Biomaterials for Regenerative Engineering 2

Timeslot: Friday, April 5, 2019 - 1:45pm to 3:45pm
Track: Tissue Engineering and Regenerative Medicine
Room: Chelan 2

About

Due to disease, degeneration, or trauma, there is a tremendous need to repair damaged tissues and organs. Although surgical replacement can be performed to address this issue, the insufficient number of donors greatly limits the applicability of this approach. Therefore, it is essential to develop engineered multifunctional biomaterials to promote tissue regeneration. Regenerative engineering combines biomaterial-based approaches with stem cell therapies and developmental biology to regenerate or repair tissues and organs. This session will cover tunable biocompatible materials such as hydrogels, fibers, proteins, carbohydrates, nano/micro-porous scaffolds, and metals, to modulate cellular microenvironments. The biomaterials that can direct cell fate and promote differentiation will also be highlighted by this session. Moreover, the biomaterials that can facilitate drug delivery and immunomodulation will be covered through oral and poster presentations. Furthermore, we will include discussions for the development and commercialization of various medical devices such as blood contacting implants, prostheses, and pacemakers in the session. In addition to engineering approaches, we will also provide discussions on clinical translation of biomaterial-based strategies. We expect that our interdisciplinary session including material science, chemistry, biology, engineering, and medicine will be of great significance to the clinicians, industry members and professors in academia.

Abstracts

  • 1:45:00 PM 453. Aligned and Conductive 3D Collagen Scaffolds for Skeletal Muscle Tissue Engineering, I. Basurto*, M. Mora, G. Christ, S. Caliari; University of Virginia, Charlottesville, VA, USA

  • 2:00:00 PM 454. Effect of a Degradable Methacrylic Acid-Based Hydrogel on Macrophage Phenotype in Skeletal Muscle, M. Carleton*, M. Sefton; University of Toronto, Toronto, ON, Canada

  • 2:15:00 PM 455. Wnt7a-Releasing Hydrogel for Enhancing Local Skeletal Muscle Regeneration, W. Han*, S. Anderson, M. Mohiuddin, A. Garcia, Y. Jang; Georgia Institute of Technology, Atlanta, GA, USA

  • 2:30:00 PM 456. Sulfated Alginate to Sequester Endogenous Growth Factors Secreted by Mesenchymal Stem Cell Spheroids, M. Gionet-Gonzales*(1), K. Leach(1,2); (1)University of California, Davis, Davis, CA, USA, (2)School of Medicine, UC Davis Health, Sacramento, CA, USA

  • 2:45:00 PM 457. Precision-Porous Templated Scaffolds Induce Unique Pro-Healing Cell and Exosome Populations, J. Bryers*(1), B. Hwang(2), M. Mulligan(2), B. Ratner(1); (1)University of Washington, Seattle, WA, USA, (2)University of Washington Medical School, Seattle, WA, USA

  • 3:00:00 PM 458. Paper-Based Biomaterials for Personalized Medicine and Regenerative Engineering, G. Camci-Unal*; University of Massachusetts Lowell, Lowell, MA, USA

  • 3:15:00 PM 459. Hyperbaric Oxygen-Generating Hydrogels for Enhanced Wound Healing, K.M. Park*; Incheon National University, Incheon, Republic of Korea

  • 3:30:00 PM 460. Developing an Economical Fibrous Gelatin-Polyurethane Scaffold for Skin Regeneration, M. Sheikholeslam*, M. Wright, N. Cheng, H.H. Oh, S. Amini-Nik, P. Santerre, M. Jeschke; University of Toronto, Toronto, ON, Canada

Biomaterials for Therapeutic Drug Delivery 1

Timeslot: Friday, April 5, 2019 - 1:45pm to 3:45pm
Track: Therapeutic Delivery
Room: Skagit 2

About

Controlled release approaches have the potential to effectively treat a variety of medical conditions, while avoiding complications such as off-site toxicity and drug-resistance. Approaches can include localized, depot-based methods as well as targeted, systemic treatments. Controlled drug delivery can result from affinity interactions, bond cleavage, reservoir or diffusion-based control, and/or stimulus-responsive methodologies. This session will focus on the development of these drug delivery systems, which include nano and microparticles, hydrogels, scaffolds, and thin films, for applications including but not limited to regenerative medicine/tissue engineering, cancer, microbial infection, and autoimmune diseases.

