Biomaterial-Tissue Interaction SIG

Timeslot: Thursday, April 4, 2019 - 1:45pm to 3:45pm
Track: Engineered Microenvironments
Room: Chelan 4

Abstracts

  • 1:45:00 PM 281. Assessment of in vivo Degradation of Polypropylene Hernia Mesh, X. Lu*(1), B. Cotton(1), T. Heniford(2), V. Augenstein(2), M. Harman(1); (1)Clemson University, Clemson, SC, USA, (2)Atrium Health, Charlotte, NC, USA

  • 2:00:00 PM 282. Toll-like Receptor Activation by Adsorbed Damage-Associated Molecular Patterns on Polymeric Surfaces, L. McKiel*, K. Woodhouse, L. Fitzpatrick; Queen's University, Kingston, ON, Canada

  • 2:15:00 PM 283. Neuronal Cell Adhesion Molecule L1 Improves Quality of Chronic Neural Recording in Mouse Visual Cortex, A. Golabchi*(1,2), K. Woeppel(1,2), X. Cui(1,2,3); (1)University of Pittsburgh, Pittsburgh, PA, USA, (2)Center for Neural Basis of Cognition, Pittsburgh, PA, USA, (3)McGowan Institute for Regenerative Medicine, Pittsburgh, PA, USA

  • 2:30:00 PM 284. The Role of Toll-like Receptors 2 and 4 in the Foreign Body Response to Poly(ethylene glycol) Hydrogels, L. Saleh*(1), D. Faulon Marruecos(1), S. Thomas(2), W. Janssen(2), S. Alper(2), D. Schwartz(1), J. Kaar(1), S. Bryant(1); (1)University of Colorado Boulder, Boulder, CO, USA, (2)National Jewish Health, Denver, CO, USA

  • 2:45:00 PM 285. Resveratrol Delivery from Porous Poly(lactide-co-glycolide) Scaffolds Promotes an Anti-inflammatory Environment within Visceral Adipose Tissue, M. Gower*, K. Murphy, M. Hendley, C. Isely, P. Annamalai; University of South Carolina, Columbia, SC, USA

  • 3:00:00 PM 286. The Anti-PEG Immune Response: Fact, Fiction, or a Legitimate Concern for Biomaterials?, A. Isaac*, V. Winklepleck, D. Alge; Texas A&M University, Bryan, TX, USA

  • 3:15:00 PM 287. Differential Degeneration Patterns of the Proximal and Distal Stumps in a Sciatic Gap-Injury Model in the Rabbit Highlight the Role of Gap-Length in Preventing Regeneration, A. Merolli*, W. Chang, J.AM. Steele, A. Pastino, J. Kohn; Rutgers - The State University of New Jersey, Piscataway, NJ, USA

  • 3:30:00 PM 288. Interaction of a Secreted Disulfide Bond Catalyst with the Extracellular Matrix in Pancreatic Cancer, C. Millar-Haskell*, J. Gleghorn; University of Delaware, Newark, DE, USA

Dental/Craniofacial Biomaterials SIG

Timeslot: Thursday, April 4, 2019 - 1:45pm to 3:45pm
Track: Musculoskeletal and Craniofacial Biomaterials
Room: Skagit 4/5

Abstracts

  • 1:45:00 PM 245. Novel Polymeric Dental Resins with Antibacterial Properties, D. Bienek*(1), S. Frukhtbeyn(1), U. Okeke(1), A. Giuseppetti(1), S. Khajotia(2), F. Esteban Florez(2), R. Hiers(2), D. Skrtic(1); (1)ADA Foundation, Frederick, MD, USA, (2)University of Oklahoma Health Science Center, Oklahoma City, OK, USA

  • 2:00:00 PM 246. Oxidation-Responsive, Nanolayered Coatings for On-Demand Therapeutic Delivery to Craniofacial Bone Defects, J. Martin*, M. Howard, S. Wang, P. Hammond; Massachusetts Institute of Technology, Cambridge, MA, USA

  • 2:15:00 PM 247. Novel Smart Dental Composite with Rechargeable Antimicrobial Capability, S. Orrego*(1,3), J. Londoño(1,2), W. Kosater(1), S. Correa(2); (1)Temple University - Kornberg School of Dentistry, Philadelphia, PA, USA, (2)Universidad EAFIT, Medellin, Colombia, (3)Temple University, Philadelphia, PA, USA

