Bioelectronics and Biosensors

Timeslot: Friday, April 5, 2019 - 10:30am to 12:30pm
Track: Sensory Biomaterials and Tissues
Room: Chelan 4

About

Bioelectronics, electronics designed to interface with biology in vitro and in vivo, are an important class of biomaterials that are gaining significant interest. Bioelectronic devices include: (i) wearable sensors for health monitoring, (ii) in vitro diagnostics and biosensors that provide an electrical signal output proportional to an analyte, (iii) implantable devices (e.g. pacemakers, blood glucose monitoring, drug delivery, optoelectronics), (iv) electrophysiology (ECG, EMG, EEG) and (v) electrical stimulation of cells or tissues for tissue engineering, enhanced regeneration and therapeutic intervention. This symposium will highlight recent efforts in bioelectronics, including fabrication advances for improved properties such as size, softness, flexibility, degradability and biocompatibility as well as investigating their use in new applications.

Abstracts

  • 10:30:00 AM 389. Invited Speaker,

  • 10:45:00 AM 390. Invited Speaker,

  • 11:00:00 AM 391. Conformal Electrode Arrays to Enable in vivo Recordings of the Enteric Nervous System, M. Ecker*, E. Guerrero, P. Rocha Flores, W. Voit; The University of Texas at Dallas, Richardson, TX, USA

  • 11:15:00 AM 392. Integration of Micropillars in Human iPS-Cell Derived Cardiomyocyte Based Microphysiological Systems for Contraction Force Measurement Enables Precise Monitoring of Pharmacology and Maturation Studies, B. Charrez*(1), N. Huebsch(2), V. Charwat(1), B. Siemons(1), S. Boggess(1), N. Deweshwar(1), A. Stahl(1), E. Miller(1), K. Healy(1); (1)University of California Berkeley, Berkeley, CA, USA, (2)Washington University in St. Louis, St. Louis, MT, USA

  • 11:30:00 AM 393. Biodegradable Piezoelectric Force Sensor for Monitoring Biological Pressures, T. Nguyen*; University of Connecticut, Storrs, CT, USA

  • 11:45:00 AM 394. Flexible Nanofiber-Based Materials for Material Property-Matched Neural Interfacing, J.D. Remer*(1), M. Skoff(1), C. Tison(1), K. Yoshida(2), A. Joshi-Imre(3), L. Costella(1); (1)Luna Innovations Incorporated, Charlottesville, VA, USA, (2)Indiana University - Purdue University Indianapolis, Indianapolis, IN, USA, (3)University of Texas at

  • 12:00:00 PM 395. A Flexible and Electrically Stable Conductive Polypyrrole Membrane for Biomedical Applications, Z. Zhang*(1,2), J. Mao(1,2,3), S. Cui(1,2,3), M. Rouabhia(3); (1)Université Laval, Quebec, QC, Canada, (2)Centre de recherche du CHU de Québec - Université Laval, Quebec, QC, Canada, (3)Université Laval Faculty of Dentistry, Quebec, QC, Canada

  • 12:15:00 PM 396. Immobilized Liquid Coatings for Implantable Neural Electronics, A. Rutz*, A. Carnicer-Lombarte, D. Barone, G. Malliaras; University of Cambridge, Cambridge, United Kingdom

Invited Speaker(s)

Biomaterial Technologies for Hemostasis and Wound Care

Timeslot: Friday, April 5, 2019 - 10:30am to 12:30pm
Track: Cardiovascular Biomaterials
Room: Yakima 1

About

Stopping bleeding (hemostasis) and providing short and long-term wound care via passive and/or bioactive mechanisms is an important area of biomaterials-based technologies and includes external, intracavitary and intravascular hemostats, dressings, powders, foams, fibers and gels. The goal of this session is to highlight recent advances in hemostatic biomaterials and to facilitate discussion of best practices for moving hemostatic technologies from the benchtop to the clinic. The proposed session will invite presentations from researchers in this field that discuss biomaterials design, structure-property-function relationships, and achieved/ongoing/future visions of technology translation pathways. An emphasis will be placed on translational aspects of hemostatic technologies.