Abstracts

  • 1:45:00 PM 409. Sustained Delivery of Glycogen Synthase Kinase Inhibitor AR28 Is Critical for Osteogenic Selectivity in MSCs, D. Benoit*(1,2), M. Newman(1,2), M. Ackun-Farmmer(1,2), Y. Wang(1,2), B. Xiao(1,2), J.E. Puzas(2); (1)University of Rochester, Rochester, NY, USA, (2)University of Rochester Medical Center, Rochester, NY, USA

  • 2:00:00 PM 410. Supramolecular PEGylation as an Innovative Approach to Biopharmaceutical Formulation and Delivery, E. Appel*, C. Maikawa, A. Smith; Stanford University, Stanford, CA, USA

  • 2:15:00 PM 411. Logical Stimuli-Triggered Delivery of Small Molecules from Hydrogel Biomaterials, C. DeForest*, E. Ruskowitz, M. Comerford, B. Badeau; University of Washington, Seattle, WA, USA

  • 2:30:00 PM 412. Assessment of Antioxidant Copolymers for Improved ROS Scavenging in Post Traumatic Osteoarthritis, A. Miskalis*(1,2), B. Dollinger(1), C. DeJulius(1), C. Duvall(1); (1)Vanderbilt University, Nashville, TN, USA, (2)Duquesne University, Pittsburgh, PA, USA

  • 2:45:00 PM 413. Biomimetic Apoptotic Erythrocyte Membrane-Coated Microparticles for Enhanced Tolerance Induction, K. Rhodes*, R. Meyer, C. State, J. Green; Johns Hopkins University, Baltimore, MD, USA

  • 3:00:00 PM 414. Polybubble Depots Functioning as a Theranostic-enabling Anti-cancer Platform Technology, S. Arun Kumar*, J. Good, D. Hendrix, W. Souery, Y.-Y. Jhan, C. Bishop; Texas A&M University, College Station, TX, USA

  • 3:15:00 PM 415. Design of Semi-Randomized Zwitterionic Peptides to Prevent Serum Aggregation of Polymeric Nanoparticles, C. Overby, III*(1), D. Benoit(1,2); (1)University of Rochester, Rochester, NY, USA, (2)University of Rochester Medical Center, Rochester, NY, USA

  • 3:30:00 PM 416. Nanofiber-based Opioid Bandages for Localized Treatment of Burn Pain, M. Skoff*(1), M. Patterson(1), J. Mao(2), Z. You(2), C. Tison(1); (1)Luna Innovations Incorporated, Charlottesville, VA, USA, (2)Massachusetts General Hospital, Boston, MA, USA

Developing Better Biomaterials: Advances in Technologies and Understanding of Surface Modification

Timeslot: Friday, April 5, 2019 - 1:45pm to 3:45pm
Track: Functional Biomaterials and Surfaces
Room: Yakima 1

About

Surface modification has become a routine procedure in designing and developing bio-friendly implants for orthopedic, dental and pacemaker applications as well as other biosensing applications. The surface of a biomaterial affects its performance in a host environment. Many techniques have been utilized to modify the surfaces of biomaterials to obtain innovative or improved properties (e.g. mechanical, biocompatible, corrosion-resistant, and biological responsive) through modification of physicochemical interactions between the biomaterial and the biological environment at the molecular, cellular, and tissue levels. In this session, recent advances in surface modification technologies and characterization, biomaterial-tissue interactions at the interface, and basic and translational studies of surface modified biomaterials will be solicited and presented.

