1A: Panel Discussion: Back to the Future - The Wild West of Biomaterials

1B: Bioactive Materials for Hard Tissue Regeneration

Timeslot: Wednesday, April 19, 2023 - 1:00pm to 2:30pm
Room: Silver Pearl 2

About

Advances in hard and soft tissue grafting in the craniofacial region have gone past autogenous grafts from the mandible, palate and iliac crest to allografts, allowlists and xenografts. Some of these materials have bioactive properties, others are mixed with growth enhancers and/or growth factors to optimize hard and/or soft tissue regeneration.

  • 1:00 PM. 5. Dual-functional Peptide DPI-VTK Promotes Migration of MSCs for Bone Regeneration. Eric Madesen, Seungeen Rhee, David Kohn, University of Michigan School of Dentistry

  • 1:15 PM. 6. Controllable Gelled Magnesium-Nanocomposite as Minimally Invasive Approach for Enhancing Angiogenesis-mediated Mandible Regeneration. Jiaxin Guo, Hao Yao, Liang Chang, Wangyong Zhu, Xu Li, Boguang Yang, Ziyi Chen, Yuxiong Su, Jiankun Xu, Ling Qin. Department of Orthopedics & Traumatology, The Chinese University of Hong Kong, Department of Dental Surgery, The University of Hong Kong-Shenzhen Hospital, Faculty of Dentistry, The University of Hong Kong

  • 1:30 PM 7. 3D Printable Carboxymethyl Chitosan-Amorphous Calcium Phosphate Nanoparticles for Bone Regeneration. Ming Yan, Hani Awad. University of Rochester.

  • 1:45 PM. 8. Effects of Micropore on Mechanical Strength and Tissue Response to Carbonate Apatite Honeycomb. Kunio Ishikawa, Keigo Shibahara, Koichiro Hayashi, Yasuharu Nakashima. Kyushu University.

  • 2:00 PM. 9. Bioinspired Scaffold for Sophisticated Regeneration of Osteoporotic Bone via Regulation of Homeostasis. Dong Keun Han, Da-Seul Kim, Jun-Kyu Lee. CHA University, Chung-Ang University.

  • 2:15 PM. 10. Filling the Gaps: Dynamic Bone Graft Substitute Embedding Biodegradable Beads Containing Human Mesenchymal Stromal Cells. Dr. Rotsiniaina Randriantsilefisoa, Dr. Ezgi Bektas, Dr. Matteo D'Este. AO Research Institute, AO Foundation, Davos

1C: Biomaterials Systems and Devices for Hemostasis and Wound Care

Timeslot: Wednesday, April 19, 2023 - 1:00pm to 2:30pm
Room: Silver Pearl 3

About

Stopping bleeding (hemostasis) and providing short and long-term wound care via passive and/or bioactive mechanisms is an important area of biomaterials-based technologies and includes external, intracavitary and intravascular hemostats, dressings, powders, foams, fibers and gels. The goal of this session is to highlight recent advances in biomaterials and biosystems/microdevices that focus on hemostasis, thrombosis, and/or wound healing. The proposed session will invite presentations from researchers in this field that discuss biomaterials design, structure-property-function relationships, microdevice design, and achieved/ongoing/future visions of technology translation pathways. Presentations focused on material considerations for microdevices for investigating hemostatic pathways are also of interest for this session.

  • 1:00 PM 11. Bioactive Material-coated Microelectrodes for Dielectric Coagulometry-based Detection of Trauma-induced Coagulopathies. Dante Disharoon, PhD, Sina Pourang, Dr. Sanjay Ahuja, MD, Michael Suster, PhD. Pedram Mohseni, PhD, Anirban Sen Gupta, PhD. Case Western University, Rainbow Babies and Children's Hospital.

  • 1:15 PM 12. Bioresorbable, battery-free and wireless electrotherapy system for wound healing and monitoring in diabetes. Joeseph Song, Prof. Hanjun Ryu, Prof Wubin Bai, Dr. Abraham Vazquez-Guardado, Prof. Guillermo Ameer, Prof. John Rogers. Northwestern University. Chung-Ang University, The University of North Carolina at Chapel Hill.

  • 1:30 PM 13. Sequential Burst and Sustained Release of P-Coumaric Acid from Shape Memory Polymer Foams for Polymicrobial Infection Prevention in Trauma-Related Hemorrhagic Wounds. Changling Du, David Fikhman, Prof. Mary Beth Monroe, PhD, BioInspired Syracuse.

