Timeslot: Thursday, April 20, 2023 - 1:30pm to 3:30pm
Room: Silver Pearl 1
About
This panel will help early-stage researchers identify the regulatory and commercial requirements to support technology development, enabling the prioritization of critical studies to accelerate the transition. Further, the objective will be developing strategies to: identify an investor that matches you and your innovation and its future capabilities, what technology transfer and commercialization VCs look for at relevant stages and identifying an initial business model to get your innovation to market. Another aspect of this panel discussion is to emphasize the need for Basic Biomaterial Science Education to the Regulatory Authority (FDA) and the Payor (CMS). Our continued objective is to assist FDA to Evaluate the Safety & Efficacy, and CMS to provide Commercial Valuation of Medical Devices through an organized Consortium.
Moderator
Subramanian Gunasekaran
Invited Speaker(s)
4B: Drug Delivery (SIG)
Timeslot: Thursday, April 20, 2023 - 1:30pm to 3:30pm
Room: Silver Pearl 2
About
The Drug Delivery Special Interest Group will deal with the science and technology of controlled release of active agents from delivery systems. Controlled drug release is achieved by the use of diffusion, chemical reactions, dissolutions or osmosis, used either singly or in combination. While the vast majority of such delivery devices are based on polymers, controlled release can also be achieved by the use of mechanical pumps. In a broader sense, controlled release also involves control over the site of action of the active agent, using the active agent using pro-drugs, targetable water soluble polymers or various microparticulate systems. Relevant aspects of toxicology, bioavailability, pharmacokinetics, and biocompatibility are also included.
1:30 PM. 142. INVITED SPEAKER
2:00 PM 143. Controlled Release of Bioactive Antibodies from a Modular Pulsatile Release Platform. Kevin McHugh, PhD, Tyler P. Graf, Erin M. Euliano, Mei-Li Laracuente, Rice University, Baylor College of Medicine.
2:15 PM 144. Direct Delivery of Plasmin using Clot-anchoring Thrombin-Responsive Nanoparticles for Targeted Fibrinolytic Therapy. Anirban Sen Gupta, PhD, Michael Sun, PhD, Maxine Hao Hao Pontius, Stephanie Yang, Shruti Raghunathan, Jordan A. Shavit, MD, PhD, Case Western Reserve University, University of Michigan.
2:30 PM 145. Evaluation of Clot-Targeted Nanogels for Anticoagulant and Fibrinolytic Dual-Delivery in a Rat Model of Disseminated Intravascular Coagulation. Ana Sheridan, Kimberly Nellenbach, PhD, Ashley C. Brown, PhD, Emily Mihalko, PhD, Nina Moiseiwitsch, Grant Scull, Elizabeth Byrnes, Sanika Pandit, North Carolina State University and University of North Carolina at Chapel Hill.
2:45 PM 146. A Conformable Compartmentalized MicroMESH for the Combinatorial Treatment of Glioblastoma. Paolo Decuzzi, PhD, Irene Guerriero, MSc, Cristiano Pesce, MSc, Daniele Dimascolo, PhD, Anna Lisa Palange, PhD, Italian Institute of Technology.
3:00 PM 147. Biodegradable Dendrimers for mRNA Therapeutics Delivery into the Ischemic Brain. Ana Paula Pego, PhD, Marília Torrado, Ana P. Spencer, Victoria Leiro, PhD, Sofia D. Santos, PhD, i3S - Instituto de Investigação e Inovação em Saúde / INEB - Instituto de Engenharia Biomédica, ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Faculdade de Engenharia da Universidade do Porto.
3:15 PM 148. Throughput-Scalable Silicon and Glass Microfluidic Platform for Manufacturing of SARS-CoV-2 mRNA Lipid Nanoparticles Vaccines. Sarah Shepherd, Dr. David Issadore, Dr. Michael Mitchell, University of Pennsylvania.