Abstracts

  • 1:45:00 PM 429. Invited Speaker: Jeremy Gilbert, PhD

  • 2:15:00 PM 431. Enzyme-Mediated Peptide Decoration of Silk Fibroin-based Hydrogels, M. McGill*, J. Grant, D. Kaplan; Tufts University, Medford, MA, USA

  • 2:30:00 PM 432. A Less-Explored Surface Property: The Electrical Double Layer and Its Molecular Interrogation Capability, G. Zhang*, Y. Zhao; University of Kentucky, Lexington, KY, USA

  • 2:45:00 PM 433. Catalyzed Nitric Oxide Release Via Cu Nanoparticles Leads to Increase in Antimicrobial Effects and Hemocompatibility for Short Term Extracorporeal Circulation, M. Douglass*, M. Goudie, J. Panta, P. Singha, S. Hopkins, H. Handa; University of Georgia, Athens, GA, USA

  • 3:00:00 PM 434. Ultra-low Fouling Biocompatible Polycarboxybetaine Coatings, K. Wu*, H.-C. Hung, P. Zhang, S. Jiang; University of Washington, Seattle, WA, USA

  • 3:15:00 PM 435. Effect of Bone Remodeling Coupling Factors on Osteogenic Differentiation of Human Mesenchymal Stem Cells Induced by Microstructured Titanium Surfaces, J. Deng*(1), D. Cohen(1), Z. Schwartz(1,2), B. Boyan(1,3); (1)Virginia Commonwealth University, Richmond, VA, USA, (2)University of Texas Health Science Center, San Antonio, TX, USA, (3)Georgia Institute of Technology, Atlanta, GA, USA

  • 3:30:00 PM 436. Promoted Osteoconductivity of Titanium with Chessboard-patterned Surface Nano Topography Fabricated by Femtosecond Laser Irradiation, P. Chen*(1), K. Takenaka(2), M. Tsukamoto(2), M. Ashida(1), Y. Tsutsumi(1), H. Doi(1), T. Hanawa(1); (1)Tokyo Medical and Dental University, Tokyo, Japan, (2)Osaka University, Osaka, Japan

Invited Speaker(s)

Functional Biomaterials to Control and Direct Cellular Function 1

Timeslot: Friday, April 5, 2019 - 1:45pm to 3:45pm
Track: Functional Biomaterials and Surfaces
Room: Chelan 4

About

This session solicits abstracts that focus on the development functional biomaterials for tissue engineering applications. Specifically, studies that investigate biomaterial-directed cellular response in the absence of external factors (e.g., growth factors) will be highlighted. These studies include development of novel biomimetic approaches for the generation of tissue scaffolds with physicochemical properties (e.g., topography, composition, structure, mechanics) akin to the target tissue and assessment of the impact of these physicochemical cues on cell migration, proliferation, differentiation and de novo matrix production. Further, this session will also showcase in vivo studies that demonstrate the clinical translational capability of next generation functional biomaterials. Lastly, studies that focus on the investigation of biomaterial-based mechanisms that modulate cellular response are of interest.

Abstracts

  • 1:45:00 PM 437. Invited Speaker: Akhilesh Gaharwar, PhD

  • 2:15:00 PM 439. Soft Hydrogel as Cell Culture Substrate to Direct MSCs Proangiogenic Potential through ROS-NRF2-HIF Signaling, H. Yang*, C.Y. Tay, M.K.H. Lee; Nanyang Technological University, Singapore, Singapore

  • 2:30:00 PM 440. Hydrogel Surfaces Promote MSC Expansion and Proregenerative Priming for Rotator Cuff Muscle Healing, M. Ogle*(1), G. Doron(1), M. Levy(1), J. Temenoff(1,2); (1)Georgia Institute of Technology and Emory University, Atlanta, GA, USA, (2)Georgia Institute of Technology, Atlanta, GA, USA

  • 2:45:00 PM 441. Hydrogel-based in vitro Glioblastoma Spheroid Models, L. Hill*, M. Imaninezhad, J. Ortlund, J. Conley, S. Zustiak; Saint Louis University, Saint Louis, MO, USA

  • 3:00:00 PM 442. Nascent Protein Secretion Directs Cell Mechanosensing and Function in Three-Dimensional Hydrogels, C. Claudia*(1,2), R. Mauck(1,2), J. Burdick(1); (1)University of Pennsylvania, Philadelphia, PA, USA, (2)VA Medical Center, Philadelphia, PA, USA

