Biomaterials for Detection, Drug Delivery and Treatment of Microbial Infections

Timeslot: Friday, April 23, 2021 - 1:45pm to 3:15pm
Room: Virtual

About

Microbial infections are becoming increasingly difficult to treat. Antimicrobial resistance has rendered many of our antimicrobial therapeutics ineffective, leading to a significant health and economic burden. Compounding this issue is a lack of development of new antimicrobial drug classes limiting the pipeline of available therapeutics. Advances in biomaterials for detection and therapy have the potential to improve outcomes for patients suffering from these infections, including bacterial, fungal, viral, and biofilm-associated infections. Innovations in biomaterials are arguably needed now more than ever in the face of the COVID-19 pandemic. This session will cover advances in biomaterials for the treatment and detection of microbial infections. Strategies discussed may include development of bacterial biosensors, antimicrobial coatings, nano- and micro-particle drug carriers, hydrogels, gene therapy approaches, etc.

Moderator:
Shijie Cao, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 240. Evaluating the Bacterial Biofilm Inhibition of a Novel Silorane-based Biomaterial for Orthopedic Applications, Grahmm Funk, BS, BS1, Elizabeth Menuey, PhD2, Michael Dold, BS1, Alexander Brown, BS1, Wyatt Osterhage, BS1, Kathleen Kilway, PhD2, Terence McIff, PhD, MBA11University of Kansas Medical Center, Kansas City, KS, USA, 2University of Missouri-Kansas City, Kansas City, MO, USA

  • 241. Bacteria-Responsive Shape Memory Polymer Wound Dressing, Maryam Ramezani, PhD student1, Mary Beth Monroe, PhD1Syracuse University, Syracuse, NY, USA

  • 242. Bacteria Responsive Biopolymer-Coated Gelatin Nanoparticles to Combat Bacterial Biofilms, Yingying Wang, Anita Shukla, PhDBrown University, Providence, RI, USA

  • 243. Engineered Fibrin Nanoparticles for Efficient Drug Delivery to Biofilms, Grant Scull, B.S.1,2, Ashley Brown, PhD1,2, Lauren Schnabel, DVM, PhD2, Jessica Gilbertie, MS, DVM, PhD21University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 2North Carolina State University, Raleigh, NC, USA

Invited Speaker(s)

Biomaterials for Organoids

Timeslot: Friday, April 23, 2021 - 1:45pm to 3:15pm
Track: Engineered Microenvironments
Room: Virtual

About

Three-dimensional ex vivo organoid cultures using biomaterial-based assembly and self-assembly have been shown to resemble and recapitulate most of the functionality of diverse multicellular tissues and organs, such as the gut, brain, liver, kidney, and lung. Organoids bridge a gap in existing model systems by providing a more stable system amenable to extended cultivation and manipulation, while being more representative of in vivo physiology. For years, bioengineers have aspired to construct biological systems and manipulate the system in a highly controlled manner with biomaterials. Discovery of new substrates, pathways and growth factors is expected to contribute significantly to clinical protocols and ameliorate concerns related to potential ethical issues. This new "Biomaterials for Organoids" Session will cover the most recent advancements of biomaterial mediated organoid technologies in regenerative medicine, cancer therapy, drug testing, environmental control and monitoring, adaptive sensing, CRISPR-Cas9 genome editing, as well as the large-scale cell manufacturing and reproducible applications of organoids transplantation.