Invited Speaker(s)
4C: Orthopaedic Biomaterials (SIG)
Timeslot: Thursday, April 20, 2023 - 1:30pm to 3:30pm
Room: Silver Pearl 3
About
The Orthopaedic Biomaterials Special Interest Group is focusing on new technologies and materials advances in orthopaedic surgery. The three immediate goals of this emerging Special Interest Group are: 1) solicitation of new members for the Special Interest Group from current Society membership and from non-members actively engaged in research and development of improved materials for orthopaedics, 2) identification of key issues in orthopaedic materials that should be addressed within the Society, and 3) cooperation between Special Interest Group membership and the chairman of the Program Committee for the Annual Meeting to assist in the coordination of the scientific program.
1:30 PM 149. Rapid elimination of Staphylococcus Aureus Achieved by Sonodynamic Au@Cu2O Hybrid Nano-Cubes. Kelvin Yeung, PhD, Yizhou Zhu, PhD, Kenneth Cheung, MD, The University of Hong Kong, The University of Hong Kong Shenzhen Hospital.
1:45 PM 150. A Resurfacing-Regenerative Approach to Repair Osteochondral Defects using a Bioprosthetic Device. Melissa Grunlan, Ph.D, Connor Demott, Ph.D, Lauren Davis, Ph.D, William B. Saunders, Ph.D, Texas A&M University.
2:00 PM 151. Physical and Biochemical Microenvironmental Cues Potentiate TGFβ-Mediated Scleraxis Expression. Robert Kent, MS, Mohamed Said, BS, Megan Busch, BS, Ariane Tsai, BS, Daniel L. Matera, PhD, William Wang, PhD, Samuel DePalma, MS, Harrison Hiraki, MS, Megan Killian, PhD, Adam Abraham, PhD, Alice Huang, PhD, Ariella Shikanov, PhD, Brendon Baker, PhD, University of Michigan, Columbia University.
2:15 PM 152. Injectable Radiopaque Hyaluronic Acid Granular Hydrogels for Intervertebral Disc Repair. Dr. Victoria Muir, Sarah Gullbrand, Jason Burdick, University of Pennsylvania, University of Colorado.
2:45 PM 154. Additive Manufactured Bioabsorbable Magnesium/Zinc Scaffolds for In Vivo Bone Regeneration. Donghui Zhu, Juncen Zhou, Stony Brook University.
3:00 PM 155. Decellularized Meniscus Scaffold and Cartilage Progenitor Cells for Total Meniscal Repair. Alexandra Dumas, Paul Gehret, Riccardo Gottardi, PhD, University of Pennsylvania, Children's Hospital of Philadelphia.
3:15 PM 156. Whitlockite-Poly(ethylene glycol) Hybrid Scaffold Promotes Bone Tissue Regeneration Through Stepwise Magnesium Ion Release. Wei Qiao, The University of Hong Kong.
4D: Immunomodulatory Biomaterials
Timeslot: Thursday, April 20, 2023 - 1:30pm to 3:30pm
Room: Coral 1-2
About
This session will focus on engineered biomaterials to modulate and regulate immune functions in the settings of autoimmune diseases, allergies, transplantation, cancer immunotherapies, etc. Specifically, the session will cover topics ranging from biomaterials for drug delivery of immunomodulators and imaging agents, antigen delivery, scaffolds for immunomodulation, microbiome modulation, cell-based therapies, etc. Cutting-edge immunoengineering platforms will be included.
Moderators:
- Ula Van Mentzer
- Loise Raberg
1:30 PM 157. Harnessing Nanoscale Architecture to Program Multi-faceted Cancer Immunity. Michelle Teplensky, PhD, Boston University, Northwestern University.
1:45 PM 158. Immune-Modulating Therapy via the Delivery of Butyrate Using Polymeric Micelles. Shijie Cao, PhD, Ruyi Wang, PhD, Mohamed E. H. Bashir, PhD, Lauren A. Hesser, Cathryn R. Nagler, PhD, Jeffrey, A. Hubbell, PhD, University of Chicago.