  • 3:15:00 PM 443. Injectable Composite Hydrogels for Bone Repair in a Sheep Bone Defect Model, M. Gionet-Gonzales*(1), G. Ingavle(1), C. Vorwald(1), L. Bohannon(2), K. Clark(2), L. Galuppo(2), K. Leach(1,3); (1)University of California, Davis, Davis, CA, USA, (2)UC Davis School of Veterinary Medicine, Davis, CA, USA, (3)School of Medicine, UC Davis

  • 3:30:00 PM 444. The Role of Substrate Stiffness in Stem Cell Transfection of Plasmid Dna Using Lipid-Based Nanocarriers, S. Modaresi*, S. Pacelli, J. Whitlow, A. Paul; University of Kansas, Lawrence, KS, USA

Invited Speaker(s)

Ophthalmic Biomaterials SIG

Timeslot: Friday, April 5, 2019 - 1:45pm to 3:45pm
Track: Sensory Biomaterials and Tissues
Room: Chelan 5

Abstracts

  • 1:45:00 PM 445. ECM Protein Shrink-Wrapped Cells Demonstrate Enhanced Integration into Corneal Endothelium, R. Palchesko*(1), Y. Du(2), J. Funderburgh(2), A. Feinberg(1); (1)Carnegie Mellon University, Pittsburgh, PA, USA, (2)University of Pittsburgh, Pittsburgh, PA, USA

  • 2:00:00 PM 446. An Antioxidant-Releasing Hydrogel Vitreous Substitute, N. Tram*(1), K. Jacobs(1), K. Swindle-Reilly(1,2); (1)The Ohio State University, Columbus, OH, USA, (2)The Ohio State University Wexner Medical Center, Columbus, OH, USA

  • 2:15:00 PM 447. Fabrication of Swellable Microneedle using Methacrylated Hyaluronic Acid for Extraction of Biomarkers in Ocular Fluids, S.H. Park*, J. Lee, W. Ryu; Yonsei University, Seoul, Republic of Korea

  • 2:30:00 PM 448. Injectable Biodegradable Bi-layered Capsule for Sustainable Delivery of Protein Therapeutics, P. Jiang*(1), J. Lannutti(1), M. Ohr(2), K. Swindle-Reilly(1,2); (1)The Ohio State University, Columbus, OH, USA, (2)The Ohio State University Wexner Medical Center, Columbus, OH, USA

  • 2:45:00 PM 449. Radiolabeling Biopolymers and Synthetic Polymers for Precise Quantification, L. Liu*, H. Sheardown; McMaster University, Hamilton, ON, Canada

  • 3:00:00 PM 450. Isolation and Characterization of Inner Wall Endothelial Cells of the Schlemm’s Canal Using a Citrate-based Polymer, S. Ramachandra*, A. Vahabikashi, M. Johnson, G. Ameer; Northwestern University, Evanston, IL, USA

  • 3:15:00 PM 451. Mucoadhesive Micelles for the Treatment of Dry Eye Disease, F. Lasowski*, B. Muirhead, E.A. Hicks, T. Rambarran, N. Yasin, H. Sheardown; McMaster University, Hamilton, ON, Canada

  • 3:30:00 PM 452. Properties of Acrylate Materials Under Different Storage Environments, C. Hu*, M. Lowery; Johnson and Johnson Vision, Santa Ana, CA, USA

Panel Discussion: Translational Considerations for 3D Printed Biomaterial-Based Constructs

Timeslot: Friday, April 5, 2019 - 1:45pm to 3:45pm
Track: Industry
Room: Yakima 2

About

The adoption of 3D printing, bioprinting, and other advanced techniques are increasingly used in new product development. In addition to advantages they may offer, these technologies have their own specific properties and limitations. While many of these processes use the same synthetic and biologic materials already used in a variety of marketed products, process-based risks must be reasonably determined and reduced to a safe level. There are notable examples of 3D printed products both in the United States and in other countries with early adoption mainly in the creation of surgical guides and models. Other products include custom tracheal implants, PEEK craniofacial plates, orthopedic implants, and the like. The ultimate promise for many is the potential to build engineered tissue structures, up to full organ replacements, to advance biomedical products well beyond the current limits. This session comprises a two-part panel discussion focused on various translational considerations including (1) advancing technology out of the lab, and (2) translating technologies into products for broad clinical use.