  • 2:30:00 PM 248. Biodegradable Shape Memory Polymer (SMP) Semi-Interpenetrating Networks (Semi-IPNs) with Highly Tunable Properties for Bone Regeneration, M. Pfau*(1), K. McKinzey(1), A. Roth(1), M. Grunlan(1,2,3); (1)Texas A&M University, College Station, TX, USA, (2)Texas A &M University, College Station, TX, USA, (3)Texas A& M University, College Station, TX, USA

  • 2:45:00 PM 249. In vivo Evaluation of Biocompatibility, Degradability, and Bone Regenerative Potential of Collagen-Elastin-like Polypeptide-Bioglass Composite Scaffolds, B. Gurumurthy*, M. Tucci, L.-W. Fan, H. Benghuzzi, P. Pal, G. Bidwell, S. Salazar Marocho, Z. Cason, A. Janorkar; University of Mississippi Medical Center, Jackson, MS, USA

  • 3:00:00 PM 250. A Preliminary Electrochemical and Ion Release Assessment of the Essure® Medical Device, C. Aslan*, J. Gilbert; Clemson University, Charleston, SC, USA

  • 3:15:00 PM 251. Enhanced Osseointegration of Zn-Mg Composites by Tuning the Release of Zn Ions with Sacrificial Mg Rich Anode Design, Y. Zheng*; Peking University, Beijing, China

  • 3:30:00 PM 252. Accelerated and Uniform Degradation of Pure Iron through Tantalum Incorporation for Medical implants, M. Lee*, T.-S. Jang, H.-E. Kim, C. Park, H. Lee; Seoul National University, Seoul, Republic of Korea

Engineering Cells and Their Microenvironments SIG

Timeslot: Thursday, April 4, 2019 - 1:45pm to 3:45pm
Track: Engineered Microenvironments
Room: Chelan 2

Abstracts

  • 1:45:00 PM 289. Understanding the Role and Timing of the Pericellular Matrix at the Cell-Hydrogel Interface, M. Kwon*, C. Loebel, T. Duan, R. Mauck, J. Burdick; University of Pennsylvania, Philadelphia, PA, USA

  • 2:00:00 PM 290. Microgel Thin Film Loss Tangent and Substrate Elasticity Direct Cell Spreading and Migration Responses, D. Chester*(1,2), J. Nortey(1), R. Kathard(1), R. Lee(1), A. Brown(1,2); (1)North Carolina State University and University of North Carolina, Raleigh, NC, USA, (2)North Carolina State University, Raleigh, NC, USA

  • 2:15:00 PM 291. Interplay Between Degradability and Integrin Signaling on Mesenchymal Stem Cell Function within Porous Poly(ethylene glycol) Microgel Scaffolds, S. Xin*(1), C. Gregory(2), D. Alge(1); (1)Texas A&M University, College Station, TX, USA, (2)Texas A&M Health Science Center, College Station, TX, USA

  • 2:30:00 PM 292. Exploiting Biomaterial-modulated Secretome Production in Artificial Stem Cell Niches, A. Gilchrist*, B. Harley; University of Illinois at Urbana-Champaign, Urbana, IL, USA

  • 2:45:00 PM 293. Mechanobiologically-Activated, Scaffold-free Transplantation of Stem cells to Repair Injured Cardiac Tissues, A. Paul*; University of Kansas, Lawrence, KS, USA

  • 3:00:00 PM 294. Hepatoblast Organoids Have Potential for Bipotential Differentiation in Engineered Liver Tissue, S. Saxton*(1), A. Ross(2), L. Vallier(2), K. Stevens(1); (1)University of Washington, Seattle, WA, USA, (2)University of Cambridge, Cambridge, United Kingdom

  • 3:15:00 PM 295. Fatty Acid Based Media Enhances Maturity and Ability to Predict Pharmacology in Human iPS-Cell Derived Cardiomyocyte Based Microphysiological Systems, N. Huebsch*(1,2), B. Charrez(1), B. Siemons(1), S. Boggess(1), V. Charwat(1), N. Jeffreys(1), F.L. Montiel(1), A. Edwards(3), S. Wall(3), K. Healy(1); (1)University of California, Berkeley, Berkeley, CA, USA, (2)Washington University in St. Louis, St. Lou

  • 3:30:00 PM 296. Valvular Myofibroblast Persistent Activation Requires Global Chromatin Condensation, C. Walker*(1,2), A. Killaars(1,2), J. Grim(2), L. Leinwand(2), K. Anseth(2); (1)University of Colorado Boulder, Boulder, CO, USA, (2)BioFrontiers Institute, Boulder, CO, USA

Immunomodulatory Biomaterials

Timeslot: Thursday, April 4, 2019 - 1:45pm to 3:45pm
Track: Immunomodulatory Biomaterials
Room: Chelan 5

About

Therapeutic modulation of the immune system is the emerging paradigm in medicine. For example, immunotherapy holds the promise of a cure for cancer, and is poised to expand into other therapeutic areas, such as inflammatory disorders, autoimmune diseases etc. However, several frontiers in immunotherapy remain to be explored. For example, can we design biomaterials for precise modulation/education of the immune system while avoiding toxicities? How can we locally active the immune response? Can we track the immune cells in real-time? The session will focus on engineered biomaterials for therapeutic immune modulation. Specifically, the session will cover topics ranging from biomaterials for delivery of immunomodulators and imaging agents, scaffolds, cell-based therapies etc. Several cutting edge immune engineering platforms will be included.

