Timeslot: Thursday, April 28, 2022 - 2:45pm to 4:45pm
Room: Harborside Ballroom A-B, 4th
About
Regenerative engineering aims to develop functional, bioactive, and instructive biomaterials and approaches for the regeneration of tissues through a convergence of engineering, medicine, developmental biology, and stem cell science. This symposium will highlight recent trends in developing functional biomaterials that play an active role in controlling cellular behaviors and tissue regeneration. We will include different classes of biomaterials such as proteins, polysaccharides, synthetic polymers, fibers, metals, ceramics, and hydrogels for applications in regenerative engineering. This session will also highlight the biomaterials that can direct cell fate and promote differentiation. Moreover, the biomaterials that can facilitate drug delivery and immunomodulation will be covered through oral and poster presentations. During the symposium, translational strategies for handling these biomaterials from ‘Bench to Bedside’ will also be addressed. We expect that our interdisciplinary session, including material science, chemistry, biology, engineering, and medicine, will be of great significance to clinicians, industry members, and academia.
Abstracts
Abstracts will be available for download on April 27, 2022.
2:45:00 PM 207. INVITED SPEAKER Lakshmi Nair, PhD, University of Connecticut
3:15:00 PM 208. Infusible Extracellular Matrix Derived Biomaterial Promotes Vascular Integrity After Traumatic Brain Injury, Miranda Diaz(1,2)*, Rebecca Kandell(1,2), Karen Christman, PhD(1,2), Ester Kwon, PhD(1,2); (1)University of California, San Diego, La Jolla, CA, USA, (2)Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA
3:30:00 PM 209. Modified Gelatin Hydrogels Induce Growth of Perfus- able Arterioles and Prevent Ischemic Tissue Damage, Ethan Lippmann*, Corinne Curry, Brian O’Grady, Sarah Sturgeon, Jeffrey Schmeckpeper, Jiro Kusunose, Adrienne Hawkes, David Florian, Alexis Yates, Kate Mlouk, Lucas Mowery, Scott Guelcher, Katherine Gibson-Corley, Charles Caskey, Vanderbilt University, Nashville, TN, USA
3:45:00 PM 210. Modulation of Type 1 immune Responses to Injectable Microgels through Degradation, Maria Coronel, PhD*, Karen Martin, Grad Student, Michael Hunckler, Grad student, Rahul Shah, Undergrad- uate student, Andres Garcia, PhD, Georgia Institute of Technology, Atlanta, GA, USA
4:00:00 PM 211. IGF-1 Nanoparticles in a Nano- fiber-Hydrogel Drug Delivery System to Improve Functional Outcomes after Peripheral Nerve Injury in Non-Human Primates Model, Chenhu Qiu, BS*, Thomas Harris, MBChB, Sami Tuffaha, MD, Zhicheng Yao, MS, Hai-Quan Mao, PhD, the Johns Hopkins University, Baltimore, MD, USA
4:15:00 PM 212. Anisotropic Scaffolds with Basic Fibroblast Growth Factor Delivery or Rehabilitative Exercise for Muscle Regeneration, Caroline Hu, BS(1), Bugra Ayan, PhD(1,2), Gladys Chiang(1), Ngan Huang, PhD(1,2)*; (1)Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA, USA, (2)Stanford University, Stanford, CA, USA
4:30:00 PM 213. A rapidly recovering hydro- gel-based delivery of disease modifying drug reduces osteo- arthritis progression in active joints, Jingjing Gao, PhD(1,2)*, Jeffrey Karp(1,2,3), Joerg Ermann(1,2), Nitin Joshi(1,2); (1)Brigham and Women’s Hospital, Boston, MA, USA, (2)Harvard Medical School, Boston, MA, USA, (3)Massachu- setts Institute of Technology, Cambridge, MA, USA
Invited Speaker(s)
Biomimetic Hydrogels for Drug Delivery and Tissue Engineering Applications 1
Timeslot: Thursday, April 28, 2022 - 2:45pm to 4:45pm
Room: Kent A-C, 4th Floor
About
Biomimetic materials draw inspiration from nature for their structure and properties. This session will focus on drug delivery and tissue engineering scaffolds that incorporate bioinspired components for scaffold physical or biological properties. We are soliciting abstracts on research that involves synthetic materials that mimic natural materials or that follow a design motif derived from nature.