Moderators:
Qun Wang, PhD
Kaitlin Bratlie, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 246. Gut organoids as a platform for evaluating delivery of nanoparticles to treat inflammatory bowel disease, Zahra Davoudi, Nathan Peroutka-Bigus, Bryan Bellaire, Albert Jergens, Michael Wannemuehler, Qun WangIowa State University, Ames, IA, USA

  • 247. Photoinduced hydrogel network reorganization facilitates in situ modulation of intestinal organoid epithelial shape, Max Yavitt1,2, Michael Blatchley1,2, Peter Dempsey3, Kristi Anseth1,21University of Colorado Boulder, Boulder, CO, USA, 2BioFrontiers Institute, Boulder, CO, USA, 3University of Colorado Anschutz Medical Campus, Aurora, CO, USA

  • 248. Engineered Organotypic Breast Tumor Model Elucidates the Role of Tumor-Stromal Interactions on Dynamic Remodeling of Tumor Microenvironment, Sunil Singh, PhD1, Gary Luker, MD2, Hossein Tavana, PhD11The University of Akron, Akron, OH, USA, 2University of Michigan, Ann Arbor, MI, USA

  • 249. A Hyaluronic Acid-Based Hydrogel Culture Platform for iPSC-derived Midbrain Neuronal Culture, Ze Zhong Wang, PhD1, Jesse Liang, MS1, Zhan Shu, PhD1, Samuel Sances, PhD2, Clive Svendsen, PhD2, Nigel Maidment, PhD1, Stephanie Seidlits, PhD11University of California, Los Angeles, Los Angeles, CA, USA, 2Cedars-Sinai Board of Governors Regenerative Medicine Institute, Los Angeles, CA, USA

  • 250. Micropattern-Guided Cardiac Organoid Production for Developmental Toxicity Screening, Plansky Hoang, PhD1,2, Andrew Kowalczewski1,2, Shiyang Sun1,2, Jeffrey Amack, PhD2,3, Zhen Ma, PhD1,21Syracuse University, Syracuse, NY, USA, 2BioInspired Syracuse Institute for Material and Living Systems, Syracuse, NY, USA, 3State University of New York Upstate Medical University, Syracuse, NY, USA

  • 251. Microstructured hydrogels to guide self-assembly and scalable growth of lung alveolar epithelial organoids, Claudia Loebel, MD PhD1, Leonardo Cardenas, PhD2, Aaron Weiner3, Andrew Vaughan, PhD3, Edward Morrisey2, Jason Burdick, PhD11Penn Center for Pulmonary Biology, University of Pennsylvania, Phildelphia, PA, USA, 2School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA, 3University of Pennsylvania, Philadelphia, PA, USA

Biomaterials for Regenerative Engineering - 3

Timeslot: Friday, April 23, 2021 - 1:45pm to 3:15pm
Track: Tissue Engineering and Regenerative Medicine
Room: Virtual

About

Due to disease, degeneration, or trauma, there is a tremendous need to repair damaged tissues and organs. Although surgical replacement can be performed to address this issue, the insufficient number of donors greatly limits the applicability of this approach. Therefore, it is essential to develop engineered multifunctional biomaterials to promote tissue regeneration. Regenerative engineering combines biomaterial-based approaches with stem cell therapies and developmental biology to regenerate or repair tissues and organs. This symposium will cover tunable biocompatible materials such as hydrogels, fibers, proteins, carbohydrates, nano/micro-porous scaffolds, and metals, to modulate cellular microenvironments. The biomaterials that can direct cell fate and promote differentiation will also be highlighted by this session. Moreover, the biomaterials that can facilitate drug delivery and immunomodulation will be covered through oral and poster presentations. Furthermore, we will include discussions for the development and commercialization of various medical devices such as blood contacting implants, prostheses, and pacemakers in the session. In addition to engineering approaches, we will provide discussions on clinical translation of biomaterial-based strategies. We will also include topics that are relevant to the rapidly changing circumstances associated with the Novel Coronavirus to improve patient putcomes. We expect that our interdisciplinary session including material science, chemistry, biology, engineering, and medicine will be of great significance to the clinicians, industry members and professors in academia.

