Cardiovascular Biomaterials SIG

Timeslot: Thursday, April 4, 2019 - 4:15pm to 6:15pm
Track: Cardiovascular Biomaterials
Room: Yakima 1

Abstracts

  • 4:15:00 PM 313. Transmembrane SCF Nanodiscs Enhance Revascularization in Ischemia and Induce CD34-/CD133+ Endothelial Progenitor Cells, E. Takematsu*(1), J. Auster(1), A. Singh(1), P.-C. Chen(1), S. Canga(1), A. DeGroot(1), M. Sherman(2), J. Stachowiak(1), A. Dunn(1), A. Baker(1); (1)University of Texas at Austin, Austin, TX, USA, (2)University of Texas Medical Branch, Galveston, TX, USA

  • 4:30:00 PM 314. Biophysical Characterization of Murine Hearts for Engineered Cardiac Tissue Mimics, D. Bousalis*(1), C. Lacko(1), P. Lim(1), H. Kasahara(2), C. Schmidt(1); (1)University of Florida, Gainesville, FL, USA, (2)University of Florida College of Medicine, Gainesville, FL, USA

  • 4:45:00 PM 315. Composite Bioresorbable Cardiovascular Stents Braided from Poly(p-dioxanone) and Polycaprolactone Yarns, F. Zhao*(1,2), F. Wang(1), M. King(2), L. Wang(1); (1)Donghua University, Shanghai, China, (2)North Carolina State University, Raleigh, NC, USA

  • 5:00:00 PM 316. A Precision-Porous Polyurethane Material for In-situ Tissue-Engineered Vascular Grafts, L. Zhen*(1), F. Simonovsky(2), S. Creason(2), B. Ratner(1,2); (1)University of Washington, Seattle, WA, USA, (2)UW, Seattle, WA, USA

  • 5:15:00 PM 317. Designing a Porous Hydrogel Pouch to Limit Adhesions During in vivo Vascular Graft Maturation, M. Sameti*(1), M. Shojaee(1), K. Vuppuluri(1), M. Ziff(2), A. Carriero(2), C. Bashur(1); (1)Florida Institute of Technology, Melbourne, FL, USA, (2)City college of New York, New York, NY, USA

  • 5:30:00 PM 318. The Potential of Polyester Fibrous Leaflets for Transcatheter Heart Valves, F. Heim*(1), N. Chakfe(2), A. Yousefi(3), P. Lakshmi(3), A. Vaeksen(1); (1)Universite de Haute Alsace, Mulhouse, France, (2)Hôpitaux Universitaires de Strasbourg, Strasbourg, France, (3)The Ohio State University, Columbus, OH, USA

  • 5:45:00 PM 319. In vitro Fatigue Evaluation of a Patient-specific Chimney Approach to Endovascular Aneurysm Repair, M. King*(1), R. Zhang(1), S. Crawford(2), T. Forbes(2), I. Robertson(3), J. Cole(4); (1)North Carolina State University College of Textiles, Raleigh, NC, USA, (2)University Health Network, Toronto, ON, Canada, (3)North Carolina State University College of

  • 6:00:00 PM 320. The Impact of Electrically Conductive and Non-Conductive Nanocomposite Hydrogels on Functionalities of Engineered Cardiac Tissues, M. Nikkhah*, A. Navaei; Arizona State University, Tempe, AZ, USA

Drug Delivery SIG

Timeslot: Thursday, April 4, 2019 - 4:15pm to 6:15pm
Track: Therapeutic Delivery
Room: Skagit 2

Abstracts

  • 4:15:00 PM 301. Invited Speaker: Shad Thaxton, PhD, Northwestern University

  • 4:45:00 PM 303. Synthetic Glycopolymer Prodrugs for Targeted Antimicrobial Delivery in the Lung, D. Ratner*, J. Chen, F.-Y. Su, P. Stayton; University of Washington, Seattle, WA, USA

  • 5:00:00 PM 304. Affinity-based Polymer Extends Drug Delivery and Retention for Wound Healing in the Esophagus, N. Rohner*(1), S. Schomisch(1), J. Marks(2), H. von Recum(1); (1)Case Western Reserve University, Cleveland, OH, USA, (2)University Hospitals Cleveland Medical Center, Cleveland, OH, USA

  • 5:15:00 PM 305. In Situ Sprayed Gel with Anti-CD47 for Post-Surgical Cancer Immunotherapy, Q. Chen*, G. Chen, G. Dotti, Z. Gu; Department of Bioengineering and California NanoSystems Institute, Las Angeles, CA, USA