Abstracts
Abstracts will be available for download on April 27, 2022.
2:45:00 PM 214. Lipid Nanoparticle-Pep- tide Hydrogels for Cell Therapy of Spinal Cord Injury, Neil Baugh*, Michael Kratochvil, PhD, Vanessa Doulames, PhD, Meghan Hefferon, Sarah Heilshorn, PhD, Stanford University, Stanford, CA, USA
3:00:00 PM 215. Bioinspired 3D Culture Isolates Highly Pluripotent Human iPSCs, James Shamul*, Jiangsheng Xu, PhD, Nicholas Staten, Alisa White, Bin Jiang, PhD, Xiaoming He, PhD, University of Maryland, College Park, MD, USA
3:15:00 PM 216. Design of an Injectable Hydrogel Carrier to Improve Bone Marrow Transplantation for Sickle Cell Disease Patients, Mykel Green, PhD*, Dana Jenkins, Elizabeth Cosgriff-Hernandez, PhD, The University of Texas at Austin, Austin, TX, USA
3:30:00 PM 217. Biomimetic Hydrogels for the Sustained Delivery of GLP-1 Analogues to Improve Treatment of Diabetes, Andrea d’Aquino, PhD*, Caitlin Maikawa, PhD, Leslee Nguyen, Katie Lu, Ian Hall, Eric Appel, Stanford University, Stanford, CA, USA
3:45:00 PM 218. Development and Characterization of Novel Transparent Bacterial Derived Cellulose, Elizabeth van Zyl*, Jeannine Coburn, PhD, Worcester Polytechnic Institute, Worcester, MA, USA
4:00:00 PM 219. 219. Biomaterial Model Systems of Age in Macro- phage-Blood Vessel Interactions, Justin Silberman, Erika Moore, PhD*, University of Florida, Gainesville, FL, USA
4:15:00 PM 220. Synthetic polymer hydrogels with defined glycan content to probe Galectin-Matrix interactions, Juanpablo Olguin*, Renjie Liu, Antonietta Restuccia, Gregory Hudalla, University of Florida, Gainesville, FL, USA
4:30:00 PM 221. Engineering Pro-An- giogenic Biomaterials via Chemoselective Extracellular Vesicle Immobilization, Phil Campbell, Yunhui Xing, Weitao Wang, Rebecca Taylor, Xi (Charlie) Ren, Saigopalakrishna Yerneni*, Carnegie Mellon univeristy, Pittsburgh, PA, USA
Bioprinting for Tissue Engineering: from Open Source to Commercial Platforms
Timeslot: Thursday, April 28, 2022 - 2:45pm to 4:45pm
Room: Laurel A-B, 4th
About
Some of the earliest work in 3D printing for tissue engineering utilized common inkjet printers that were hacked to be able to dispense biomaterial and cells. More recently, increasingly sophisticated technologies to build 3D constructs ranging from extrusion through microfluidics-based dispensing to electro-writing and spinning have been incorporated into commercially available bioprinters. This session will look to explore cutting edge research to develop novel bio-inks, create complex scaffold designs, etc. in the context of applying bioprinting technologies to tissue engineering. Abstracts are encouraged to be submitted by those working with self-built or open source bioprinting platforms as well as from those developing or using advanced commercially available systems. The goal of the session is to demonstrate a diversity of perspectives regarding technology development ranging from academia to industry.
Abstracts
Abstracts will be available for download on April 27, 2022.