Abstracts

  • 1:45:00 PM 265. Nanomaterial Vaccines to Overcome Poor Immune Response in Gut Microbiome-mediated Metabolic Syndrome, A. Singh*, M. Mosquera, S. Kim, H. Zhou, I. Brito; Cornell University, Ithaca, NY, USA

  • 2:00:00 PM 266. Bridging the Gap Between Systemic Vaccine and Mucosal Immunity to Fight Cancer, S. Ferber*(1,2,3), U. von Andrian(3), R. Langer(2), N. Artzi(1,2,3,4); (1)Brigham and Women’s Hospital, Cambridge, MA, USA, (2)Massachusetts Institute of Technology, Cambridge, MA, USA, (3)Harvard Medical School, Boston, MA, USA, (4)Broad Institute of Har

  • 2:15:00 PM 267. Enhanced T-cell Immunity in vivo Using Cell-instructive Scaffolds, N. Shah*(1), A. Mao(2), T.-Y. Shih(2), M. Kerr(1), D. Mooney(2), D. Scadden(2); (1)University of California, San Diego, La Jolla, CA, USA, (2)Harvard University, Cambridge, MA, USA

  • 2:30:00 PM 268. The Biologic Scaffold Immune Microenvironment Inhibits Tumor Formation and Synergizes with Immunotherapy, M. Wolf*, J. Elisseeff; Johns Hopkins University, Baltimore, MD, USA

  • 2:45:00 PM 269. Combinatorial, Microparticle-based Delivery of Immune Modulators Reprograms Dendritic Cell Phenotype and Promotes Remission of Collagen-induced Arthritis in Mice, R. Allen*(1), J. Lewis(1), S. Raychaudhuri(2), L. McKibbin(1), S. Chizari(1); (1)UC Davis, Davis, CA, USA, (2)UC Davis School of Medicine, Mather, CA, USA

  • 3:00:00 PM 270. Immunomodulatory Biomaterials to Improve Allogeneic Islet Graft Survival in a Murine Diabetic Model, M. Coronel*(1), J. Weaver(1), M. Hunckler(1), E. Yolcu(2), H. Shirwan(2), A. Garcia(1); (1)Georgia Institute of Technology, Atlanta, GA, USA, (2)University of Louisville, Louisville, KY, USA

  • 3:15:00 PM 271. Heparin-based IL-12 Complex Coacervate Inhibits B16F10 Melanoma Tumor Progression, M. Hwang*(1), R. Fecek(2), T. Qin(1), W. Storkus(2), Y. Wang(1); (1)Cornell University, Ithaca, NY, USA, (2)University of PIttsburgh, Pittsburgh, PA, USA

  • 3:30:00 PM 272. A Bacterial Membrane Coated Nanoparticle in Combination with Radiation Therapy for In Situ Tumor Vaccination, M. Ye*(1), R. Patel(2), P. Carlson(2), B. Ma(1), Y. Wang(1), L. Zangl(2), I. Arthur(2), P. Sondel(2), Z. Morris(2), S. Gong(1); (1)University of Wisconsin–Madison, Madison, WI, USA, (2)University of Wisconsin School of Medicine and Public Health, Madison, WI, USA

Next-Gen Tissue Adhesives and Clinical Applications

Timeslot: Thursday, April 4, 2019 - 1:45pm to 3:45pm
Track: Functional Biomaterials and Surfaces
Room: Yakima 1

About

There is an urgent need for tissue adhesives that can provide convenient and simple methods to seal wounds and affix medical devices on and in the body. While there are multiple types of adhesives under development, the need remains critical and there exists a wide gap between what academic labs are producing and what clinicians need. This session is intended to close the gap by engaging researchers in multiple sectors - including chemists and biomaterials experts, companies, and clinicians to present the latest innovations and challenges that remain

Abstracts

  • 1:45:00 PM 273. Elastagen: Commercial Translation of a Biomaterial from Lab to Trade Sale, A. Weiss*; University of Sydney, Sydney, Australia