Abstracts

  • 10:30:00 AM 369. Modular Amplification of Hemostatic Output with Platelet-inspired Particles using Clot-augmenting Nanomaterials, U.D.S. Sekhon*, N. Luc, K. Swingle, A. Sen Gupta; Case Western Reserve University, Cleveland, OH, USA

  • 10:45:00 AM 370. Stiffness-dependent toxicity of platelet-like particles, J. Nicosia*(1,2), D. Chambers(1,2), M. Fay(1,2), D. Abebayehu(3), M. Harp(3), S. Landes(3), A. Brown(4,5), W. Lam(1,2), T. Barker(3); (1)Georgia Institute of Technology, Atlanta, GA, USA, (2)Emory University, Atlanta, GA, USA, (3)University of Virginia, C

  • 11:00:00 AM 371. Porcine Wound Healing Testing of ROS-degradable Poly(thioketal) Urethane Scaffold Variants, P. Patil*(1), J. Martin(1), A. Pollins(2), N. Cardwell(2), J. Davidson(2), S. Guelcher(1), L. Nanney(2), C. Duvall(1); (1)Vanderbilt University, Nashville, TN, USA, (2)Vanderbilt University Medical Center, Nashville, TN, USA

  • 11:15:00 AM 372. Self-Healable and Sustained Release Zwitterionic Cryogels for Wound Healing, J. Newsom*(1), M. Krebs(1), G. Sener(1), S. Hilton(2), C. Zgheib(2), S. Singh(3), S. Seal(3), K. Liechty(2); (1)Colorado School of Mines, Golden, CO, USA, (2)University of Colorado School of Medicine and Children's Hospital, Aurora, CO, USA, (3)University

  • 11:30:00 AM 373. Ultrasound Stimulation Enhances Platelet-like Particle Mediated Matrix Deformation to Improve Healing Outcomes, S. Nandi*(1,2), A. Joshi(3), K. Mohanty(3), E. Sproul(1,2), M. Muller(1,3), A. Brown(1,2); (1)North Carolina State University/The University of North Carolina at Chapel Hill, Raleigh, NC, USA, (2)NC State University, Raleigh, NC, USA, (3)North Carolina St

  • 11:45:00 AM 374. A Flexible Electronic/Smart Hydrogel Integrated System for Real-Time Infection Monitoring and Dynamic Treatment, Q. Pang*, D. Lou, C. Gao, M. Lie; Zhejiang University, Hangzhou, China

  • 12:00:00 PM 375. Chromophore-free Tissue Sealing and Repair using Mid Infrared Lasers, I. Ridha*(1), A. Basiri(1), S. Gudesala(1), D. Gosh(1), J. Keun Lee(2), J. Kilbourne(1), Y. Yao(1), K. Rege(1); (1)Arizona State University, Tempe, AZ, USA, (2)Midwestern University, Tempe, AZ, USA

  • 12:15:00 PM 376. Noninvasive Photochemical Epithelial Tissue Bonding Using Upconversion Nanoparticles / Hyaluronate – Rose Bengal Conjugate Complex, S.K. Hahn*, S. Han; Pohang University of Science and Technology, Pohang, Republic of Korea

Biomaterials for Regenerative Engineering 1

Timeslot: Friday, April 5, 2019 - 10:30am to 12:30pm
Track: Tissue Engineering and Regenerative Medicine
Room: Chelan 2

About

Due to disease, degeneration, or trauma, there is a tremendous need to repair damaged tissues and organs. Although surgical replacement can be performed to address this issue, the insufficient number of donors greatly limits the applicability of this approach. Therefore, it is essential to develop engineered multifunctional biomaterials to promote tissue regeneration. Regenerative engineering combines biomaterial-based approaches with stem cell therapies and developmental biology to regenerate or repair tissues and organs. This session will cover tunable biocompatible materials such as hydrogels, fibers, proteins, carbohydrates, nano/micro-porous scaffolds, and metals, to modulate cellular microenvironments. The biomaterials that can direct cell fate and promote differentiation will also be highlighted by this session. Moreover, the biomaterials that can facilitate drug delivery and immunomodulation will be covered through oral and poster presentations. Furthermore, we will include discussions for the development and commercialization of various medical devices such as blood contacting implants, prostheses, and pacemakers in the session. In addition to engineering approaches, we will also provide discussions on clinical translation of biomaterial-based strategies. We expect that our interdisciplinary session including material science, chemistry, biology, engineering, and medicine will be of great significance to the clinicians, industry members and professors in academia.