2:45:00 PM 222. Contactless Acoustic Cell Patterning to Promote Vascular Formation, Weiping Li*, Eric Hobson, Cheri Deng, Jan Stege- mann, University of Michigan, Ann Arbor, MI, USA
3:00:00 PM 223. Generalizing hydrogel microparticles into a new class of bioinks for extrusion bioprint- ing, Kaivalya Deo*, Shangjing Xin, PhD, Jing Dai, PhD, Navaneeth Krishna Rajeeva Pandian, PhD, David Chimene, Robert Moebius, Abhishek Jain, PhD, Arum Han, PhD, Akhilesh Gaharwar, PhD, Daniel Alge, PhD, Texas A&M University, College Station, TX, USA
3:15:00 PM 224. 3D-printed Silk/Hydroxyapatite Scaffolds for Regeneration of Innervated and Vascularized Bone, Vincent Fitzpatrick, PhD*, Zaira Martin-Moldes, PhD, Anna Deck, Ruben Torres-Sanchez, Anne Valat, PhD, Riley Patten, Chunmei Li, PhD, David Kaplan, PhD, Tufts University, Medford, MA, USA
3:30:00 PM 225. Variable stiffness of direct-writ- ten gelatin fibers with crosslink- ing technique: Toward a tendon tissue-on-a-chip model, Zachary Davis(1,2,3)*, Grant Scull(1,2,3), Matthew Fisher, PhD(1,2,3), Ashley Brown, PhD(1,2,3); (1)North Carolina State University, Raleigh, NC, USA, (2)University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, (3)Comparative Medicine Institute, Raleigh, NC, USA
3:45:00 PM 226. Computational Modeling and Experimental Characterization of Extrusion Printing into Suspension Baths, Margaret Prendergast*, Jason Burdick, PhD, University of Pennsylvania, Philadelphia, PA, USA
4:00:00 PM 227. Characterizing Properties of Solvent-Cast 3D-Printed Bioma- terials, Diana Hammerstone(1), Tomas Babuska(2), Brandon Krick(2), Lesley Chow(1), John Tolbert(1)*; (1)Lehigh University, Bethlehem, PA, USA, (2)Florida State University, Tallahassee, FL, USA
4:15:00 PM 228. 3D Printing of Perfusable Channels within Cell-Dense Microgel-Based Support Media, Julia Tumbic*, Chris Highley, University of Virginia, Charlottesville, VA, USA
4:30:00 PM 229. A Platform of Customizable Solvent-Free Polyester-Based Resins for 3D-Printed Tissue Scaffolds, Mathew Stanford, MS*, Hafiz Busari, Debra Tindall, PhD, Michael Vaughn, PhD, Poly-Med, Inc., Anderson, SC, USA
Engineered Biomaterials for Neural Applications
Timeslot: Thursday, April 28, 2022 - 2:45pm to 4:45pm
Room: Laurel C-D, 4th
About
Engineered biomaterials are uniquely positioned for use in creating, testing, and regenerating neural tissue with applications like in vitro models of injury and disease, therapeutic treatments, understanding neural development, and mapping the brain. This session will focus on cutting edge research in neural biomaterials including fundamental material development through pre-clinical studies. These include big questions surrounding understanding and treating diseases and injuries of the peripheral and central nervous systems spanning stem and progenitor cells, neurons, astrocytes, oligodendrocytes, microglia, and Schwann cells.
Abstracts
Abstracts will be available for download on April 27, 2022.
