Biomaterials for Women's and Fetal Health *BTI*

Timeslot: Wednesday, April 21, 2021 - 4:45pm to 6:15pm
Room: Virtual

About

Maternal and fetal health are closely linked to long term health. Conditions such as preeclampsia can increase both a mother and child's risk for health complications including heart disease and high blood pressure later in life. Exposure to various environmental toxicants have been linked to increased risk of pregnancy complications such as gestational diabetes and miscarriage. Biomaterials can play an important role in understanding and promoting maternal and fetal health. These materials can be used to achieve new models, treatments, and diagnostics for prenatal and maternal healthcare. This session will cover advances in this field, including, but not limited to, organ-on-a-chip approaches to drug toxicity screening, development of models of the maternal-fetal interface, treatments for pregnancy complication (e.g., preterm birth, preeclampsia, etc.), placental membranes, biomechanics during pregnancy, new fertility treatments, and fetal cell isolation

Moderators:
Christaina Bailey-Hytholt, PhD
David Martin, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 109. A Gelatin Hydrogel Model of the Endometrium and Trophoblast Invasion, Samantha Zambuto, ScM1, Ishita Jain1, Shemona Rattila2, Kathryn Clancy, PhD1, Gabriela Dveksler, PhD2, Gregory Underhill, PhD1, Brendan Harley, PhD11University of Illinois Urbana-Champaign, Urbana, IL, USA, 2Uniformed Services University of the Health Sciences, Bethesda, MD, USA

  • 110. Engineering Lipid Nanoparticles for In Utero mRNA Delivery, Margaret Billingsley, Michael Mitchell, PhDUniversity of Pennsylvania, Philadelphia, PA, USA

  • 111. Fully Absorbable Poly-4-hydroxybutyrate (P4HB) Scaffold Provides Mechanical Support at 12 months Following Vaginal Implantation in an Ovine Model, Zeliha Guler, PhD, University of Amsterdam, Amsterdam, Netherlands

  • 112. Design and Prototyping of Dynamic Midurethral Sling for The Treatment of Stress Urinary Incontinence, Seelay Tasmim1, Philippe Zimmern2, Taylor Ware11Texas A&M University, College Station, TX, USA, 2The University of Texas Southwestern Medical Center, Dallas, TX, USA

  • 113. Evaluation of Immunomodulatory Mesh for Pelvic Floor Reconstruction in a Rabbit Colpopexy Model, Bryan Brown, PhD1,2, Aimon Iftikhar, PhD1,2, Alexis Nolfi1,2, Clint Skillen1,2, Branimir Popovic, DVM1,2, Pamela Moalli, MD, PhD1,21University of Pittsburgh, Pittsburgh, PA, USA, 2McGowan Institute for Regenerative Medicine, Pittsburgh, PA, USA

  • 114. Poly-4-hydroxybutyrate (P4HB) Fully Absorbable Scaffolds for Soft Tissue Support in 3D Applications, David Martin, PhD, Kai Guo, PhD, Jeffrey Scott, PhD, Antonio Fosco, Amit Ganatra, Said RizkTepha, Inc., Lexington, MA, USA

Biomaterials-based Strategies for Endogenous Tissue Regeneration - 2

Timeslot: Wednesday, April 21, 2021 - 4:45pm to 6:15pm
Room: Virtual

About

Large tissue defects are still challenging to be effectively repaired by using current methods. Instead of relying on a large number of exogenous cells and/or proteins-based tissue engineering approaches, the strategies that using biomaterials to promote tissue regeneration by activating and harnessing endogenous reparative cells and signaling pathways are more promising and translational. Interesting endogenous signaling pathways that contribute to tissue regeneration include but not limited to angiogenesis, inflammation, stem cell recruitment, and differentiation, etc. This session will focus on introducing the emerging concepts and strategies in the development of innovative biomaterials/drug/gene delivery/stem cell techniques for challenged tissue regeneration, e.g., cartilage, bone, teeth, skin, muscle, etc. Long term goal for this session is to develop new biomaterials-based regenerative treatments by using the body's innate ability through promoting the collaborations from the multidisciplinary filed.

Moderator:
Hongli Sun, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 115. Controlling Osteogenesis by Grafting Peptide Mimetics via Orthogonal Click Chemistries to Alginate Hydrogels, Sydney Neal1, Era Jain, PhD1, Xiaohong Tan1, Hannah Graf2, Rama Balasubramaniam1, Nathaniel Huebsch, PhD11Washington University in St. Louis, St. Louis, MO, USA, 2Eberhard-Karls University, Tübingen, Germany

  • 116. Neurotization of Decellularized Muscle Matrix Improves Functional Recovery and Promotes Unique mRNA Profiles in a Volumetric Muscle Loss Model, James Redden, B.S. Biomedical Engineering, David Cohen, Lucas Olson, Luke Krebs, Gettanjali Bendale, Jonathan Isaacs, Zvi Schwartz, Michael McClureVirginia Commonwealth University, Richmond, VA, USA