Abstracts

  • 10:30:00 AM 397. Invited Speaker,

  • 10:45:00 AM 398. Invited Speaker,

  • 11:00:00 AM 399. MicroRNA-200c Incorporated 3D-Printed Tricalcium Phosphate Enhances Bone Regeneration, M. Remy*(1,2), A. Akkouch(2), L. He(3), M. Sweat(2), F. Qian(2), X. Song(3), B. Amendt(2), L. Hong(2); (1)University of Iowa College of Engineering, Iowa City, IA, USA, (2)University of Iowa College of Dentistry, Iowa City, IA, USA, (3)University of Iowa,

  • 11:15:00 AM 400. Biomolecule Delivery to Synergistically Mobilize and Locally Recruit Bone Marrow Cells Enhances Muscle Regeneration Following Rotator Cuff Tear, L. Anderson*, L. Tellier, A. Brimeyer, E. Botchwey, J. Temenoff; Georgia Institute of Technology, Atlanta, Georgia

  • 11:30:00 AM 401. BMP-2 Modified Fiber Meshes to Facilitate Bone Integration for Ligament Reconstruction, A. Goldstein*, D. Gadalla; Virginia Tech, Blacksburg, VA, USA

  • 11:45:00 AM 402. Synthesis and Characterization of Osteoinductive Adhesive Composites with Antimicrobial Properties, N. Annabi*(1), R. Portilo Lara(2), A. Moghanian(2), E. Shirzaei Sani(1), H. Konisky(2); (1)University of California, Los Angeles, Los Angeles, CA, USA, (2)Northeastern University, Boston, MA, USA

  • 12:00:00 PM 403. Engineering 3D Skeletal Muscle Primed for Neuromuscular Regeneration Following Volumetric Muscle Loss, J. Gilbert-Honick*(1), K. Wagner(2), H.-Q. Mao(1,3), W. Grayson(1,3); (1)Johns Hopkins School of Medicine, Baltimore, MD, USA, (2)Johns Hopkins University School of Medicine, Baltimore, MD, USA, (3)Johns Hopkins University, Baltimore, MD, USA

  • 12:15:00 PM 404. Microporous Annealed Particle Hydrogel-based Muscle Repair in Rat Model of Volumetric Muscle Loss, A. Rodriguez Ayala*, S. Shah, D. Griffin, G. Christ; University of Virginia, Charlottesville, VA, USA

Invited Speaker(s)

Non-Viral Delivery for Gene Therapy and Editing

Timeslot: Friday, April 5, 2019 - 10:30am to 12:30pm
Track: Therapeutic Delivery
Room: Skagit 2

About

Targeted genome editing using programmable nucleases has recently rapidly transformed from a technique on the bench to a potential avenue for the treatment of genetic disorders and diseases. Three main types of nucleases, including zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and the clustered, regularly interspaced, short palindromic repeat (CRISPR)-associated endonuclease Cas9 have been harnessed to introduce precise and specific genome sequence change at virtually any genome locus of interest. The therapeutic relevance of genome editing, however, is challenged by the safe and efficient delivery of nuclease into targeted cells ex vivo and in vivo. This symposium will cover the fundamentals, perspective and challenge of genome editing, and highlight the recent advances that have been made on non-viral delivery of genome-editing nucleases for therapy.

Abstracts

  • 10:30:00 AM 353. Dendrimer-based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I, D. Siegwart*; UT Southwestern Medical Center, Dallas, TX, USA

  • 10:45:00 AM 354. Non-viral Intracellular mRNA Delivery in Human Primary Cytotoxic T Lymphocytes Using Synthetic Lipidoid Nanoparticles, X. Zhao*, Q. Xu; Tufts University, MA, MA, USA

  • 11:00:00 AM 355. Carboxylated Branched Poly(B-amino ester) Nanoparticles Enable Robust Intracellular Protein Delivery and CRISPR/Cas9 Gene Editing, Y. Rui*, D. Wilson, K. Sanders, J. Green; Johns Hopkins University School of Medicine, Baltimore, MD, USA

  • 11:15:00 AM 356. Polymer Nanoparticles for Secreted TRAIL Cancer Therapy, H. Vaughan*, C. Zamboni, N. Radant, P. Bhardwaj, D. Francisco, J. Green; Johns Hopkins University, Baltimore, MD, USA

  • 11:30:00 AM 357. Combinatorial Therapy of siMDR1 and Doxorubicin to Overcome Drug Resistance in Breast Cancer Models, J. Lee*(1), D. Oglesby(1), W. Cornett(2); (1)Clemson University, Clemson, SC, USA, (2)Greenville Health System, Greenville, SC, USA