Abstracts

  • 1:45 PM 417. Invited Speaker

  • 2:15 PM 418. Invited Speaker

  • 2:45 PM 419. Invited Speaker

  • 3:15 PM 420. Invited Speaker

Invited Speaker(s)

SFB Business Plan Competition *BTI*

Timeslot: Friday, April 5, 2019 - 1:45pm to 3:45pm
Track: Industry
Room: Skagit 4/5

About

Students and post docs: Medical technology requires more than just laboratory results to become a reality. Do you believe that your biomaterials-based research innovation has the potential to succeed in the medical device industry? Put your skills to the test in this unique session designed to challenge you to consider the commercialization aspects of your research. Individuals and groups (your choice) will be judged by experts from investing, industry, regulatory, and academia on the strength of their commercialization plans. Prizes will be awarded to the top teams, including audience’s choice. To participate, submit an abstract that contains your Executive Summary, including information on your technology, the market, and the commercialization strategy. Those selected will give a 10 minute pitch followed by Q&A “Shark Tank” style from judges and audience. Visit biomaterials.org to download complete instructions on how to submit your abstract.

Abstracts

  • 1:45:00 PM Introduction, Eric Sussman, PhD, Mark Van Dyke

  • 2:00:00 PM 421. SAPHTx: Injectable Hydrogel for Treating Neovascular Ocular Diseases, B. Sarkar*, P. Nguyen, Z. Siddiqui, V. Kumar; New Jersey Institute of Technology, Newark, NJ, USA

  • 2:15:00 PM 422. Evoke Medical, LLC: PiezoNail -- Stimulating a Pathway to Better Fracture Healing, Z. Pessia*(1), C. Cunningham(2), E. Krech(2), E. Friis(1,2,3); (1)University of Kansas, Lawrence, KS, USA, (2)KU, Lawrence, KS, USA, (3)Evoke Medical, LLC, Lawrence, KS, USA

  • 2:30:00 PM 423. HumeurVitrée : Revolutionizing Retinal Detachment Surgery, F. Lasowski*, B. Muirhead, H. Sheardown; McMaster University, Hamilton, ON, Canada

  • 2:45:00 PM 424. B-CULTURE, R. Canadas, J. M. Oliveira, A. P. Marques, R.L. Reis., 3B's Research Group, University of Minho, PORTUGAL

  • 3:00:00 PM Q&A

  • 3:15:00 PM VOTING

  • 3:30:00 PM RESULTS ANNOUNCED, AND AWARDS MADE

Tutorial: Advocating for Biomaterials

Timeslot: Friday, April 5, 2019 - 1:45pm to 3:45pm
Track: Thought Leader
Room: Skagit 3

About

Past federal investments in basic biomedical research have led to significant innovations and advancements in medicine. Today however, Congress seems less interested in past accomplishments as they assume new priorities to balance the budget, reduce government, and free private sector to assume long-standing government responsibilities for innovation and discovery. How did Congress make spending decisions to permit federal R&D spending to be flat for over a decade? Learn why Congress is no longer accountable for reduced investments in research. Discover three secrets to making a winning case for federal funding for biomedical research. Learn practical steps to successfully getting your point across to a Member of Congress. Arming yourself with these strategies for the political warfare for biomedical innovation is more than just changing public policy; it is key to changing the future landscape of new biomedical materials, products or procedures.

Abstracts

  • 1:45 PM 405. Invited Speaker - Milan Yager, AIMBE

  • 2:15 PM 406. Invited Speaker,

  • 2:45 PM 407. Invited Speaker,

  • 3:15 PM 408. Invited Speaker

Invited Speaker(s)