Timeslot: Friday, April 29, 2022 - 11:30am to 12:30pm
Room: Kent A-C, 4th Floor
About
Has the future arrived where implantable biomaterials degrade on cue or materials adapt to the physical, chemical and/or mechanical environment? Do they react to physiological stimuli to assist with treatment? This could be scaffolds that stay or go depending on the need in the local environment. It could be materials that get stronger with exercise. It could be drug delivery only as needed based on physiological triggers. If you have been working on bioactive, biodegradable, or reactive biomaterials at any stage of research then submit an abstract for this session. Those abstracts that can show variation in modification of the behavior of the material for a clinical purpose have the best chance of being accepted.
Abstracts
Abstracts will be available for download on April 27, 2022.
11:30:00 AM 253. Exercise-induced piezoelectric stimulation for cartilage regeneration, Yang Liu, Thanh Nguyen*, University of Connecticut, Storrs, CT, USA
11:45:00 AM WITHDRAWN
12:00:00 PM 255. Active Learning Driven Design of Enzyme Stabi- lizing Polymers, Matthew Tamasi(1)*, Shashank Kosuri(1), Adam Gormley, PhD(1), Carlos Borca, PhD(2), Roshan Patel(2), Michael Webb, PhD(2); (1)Rutgers University, New Brunswick, NJ, USA, (2)Princeton University, Princeton, NJ, USA
12:15:00 PM 256. Hydrolytically Degradable PEG-based Inverse Electron-Demand Diels-Alder (iEDDA) Click Hydrogels, Nathan Dimmitt*, Fang-Yi Lin, PhD, Chien-Chi Lin, PhD, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA
Biomaterials for Pancreatic Islet Replacement and Immune Tolerance in T1D-1
Timeslot: Friday, April 29, 2022 - 11:30am to 12:30pm
Room: Harborside Ballroom D-E, 4th Floor
About
The advent of new sources of beta cells, including from stem cells, has greatly advanced the potential of beta cell replacement as a functional cure for type 1 diabetes and some forms of type 2 diabetes. A major barrier that remains to be solved is blocking or modulating immune effectors while simultaneously promoting islet survival and function. Biomaterials play a central role in addressing this challenge, as vehicles for islet delivery, as microenvironments supportive of islet function, and as sites of immune modulation.
Abstracts
Abstracts will be available for download on April 27, 2022.
11:30:00 AM 257. Delivery of Dissociated Islets Cells within Micro- porous Annealed Particle Scaffold to Treat T1D, Colleen Roosa*, Mingyang Ma, Preeti Chhabra, PhD, Kenneth Brayman, PhD, MD, Donald Griffin, PhD, University of Virginia, Charlottesville, VA, USA
11:45:00 AM 258. . Parallel Evaluation of Polyethylene Glycol Conformal Coating and Alginate Encapsulation as Immunoisolation Strat- egies for Pancreatic Islet Transplantation, Teresa De Toni(1,2)*, Aaron Stock(1,2), Peter Buchwald(1,3), Alice Tomei(1,2); (1)Diabetes Re- search Institute, Miami, FL, USA, (2)Department of Biomedical Engineering, Coral Gables, FL, USA, (3)Department of Molecular and Cellular Pharmacology, Miami, FL, USA
12:00:00 PM 259. Biomimetic Scaffolds with Controlled Microarchitec- ture Enhance Beta Cell Viability and Function for the Treatment of Type 1 Diabetes, Bhushan Kharbikar, PhD*, Sudipta Ashe, PhD, Qizhi Tang, PhD, Matthias Hebrok, PhD, Tejal Desai, PhD, University of California San Francisco, San Francisco, CA, USA
12:15:00 PM 260. Efficacy of VEGF-deliver- ing hydrogel to promote vascularization in the porcine subcutaneous space, Michelle Quizon, BS(1)*, Juline Deppen(2), Rebecca Levit(2), Andres Garcia(1); (1)Georgia Institute of Technology, Atlanta, GA, USA, (2)Emory University, Atlanta, GA, USA
Biomaterials for Regenerative Engineering 2
Timeslot: Friday, April 29, 2022 - 11:30am to 12:30pm
Room: Harborside Ballroom A – B, 4th Floor
About
Regenerative engineering aims to develop functional, bioactive, and instructive biomaterials and approaches for the regeneration of tissues through a convergence of engineering, medicine, developmental biology, and stem cell science. This symposium will highlight recent trends in developing functional biomaterials that play an active role in controlling cellular behaviors and tissue regeneration. We will include different classes of biomaterials such as proteins, polysaccharides, synthetic polymers, fibers, metals, ceramics, and hydrogels for applications in regenerative engineering. This session will also highlight the biomaterials that can direct cell fate and promote differentiation. Moreover, the biomaterials that can facilitate drug delivery and immunomodulation will be covered through oral and poster presentations. During the symposium, translational strategies for handling these biomaterials from ‘Bench to Bedside’ will also be addressed. We expect that our interdisciplinary session, including material science, chemistry, biology, engineering, and medicine, will be of great significance to clinicians, industry members, and academia.