  • 11:45:00 AM 358. Flash Nanocomplexation as a Scalable Production Method for Therapeutic pDNA/lPEI Nanoparticles, H.-w. Liu*(1,2), Y. Hu(3), I. Minn(4), H.-Q. Mao(1,2,3,5); (1)Johns Hopkins University Whiting School of Engineering, Baltimore, MD, USA, (2)Johns Hopkins University INBT, Baltimore, MD, USA, (3)Johns Hopkins University School of Medicine, Baltimore, MD,

  • 12:00:00 PM 359. Characterization of Long-term Stability of PgP/pGFP Polyplexes with Varying Cryoprotectants, J.S. Lee*(1), J. Woo(1,2), K.-T. Kim(1), C. Macks(1); (1)Clemson University, Clemson, SC, USA, (2)Johns Hopkins University, Baltimore, MD, USA

  • 12:15:00 PM 360. Dendritic Lipopeptides for High Gene Transfection Efficiency with Structure Optimization by Molecular Dynamic Simulation, H. Liang, III*, X. Chen, A. Hu, R. Jin, K. Wang, Y. Nie; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China

Panel Discussion: Establishing Industry Experiences During Graduate School

Timeslot: Friday, April 5, 2019 - 10:30am to 12:30pm
Track: Career Catalysis
Room: Yakima 2

About

Graduate programs offer students rigorous scientific training in an academic setting, but rarely provide the opportunity to explore career paths in industry. In our proposed session, we seek to disseminate best practices for establishing a training program at a university where graduate students are able to gain industry experience during their academic training. We will host professors that have successfully established training programs at their universities, as well as PhD trainees that have completed such programs, to discuss the benefits and potential drawbacks of incorporating industry experience during PhD training. This session is being proposed by the Young Scientist Group and would be included in the Career Catalysis Track

Abstracts

  • 10:30:00 AM 377. Invited Speaker: Teja Guda, PhD

  • 11:00:00 AM 378. Invited Speaker: Michele Jen, PhD

  • 11:30:00 AM 379. Invited Speaker: TBD

  • 12:00:00 PM 380. Invited Speaker: TBD

Invited Speaker(s)

Recent Advances in Antimicrobial and Antibiofilm Materials 2

Timeslot: Friday, April 5, 2019 - 10:30am to 12:30pm
Track: Musculoskeletal and Craniofacial Biomaterials
Room: Skagit 3

About

Microbial infections are among the leading causes of death worldwide. Drug resistance and lack of new antimicrobial therapeutics increase the difficulty of treating these infections. Microbial biofilms can also severely complicate treatment and lead to chronic infections. These three-dimensional, surface attached microbial structures can form on a range of medical devices and biological surfaces and exhibit sophisticated defense mechanisms, evading traditional antimicrobial therapies. This session will focus on recent advances spanning industry and academia in developing materials for the treatment of bacterial, fungal, viral, biofilm and polymicrobial infections. Strategies discussed may range from synthesis of new antimicrobial molecules and macromolecules to fabrication of antimicrobial surfaces, device coatings, nano- and micro-particle drug carriers, hydrogels, etc.

Abstracts

  • 10:30:00 AM 361. Invited Speaker: Horst von Recum, PhD

  • 11:00:00 AM 363. Influence of Poly-L-Lysine Molecular Weight on Antibacterial Activity of Polyelectrolyte Multilayer Films, A. Shukla*, D. Alkekhia; Brown University, Providence, RI, USA

  • 11:15:00 AM 364. Nano-patterned Bacterial Cellulose Hydrogel Exhibits Bactericidal Activity Against E. coli and K. pneumoniae, S. Arias*, M.K. Cheng, A. Civantos, J. Devorkin, C. Jaramillo, J.P. Allain; University of Illinois at Urbana-Champaign, Urbana, IL, USA

  • 11:30:00 AM 365. Adhesive Antimicrobial Wraps to Treat Infection and Improve Bone Regeneration, T. Buie*, J. McCune, E. Cosgriff-Hernandez; University of Texas at Austin, Austin, TX, USA

  • 11:45:00 AM 366. Biomimetic Recyclable Microgels for On-demand Generation of Hydrogen Peroxide and Antipathogenic Application, R. Pinnaratip*(1), H. Meng(1), P. Kord Forooshani(1), P. Joshi(2), J. Osborne(1), X. Mi(2), M. Frost(1), C. Heldt(2), B. Lee(1), C. Meingast(3); (1)Department of Biomedical Engineering, Michigan Technological University, Houghton, MI, USA, (2)Department o