2:00 PM 159. Microneedle-mediated Delivery of Immunomodulators Restores Immune Privilege in Hair Follicles and Reverses Alopecia Areata. Núria Puigmal, PhD, Nour Younis, MD, Diane Cruz, Andrea Daccache, Anis Saad, Triana Huerta, Ahmad Halawi, Christa Deban, Dongliang Zhang, Prof. Jamil R. Azzi, Prof. Natalie Artzi, Brigham and Women's Hospital, Harvard Medical School, Massachusetts Institute of Technology, Wyss Institute at Harvard.
2:15 PM 160. Induction of Antigen Specific Immunity with a Biologic Scaffold Assisted Therapeutic Cancer Vaccine. Matthew Wolf, PhD, Sanjay Pal, PhD, Brenna Hill, PhD, National Cancer Institute.
2:30 PM 161. Microribbon Hydrogels with Tunable Compositions Enhances Bone Regeneration through Immunomodulation. Ni Su, PhD, Cassandra Villicana, Fan Yang, Stanford University.
2:45 PM 162. Immunomodulatory Biomaterials Designs for Long-term Delivery of Cell Therapeutics. Boram Kim, Sudip Mukherjee, Lauren Cheng, PhD, Amanda Nash, Samantha Fleury, Michael Doerfert, Peter Rios, Jose Oberholzer, PhD, David Zhang, PhD, Omid Veiseh, PhD, Rice University, CellTrans, Inc..
3:00 PM 163. Engineering Injectable Nanoparticle-Based Hydrogels for Immune Niche Modulation and Improved Immunotherapy. Emily Meany, Santiago Correa, PhD, Eric Appel, PhD, Stanford University.
3:15 PM 164. An Infusible Extracellular Matrix Material for the Mitigation of Severe Systemic Inflammation in an Aged Mouse Model. Maria Karkanitsa, Raymond M. Wang, PhD, Anne Lyons, Ryan Middleton, PhD, Mark Hepokoski, MD PhD, Karen L. Christman, PhD, University of California San Diego. ,
4E: Nanomaterials (SIG)
Timeslot: Thursday, April 20, 2023 - 1:30pm to 3:30pm
Room: Coral 3-4
About
In this study, we show the effect of various LED wavelengths (blue, green, red and near infrared (NIR)) as physical regulators for gene delivery to stem cells by promoting nanomaterials behavior and regulating cell membrane permeability.
The size of nanoparticles produced with various LED wavelengths was evaluated in the colloidal state (agglomeration to single form). And physical stimulation of cell membranes using two type of LED wavelengths (blue and NIR) enhanced penetration of extracellular substances. The regulation of nanoparticles size and cell membrane permeability effectively increased the gene delivery to cells and protein expression by accelerating transfection process (cellular uptake, endosomal escape, PEI-gene dissociation).
LED effects on nanoparticles was confirmed using DLS, SEM, and Nanosight. In addition, cell membrane permeability was assessed by confocal laser microscopy, FACS and then transfection efficiency was demonstrated using confocal laser microscopy, FACS and Western blot.
Reduction of nanoparticles size by LED have potential value for stem cell therapy as LED-induced gene delivery system. Also, by increasing the cell membrane permeability, extracellular substances that cannot easily penetrate the cell membrane can be delivered effectively.
1:30 PM. 165. Ionizable Lipid Nanoparticle Platform for in Vivo Delivery of Small Protein Scaffolds for Potent RAS Inhibition. Rebecca Haley, Alexander Chan, Margaret Billingsley, Andrew Tsourkas, Michael Mitchell, PhD, University of Pennsylvania.
1:45 PM 166. Bone Marrow Vascular Microenvironment Combination RNAi Nanomaterials Therapy for Multiple Myeloma. Christian Figueroa-Espada, Pedro P. G. Guimarães, PhD, Michael J. Mitchell, PhD, University of Pennsylvania, Universidade Federal de Minas Gerais.