  • 2:00:00 PM 274. Invited Speaker - Anthony Weiss,

  • 2:15:00 PM 275. In vivo Evaluation of Bioadhesive and Biodegradable Closure Device for Sealing of Femoral Artery Punctures, M. Kim*(1), E. Lih(1), S. Lee(1), D. Lee(1), Y. Choi(1), Y. Joung(2), S. Park(3), C.J. Yoon(4), H.-H. Jung(1); (1)Hansbiomed Co..ltd, Seoul, Republic of Korea, (2)Korea Institute of Science and Technology, Seoul, Republic of Korea, (3)College of Medicine,

  • 2:30:00 PM 276. Novel Measurement Method for Cyanoacrylates Polymerization Thermal Properties, K. Garcia*, J. Corbett, M. Taylor; Poly-Med, Inc., Anderson, SC, USA

  • 2:45:00 PM 277. Bioinspired Elastin-based Protein Adhesives, J. Liu*, S. Hollingshead, C.-Y. Lin, J. Wilker; Purdue University, West Lafayette, IN, USA

  • 3:00:00 PM 278. An Effective Post-Operative Adhesion Barrier Utilizing Physical Hydrogels, E. Appel*, Y.J. Woo, L. Stapleton; Stanford University, Stanford, CA, USA

  • 3:15:00 PM 279. Tannic Acid or Gallol-involved Biomaterials for Bioadhesives and Protein Heart Targetings, H. Lee*, KAIST, Daejeon, South Korea

  • 3:30:00 PM 280. Therapeutic Luminal Coating of the Intestine, Y. Lee*(1), T. E. Deelman(2), K. Chen(1), D. S. Y. Lin(1), A. Tavakkoli2(), J. M. Karp(1), (1)Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA, (2)Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

Invited Speaker(s)

Next-Generation Biomaterials for Treatment of Type 1 Diabetes

Timeslot: Thursday, April 4, 2019 - 1:45pm to 3:45pm
Track: Therapeutic Delivery
Room: Skagit 3

About

Type 1 diabetes is an autoimmune disease in which the insulin-producing beta cells of the pancreas are destroyed. This symposium will focus on translational biomaterials technologies for type 1 diabetes to improve survival, function, and/or delivery of insulin-producing cells or to improve diabetes monitoring and standards of care. Examples include: (i) materials delivering bioactive or immunomodulatory therapies, (ii) biomaterials addressing islet hypoxia, inflammation, and vascularization, (iii) biomaterial strategies for delivery of renewable sources of beta cells, and (iv) advancements in implantable glucose sensing technologies.

Abstracts

  • 1:45:00 PM 237. Invited Speaker: Ted Lee, PhD

  • 2:15:00 PM 239. Assembly of a Laminin-Nidogen Peri-Islet Matrix Improves Islet Function and Viability in PEG Hydrogels, J. Simonovich*(1), Y. Gonzalez-Vargas(1,2), N. Abuid(1), K. Ling(1), M. Becker(1), C. Stabler(1), E. Phelps(1); (1)University of Florida, Gainesville, FL, USA, (2)University of Puerto Rico-Mayagüez, Mayagüez, Puerto Rico

  • 2:30:00 PM 240. Engineering Transferrable Microvascular Meshes for a “Subcutaneous Pancreas”, M. Ma*; Cornell University, Ithaca, NY, USA

  • 2:45:00 PM 241. Phase-Changing Antioxidant Scaffold Shows Promise for Omentum Islet Transplantation: A Non-Human Primate Case Study, J. Burke*(1,2), Y. Zhu(1,2), X. Zhang(1,2), J. Post(3), D. Kaufman(3), X. Luo(2,4), G. Ameer(1,2,4); (1)McCormick School of Engineering, Northwestern University, Evanston, IL, USA, (2)Center for Advanced Regenerative Engineering, Northwestern University,

  • 3:00:00 PM 242. Methacrylic-Acid Based Polymer Coating of Polypropylene Mesh Device Improves Subcutaneous Islet Engraftment, V. Coindre*(1), S. Kinney(2), M. Sefton(1,2); (1)University of Toronto, Toronto, ON, Canada, (2)University of Toronto, Toronto, ON, Canada

  • 3:15:00 PM 243. Preventing Cell Death and Dysfunction for Human-sourced Beta Cells via Oxygen-generating Disk, J. Liang*, M. Coronel, C. Stabler; University of Florida, Gainesville, FL, USA