  • 117. The Macroarchitecture of Biomimetic Proteoglycans is Responsible for the Micromolecular Engineering of Cartilage Pericellular Matrix, Elizabeth Kahle1, Biao Han, PhD1, Prashant Chandrasekaran, PhD1, Katsiaryna Prudnikova, PhD1, Michele Marcolongo, PhD, PE1,2, Lin Han, PhD11Drexel University, Philadelphia, PA, USA, 2Villanova University, Villanova, PA, USA

  • 118. Enhanced satellite cell differentiation and muscle regeneration by semi-synthetic Hyaluronic acid hydrogel-mediated delivery of Fibro-Adipogenic Progenitors in Volumetric Muscle Loss, Shane Browne, PhD1, Anouk Killaars, PhD1, Mengyao Liu, BA2, Xuhui Li, MD2, Hubert Kim, MD, PhD2, Brian Feeley, MD2, Kevin Healy, PhD11University of California, Berkeley, Berkeley, CA, USA, 2University of California, San Francisco, San Francisco, CA, USA

Business Plan Competition

Timeslot: Wednesday, April 21, 2021 - 4:45pm to 6:15pm

About

Students and post docs: Medical technology requires more than just laboratory results to become a reality. Do you believe that your biomaterials-based research innovation has the potential to succeed in the medical device industry?

Put your skills to the test in this unique session designed to challenge you to consider the commercialization aspects of your research.

Individuals and groups (your choice) will be judged by experts from investing, industry, regulatory, and academia on the strength of their commercialization plans.

Prizes will be awarded to the top teams. To participate, submit an abstract that contains your Executive Summary, including information on your technology, the market, and the commercialization strategy.

Those selected will give a 10 minute pitch followed by Q&A "Shark Tank" style from judges.

Abstracts

Abstracts will be available for download on April 20, 2021.

  • Moderator: Bob Hastings

    Judges:
    Larry Thatcher TESco Associates
    Kip Thacker LifeCore Biomedical
    Jim Curtis
    Stephanie Steichen, DuPont
    Eric Sussman, FDA

  • 276. Bioresorbable stents for congenital heart disease
    Tre Raymond Welch, PhD, Jamie Wright, PhD
    UT Southwestern Medical Center

  • 277. Modular cell culture platform for preclinical testing
    Ram Saraswat South Dakota School of Mines & Technology

  • 278. Immuno-protection Device for Hypoxia Reduction in Cellular Therapy
    Chen Yang, Tran Minh Phuong Nam, Pham Hoang Linh Chi, Dang Thuy Tram*
    School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore.

  • 279. MetastaticPrecision – Rapid Diagnostic Test for Canine Lymphoma Kelsey Collins1, Scott Taylor2, Karen J.L. Burg1
    Department of Small Animal Medicine & Surgery, University of Georgia and 2Poly-Med, Inc.

  • 280. Biodegradable Piezoelectric Surgical Mask
    Vinayak Mishra
    Molecular & Cell Biology | University of Connecticut 2021

Panel: Biomaterials Education and Research in the Time of COVID

Timeslot: Wednesday, April 21, 2021 - 4:45pm to 6:15pm
Room: Virtual

About

The COVID-19 pandemic necessitated a rapid shift to remote instruction, shuttered labs temporarily, and had severe economic impacts on University Research. The rapid adoption of online and remote learning tools has highlighted, as well as opportunities for educational innovation for science, technology, engineering and mathematics (STEM) disciplines. This panel will invite discussion of perspectives and suggestions from faculty, students, and the scientific community with a specific focus on three major areas: Instructional methods and remote delivery, Student experiences, and Mentoring adaptations.

Abstracts

Abstracts will be available for download on April 20, 2021.

  • Moderator:

    Cheryl T. Gomillion, Ph.D.
    Jessica Amber Jennings, PhD

Invited Speaker(s)

Supramolecular Nanomaterials for Drug Delivery, Imaging, and Immunoengineering

Timeslot: Wednesday, April 21, 2021 - 4:45pm to 6:15pm
Room: Virtual

About

Due to their versatility and diversity in materials properties, a wide range of biomedical applications have emerged in recent years using supramolecular nanomaterials. The bottom up approach to design functional objects at the nanoscale have been used to develop individual nanoparticles or to produce highly oriented materials for a growing number of applications including drug delivery, imaging, theranostics, vaccines, and immunotherapy. In addition, there are exciting opportunities for local therapeutic modulation. This session highlights recent advances in nanomaterials designs aimed to enhance the in vivo delivery of therapeutic or imaging payloads for a variety of diseases including those affecting the skin, gastrointestinal and respiratory tracts, cardiovascular system, cancer, and other diseased tissues.