2:00 PM 167. Targeting of Porous Silicon Nanoparticles to the Traumatically Injured Brain for the Delivery of Growth Factors. Jonathan M. Zuidema, PhD, Lauren E. Waggoner, Jinyoung Kang, PhD, Sanahan Vijayakumar, PhD, Alan A. Hurtado, Michael J. Sailor, PhD, Ester J. Kwon, PhD, University of California San Diego, Mario Negri Institute for Pharmacological Research.
2:15 PM 168. Use of a Keap1-inhibiting Peptide Brush Polymer for Myocardial Infarction Treatment. Joshua M. Mesfin, Kendal P. Carrow, Alexander Chen, Emma Zelus, Jervaughn Hunter, Elyse G. Wong, Colin G. Luo, Nathan C. Gianneschi, Karen L. Christman, UC San Diego, Sanford Consortium for Regenerative Medicine, Northwestern University.
2:30 PM 169. Characterizing NP Fate in the CNS After Intrathecal Administration: A PET/CT Imaging Approach. Rachael Sirianni, Oluwatobi Babayemi, Corinne Fotso, Fred Christian Velasquez, Sauradip Chaudhuri, Lindsey Sablatura, Janelle Morton, Eva Sevick-Muraca, Rice University.
2:45 Pm 170. Reprogramming Clots for In Vivo Chemical Targeting of Nanomaterials in Traumatic Brain Injury. Rebecca Kandell, Jason Wu, Ester J. Kwon, PhD, UC San Diego.
3:00 PM 171.Nanoformulation of a Peptide Prophylactic for the Treatment of Traumatic Brain Injury. Jason Wu, Akash Canjels, Ester J. Kwon, University of California-San Diego.
3:15 PM 172. Development of Lipid-Polymer Hybrid Nanoparticles for the Co-Encapsulation of 6-Bromo-Indirubin-3’-Oxime and Copper Diethyldithiocarbamate for Synergistic Cancer Therapy. Radu Paun, Daciana C. Dumut, Danuta Radzioch, Maryam Tabrizian, Faculty of Medicine and Health Sciences, McGill University, Research Institute of the McGill University Health Centre, Faculty of Dental Medicine and Oral Health Sciences, McGill Universit.
4F: Engineering Complex Tissues
Timeslot: Thursday, April 20, 2023 - 1:30pm to 3:30pm
Room: Coral 5
About
Native tissues are hierarchically organized and composed of multiple cell types and extracellular matrix molecules that are critical for normal tissue function and dysregulated in disease states. This session will focus on novel methodologies to engineer complex tissues and systems for applications in tissue regeneration, disease modeling, drug screening, developmental biology, etc. Abstracts describing approaches to generate multicomponent systems with multiple cell types and biochemical and physical cues are of particular interest.
1:30 PM 173. Mechanically-Mediated Biochemical Signaling Guides Assembly and Maturation of Engineered Multicellular Tissues. Ritu Ramen, Naomi Lynch, Angel Bu, Massachusetts Institute of Technology.
1:45 PM 174. 3D Bioprinting of Dense Cellular Structures within Functional Hydrogels. Murat Guvendiren, PhD, Alperen Abaci, New Jersey Institute of Technology.
2:00 PM 175. A Modular Microreactor for the Preparation, Maintenance and Conditioning of Multilayer Tissues or Multi-Tissue Structures. Luca Gasperini, Ana I. Soares, Zahara Eltayari, Rui L. Reis, Alexandra P. Marques, 3B’s Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, ICVS/3B’s – PT Government Associate Laboratory.
2:15 PM 176. Investigating Paracrine Signaling in a Triphasic Biomaterial for Rotator Cuff Repair. Kyle B. Timmer, Megan Killian, PhD, Brendan A. Harley, Sc.D., University of Illinois Urbana-Champaign, University of Michigan.
2:30 PM 177. Cytokine and T cell Stimulus Differentially Regulates Aged B cell Activation and ECM Remodeling. Secil Demir, PhD, Zhe Zhong, Sona Desai, Dr. Ankur Singh, Georgia Institute of Technology.