2:45:00 PM 230. INVITED SPEAKER: Engineering Models and Developing Therapies for the CNS, Erin Lavik, ScD, UMBC
3:15:00 231. Activated astrocyte extracel- lular vesicles delivered from MAP promote in situ brain repair after stroke, Shangjing Xin, PhD, Nhi Phan, Lucy Zhang, Tatiana Segura, PhD*, Duke University, Durham, NC, USA
3:30:00 PM 232. Peripheral nerve regeneration using silk fibroin based conducting conduits, Mamatha Pillai, PhD(1)*, Shadi Hoshyar, PhD(2), Rajiv Padhye, PhD(2), Amitava Bhattacharyya, PhD(3); (1)Indian Institute of Technology Bombay, Mumbai, India, (2)RMIT University, Melbourne, Australia, (3)PSG Institute of Advanced Studies, Coimbatore 641004, India, Coimbatore, India
3:45:00 PM 233. Implantation of Human Tis- sue Engineered Nigrostriatal Pathways in a Rat Model of Parkinson’s Disease, Wisberty Gordián-Vélez(1,2,3)*, Kevin Browne(2,3), James Lim(2,3), Bella Chau(1,2,3), John Duda, MD(3), Rodrigo España, PhD(4), Jason Burdick, PhD(1), H. Isaac Chen, MD(2,3), D. Kacy Cullen, PhD(1,2,3); (1)University of Pennsylvania School of Engineering and Applied Science, Philadelphia, PA, USA, (2)University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA, (3)Center for Neurotrauma, Neurodegeneration & Restoration, Philadelphia, PA, USA, (4)Drexel University College of Medicine, Philadelphia, PA, USA
4:00:00 PM 234. A 3D In Vitro Hydrogel Model to Study Oligodendrocyte Progenitor Cell Response to Traumatic Brain Injury, Rachel Mazur(1)*, Ryosuke Yokosawa(2), Pamela VandeVord(2), Kyle Lampe(1); (1)University of Virginia, Charlottesville, VA, USA, (2)Virginia Polytechnic Institute and State University, Blacksburg, VA, USA
4:15:00 PM 235. Non-Viral Gene Editing in Mouse Brain Achieved by Focused Ultrasound via Systemic Delivery, Shuting Cai, MS*, Robin Ji, MS, Nancy Kwon, Joyce Zhou, Yeh-Hsing Lao, Naoto Yoshinaga, Ding Tang, Elisa Konofagou, Kam Leong, Columbia University in the City of New York, New York, NY, USA
4:30:00 PM 236. Designer Hydrogel Delivery of Human Neurons into the Adult Injured Cervical Spine, Vanessa Doulames, PhD(1,2)*, Laura Marquardt, PhD(2), Meghan Hefferon(1,2), James Weimann, PhD(1), Theo Palmer, PhD(1), Giles Plant, PhD(1), Sarah Heilshorn, PhD(2); (1)Stanford University School of Medicine, Stanford, CA, USA, (2)Stanford University School of Engineering, Stan- ford, CA, USA
Attachments
Invited Speaker(s)
Engineering Cells and Their Microenvironments 1 (SIG)
Timeslot: Thursday, April 28, 2022 - 2:45pm to 4:45pm
Room: Harborside Ballroom D-E, 4th Floor
About
The Engineering Cells & Their Microenvironments Special Interest Group focuses on approaches to alter cell microenvironments. These approaches can be used to control biomaterial-induced cell signaling to enable stem cell manufacturing and differentiation, immunoengineering, as well as for the development of biomaterials for cell-based detection and diagnosis. These biomaterial-based approaches can also be utilized to direct cellular responses (e.g., proliferation, differentiation, morphological regulation, motility, matrix production) without the addition of external growth factors, chemicals, or drugs, thereby mitigating potential side-effects and facilitating improved in vitro and in vivo cellular outcomes. This session will focus on translation of these techniques toward a variety of specific applications ranging from, but not limited to, tissue engineering for dynamic disease models and regenerative medicine to therapeutics and direction of stem cell differentiation. Studies that develop biomimetic materials which provide specific physicochemical cues (e.g., composition, topography, stiffness) to achieve a desired cellular response will also be highlighted.
Abstracts
Abstracts will be available for download on April 27, 2022.
