Timeslot: Friday, April 21, 2023 - 2:00pm to 3:30pm
Room: Silver Pearl 1
Invited Speaker(s)
7B: Biomaterial-Based Vitro Cancer/Tumor Models for Drug Screening and Diagnostics 1
Timeslot: Friday, April 21, 2023 - 2:00pm to 3:30pm
Room: Silver Pearl 2
About
Biomaterial-based in vitro cancer/tumor models offer a close mimic of the complex tumor microenvironment, providing versatile platforms for drug and toxicology screening as well as diagnostics. The implementation of these preclinical tools can afford low-cost, easy-to-use systems to evaluate cancer treatments, enhancing the efficacy and toxicological assessment for specific patients, mitigating the limitations of current technologies, and expanding the treatment options and patient’s quality of life.
2:00 PM. 347. INVITED SPEAKER
2:30 PM 348. Adhesion Strength of Disseminating Tumor Cells Predicts Severity of Metastatic Disease. Katherine Birmingham, PhD, Benjamin Yeoman, PhD, Madison Kane, Pranjali Beri, PhD, Jeremy Tuler, Isabelle Williams, Aditya Kumar, PhD, Sarah Klein, Parag Katira, PhD, Adam Engler, PhD, University of California, San Diego, San Diego, CA, USA, San Diego State University, San Diego, CA, USA, Genomics Institute of the Novartis Foundation, San Diego, CA, USA, Moores Cancer Center, San Diego, CA, USA, Sanford Consortium for Regenerative Medicine, San Diego, CA, USA.
2:45 PM 349. Gold-Coated Microfluidic-Based Enhanced Capture, Controlled Release, and In Vitro Culture of Heterogeneous Circulating Tumor Cells. Elyahb Allie Kwizera, PhD, Xiaoming He, PhD, Katherine Tkaczuk, MD, University of Maryland Baltimore, Baltimore, MD, USA.
3:00 PM 350. A Versatile, Reductionist Platform for Studying 3D Microenvironmental Interactions in Colorectal Cancer. Irina Kopyeva, Ross Bretherton, Jessica Ayers, Ming Yu, William Grady, Cole DeForest, PhD, University of Washington, Seattle, WA, USA, Fred Hutchinson Cancer Center, Seattle, WA, USA.
3:15 PM 351. Tuning Mineral Cues Modulates Breast Cancer-Bone Metastasis in a Spatially Patterned 3D Model. Michelle Tai, Eva González Díaz, PhD, Angelina Mao, Fan Yang, PhD, Stanford University, Palo Alto, CA, USA.
Invited Speaker(s)
7C: Business Pitch Competition
Timeslot: Friday, April 21, 2023 - 2:00pm to 3:30pm
Room: Silver Pearl 3
About
A unique session designed to challenge you to consider the commercialization aspects of your research. Individuals and groups (your choice) will be judged by experts from investing, industry, regulatory, and academia on the strength of their commercialization plans. Prizes will be awarded to the top individuals/teams, including the audience’s choice.
7D: Biofunctionalized Biomaterial Surfaces for Cellular and Tissue Engineering
Timeslot: Friday, April 21, 2023 - 2:00pm to 3:30pm
Room: Coral 1-2
About
This symposium is focused on biostructured biomaterials and surfaces. We aim at creating an excellent forum for the debate of the cutting edge research on nano and biotechnologies applied to the development of new, smarter and super effective biomaterials able to overcome clinically-oriented unsolved problems or elegant new technologies maximizing the efficacy of minimally-invasive clinical therapies.
2:00 PM 360. Synthetic Matrix Fibers Promote 3D Vasculogenesis via Intercellular Mechanical Signaling. Firaol Midekssa, Christopher Davidson, Jordan Kamen, Megan Wieger, Brendon Baker, University of Michigan, Ann Arbor, MI, USA.
2:15 PM 361. Nitric Oxide Releasing Nanomatrix Gel for Dialysis Fistula Maturation Enhancement. Patrick Hwang, PhD, Maheshika Somarathna, PhD, Benjamin Estep, Jennifer Sherwood, Brigitta Brott, MD, Timmy Lee, MD, Ho-Wook Jun, PhD, Endomimetics, Birmingham, AL, USA, University of Alabama at Birmingham, Birmingham, AL, USA.
2:30 PM 362. Engineering of Architectural Complexities of Conical Cardiac Ventricle Using Polyesters. Sargol Okhovatian, BASc, Shira Landau, PhD, Mohammad Hossein Mohammadi, Houman Savoji, PhD, Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
2:45 PM 363. Effects of Engineering Nanotopography on the Inflammatory Response of Silk-Fibroin Hydrogels. Viviana Posada, PhD, Andrea Mesa-Restrepo, MSc, Alexandru Marin, PhD, Jean Paul Allain, Pennsylvania State University, University Park, PA, USA.