  • 5:30:00 PM 306. Sustained and Prolonged Delivery of Protein Therapeutics Using 2D Nanosilicates, A. Gaharwar*, L. Cross, J. Carrow, K.A. Singh; Texas A&M University, College Station, TX, USA

  • 5:45:00 PM 307. Conductive Microneedles for Transdermal Delivery in Dentistry, C. Xu*(1), R. Z. Seeni(1), Y. Liu(2), B.T. Goh(2); (1)Nanyang Technological University, Singapore, Singapore, (2)National Dental Centre Singapore, Singapore, Singapore

  • 6:00:00 PM 308. Nanoparticle Dopants Enhance Electrically Controlled Drug Release from Conducting Polymer Coatings, K. Woeppel*(1,2), S. Zheng(1), T. Cui(1,2); (1)University of Pittsburgh, Pittsburgh, PA, USA, (2)Center for the Neural Basis of Cognition, Pittsburgh, PA, USA

Invited Speaker(s)

Engineering Reproduction

Timeslot: Thursday, April 4, 2019 - 4:15pm to 6:15pm
Track: Tissue Engineering and Regenerative Medicine
Room: Chelan 2

About

As a field, biomedical engineering continues to change the landscape of options available to individuals facing reproductive or endocrine failure for various reasons, such as genetic predisposition, age, iatrogenic effects of treatment, or disease. Engineered reproductive tissues that restore and support normal organ function are now emerging from work being done at the interface of reproductive biology, materials science, bioengineering, and advanced manufacturing. These engineered reproductive tissues and culture systems are enabling more physiologic in vitro modeling of homeostasis, development, disease, pregnancy, and aging. They are also being used for efficient screening of new pharmacologic agents for efficacy and reproductive toxicity. In this symposium, we will focus on recent work describing new engineering methods and applications in reproductive science and medicine, with a focus on biomaterials and microfluidic approaches that permit the generation of functional constructs at the “tissue/organ” level for use in both research and the clinic, with broader applications in other fields.

Abstracts

  • 4:15:00 PM 333. Invited Speaker

  • 4:30:00 PM 334. Invited Speaker

  • 4:45:00 PM 335. Rescuing the Primary: Lessons Learned from Inter-follicular Synergy, A. Jones*(1), H. Zhou(1), A. Shikanov(1,2); (1)University of Michigan, Ann Arbor, MI, USA, (2)The University of Michigan, Ann Arbor, MI, USA

  • 5:00:00 PM 336. Reconstructing the Ovarian Microenvironment: Culturing Follicles in an ECM-Sequestering PEG Matrix, C. Tomaszewski*(1), I. Kopyeva(2), A. Shikanov(1,3); (1)University of Michigan, Ann Arbor, MI, USA, (2)The University of Michigan, Ann Arbor, MI, USA, (3)U of Michigan, Ann Arbor, MI, USA

  • 5:15:00 PM 337. Bovine Ovary-derived Extracellular Matrix Hydrogel Supports in vitro Growth of Bovine Early Antral Follicles, E. Gargus*, H.C. Lee, J. Zhang, T. Woodruff; Northwestern University Feinberg School of Medicine, Chicago, IL, USA

  • 5:30:00 PM 338. Immunoisolating Poly(ethylene glycol)-Vinyl Sulfone Matrix Prevents Cancer Cells from Spreading Following Ovarian Tissue Autotransplantation, A. David, J. Day*, M. Hammersley, C. Long, A. Shikanov; University of Michigan, Ann Arbor, MI, USA

  • 5:45:00 PM 339. Dual Phased Poly(ethylene glycol) Immunoisolating Capsule Supports Ovarian Tissue Development and Precludes Sensitization of the Host Immune Response, J. Day*(1), A. David(1), M. Hammersley(1), M. Barbosa(2), M. Cascalho(2), A. Shikanov(1); (1)University of Michigan, Ann Arbor, MI, USA, (2)Michigan, Ann Arbor, MI, USA

  • 6:00:00 PM 340. Development of a Biomaterial Model of the Decidualized Endometrium, S. Zambuto*, B. Harley; University of Illinois at Urbana-Champaign, Urbana, IL, USA

Invited Speaker(s)

Multifunctional Biomaterials: Recent Developments and Future Directions

Timeslot: Thursday, April 4, 2019 - 4:15pm to 6:15pm
Track: Functional Biomaterials and Surfaces
Room: Chelan 5

About

There are increasing demands for biomaterials that are responsive to local stimuli (e.g. change in pH, ionic strength, light, temperature), and/or play multiple biological roles in a single application (e.g. tissue engineering, drug delivery, and treatment of cancer, tumor, cardiovascular disease, infection). Various approaches have been studied to develop multifunctional biomaterials including 3D printing, electrospinning, self-assembly, photolithography, and so on. In this symposium, the recent developments and breakthroughs of biomaterials with multiple biological functions and the methods to create such biomaterials will be reported along with the challenges and translational studies. Mixed presentations from the U.S., Canada, Europe, and other countries are expected.