Moderator:
Gulden Camci-Unal, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 252. Self-healing, Injectable Photo-Zwitterionic Hydrogels for Chronic Diabetic Wounds, Michael Stager1, Matthew Osmond1, James Bardill2, Carlos Zgheib2, Sudipta Seal3, Kenneth Liechty, MD2, Melissa Krebs11Colorado School of Mines, Golden, CO, USA, 2University of Colorado Anschutz Medical Campus, Aurora, CO, USA, 3University of Central Florida, Orlando, FL, USA

  • 253. A Nanofiber-Hydrogel Composite to Treat Fistula in Crohn’s Disease in a Porcine Model, Zhicheng Yao1,2,3, Ling Li4, Susan Gearhart5, Calvin Chang2,3,6, Jiayuan Kong2,3,6, Jeffrey Chao2,3,7, Alyssa Parian4, Florin Selaru4, Hai-Quan Mao1,2,3,61The Johns Hopkins University, Whiting School of Engineering, Department of Materials Science and Engineering, Baltimore, MD, USA, 2The Johns Hopkins University School of Medicine, Translational Tissue Engineering Center, Baltimore, MD, USA, 3The Johns Hopkins University, Institute for NanoBioTechnology, Baltimore, MD, USA, 4The Johns Hopkins University School of Medicine, Division of Gastroenterology and Hepatology, Baltimore, MD, USA, 5The Johns Hopkins University School of Medicine, Department of Surgery, Baltimore, MD, USA, 6The Johns Hopkins University, Whiting School of Engineering, Department of Biomedical Engineering, Baltimore, MD, USA, 7The Johns Hopkins University, Krieger School of Arts and Sciences, Department of Public Health Study, Baltimore, MD, USA

  • 254. Computerized-tomography (CT) analysis of 3D-printed porous bone ingrowth materials, Robert Kane, PhD, Weidong Tong, PhD, Brett English, Joshua Auger, Rakshak NemirajDePuy Synthes, Warsaw, IN, USA

  • 255. Interlinked PEG-4MAL Microgels for Rapid Immune Cell Migration, Adrienne Widener, Edward PhelpsUniversity of Florida, Gainesville, FL, USA

  • 256. Electrospun chitosan-elastin for improved wound healing, Alex Bryan, BS BME, Joel Bumgardner, PhD11The University of Memphis, Memphis, TN, USA

  • 27. Starch-Based Shape Memory Polymers for Crohn’s Fistula Healing, Henry Beaman, Priya Ganesh, Mary Monroe, PhD

Biosensor/Nanotechnology

Timeslot: Friday, April 23, 2021 - 1:45pm to 3:15pm
Track: Sensory Biomaterials and Tissues
Room: Virtual

About

The following session will present recent findings and current efforts on nanomaterials, with application emphasis on biomedical imaging and biosensing applications. Molecular imaging is envisioned to play a pivotal role in the early diagnosis and simultaneous treatment of diseases. Recent advances in the imageable nano/ biomaterials as well as imaging modalities have made the preemptive treatment of the diseases and image guided surgery a reality. In this session, presenters will emphasize the role of imageable small molecules, engineered biological entities (e.g. proteins), nanoparticles, and hydrogels in cutting-edge imaging methods. For biosensing applications, the interface of biomaterials and biological fluids offers a unique opportunity for binding, detecting, and reporting the presence of analytes. Recent studies have shown that, by tuning the composition of materials and/or coupling recognitive molecules, it is possible to generate materials with selective affinity for biological analytes. In this session, presenters will highlight recent advancements in biomaterials as components of biosensors, including fundamental and translational studies.

Moderators:
Fatemeh Ostadhossein, PhD
Ming Su, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 258. Investigating Oxidative Susceptibility of Peptoid-Based Materials for Selective Biosensing Applications, Hattie Schunk, Adrianne Rosales, PhD, Laura Suggs, PhDThe University of Texas at Austin, Austin, TX, USA

  • 259. Stable Thermally Modulated Nanodroplet Ultrasound Contrast Agents, Anastasiia Vasiukhina, Javad Eshraghi, Adib Ahmadzadegan, Craig Goergen, PhD, Pavlos Vlachos, PhD, Luis Solorio, PhDPurdue University, West Lafayette, IN, USA