Abstracts
Abstracts will be available for download on April 27, 2022.
11:30:00 AM 261. Characterization of Porous Poly(glyc- erol-dodecanoate) Scaffolds for Cartilage Repair, Yue Qin, PhD Candidate(1)*, Scott Hollister, PhD(2), Rhima Coleman, PhD(1); (1)University of Michigan, Ann Arbor, MI, USA, (2)Georgia In- stitute of Technology, Atlanta, GA, USA
11:45:00 AM 262. Engineering Injectable Synthetic ECM-Based Hydrogels as Vehicles for Retinal Progenitor Cells Transplanta- tion, Peng ZHAO(1)*, Joydip Kundu(1), Ashav Desai(1), Sidi Bencherif(1), Michael Young(2), Rebecca Carrier(1); (1)Northeastern University, Boston, MA, USA, (2)Schepens Eye Research Institute, Boston, MA, USA
12:00:00 PM 263. A Decellularized Cartilage Biomaterials Approach to Pediatric Laryngotracheal Reconstruction, Paul Gehret, BSc(1), Soheila Ali Akbari Ghavimi, PhD(2), Alexandra Dumas(1), Ryan Borek, MD(1,2), Ian Jacobs, MD(1,2), Riccardo Gottardi, PhD(1,2)*; (1)University of Pennsylvania, Philadelphia, PA, PA, USA, (2)Children’s Hospital of Philadelphia, Philadelphia, PA, USA
12:15:00 PM 264. A balance between pro-inflammatory and pro-reparative macro- phages is observed in regenerative D-MAP scaffolds, Yining Liu*, Alejandra Suarez-Arne- do, Eleanor Caston, Ethan Ho, Tatiana Segura, PhD, Duke University, Durham, NC, USA
Biomaterials for Trauma, Surgery and Would Healing Applications 2 *BTI*
Timeslot: Friday, April 29, 2022 - 11:30am to 12:30pm
Room: Dover A-C, 4th Floor
About
Stopping bleeding (hemostasis) and providing spatio-temporal wound care via passive and/or bioactive mechanisms is an important translational area of biomaterials-based technologies and includes external, intracavitary and intravascular hemostats, dressings, powders, foams, fibers and gels. The goal of this session is to highlight recent advances in biomaterials, biosystems/microdevices and related technologies that focus on hemostasis, thrombosis, and/or wound healing. The proposed session will invite presentations from researchers in this field that emphasize biomaterials design, structure-property-function relationships, device/technology design, and relevant translation pathways. Presentations focused on material considerations for microdevices for investigating hemostatic pathways are also of interest for this session.
Abstracts
Abstracts will be available for download on April 27, 2022.