2:45 PM 178. Engineering Microscale Co-cultures of iPSC-derived Cardiomyocytes and Fibroblasts via Photopatterned Alginate. Derrick Wells, MS, Yong Duk Han, PhD, Eben Alsberg, PhD, Salman R. Khetani, PhD, University of Illinois at Chicago.
3:00 PM 179. Heart-On-A-Chip with Vascular Plexus for Drug Testing. Yimu Zhao, PhD, Gordana Vunjak-Novakovic, PhD, Milica Radisic, PhD, University of Toronto, Columbia University.
3:15 PM 180. Cell Assembled 3D Tumor Stroma In-A-Dish Using Decellularized Extracellular Matrix Scaffolds. Matthew Wolf, PhD, Michael Buckenmeyer, PhD, Elizabeth Brooks, PhD, Madison Taylor, National Cancer Institute.
4G: Biomaterials for Cell Therapy
Timeslot: Thursday, April 20, 2023 - 1:30pm to 3:30pm
Room: Seaglass
About
Biomaterials-assisted cell therapy has tremendous clinical potential in improving disease outcomes. Biomaterial carriers have been designed to modulate cell behavior, protect cells from immune attacks, guide patient-specific cellular activity or stimulate endogenous cell recruitment. Biomaterials has been used in cell transplantation, cell microencapsulation, cell delivery, or cell reprogramming and cell expansion ex vivo. This session will cover all applications of biomaterials in protecting or enhancing the function of cells or facilitating their delivery.
1:30 PM. 181. INVITED SPEAKER .
2:00 PM 182. Intracellular Control of Macrophage Phenotype via Dexamethasone-loaded Microparticles for Cell Therapy. Tina Tylek, PhD, Kara Spiller, PhD, Joanna Wong, Andrew Vaughan, Drexel University, University of Pennsylvania.
2:15 PM 183. Microporous Scaffold with Vasculogenic Modification for Transplantation of Stem Cell-Derived β-Cells. Kelly Crumley, Nicholas Schott, PhD, Elizabeth, Jan Stegemann, PhD, Lonnie Shea, PhD, University of Michigan.
2:30 PM 184. Reduction of Hypoxia-Induced Cell Death by Macro-Encapsulation of Toroid-Shaped Microtissues in Homogeneous Spatial Distribution. Tram Dang, PhD, Yang Chen, PhD, Yicong Zuo, PhD, Nam Tran, Vernice JR Tan, Nanyang Technological University.
2:45 PM 185. Cell-Assembling Collagen Microgel for Stem Cell Therapy in Critical Limb Ischemia. Haeun Chung, Sangheon Kim, Korea Institute of Science and Technology.
3:00 PM 186. Development of a Decellularized Bone Model to Test Efficacy of a Hydrogel Cell Carrier for HSC Transplantation. Mykel Green, PhD, Taylor Sullivan, Patience Oliveira, Elizabeth Cosgriff-Hernandez, PhD, The University of Texas at Austin.
3:15 PM 187. Vasculogenic, Synthetic Hydrogel Supports the Engraftment and Real-Time Tracking of Human Pluripotent Stem Cell-derived β-cells. Sophia Kioulaphides, MS, Michael Hunckler, PhD, Andres Garcia, PhD, Georgia Institute of Technology.
Invited Speaker(s)
4H: Black and LatinX Voices in Biomaterials
Timeslot: Thursday, April 20, 2023 - 1:30pm to 3:30pm
Room: Shorebreak
About
The purpose of this session is to highlight the research conducted by biomaterials scientists and engineers from historically excluded groups and marginalized communities, including but not limited to Black/African American, Hispanic/Latinx, and Native/Indigenous groups. Our session will consist of one invited keynote speaker and 10 short talks from submitted abstracts to our session.
1:30 PM 188 INVITED SPEAKER.