2:45:00 PM 237. Engineered Matrices with Dynamic Crosslinks as a Viscoelastic Matrix for Human Neural Progenitor Cells, Michelle Huang*, Julien Roth, Sarah Heilshorn, PhD, Stanford University, Stanford, CA, USA
3:00:00 PM 238. Hypertrophic Cardiomyopathy Asso- ciated MYBPC3 Mutations Sensitize iPSC-Derived Micro-Heart Muscle to Mechanical Loading, Jingxuan Guo*, MS, David Schuftan, Nathaniel Huebsch, PhD, Washington Universi- ty in Saint Louis, St. Louis, MO, USA
3:15:00 PM 239. ECM protein -decorated micro- particles to maintain cell survival and liver-specific function, Mona Mansouri, PhD*, William Imes, BS, Nic Leipzig, PhD, The University of Akron, Akron, OH, USA
3:30:00 PM 240. Porous bio-click microgel scaffolds to study and control the osteoporotic mesenchymal stromal cell secretory profile, Varsha Rao(1,2)*, Emily Cravens(3), Marissa Wechsler, PhD(4), Samantha Wojda, PhD(3), Kristi Anseth, PhD(1,2), Seth Donahue, PhD(3); (1)University of Colorado Boulder, Boulder, CO, USA, (2)Biofrontiers Institute, Boulder, CO, USA, (3)University of Massachusetts Amherst, Amherst, MA, USA, (4)University of Texas San Antonio, San Antonio, TX, USA
3:45:00 PM 241. A Biomaterial-based Stroma-free Synthetic Germinal Center: Using Lipid Membrane-Based Antigen Presentation as artificial FDCs and microbead-based CD40L as artificial TFH cells for efficient B cell signaling, Liana Kramer, MS(1,2)*, Hannah Song, PhD(1), Kaiya Mitchell(1), Mythili Kartik(1), Ankur Singh, PhD(1,2), Krishnendu Roy, PhD(1,2); (1)Georgia Institute of Technology, Atlanta, GA, USA, (2)Emory University, Atlanta, GA, USA
4:00:00 PM 242. Elucidating the combinatorial effect of substrate stiffness and surface viscoelasticity on cellular phenotype, Daniel Chester, PhD, Veronica Lee, Paul Wagner, Matthew Nordberg, Matthew Fisher, PhD, Ashley Brown, PhD*, North Carolina State University and University of North Carolina at Chapel Hill, Raleigh, NC, USA
4:15:00 PM 243. Stiffening viscoelastic hydrogels to investigate fibroblast activation and chromatin organization, Jenna Sumey*, Abigail Harrell, Steven Caliari, University of Virginia, Charlot- tesville, VA, USA
4:30:00 PM 244. Incorporation of human extracel- lular matrix into hybrid-hydrogel models of fibrosis, Rukshika Hewa- wasam, PhD*, Predrag Serbedzija, PhD, Chelsea Magin, PhD, University of Colorado, Denver
Anschutz Medi- cal Campus, Aurora, CO, USA
Nanomaterials (SIG)
Timeslot: Thursday, April 28, 2022 - 2:45pm to 4:45pm
Room: Dover A-C, 3rd Floor
About
The nanoscience and nanotechnology of biomaterials involves the unique science and technology present in biomaterials at the nanoscale and their related biological effects. Such nanobiomaterials present the creation of new and better biomaterials and devices, diagnostics and therapeutics for biomedical applications.
Abstracts
Abstracts will be available for download on April 27, 2022.