3:00 PM 364. A Versatile, Reductionist Platform for Studying 3D Microenvironmental Interactions in Colorectal Cancer. Irina Kopyeva, Ross Bretherton, Jessica Ayers, Ming Yu, William Grady, Cole DeForest, PhD, University of Washington, Seattle, WA, USA, Fred Hutchinson Cancer Center, Seattle, WA, USA.
3:15 PM 365. Hydrogel Nanocomposite Emulsion for siRNA Drug Delivery into Adipocytes. Ruth Negru, MAS, Jessica Park, Fouad Teymour, PhD, Georgia Papavasiliou, PhD, Marcella Vaicik, PhD, Illinois Institute of Technology, Chicago, IL, USA.
7E: Musculoskeletal Regeneration
Timeslot: Friday, April 21, 2023 - 2:00pm to 3:30pm
Room: Coral 3-4
About
Advances in tissue engineering and regenerative therapies have led to the development of innovative materials and approaches for the functional regeneration of musculoskeletal tissues, including muscles, bones, cartilage, tendons, and neural tissues. However, given the intricate nature of the musculoskeletal system and its interconnection with other bodily systems, there is a crucial need for continued progress in translational therapies that integrates engineering, medicine, immunology, developmental biology, stem cell research, and bioinformatics. The focus of this session is on the latest breakthroughs in the development of functional biomaterials, preclinical models, and engineered strategies for repairing and regenerating musculoskeletal tissues affected by disease, trauma, and aging.
2:00 PM 366. Engineered Skeletal Muscle in Space as a Novel Model Sarcopenia. Mahdis Shayan, PhD, Bugra Ayan, PhD, Soochi Kim, PhD, Thomas Rando, MD, PhD, Ngan Huang, PhD, Stanford University, Stanford, CA, USA.
2:15 PM 367. The Anti-SASP Ruxolitinib Modulates Aged Macrophage Phenotype Transitions and Promotes Aged Bone Healing. Yamin Liu, PhD, Kara Spiller, PhD, Liisa Kuhn, PhD, University of Connecticut Health Center, Farmington, CT, USA, Drexel University, Philadelphia, PA, USA.
2:30 PM 368. Sliding Hydrogels Attenuate the Inflammatory Phenotype of Osteoarthritic Chondrocytes via Mechanotransduction. Manish Ayushman, Xinming Tong, Pranay Agarwal, Nidhi Bhutani, Fan Yang, Stanford University, Stanford, CA, USA.
2:45 PM 369. Aspirin Synergizes with Optimized Calcium Phosphate Particles to Enhance Macroporous Scaffold-Mediated Bone Regeneration in Vivo. Ni Su, PhD, Cassandra Villicana, Fan Yang, Professor, Stanford University, Palo Alto, CA, USA.
3:00 PM 370. Biomimetic Proteoglycans Molecularly Engineer and Mechanically Modulate Human Osteoarthritic Cartilage. Elizabeth Kahle, Colette Trouillot, Paul DeSantis, Anish Aitha, Lin Han, Michele Marcolongo, Drexel University, Philadelphia, PA, USA, Villanova University, Villanova, PA, USA.
3:15 PM 371. Nanofibrillar Engineered Muscle Therapy Enhances Muscle and Bone Functional Healing in Composite Lower Extremity Trauma. Karina Nakayama, PhD, Cynthia Alcazar, Krista Habing, Zachary Working, MD, Nick Willett, PhD, Anthony Tahayeri, Luiz Bertassoni, DDS, PhD, Oregon Health & Science University, Portland, OR, USA, University of Oregon, Eugene, OR, USA.
7F: Development of Novel Bioinks for Tissue Engineering
Timeslot: Friday, April 21, 2023 - 2:00pm to 3:30pm
Room: Coral 5
About
Bioinks play an important role in 3D printing for the creation of tissue-engineered constructs. They require careful development of the biomaterial formulation to balance the requirements of suitable rheological and mechanical properties for printing with the ability to support cell viability, proliferation, and phenotype. Bioinks are most often based on hydrogels, either from naturally derived or synthetic sources, and may include additives such as nanomaterials to improve their materials properties and/or functionalization with biologically active molecules. Abstracts submitted to this session will focus on the development of novel bioink formulations, the characterization of bioinks and their use with different 3D printing technologies, and/or the application of these bioinks to fabricate 3D tissues.
2:00 PM 372. Microporogen-structured Collagen Matrices for Embedded Bioprinting of Functional Tumor Models. Daniel Reynolds, Ph.D, Irene de Lazaro, Ph.D, Manon Blache, M.S., Ramsey Doolittle, David Mooney, Ph.D, Jennifer Lewis, Sc.D, Harvard University, Cambridge, MA, USA, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland.
2:15 PM 373. Spheroid-only Bioinks for Suspension Bioprinting of Tissue Engineered Cartilage Constructs. Megan Cooke, PhD, Jason Burdick, PhD, University of Colorado Boulder, Boulder, CO, USA.