  • 1:45 PM 14. Bioadhesive Hydrogels with Ultrafast Gelation Promote Gastric Ulcer Healing and Arrest Acute Gastric Hemorrhage. Xiayi Xu, PhD, Department of Mechanical and Automation Engineering, The Chinese University of Hong Kong. 2:00 PM 15. Sprayable Hydrogel for Instant Sealing of Vascular Anastomosis. Gonzalo Munoz, MBA, Dr. Pere Dosta, Dr. Natalie Artzi, Elazer Edelman. Institut Quimic de Sarria, Massachusetts Institute of Technology, BioDevek, Brigham and Women's Hospital, Wyss Institute.

  • 2:15 PM 16. Engineering thermoresponsive shear-thinning hydrogel (T-STH) hemostats with improved coagulation. Marvin Mecwan, PhD, Emily Torres, Reihaneh Haghniaz, PhD, Alireza Hassani, PhD, Johnson John, PhD, Ali Khademhosseini, PhD, Terasaki Institute for Biomedical Innovation.

1D: Peptides as Therapeutics and Biomaterials

Timeslot: Wednesday, April 19, 2023 - 1:00pm to 2:30pm
Room: Coral 1-2

About

Peptides are chemically defined and possess a wide range of biofunctions including ligand binding, proteolytic susceptibility, and self-assembly. Owing to these features, peptide-based biomaterials show wide range of capacities to encapsulate payload, to engage cellular receptors, respond to stimuli and surrounding environments, and modulate cell functions as drug or immune antigens. These unique advantages, along with an outstanding safety profile, make peptide-based biomaterials very attractive in a variety of biomedical applications including stimuli-responsive biomaterials, drug delivery, tissue regeneration, and immune modulation. This session will cover all aspects of peptide-based therapeutics and biomaterials ranging from fundamental concepts of self-assembly to therapeutic applications. We will feature recent advances in the development of biomaterials including, but not limited to, peptides acting as bioactive components, peptides functioning as targeting ligands, and peptides serving as scaffold building blocks. We will highlight applications including biomedical imaging, disease diagnosis and treatment, tissue regenerations, and immune modulations.

  • 1:00 PM 17. Targeted Delivery of Peptide-Functionalized Nanoparticles to Improve Tendon Healing. Emmanuella Adjei-Sowah, Alayna Loiselle, PhD, Danielle Benoit, PhD, University of Rochester, University of Oregon.

  • 1:15 PM 18. Spatial Configuration of Charge Modulates Transport of Cationic Carriers in Cartilage Matrix. Bill Hakim, Timothy Boyer, Dr. Ambika Bajpayee. Northeastern University.

  • 1:30 PM 19. A Targeted Fusogenic Peptide Alters siRNA Delivery in Ovarian Cancer. Kharimat Lora Alatise, Angela Alexander-Bryant, PhD. Clemson University.

  • 1:45 PM 20. Temperature Modulates the Assembled Structure of Co-Assembling Synthetic Peptides. Ryan Clark, Benjamin Keselowsky, PhD, Gregory Hudalla, PhD, University of Florida.

  • 2:00 PM 21. Post-translational glycosylation of polypeptide tags for modification of protein assembly and receptor targeting. Eric Hill,MS; Alexander Kwiatkowski, PhD, Gregory Hudalla, PhD, Benjamin Keselowsky, PhD. University of Florida.

  • 2:15 PM 22. Epsin mimetic UPI peptide delivery strategies to improve endothelization of vascular grafts. Dr. Chris Bashur, Shirin Changizi, Dr. Mayyar Sameti, Dr. Hong Chen, Florida institute of Technology, Boston Children’s Hospital - Harvard University.

1E: Post-Doc Recognition Award Session

Timeslot: Wednesday, April 19, 2023 - 1:00pm to 2:30pm
Room: Coral 3-4

About

Sponsored by Royal Society of Chemistry. The goal of the SFB-PRA is to recognize excellence in future leaders of biomaterials and provide a platform to present their work to faculty and potential recruiters. Finalist will present at the PRA competition and the award recipients will be selected upon the quality and presentation of their work.

  • 1:00 PM. 23. Caspase-3-Responsive Plasmonic Nanosensors for In Vivo Monitoring of Stem Cell Location and Viability. Jinhwan Kim. Georgia Institute of Technology.

  • 1:10 PM 24. Branched Lipid Architecture Enhances LNP-mediated mRNA Delivery to the Liver via Enhanced Endosomal Escape. Marshall Padilla, PhD, Michael Mitchell, University of Pennsylvania, Philadelphia, PA, USA.

  • 1:20 PM 25. Cell Membrane-coated Microribbon Scaffolds Elicit Regenerative Immune Responses and Enhance Endogenous Cranial Bone Regeneration in Vivo. Ni Su, Stanford University.