Moderator:
Eunji Chun, PhD
Bret Ulery, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 121. Randomized Peptide Assemblies for Improving the Efficacy of Epitope-Based Influenza Vaccines, Nicole Votaw, Lucas Shores, Andy Miranda, Alfred Harding, Nicholas Heaton, PhD, Joel Collier, PhDDuke University, Durham, NC, USA

  • 122. Synthetic Self-Assembled Nanorod Vaccine Confers Protection Against Influenza A Virus, Mélanie Côté-Cyr1,2, Ximena Zottig1,2, Soultan Al-Halifa1,2, Denis Archambault1, Steve Bourgault1,21Université du Québec à Montréal, Montréal, QC, Canada, 2Quebec Network for Research on Protein Function, Engineering and Applications (PROTEO), Québec, QC, Canada

  • 123. Methacrylate-Modified Gold Nanoparticles Enable Non-Invasive Monitoring of Photopolymerized Hydrogel Scaffolds, Lan Li1, Carmen Gil2, Vahid Serpooshan, PhD2, Ryan Roeder, PhD11University of Notre Dame, South Bend, IN, USA, 2Emory University and Georgia Institute of Technology, Atlanta, GA, USA

  • 124. Development of needle free transdermal microparticulate vaccine for Coronavirus Disease, Sharon Vijayanand, B.Pharm, Smital Patil, B.Pharm, Devyani Joshi, B.Pharm, Keegan Braz Gomes, B.S, Ipshita Menon, M.Pharm, Martin D'Souza, PhD, Mohammad Uddin, PhDMercer University College of Pharmacy, Atlanta, GA, USA

  • 125. A polymeric particulate vaccine for Zika for transdermal immunization using microneedle patch, Akanksha Kale, Martin D'Souza, PhDMercer University College of Pharmacy, Atlanta, GA, USA

  • 126. Fighting the Flu: Pain-free administration of a cross-protective subunit Influenza vaccine, Sharon Vijayanand, B.Pharm, Keegan Braz Gomes, B.S. in Biology, Kimberly Braz Gomes, PhD, Martin D'Souza, PhD, Sang Moo Kang, PhD

Surface Modification of Biomaterials 1

Timeslot: Wednesday, April 21, 2021 - 4:45pm to 6:15pm
Track: Functional Biomaterials and Surfaces
Room: Virtual

About

In biomedical applications, the surface properties of biomaterials are critical. The surface of biomaterials determines the outcomes of biological-biomaterial interactions. Only certain surface properties can induce optimized cell interaction and adhesion thereby improving cell attachment and biocompatibility of the biomaterials. Various surface modification technologies have been developed and assessed to control the physicochemical interactions between biomaterials and the biological environment at the molecular, cellular, and tissue levels. This symposium aims to highlight the recent advances and challenges in surface modification technologies and fundamental understandings of the biomaterials-tissue interaction in orthopedic and other areas. This symposium will cover topics related to advanced surface modification methods that are well established and those that are still in the early stage of development, and applications of such methods to optimize surface chemistry, morphology, and structures, and discuss how such modifications may lead to the development of promising biomaterials and successful medical devices.

Moderators:
Guigen Zhang, PhD
Bingyun Li, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • Lamb-Type Surface Acoustic Wave Excitation for Generating Tunable MHz-GHz Ultrasonic Waves Guigen Zhang, Ph.D. F. Joseph Halcomb III, M.D. Department of Biomedical Engineering, College of Engineering University of Kentucky, Lexington, KY, USA

  • 128. Controlling Microbial Infection by Submicron Textured Surfaces, Lichong Xu Xu, PhD, Christopher Siedlecki, PhDPenn State University College of Medicine, Hershey, PA, USA

  • 129. Smart ZnO Nanorod Arrays and PLGA Hybrid Coatings – A Biodegradable and Multifunctional Drug Release System on Titanium Implants, Juncen Zhou, PhD, Donghui Zhu, PhDStony Brook University, stony brook, NY, USA

  • 130. Tannin/glycosaminoglycan-based Polyelectrolyte Multilayers Improve the Endothelialization of TiO2 Nanotubes, Roberta Maia Sabino, BS, Matt Kipper, PhD, Alessandro Martins, PhD, Ketul Popat, PhDColorado State University, Fort Collins, CO, USA

  • 131. Ultraviolet Functionalized Surface Treatment of 3D Printed PEEK resulted in Calcium Phosphate Layer Formation, Paul DeSantis1, Tony Yu, PhD1, Cemile Basgul1, Steven Kurtz, PhD1,2, Michele Marcolongo, PhD, PE11Drexel University, Philadelphia, PA, USA, 2Exponent, Inc., Philadelphia, PA, USA

  • 132. Development of a Fully Reversible In Vitro Platform to Spatiotemporally Control Multiple Bioactive Peptides Using DNA Handles, Fallon Fumasi, Tara MacCulloch, Nicholas Stephanopoulos, PhD, Julianne Holloway, PhDArizona State University, Tempe, AZ, USA

Invited Speaker(s)