2:00 PM 189. An Injectable Smart Piezoelectric Hydrogel for Periodontal Disease Treatment. Lina Roldan DDF, Carolina Montoya, PhD, Varun Solanki, DDS Temple University.
2:06 PM 190. Tuberculosis Treatment Strategies Through Sustained Local Delivery. Emmanuel Opolot, Horst von Recum. Case Western Reserve University, Cleveland, OH, USA.
2:12 PM 191. Evaluating Therapeutic Potential of Silk Fibroin Nanoparticles for Intravenous Oxygen Delivery. Marisa Pacheco, Jostin Armada, Hannah Bagnis, Bruce Spiess, Whitney Stoppel, PhD, University of Florida, Gainesville, FL, USA.
2:18 PM 192. Modeling of Carbon Monoxide Delivery for Treating Disruptions in the Blood Brain Barrier Endothelium. Rubens Jourdain, Tanya Enderly, Venkat Keshav Chivukula, PhD, Chris Bashur, PhD, Florida Institute of Technology, Melbourne, FL, USA.
2:30 PM 194. Investigating Bio-Nano Interactions of Polyamidoamine Dendrimers within Synovial Joints. Juan Aleman, Brandon Johnston, Alan Grodzinsky, Paula Hammond, Simone Douglas-Green,Massachusetts Institute of Technology, Cambridge, MA, USA.
2:36 PM 195. Development of a Nanoparticle-Hydrogel Composite for Gene Editing in Osteoarthritis. Larry Stokes, II, Isom Kelly, PhD, Brock Fletcher, Richard Darcy, PhD, Bryan Dollinger, PhD, Craig Duvall, PhD, Vanderbilt University, Nashville, TN, USA.
2:42 PM 196. "Gabriela Cervantes-Gonzales, Teja Guda, The University of Texas at San Antonio, San Antonio, TX, USA.
2:48 PM 197. SHIELD Hydrogels Allow for Long-Term Survival and Integration of Human Cortical Neurons into a Chronic Adult Cervical Spinal Cord Injury. Vanessa Doulames, PhD, Meghan Hefferon, Riley Suhar, PhD, Neil Baugh, Theo Palmer, PhD, Sarah Heilshorn, PhD, Stanford University, Stanford, CA, USA.
2:54 PM 198. Culturing Primary Hepatocytes in Glycosaminoglycan-Based Capsules: Interior ECM Components Promote Hepatic Organization and Function. "Rafael Ramos, MS1,2, Howard Matthew, PhD1,1Wayne State University, Wayne State University School of Medicine, Detroit, MI, USA.
3:00 PM 199. Co-Assembling Peptide Hydrogels for Protein Localization: Humoral Immune Response. Lucas Melgar, Gregory Hudalla, Bethsymarie Soto-Morales, University of Florida, Gainesville, FL, USA.
3:06 PM 200. Alginate-Based Artificial Antigen Presenting Cells Improve CD8+ T cell Memory Formation. Mary Omotoso, Savannah Est-Witte, Sarah Neshat, Jordan Green, PhD, Jonathan Schneck, MD, PhD, Johns Hopkins University, Baltimore, MD, USA.
3:12 PM 201. A Thy-1 Negative Inflammatory Fibroblast Subpopulation Emerges as a Key Determinant of Fibrotic Outcomes to Biomaterials. Daniel Abebayehu, PhD, Blaise Pfaff, Grace Bingham, Andrew Miller, Donald Griffin, PhD, Thomas Barker, PhD, University of Virginia, Charlottesville, VA, USA.
3:18 PM 202. Elyahb Allie Kwizera, PhD, Xiaoming He, PhD, Katherine Tkaczuk, MD,University of Maryland Baltimore, Baltimore, MD, USA.
3:24 PM 203. Cancer Engineering a Three-Dimensional Multilayer Multicellular Model of Endometrial Cancer for High Throughput Drug Screening. Ines Cadena, Mina Buchanan, Kaitlin Fogg,Oregon State University, Corvallis, OR, USA.