  • 12:00:00 PM 367. Evaluation of Blended Chitosan/Polyol injectable Paste in an in vitro Model of Osteomyelitis, L. Pace*, Z. Harrison, J.A. Jennings; University of Memphis, Memphis, TN, USA

  • 12:15:00 PM 368. Bacteriophage Delivering Hydrogels Reduce Biofilm Formation in vitro and Infection in vivo, J. Wroe*(1), C. Johnson(1,2), A. García(1); (1)Georgia Institute of Technology, Atlanta, GA, USA, (2)Emory University, Atlanta, GA, USA

Invited Speaker(s)

Surface Characterization and Modification SIG

Timeslot: Friday, April 5, 2019 - 10:30am to 12:30pm
Track: Functional Biomaterials and Surfaces
Room: Chelan 5

Abstracts

  • 10:30:00 AM 381. ImageJ and Atomic Force Microscopy Characterization of Drug-stabilized Microtubules, Y.-L. Chiang*(1,2), J. Zhou(2), S. Wu(2), K. Richardson(2), D. Sackett(3), A. Jin(2); (1)NIBIB/NIH, Bethesda, MD, USA, (2)National Institute of Biomedical Imaging and Bioengineering/NIH, Bethesda, MD, USA, (3)Eunice Kennedy Shriver National Institute of C

  • 10:45:00 AM 382. Surface Conjugation of Anti-fouling Polymers via Pyrogallol-based Chemistry, S.-L. Yeh*, W.-B. Tsai; National Taiwan University, Taipei, Taiwan

  • 11:00:00 AM 383. Synthetic Glycocalyx on Cell Surfaces for Enhancing Anti-tumor Responses of Immune Cells, H. Chen*, Q. Liu, G. Chen; Soochow University, Suzhou, China

  • 11:15:00 AM 384. Analysis of Shear Forces Between Satellite Telemetry Tag and Whale Blubber in a Drag Force Simulation, E. Bloch*, R. Jones, E. Johnson, J. Jiang, A. Zerbini(1), J. Robbins(2), R. Rajachar; (1)Alaska Fisheries Science Center, Seattle, WA, USA, (2)Center for Coastal Studies, Provincetown, MA, USA

  • 11:30:00 AM 385. Surface Modification Using Elastin-Like Polypeptide and Polyethyleneimine for Three-Dimensional Cell Cultures, J. Cobb*, P. Pal, A. Janorkar; University of Mississippi Medical Center, Jackson, MS, USA

  • 11:45:00 AM 386. Incorporation of Biochemical Stimuli by Surface Coating Fiber Based Scaffolds for Tissue Engineering a Tendon-Bone Junction, H. Ramakrishna*(1), M. King(1,2); (1)North Carolina State University, Raleigh, NC, USA, (2)Donghua University, Shanghai, China

  • 12:00:00 PM 387. Synthesis and Characterization of a Novel Porous Bioactive SiC Tissue Engineering Scaffold, M. Greenier*, I. Marriott, M. Johnson, A. El-Ghannam; University of North Carolina at Charlotte, Charlotte, NC, USA

  • 12:15:00 PM 388. Photocatalytic Activity and Antibacterial Efficacy of UVA-Treated Titanium Oxides, H. Johnson*(1), A. Janorkar(1), M. Marquart(2), R. Williamson(1), M. Roach(1); (1)University of Mississippi Medical Center, Jackson, MS, USA, (2)University of Mississippi Medical Center, Jackson, MS, USA

Thought Leader: ICF Fellows Session: Debate: In-situ Approaches for Tissue Creation are Better than ex-vivo Approaches

Timeslot: Friday, April 5, 2019 - 10:30am to 12:30pm
Track: Thought Leader
Room: Skagit 4/5

About

This is a special session, organized by the International College of Fellows of Biomaterials Science and Engineering. Following the model of a traditional British debate, a team of Fellows will argue that the creation of tissues in-situ is a better approach than the pre-assembly of tissues ex-vivo. Another team will argue for the opposite. In the course of the debate, this fundamental choice in tissue engineering will be thoroughly illuminated from multiple angles and the audience will vote on which team provided the most convincing arguments.

Abstracts

  • 10:30:00 AM 349. Thomas Webster

  • 11:00:00 AM 350. Shelly Sakiyama- Elbert

  • 11:30:00 AM 351. Hassan Huludag

  • 12:00:00 PM 352. Ali Khademhosseini

Invited Speaker(s)