2:30 PM 374 Cell-Laden Composite Hydrogel Bioinks with Human Bone Allograft Particles to Enhance Stem Cell Osteogenesis. Hadis Gharacheh, Murat Guvendiren, PhD, New Jersey Institute of Technology, Newark, NJ, USA.
2:45 PM 375. Tuning the Rheology of Wholly-Cellular Bioinks for Bioprinting. Jianyi Du, PhD, Stacey Lee, PhD, Debbie Ho, Soham Sinha, Mengdi He, Mark Skylar-Scott, PhD, Stanford University, Stanford, CA, USA, Carnegie Mellon University, Pittsburgh, PA, USA, Chan Zuckerberg Biohub, San Francisco, CA, USA.
3:00 PM 376. Development of Bioinks for 3D Bioprinting of an Osteochondral Tissue Substitute. Mahdieh Heydarigoojani, M.Sc., Eric Lehoux, Ph.D., Isabelle Catelas, Ph.D., P.Eng., FIOR, University of Ottawa, Ottawa, ON, Canada.
3:15 PM 377 Bioinks Designed for Contrast-Enhanced X-ray Imaging with Photopolymerizable and Renally-Clearable Nanoparticles. Lan Li, MEng, Carmen Gil, Xiaoqi Yu, Vahid Serpooshan, Ryan Roeder, University of Notre Dame, Notre Dame, IN, USA, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.
7G: Biophysical Strategies for Regulation of Cellular Microenvironments
Timeslot: Friday, April 21, 2023 - 2:00pm to 3:30pm
Room: Seaglass
About
Biophysical factors directed by biomaterials are known to play important roles in regulating cellular behavior by influencing gene and protein expression, protein localization, and cell signaling activity. This session focuses on biomaterial-based strategies for regulating biophysical factors in engineered cellular microenvironments. Topics include but are not limited to novel uses of biomaterials for regulation of nano- and micro-topographical and ligand patterning cues, normal and shear stress environments, thermosensitive properties, and physical parameters of fiber networks for regulating cellular phenotype. This includes studies incorporating novel strategies for control of biophysical parameters in biomaterial design for engineering of physiological models as well as fundamental studies of the mechanisms by which cells utilize biophysical cues from the biomaterials in their microenvironment to elicit specific biological outcomes. The studies presented in this session will contribute to the design of next-generation biomaterials capable of precisely and predictably directing cellular behaviors.
2:00 PM 378. Multisized Photoannealable Microgels Regulate Cell Aggregation and Macrophage Phenotype through Microporous Void Space. Jeremy Lowen, Gabriella Bond, Katherine Griffin, Nathan Shimamoto, Victoria Thai, Jonathan Leach, University of California Davis, Davis, CA, USA.
2:15 PM 379. Regulating Biophysical Cues in Engineered Extracellular Matrices with Peptoids. Adrianne Rosales, Logan Morton, David Castilla-Casadiego, The University of Texas at Austin, Austin, TX, USA.
2:30 PM 380. Alginate Microfibers as Anisotropic Porogens to Enhance Vasculogenic Assembly in Dense Fibrin Hydrogels. Firaol Midekssa, Maggie Jewett, Megan Busch, Megan Wieger, Jordan Kamen, Brendon BakerUniversity of Michigan, Ann Arbor, MI, USA.
2:45 PM 381. Mobile Sliding Hydrogels with Tunable Stiffness Enhance MSC Osteogenesis in 3D via Mechanosensing. Georgios Mikos, Manish Ayushman, Xinming Tong, PhD, Sarah Jones, Fan Yang, PhD, Stanford University, Stanford, CA, USA.
3:00 PM 382. Reciprocal Cell-ECM Dynamics Drive Nematic Ordering of C2C12 Myotubes on Anisotropic Liquid Crystalline Polymer Networks. Nathaniel Skillin, BS, Katie Herbert, PhD, Bruce Kirkpatrick, BS, Grace Hach, Kemal Gunay, PhD, Frank DelRio, PhD, Ryan Khan, PhD, Kristi Anseth, PhD, Timothy White, PhD, University of Colorado Boulder, Boulder, CO, USA, Sandia National Laboratories, Albuquerque, NM, USA.
3:15 PM 383. Small Molecules to Modulate Hydrogel Gelation and Mechanics for Dynamic Organoid Culture. Aidan Gilchrist, PhD, Yueming Liu, Yuan Guan, PhD, Gary Peltz, MD, PhD, Sarah Heilshorn, PhD, Stanford Univeristy, Stanford, CA, USA.
,
7H: 3-Minute Thesis
Timeslot: Friday, April 21, 2023 - 2:00pm to 3:30pm
Room: Shorebreak
About
In a 3-Minute Thesis (“3MT”) Competition, students present a single static slide as a compelling summary of their dissertation research and its broader impacts. Presentations must be at most three minutes. 3MT is a great way to think about how to convey the significance of your work.