2:45:00 PM 245. Machine Learning Guided Design of Bioactive Single Chain Polymer Nanoparticles Prepared by Polymer Automation, Rahul Upadhya*, Matthew Tamasi, N. Sanjeeva Murthy, Adam Gormley, Rutgers Universi- ty, Piscataway, NJ, USA
3:00:00 PM 246. A Novel Library of Ionizable Cationic Lipid Nanoparticle-mediated mRNA COVID-19 Vaccines Enables Long-term Storage, Zhongyu Li*, William Ho, Fengqiao Li, Xiaoyang Xu, New Jersey Institute of Technology, Newark, NJ, USA
3:15:00 PM 247. Real-time Visualization of Nanobubble Ultrasound Contrast Agent Flow, Ex- travasation, and Diffusion through an Extracellular Matrix using Microfluidics, Michaela Cooley*, William Wulftange, Umut Gurkan, PhD, Agata Exner, PhD, Case Western Reserve University, Cleveland, OH, USA
3:30:00 PM 248. Biomaterials-based NanoInk Tattoo for Improved Endoscopic Imaging, Subhadeep Dutta(1)*, Jordan Yaron(1), Rahul Pannala(2), Kaushal Rege(1); (1)Arizona State University, Tempe, AZ, USA, (2)Mayo Clinic, Scottsdale, AZ, USA
3:45:00 PM 249. Quaternary Complex Nanoparticles Enable Sustained Release of Borte- zomib for Local Chemother- apy of Hepatocellular Car- cinoma, Yicheng Zhang*, Yizong Hu, Ling Li, Florin Selaru, Hai-Quan Mao, Johns Hopkins University, Baltimore, MD, USA
4:00:00 PM 250. A Lysyl Oxidase Respon- sive Peptide Brush Polymer for Targeting Myocardial In- farction, Joshua Mesfin(1,2)*, Mary Cassidy(3), John-Paul Pham(1,2), Colin Luo(1,2), Nathan Gianneschi(3), Karen Christman(1,2); (1)Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA, (2)UC San Diego, La Jolla, CA, USA, (3)Northwestern University, Evanston, IL, USA
4:15:00 PM 251. MMP-responsive polymers for targeting acute myo- cardial infarction, Holly Sullivan(1)*, Spencer Burton(2), Nathan Gianneschi, PhD(2), Karen Christman, PhD(1); (1)University of California San Diego, La Jolla, CA, USA, (2)Northwestern University, Evanston, IL, USA
4:30:00 PM 252. Fusogenic Peptide-Mediat- ed Delivery of siRNA in vivo to Treat Ovarian Cancer, Timothy Samec, Kharimat Alatise*, Jessica Boulos, Carleigh Coffin, Serena Gilmore, Anthony Hazleton, Angela Alexander-Bryant, Clemson University, Clemson, SC, USA
Panel Discussion: Medical Device Product Development – From Lab to Patient
Timeslot: Thursday, April 28, 2022 - 2:45pm to 4:45pm
Room: Waterview Ballroom, Ground Level
About
Ever wonder how biomaterials translate into commercial medical devices that are used in hospitals for treating patients? Attend our panel discussion with industry scientists and gain some insight into about how they explore and evaluate ideas and turn them into medical devices that can improve the lives of patients. These researchers will talk about the various stages and processes involved in developing medical devices and manufacturing. Learn more about the process as the panel share their own experiences, their stories of successful ventures and even some failures.
Abstracts
Abstracts will be available for download on April 27, 2022.
Bre Jacobs, Medtronic
Guillermo Ameer, Northwestern University
James M. Lindsey, Zeus
Ken Malone, Materic
Invited Speaker(s)
Panel Discussion: Osteonecrosis: From Scaffolds to Cells to Biologics
Timeslot: Thursday, April 28, 2022 - 2:45pm to 4:45pm
Room: Essex A-C, 4th Floor
About
This panel discussion will feature world renown experts in the field of osteonecrosis emphasizing the clinical aspects of the condition as well as important developments and outcomes of preclinical and translational studies for treatment, including novel scaffolds, cell therapy, and biologics.
Abstracts
Abstracts will be available for download on April 27, 2022.
Stuart Goodman, MD, PhD, Stanford University
Quanjan (Trey) Cui, MD, University of Virginia
Lynne C. Jones, PhD, Johns Hopkins University School of Medicine
Warren Grayson, PhD, Johns Hopkins University
Michael Mont, Sinai Hospital of Baltimore