11:30:00 AM 265. Stem Cells Delivered on Human Decellularized Muscle to a Volumetric Injury Regulate RAGE and P38 MAPK, Lucas Olson(1)*, David Cohen, MD(1), James Redden(1), Josephina Vossen, MD(1), Barbara Boyan, PhD(1,2), Zvi Schwartz, PhD(1,3), Michael McClure, PhD(1); (1)Virginia Commonwealth University, Richmond, VA, USA, (2)Georgia Institute of Technology, Atlanta, GA, USA, (3)University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
11:45:00 AM 266. Targeted Modulation of Fibrin Formation and Stability with Intravenous Hemostatic Nanotechnologies, Ketan Jolly*, Aditya Girish, PhD, Arielle Rechhione, Maria Fuente, Elizabeth Wakelin, Norman Luc, Marvin Nieman, PhD, Anirban Sen Gupta, PhD, Case Western Reserve University, Cleveland, OH, USA
12:00:00 PM 267. VEGF produced by fibroblasts in VEGF-encoding, gene-activated matrices promotes blood vessel formation for the treatment of chronic wounds, Jeongmin Hwang*, Kristi Kiick, PhD, Millicent Sullivan, PhD, University of Delaware, Newark, DE, USA
12:15:00 PM 268. Adhesive Poly(glycerol sebacate): A Novel Application to Support and Reinforce Internal Suture Lines, George Aninwene, II, PhD(1)*, Hossein Montazerian(2,3), Peyton Tebon(2), Reihaneh Haghniaz, PhD(3), Marvin Mecwan, PhD(3), Kalpana Mandal, PhD(3), HanJun Kim(3), Ali Khademhossein, PhD(3), Renea Sturm, MD, FAAP(1); (1)UCLA-David Geffen School of Medicine, Los Angels, CA, USA, (2)UCLA, Los Angeles, CA, USA, (3)Terasaki Institute for Biomedical Innovation, Los Angeles, CA, USA
Drug Delivery for Cardiovascular Applications
Timeslot: Friday, April 29, 2022 - 11:30am to 12:30pm
Room: Laurel A-B, 4th Floor
About
Drug delivery is currently an important part of cardiovascular biomaterials including drug-eluting stents, vascular grafts, cardiac patches, and angiogenesis strategies. However, there are still new biomaterials and controlled release strategies that are needed. Topics of interest include methods to prevent thrombosis, intimal hyperplasia, scar tissue formation, and infection of cardiovascular grafts.
Abstracts
Abstracts will be available for download on April 27, 2022.
11:30:00 269. Fibrin-Specific pNIPAM Nanogels for Targeted Delivery of Fibrino- lytics and Anticoagulants to Treat Thrombotic Complications, Ana Sheridan(1,2)*, Nina Moiseiwitsch(1,2), Emily Mihalko, PhD(1,2), Kimberly Nellenbach, PhD(1,2), Manasi Krishnakumar(1,2), Abhichart Krissanaprasit, PhD(1), Joshua Degennaro(1,2), Jennifer Sollinger(1,2), Jerrold Levy, MD,FAHA,FCCE(3), Brian Cooley, PhD(2), Thom LaBean, PhD(1), Ashley Brown, PhD(1,2); (1)North Carolina State University, Raleigh, NC, USA, (2)University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, (3)Duke University, Durham, NC, USA
11:45:00 PM 270. An Adventitial Painting Modality of Local Drug Delivery to Abate Intimal Hyperplasia, Nisakorn Yodsanit(1,2)*, Takuro Shirasu, MD, PhD(3), Xiujie Xie, MD, PhD(3), Yuyuan Wang, PhD(1,2), Ruosen XIe, PhD(1,2), Yitao Huang(3), Bowen Wang, PhD(3), Lian-Wang Guo(3), K. Kent, MD(3), Shaoqin Gong, PhD(1,2); (1)University of Wisconsin-Madison, Madison, WI, USA, (2)Wisconsin Institute for Discovery, Madison, WI, USA, (3)University of Virginia, Charlottesville, VA, USA
12:00:00 PM 271. nterpenetrating Network Hydrogels for Enhanced Cardiac Retention of Extracellular Vesicles, Selen Uman(1)*, Mark Helmers, MD(2), Noah Weingarten, MD(2), Alexis Schiazza(2), Danika Meldrum(2), Sara Guevara-Plunkett(2), Pavan Atluri, MD(2), Jason Burdick, PhD(1); (1)University of Pennsylvania, Philadelphia, PA, USA, (2)Perelman School of Medicine, Philadelphia, PA, USA
12:15:00 PM 272. Poly[I:C] loaded Liposomes for Pulmonary Arterial Hypertension Treatment, Vidit Singh(1)*, Hu Yang, Laszlo Farkas(2), Hongliang He(3), Jawahar Khetan(1), Da Huang(1), Natalie Hall(1), Lavanya Bhargava(1); (1)Linda and Bipin Doshi Department of Chemical & Biochemical Engineering, Missouri University of Science and Technology, Rolla, MO, USA, (2)Department of Internal Medicine Division of Pulmonary, Critical Care and Sleep Medicine Davis Heart & Lung Research Institute, Ohio State University, Columbus, OH, USA, (3)Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, USA
Opthalmic Biomaterials (SIG)
Timeslot: Friday, April 29, 2022 - 11:30am to 12:30pm
Room: Laurel C-D, 4th Floor
About
The Ophthalmic Biomaterials SIG Session welcomes submissions that describe the development and/or testing of biomaterials for use in ophthalmology. This may include drug delivery strategies or cell-based approaches, regenerative medicine applications, or unique animal models that have a primary focus in preserving or restoring the form and/or function of the eye. Abstracts from related areas of research with strong applicability in the visual system may also be submitted for this SIG Session.