  • 1:30 PM 26. Bioinspired Patch Platform for Translational Adhesive Technologies. Jingjing Wu, PhD, Hyunwoo Yuk, Xuanhe Zhao, Massachusetts Institute of Technology, Cambridge, MA, USA.

  • 1:40 PM 27. Strain-Stiffening Bottlebrush Polymer Hydrogels Influence hMSC Morphology and Mechano-transduction. Monica Ohnsorg, Varsha Rao, Alex Khang, Kristi Anseth, University of Colorado Boulder, Boulder, CO, USA.

  • 1:50 PM 28. Immunometabolism and Polylactide Stereochemistry: Reconciling a Decades-Long Controversy. Chima Maduka, DVM, MS, PhD, Christopher Contag, PhD, Michigan State University, East Lansing, MI, USA.

  • 2:00 PM 29. Engineering Siloxane-Derived Lipid Nanoparticles for Tissue-Specific mRNA Therapeutics Delivery. Lulu Xue, PhD, Gan Zhao, PhD, Ningqiang Gong, PhD, Xuexiang Han, Sarah Shepherd, Claude Clarence Warzecha, Rakan El-Mayta, Mohamad-Gabriel Alameh, Lili Wang, Drew Weissman, Andrew Vaughan, James Wilson, Michael Mitchell. Department of Bioengineering, Philadelphia, PA, USA, School of Veterinary Medicine, Philaldelphia, PA, USA, Perelman School of Medicine, Philadelphia, PA, USA, Department of Medicine, Phialdelphia, PA, USA.

  • 2:10 PM 30. Stimuli-Activated Hydrogel Tissue Expanders for Guiding Facial Growth in Microphthalmia Patients. Stephanie Fung, PhD, James Katowitz, MD, Riccardo Gottardi, PhD, Children's Hospital of Philadelphia, Philadelphia, PA, USA, University of Pennsylvania, Philadelphia, PA, USA.

1F: Ophthalmic Biomaterials (SIG)

Timeslot: Wednesday, April 19, 2023 - 1:00pm to 2:30pm
Room: Coral 5

About

The Ophthalmic SIG of Society for Biomaterials session focuses on biomaterials used in ocular applications. This will focus on the latest research in ocular biomaterials from basic science to clinical applications, with a special emphasis on translational research and the challenges associated with translating research to commercial applications. Research topics include, but are not limited to, biomaterials science, tissue engineering, drug delivery, cell-material interactions, and medical devices with ophthalmic applications. Diverse research topics and perspectives are strongly encouraged in this session. In particular, this session will showcase research from academia and industry, including ocular biomaterials currently being translated to the clinic.

  • 1:00 PM. 32. Drug-Eluting Adhesive Patches for the Treatment of Ocular Injuries. Prof. Nasim Annabi, Dr. Shima Gholizadeh, Xi Chen, Dr. Yavuz Oz, Prof. Reza Dana. Schepens Eye Research Institute.

  • 1:15 PM 33. Improved Eye Drop Formulation Targeting Glaucoma Therapy. Dr. Frances Lasowski, Dr. Lina Liu, Dr. Ben Muirhead, Dr. Talena Rambarren, Dr. Heather Sheardown. McMaster University.

  • 1:30 PM. 34. Stimuli-Activated Hydrogel Tissue Expanders for Guiding Facial Growth in Microphthalmia Patients. Stephanie Fung, PhD, James Katowitz. MD, Riccardo Gottardi, PhD, Children's Hospital of Philadelphia, University of Pennsylvania.

  • 1:45 PM 35. Wireless Theranostic Smart Contact Lens for Monitoring and Control of Intraocular Pressure in Glaucoma. Dr. Tae Yeon Kim, Prof. Sei Kwang Hahn. Pohang University of Science and Technology (POSTECH), PHI BIOMED Co.

  • 2:00 PM 36. Mucoadhesion and mucopenetration of self-assembled poly(lactic acid)-block-poly(oligoethylene glycol methacrylate) block copolymer nanoparticles with different ethylene oxide side-chain lengths. Ridhdhi Dave, Prof. Cecile Fradin, Prof. Francisco Goycoolea, Prof. Heather Sheardown, Prof. Todd Hoare. McMaster University, University of Leeds.

  • 2:15 PM. 37. Surface Modified Fibrous Scaffold for Ocular Surface Regeneration. Nasif Mahmood, Mohamed Eletmany, Ahmed El-Shafei, PhD, Ummay Mowshome Jahan, Dr. Jessica Gluck. North Carolina State University.