  • 260. Non-Viral Nanocarriers for CRISPR-Based Genome Editing Tool Delivery, Yuyuan Wang, PhD, Shaoqin Gong, PhDUniversity of Wisconsin-Madison, Madison, WI, USA

  • 261. Effect of physicochemical properties of polymeric nanoparticles on in vitro and in vivo toxicity, Binapani Mahaling, PhD1,2,3, Dadi A Srinivasa Rao, MPharm1, Namrata Baruah, MS1, Nadim Ahamad, PhD1, Sri Sivakumar, PhD2, Erin Lavik, DSc3, Dhirendra S Katti, PhD11Indian Institute of Technology Kanpur, Department of Biological Sciences and Bioengineering, Kanpur, India, 2Indian Institute of Technology Kanpur, Department of Chemical Engineering, Kanpur, India, 3University of Maryland Baltimore County, Baltimore, MD, USA

  • 262. Fabrication of Hydrogel-Coated Gold Nanoshells as a Biosensor for Protein Biomarker Quantification, Andrew Murphy1,2, Marissa Wechsler2,3, Kiana Bahrami3, Catherine Ludolph1, Ayushi Sahu3, H.K.H Jocelyn Dang3, Nicholas Peppas1,2,3,4,51Department of Chemical Engineering, Austin, TX, USA, 2Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, Austin, TX, USA, 3Department of Biomedical Engineering, Austin, TX, USA, 4College of Pharmacy, Austin, TX, USA, 5Department of Surgery and Perioperative Care, Austin, TX, USA

  • 263. In Situ Magnetic Relaxation Localization and Hydrogel Coating of a Nanomaterial Biosensor Device for Continuous Biochemical Surveillance, Richard Murdock, BSME1,2, Michael Cima, PhD1,21Massachusetts Institute of Technology, Cambridge, MA, USA, 2Koch Institute for Integrative Cancer Research, Cambridge, MA, USA

Drug Delivery SIG 3

Timeslot: Friday, April 23, 2021 - 1:45pm to 3:15pm
Track: Therapeutic Delivery
Room: Virtual

About

The Drug Delivery Special Interest Group will deal with the science and technology of controlled release of active agents from delivery systems. Controlled drug release is achieved by the use of diffusion, chemical reactions, dissolutions or osmosis, used either singly or in combination. While the vast majority of such delivery devices are based on polymers, controlled release can also be achieved by the use of mechanical pumps. In a broader sense, controlled release also involves control over the site of action of the active agent, using the active agent using pro-drugs, targetable water soluble polymers or various microparticulate systems. Relevant aspects of toxicology, bioavailability, pharmacokinetics, and biocompatibility are also included.

Moderators:
Michael Mitchell, PhD
Omid Veiseh, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 264. Intravitreal injectable hydrogel incorporating microgel for prolonged protein delivery, Si Min Lee1, Joo Young Son1, Hye Kyoung Hong2, Min Hee Ham2, Se Joon Woo, PhD2, Ki Dong Park, PhD11AJOU UNIVERSUTY, Suwon, Republic of Korea, 2Seoul National University Bundang Hospital, Seongnam, Republic of Korea

  • 265. Targeting Peptide-Mediated Delivery of siRNAs into Ovarian Cancer Cells, Serena Gilmore, Timothy Samec, M.S., Anthony Hazelton, Angela Alexander-Bryant, PhDClemson University, Clemson, SC, USA

  • 266. Using vesicle lipid domains to enhance liposomal TRAIL, Timothy Vu, Justin Peruzzi, Sraeyes Sridhar, Milan Mrksich, PhD, Neha Kamat, PhDNorthwestern University, Evanston, IL, USA

  • 268. The Development of Lubricated Drug-Eluting Composite Coatings for Endotracheal Tubes, Solaleh Miar1, Flavia Fernandes1, Yamuna Pillai1, Gregory R Dion2, Joo L Ong1, Rena Bizios1, Teja Guda11The University of Texas at San Antonio, San Antonio, TX, USA, 2U.S. Army Institute of Surgical Research, San Antonio, TX, USA