Abstracts

  • 4:15:00 PM 325. Functionalized Glycopolymer Materials for Improving Detection for Glycan Interactions, A. Michalak*, K. Godula; University of California, San Diego, La Jolla, CA, USA

  • 4:30:00 PM 326. A Membrane Logic Gate to Control Secretion from Vesicles, N. Kamat*, C. Hilburger, K. Lewis, M. Jacobs; Northwestern University, Evanston, IL, USA

  • 4:45:00 PM 327. Aza-Michael Addition Cross-Linking Strategy for Formation of Dendrimer Hydrogels, Micro/Nanogels, and Cryogels, J. Wang*(1), H. Yang(1,2,3); (1)Virginia Commonwealth University, School of Engineering, Richmond, VA, USA, (2)Virginia Commonwealth University, Massey Cancer Center, Richmond, VA, USA, (3)Virginia Commonwealth University, School of Pharmacy, Richmond, VA

  • 5:00:00 PM 328. New Textured Polyphosphazene Biomaterials with Improved Biocompatibility, L.-C. Xu*(1), C. Chen(2), H. Allcock(2), C. Siedlecki(1); (1)Penn State University College of Medicine, Hershey, PA, USA, (2)The Pennsylvania State University, University Park, PA, USA

  • 5:15:00 PM 329. Multi-functional Conductive Self-Healing Hydrogels with Pressure Sensitivity, Stretchability, and 3D Printability, M. Xing*, M. Darabi; University of Manitoba, Winnipeg, MB, Canada

  • 5:30:00 PM 330. Extent and Type of Modification of Hyaluronic Acid Influence CD44 Binding in Soluble and Hydrogel Forms, M. Kwon*(1), C. Wang(2), L. Han(2), J. Burdick(1); (1)University of Pennsylvania, Philadelphia, PA, USA, (2)Drexel University, Philadelphia, PA, USA

  • 5:45:00 PM 331. Capsule Integrated Polypeptide Multilayer Films for On-Demand Multiple Drug Co-Delivery, S. Zhang*, B. Li; West Virginia University, Morgantown, WV, USA

  • 6:00:00 PM 332. Strain-induced Stiffening of Fibrous Biomaterials Through Dynamic Covalent Chemistry, M. Davidson*(1), A. Schoonen(1), M.-H. Lee(1), E. Bonnevie(2), R. Mauck(1,2), J. Burdick(1); (1)University of Pennsylvania, Philadelphia, PA, USA, (2)University of Pennsylvania, Philadelphia, PA, USA

Panel Discussion: How to Translate your Research into Successful Biomaterials Therapies

Timeslot: Thursday, April 4, 2019 - 4:15pm to 6:15pm
Track: Career Catalysis
Room: Skagit 3

About

Feel like you’ve worked really hard on your research and do not want to see it simply published and forgotten? Do you want to see patients actually benefit from this research? This panel of researchers and experts will explain your options for translating your work from benchtop to bedside while considering the need to publish findings. Also, if you want to continue along the same path and work post-graduation, our panel will discuss how this can be accomplished and what steps should be taken now as a student. For academic investigators and professors, this session will explain the options for pursuing commercialization and the balance between publishing, patenting, and being an entrepreneur to push your technology forward. Speakers will include members of regulatory commissions, biotech startup founders, and industry personnel who have successfully brought medical breakthroughs into the clinic.