1G: Biomaterials Education (SIG)

Timeslot: Wednesday, April 19, 2023 - 1:00pm to 2:30pm
Room: Seaglass

About

The Biomaterials Education SIG members’ mission is to affect the quality of teaching and learning through the discussion, generation, and implementation of innovative ideas Through this, they seek to advance the interest and goals of the biomaterials community by attempting to bridge the gap between classroom theory and clinical application. As the field of biomaterials rapidly evolves, so must biomaterials education. The Biomaterials Education Special Interest Group is dedicated to the belief that all members of the biomaterials education community should be provided with high quality educational opportunities in a stimulating environment. This session will focus on topics including methods for integrating new standards education modules into established biomaterials curriculums, incorporating innovation and entrepreneurial process in curriculums, maximizing learning through the integration of virtual and in-person learning activities in a post-pandemic classroom environment, and methods for engaging the end-user, industry, and entrepreneurial communities in student education.

  • 1:15 PM 39. Gleaning Best Practices from a Biomaterials Summer Bridge Program. Dr. Timothy Burg, Cheryl Gomillion, Dr. Karen Burg. University of Georgia.

  • 1:30 PM. 40. A Case Study for Active Learning in a First-Year Biomaterials Design Course. Joseph Choy. Johns Hopkins University.

  • 1:45 PM 41. Soft Robotics in Education: Impact on and Students’ Attitude towards a Soft Material Robotics Curriculum. Prof. Holly Golecki, PhD, Elizabeth McNeela, Thomas Tran, Prof. Karen Jensen, PhD; University of Illinois at Urbana Champaign, University of Michigan.

  • 2:00 PM 42. How to make a new nose when it is off entirely and the dog has eaten it: the Lab Tales workshop as an approach to teach biomaterials trainees the art of narrative storytelling in science. Daniel Cohen, Princeton University.

  • 2:15 PM 38. Undergraduate Biomaterials Instruction with Basic Introduction to Design. Joel Bumgardner, PhD, FBSE, FAIMBE. Jessica Jennings, PhD; The University of Memphis

1H: Biomaterials in Engineering the Tumor Immune Microenvironment

Timeslot: Wednesday, April 19, 2023 - 1:00pm to 2:30pm
Room: Shorebreak

About

Malignant cells of the tumor co-exist with non-malignant cells in a 3D space. Immune cells of many types such as macrophages, dendritic cells, mast cells, T-cells and more make up the tumor immune microenvironment (TIME). Biomaterials are incorporated in bioengineering the TIME for multiple purposes: (1) creating bioengineered models to further fundamental immuno-oncology studies; and (2) modulating anti-tumor immune response. Cancer-immune cell interactions in the TIME are specifically important to study for the development of immunotherapies to treat various types of cancer. Not only is engineering the TIME useful for drug discovery, it can also provide mechanistic insights into cancer-immune cell interactions within the TIME that can be used to develop targeted immuno-therapies.
In this session, we will explore all aspects of biomaterials used to engineer or modulate the tumor immune microenvironment.

  • 1:00 PM 44. INVITED SPEAKER. Activation of Adaptive and Innate Immune Cells via Localized Cytokine Delivery for Cancer Immunotherapy.

  • 1:30 PM. 45. Engineered Macrophages eliminate Solid Tumors and initiate Anti-tumor Immunity. Prof. Dennis Discher. University of Pennsylvania.

  • 1:45 PM. 46. Conjugated STING-agonist nanoparticles enhance antitumor immunity in multiple tumor models. Dr. Pere Dosta Pons, Dr. Alexander Cryer, Michelle Dion, Dr. Tsubasa Shiraishi, Dr. Steven Langston, Dr. David Lok, Michaela Prado, Alma Rodriguez, Dr. Adnan Abu-Yousif, Dr. Natalie Artzi. Brigham and Women's Hospital, Massachusetts Institute of Technology, Takeda Development Center Americas, Inc.

  • 2:00 PM 47. Multi-niche Human Bone Marrow On-A-Chip for Studying Interactions of Cell Therapies With Multiple Myeloma. Delta Ghoshal, Abel Thomas, Ingrid Peterson, Prof. Krishnendu Roy. Georgia Institue of Technology.

  • 2:15 PM 48. Multi-omics Guided Design of Biomaterials-based Lymphoid Tissues to Study BCR-TLR Signaling in Lymphomas. Ankur Singh, Christopher Carlson, Dr. Shivem Shah, Zhe Zhong, Mayar Allam, Lauren Walter, Karen Martin, Benjamin Cogrove, Andres Garcia, Ahmet Coskun, Jean Koff. Georgia Institute of Technology, Cornell University, Emory University.

Invited Speaker(s)