Abstracts
Abstracts will be available for download on April 27, 2022.
11:30:00 PM 273. Insight into Cellular Uptake and Transport Mechanism of PLGA Nanoparticles in Cor- nea, Marjan Azadi*, Allan David, Auburn University, Auburn, AL, USA
11:45:00 AM 274. Development of a Biocom- patible Noggin Coated Electrospun Scaffold for Use as a Corneal Bandage for Treatment of Corneal Wound Healing, Nasif Mahmood*, Eelya Sefat, Darby Roberts, Brian Gilger, DVM, Jessica Gluck, PhD, North Carolina State University, Raleigh, NC, USA
12:00:00 PM 275. 3D Printable, Covalently Crosslinked Collagen Type I with Enhanced Stability for Corneal Replacement, Lucia Brunel*, Sarah Hull, Patrik Johansson, PhD, David Myung, PhD, Sarah Heilshorn, PhD, Stanford University, Stanford, CA, USA
12:15:00 PM 276. Antioxidant Microparticles for Delivery of Erythropoietin in a Mouse Glaucoma Model, Carlise DeJulius(1)*, Sarah Naguib(2), Tonia Rex, PhD(2), Craig Duvall, PhD(1,2); (1)Vanderbilt University, Nashville, TN, USA, (2)Vanderbilt University Medical Center, Nashville, TN, USA
Panel Discussion: The Commercialization Highway - How to Navigate your Discovery to the Marketplace
Timeslot: Friday, April 29, 2022 - 11:30am to 12:30pm
Room: Waterview Ballroom, Ground
About
Not all great ideas are generated, or excellent research is conducted at top universities and institutes. When it happens elsewhere, the researchers involved are often less able to acquire capital or the means to commercialize their innovations due to their institutional affiliation. Smaller, less-established universities face numerous challenges attracting venture capital investment for their researchers' spin-off and student-led startups. The panel will focus on the issues facing small and mid-sized colleges, as well as equity, diversity and inclusion issues facing researchers who are not well-represented in academic spin-off activities. Panelists will include speakers from states that were once left behind in their biosciences sector but have made significant improvements in developing their bioscience and biomaterial commercialization successes and have strategically positioned themselves in niche areas. Other impediments posed by regulatory requirements and potential issues with ethics, scientific integrity, and inclusion during biomaterials research, development, and commercialization will be addressed.
Abstracts
Abstracts will be available for download on April 27, 2022.
David Mills, PhD, Louisiana Tech University
Marian Ackun-Farmmer, PhD, University of Maryland
Navigating the Valley of Death, Brent Upshaw, Grind Capital
John L. Ricci, NYU College of Dentistry
Invited Speaker(s)
Postdoctoral Recognition Award Competition
Timeslot: Friday, April 29, 2022 - 11:30am to 12:30pm
Room: Essex A-C, 4th Floor
About
The goal of the SFB-PRA is to recognize excellence in future leaders of biomaterials and provide a platform to present their work to faculty and potential recruiters. Finalists will present at the PRA competition and the award recipients will be selected upon the quality and presentation of their work.
Abstracts
Abstracts will be available for download on April 27, 2022.