  • 3:30:00 PM 244. 3D-Printed Vascularizing Device for Immunoisolation of Islets, S. Parkhideh*(1), D. Sazer(1), G. Calderon(1), I. Kintslinger(1), Y. Wang(2), J. Oberholzer(2), J. Miller(1), O. Veiseh(1); (1)Rice University, Houston, TX, USA, (2)University of Virginia, Charlottesville, VA, USA

Invited Speaker(s)

Panel Discussion: Regulatory Translational Science Focused on Commercialization Challenges for Surface Modification and their Characterization: SIG-SQUARED

Timeslot: Thursday, April 4, 2019 - 1:45pm to 3:45pm
Track: Industry
Room: Yakima 2

About

This session will illuminate the tools, standards, and approaches to Surface Characterization leading to the assessment of the safety, effectiveness, quality, toxicity, public health impact, and performance of FDA-regulated surface modified products. Although this topic is focused on the Surface Modification and Characterization combining perspectives with the Biomaterials and Medical Devices Commercialization SIG, the session can inform a broad audience on the demands of regulatory translational science when developing a modification to a surface (such as nano-texturing or drug coatings) to commercial use. We will examine how Regulatory Science can be different from the science of biomaterials research.

Abstracts

  • 1:45 PM 261. Invited Speaker,

  • 2:15 PM 262. Invited Speaker,

  • 2:45 PM 263. Invited Speaker,

  • 3:15 PM 264. Invited Speaker

Invited Speaker(s)

Recent Advances in Antimicrobial and Antibiofilm Materials 1

Timeslot: Thursday, April 4, 2019 - 1:45pm to 3:45pm
Track: Musculoskeletal and Craniofacial Biomaterials
Room: Skagit 2

About

Microbial infections are among the leading causes of death worldwide. Drug resistance and lack of new antimicrobial therapeutics increase the difficulty of treating these infections. Microbial biofilms can also severely complicate treatment and lead to chronic infections. These three-dimensional, surface attached microbial structures can form on a range of medical devices and biological surfaces and exhibit sophisticated defense mechanisms, evading traditional antimicrobial therapies. This session will focus on recent advances spanning industry and academia in developing materials for the treatment of bacterial, fungal, viral, biofilm and polymicrobial infections. Strategies discussed may range from synthesis of new antimicrobial molecules and macromolecules to fabrication of antimicrobial surfaces, device coatings, nano- and micro-particle drug carriers, hydrogels, etc.

Abstracts

  • 1:45:00 PM 253. Invited Speaker: Vincent Rotello, PhD

  • 2:15:00 PM 255. Dual Antibacterial Drug Loaded Nanoparticles Synergistically Improve Anti-Oral Biofilm Treatments, K. Sims, Jr.*(1), B. He(2), J. Maceren(2), Y. Liu(3), G. Hwang(3), H. Koo(3), D. Benoit(2); (1)University of Rochester School of Medicine and Dentistry, Rochester, NY, USA, (2)University of Rochester, Rochester, NY, USA, (3)University of Pennsylvania, Phi

  • 2:30:00 PM 256. Optimization of PLGA Nanoparticles for Encapsulation of Enzyme for Elimination of Bacterial Biofilms, A. Doiron*(1), C. Han(2), J. Goodwine(2), K. Sauer(2); (1)University of Vermont, Burlington, VT, USA, (2)Binghamton University, Binghamton, NY, USA

  • 2:45:00 PM 257. Codelivery of Lysostaphin and BMP-2 to Eliminate Acute Infections and Heal Critical-sized Segmental Bone Defects, P. Kalelkar*, C. Johnson, A. Garcia; Georgia Institute of Technology, Atlanta, GA, USA

  • 3:00:00 PM 258. Delivery of Bupivacaine and Tolfenamic Acid from Ultra-High Molecular Weight Polyethylene: Multimodal Pain Relief and Synergistic Antibacterial Properties from Total Joint Implants, S. Grindy*(1,2), D. Gil(1,2), S. Hugard(1,2), O. Muratoglu(1,2), E. Oral(1,2); (1)Harvard Medical School, Boston, MA, USA, (2)Massachusetts General Hospital, Boston, MA, USA

  • 3:15:00 PM 259. Investigating Antibiofilm Properties of IDR-1018 Peptide Loaded Hydrogels, S. Shukla*, A. Shukla; Brown University, Providence, RI, USA

  • 3:30:00 PM 260. Biomimetic Phage Mimicking Antimicrobial Nanoparticles for Antibiotic Free, Bactericidal Action Against the ESKAPE Class of Pathogens, J. Hopf*, V. Kalwajtys, M. Waters, F. Fields, S. Lee, P. Nallathamby; University of Notre Dame, Notre Dame, IN, USA

Invited Speaker(s)