synthesized by Inverse Emulsion Polymerization, J. Clegg*, J. Sun, E. Ander, A. Venkataraman, N. Peppas; The University of Texas at Austin, Austin, TX, USA

Thought Leader: Allan Hoffman - Part 1

Timeslot: Thursday, April 4, 2019 - 10:30am to 12:30pm
Track: Thought Leader
Room: Skagit 4/5

Abstracts

  • 10:30 AM 177. Invited Speaker: The Early Days of Smart Biomaterials, Allan Hoffman, PhD, Univeristy of Washington

  • 10:54 AM 178. Invited Speaker: Immunomodulatory Biomaterials for Cell-Based Therapeutics, Omid Veiseh*, Daniel G. Anderson, and Robert Langer, MIT

  • 11:18 AM 179. Invited Speaker: Local delivery of paclitaxel and signal transduction inhibitors by thermosensitive hydrogel (Regel(r)) for cancer therapy, Glen Kwon, PhD, University of Wisconsin

  • 11:42 PM 180. Invited Speaker: Uptake and Function of Membrane‐destabilizing Cationic Nanogels for Intracellular Drug Delivery, Nicholas A Peppas, ScD*, Julia F Vela Ramirez and Aaliyah Shodeine, University of Texas at Austin

  • 12:06 PM Invited Speaker: Kinam Park PhD, Purdue University

Invited Speaker(s)