Panel: Dental Biomaterials in Translation: Considerations in Regulatory Approval and Clinical Adoption (Joint Inter-Society SFB-IADR)

Timeslot: Friday, April 23, 2021 - 1:45pm to 3:15pm
Track: Musculoskeletal and Craniofacial Biomaterials
Room: Virtual

About

Innovation in dental treatments relies on a clear pathway from the laboratory bench to the dental chair, but the path can be riddled with hurdles along the way. Regulatory approval may seem like the greatest challenge, but market penetration may be far more difficult. How have innovations such as 3D printing and digital dentistry challenged the established paradigms of dentistry and oral surgery? How can future technologies deliver on the potential for improved production time, fidelity, and quality to patients? This session features perspectives on how disruptive ideas can be realized in clinical applications.

Abstracts

Abstracts will be available for download on April 20, 2021.

  • Moderator(s):
    Daniel Harrington, PhD
    Carmem S. Pfeifer, DDS, PhD

Invited Speaker(s)

Surface Modification of Biomaterials 2

Timeslot: Friday, April 23, 2021 - 1:45pm to 3:15pm
Track: Functional Biomaterials and Surfaces
Room: Virtual

About

In biomedical applications, the surface properties of biomaterials are critical. The surface of biomaterials determines the outcomes of biological-biomaterial interactions. Only certain surface properties can induce optimized cell interaction and adhesion thereby improving cell attachment and biocompatibility of the biomaterials. Various surface modification technologies have been developed and assessed to control the physicochemical interactions between biomaterials and the biological environment at the molecular, cellular, and tissue levels. This symposium aims to highlight the recent advances and challenges in surface modification technologies and fundamental understandings of the biomaterials-tissue interaction in orthopedic and other areas. This symposium will cover topics related to advanced surface modification methods that are well established and those that are still in the early stage of development, and applications of such methods to optimize surface chemistry, morphology, and structures, and discuss how such modifications may lead to the development of promising biomaterials and successful medical devices.

Moderators:
Guigen Zhang, PhD
Bingyun Li, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 270. Acylation of electrospun chitosan membranes with medium chain fatty acids, Landon Choi1, Jessica Jennings, PhD1, Joel Bumgardner, PhD1, Tomoko Fujiwara, PhD2, Zoe Harrison1, Carlos Wells11University of Memphis, Memphis, TN, USA, 2(University of Memphis), Memphis, TN, USA

  • 271. Effects of Zwitterionic Polymer Brush Density and Chain Length on Resisting Protein Adsorption, Julia King, Prabhleen Kaur, Buddy Ratner, PhDUniversity of Washington, Seattle, WA, USA

  • 272. Sub-Nano to Nanoscale Wear of Titanium Oxide-Metal Surfaces Using Atomic Force Microscopy, Yangping Liu, Jeremy GilbertClemson University, Charleston, SC, USA

  • 273. Tunable Membrane Modification of Milk Exosomes for Mucus Penetration, Chenzhen Zhang, Bachelor, Armin Vedadghavami, Bachelor, Matthew Warren, High scool, Ambika Bajpayee, PhDNortheastern University, Boston, MA, USA

  • 274. Evaluation of Electrosprayed Chitosan Coatings with Incorporated Calcium Phosphate Nanoshells, Andrew Watson, Joel Bumgardner, PhD, Ranganathan Gopalakrishnan, PhD, Tomoko Fujiwara, PhD, Sanjay Mishra, PhDUniversity of Memphis, Memphis, TN, USA

  • 275. Quantifying Crosslinking Density of Photopolymerized Hydrogels with NMR, Jonathan Zatorski, Emma Parker, Jeff Ellena, PhD, Rebecca Pompano, PhDUniversity of Virginia, Charlottesville, VA, USA