Abstracts

  • 4:15:00 PM 321. Invited Speaker: Joachim Kohn, PhD

  • 4:45:00 PM 322. Invited Speaker: Ben Hwang, PhD

  • 5:15:00 PM 323. Invited Speaker: Daniel Harrington, PhD

  • 5:45:00 PM 324. Invited Speaker: TBD

Invited Speaker(s)

Panel Discussion: Recent Developments in ISO 10993 Series of Standards for Biocompatibility Testing and Evaluation

Timeslot: Thursday, April 4, 2019 - 4:15pm to 6:15pm
Track: Industry
Room: Yakima 2

About

This session will focus on the recent developments in biocompatibility testing for medical devices, especially on the recent revisions/updates on ISO 10993 series of standards and the FDA’s guidance document on the use of such standards. The industry speakers who are leading experts in the field of biocompatibility testing will be invited to participate in this session to talk about the history of ISO 10993-1, risk management for biocompatibility evaluations, general biocompatibility testing considerations, test-specific considerations, and chemical assessments including extractables and leachables. The speakers will also talk about biocompatibility regulations and guidance in compliance with applicable global regulatory requirements (FDA, ISO, MHLW, and CFDA) for Class I to Class III devices. This session would be of great interest to Industry members, biomedical scientists, students and faculties, and regulatory professionals.

Abstracts

  • 4:15 PM 309. Deanna Porter, Abbott

  • 4:45 PM 310. Kent Grove, Abbott

  • 5:15 PM 311. Don Phol, NAMSA

  • 5:45 PM 312. Cindy Dingee, WuXi AppTec

Invited Speaker(s)

Tissue Engineering SIG

Timeslot: Thursday, April 4, 2019 - 4:15pm to 6:15pm
Track: Tissue Engineering and Regenerative Medicine
Room: Chelan 4

About

The field of tissue engineering has made significant progress in the last two decades through the development of novel biomaterials and three-dimensional scaffold fabrication methods. Efforts to engineer cell niches to control cell behavior over multiple length scales and precisely guide tissue regeneration have advanced the field. To achieve this, a diverse range of novel technologies have been leveraged, including 3D bioprinting, electrospinning, microfluidics, light-based patterning, and directed assembly, to enable notable progress in controlled release and spatial presentation of biomolecules, organ integration, production of tissue models, single cell-level presentation of microenvironmental cues, and molecular-level control of biomaterial composition. This session will highlight recent trends in novel biomaterials and scaffold development and advanced biofabrication techniques towards the development of sophisticated tool kits for tissue engineers.

Abstracts

  • 4:15:00 PM 341. Conductive Inks for 3D Printing from Jammed Hyaluronic Acid Microgels, M. Shin*, K.H. Song, J. Burdick; University of Pennsylvania, Philadelphia, PA, USA

  • 4:30:00 PM 342. 3D Bioprinting with an Engineered Elastin Like Protein (ELP), K. Lampe*, E. Meco, M. Azimi, A. Sharma, M. Hefferon, D. Meador, B. Corliss, M. Rikard, H. Shariff, S. Peirce; University of Virginia, Charlottesville, VA, USA

  • 4:45:00 PM 343. Evaluating the Effect of Elastin in the Angiogenic Response of Silk Fibroin 3D Printed Scaffolds, J. Silva-Correia(1,2), L. Costa(1,2), J. Costa*(1,2,3), J. Oliveira(1,2,3), R. Reis(1,2,3); (1)University of Minho, Guimarães, Portugal, (2)ICVS/3B’s–PT Government Associate Laboratory, Braga/Guimara?es, Portugal, (3)The Discoveries Centre for Regenerativ

  • 5:00:00 PM 344. Highly Elastic, Biodegradable Hydrogel with Shear-thinning Properties for Bioprinting, C. Xu*(1), W. Lee(2), G. Dai(2), Y. Hong(1); (1)University of Texas at Arlington, Arlington, TX, USA, (2)Northeastern University, Boston, MA, USA

  • 5:15:00 PM 345. Contractile Imbalance of Human Cardiac Microtissues on the Mechanical Hybrid Filamentous Matrices, Z. Ma*(1), C. Wang(1), S. Koo(2), P. Hoang(1), C. Grigoropoulos(2), K. Healy(2); (1)Syracuse University, Syracuse, NY, USA, (2)University of California Berkeley, Berkeley, CA, USA

  • 5:30:00 PM 346. Engineered Liver Tissue as an in vivo Model to Probe the Dynamics of Human Liver Regeneration Over Time, C. Fortin*, S. Saxton, F. Johansson, K. Stevens; University of Washington, Seattle, WA, USA

  • 5:45:00 PM 347. Rapid Encapsulation of Cells in Hydrogel Microspheres Using A Novel Microfluidic Platform, Y. Tian*, W. Seeto, S. Pradhan, P. Kerscher, E. Lipke; Auburn University, Auburn, AL, USA

  • 6:00:00 PM 348. Proteome-wide Analysis of Cellular Response to Ultraviolet Light for Photoresponsive Biomaterials, E. Ruskowitz*, C. DeForest; University of Washington, Seattle, WA, USA