Con-current Oral Abstract Presentations Session 1

Biomimetic Materials for Tissue Engineering I

Bioactive Hydrogels based on Collagen-Mimetic Proteins for Controlled MSC Differentiation

D. J. Munoz-Pinto¹, B. Wang¹, T. Wilems¹, M. Browning¹, E. Cosgriff-Hernandez¹, B. Russell², J. Rivera², M. Hook², M. S. Hahn¹;

¹Texas A&M Univ., College Station, TX, ²Texas A&M Univ. Hlth.Sci. Ctr., Houston, TX.

Heparin-Based Hydrogel as a Matrix for Cultivation of Primary Hepatocytes

M. Kim, G. Tae;

Gwangju Inst. of Sci. and Technology, Gwangju, KOREA, REPUBLIC OF.

Covalently Immobilized PDGF-BB Stimulates Angiogenesis in Poly (ethylene glycol) Based Hydrogels

J. E. Saik¹, R. A. Poche², E. M. Watkins¹, J. E. Barbick¹, M. E. Dickinson², J. L. West¹;

¹Rice Univ., Houston, TX, ²Baylor Coll. of Med., Houston, TX.

Mechanism of Vascular Smooth Muscle Adhesion to Elastin-like Polypeptide Surface Enriched Materials

P. H. Blit¹, K. G. Battiston¹, M. Yang¹, K. A. Woodhouse², J. P. Santerre¹;

¹Univ. of Toronto, Toronto, ON, CANADA, ²Queen's Univ., Kingston, ON, CANADA.

Gradient Formation Mediated By Density Differences Of Polyethylene Glycol Microspheres

J. Roam, D. L. Elbert;

Washington Univ., St. Louis, MO.

Engineered, Dynamic Materials Improve Cardiomyocyte Differentiation

J. L. Young, A. J. Engler;

Univ. of California, San Diego, La Jolla, CA.

Laminin-Polycaprolactone Blend Nanofibers Promote Neurite Extension

R. A. Neal¹, N. Swami¹, R. C. Ogle², E. A. Botchwey¹;

¹Univ. of Virginia, Charlottesville, VA, ²LifeNet Hlth., Virginia Beach, VA.

Extracellular matrix molecules incorporated into bioinert hydrogels enhance matrix deposition and retention

S. J. Bryant¹, G. D. Nicodemus¹, J. J. Roberts¹, S. Guinta²;

¹Univ. of Colorado, Boulder, CO, ²Univ. of Rochester, Rochester, NY.

Biomaterial Technologies for Treating Non-union Bone Defects: Research Developments and Clinical Applications

Mechanically Competent Polyphosphazene Nano-structured Biomimetic Scaffolds: Accelerated Osteoblast Differentiation

M. Deng¹, S. G. Kumbar², L. S. Nair², A. L. Weikel³, H. R. Allcock³, C. T. Laurencin²;

¹Univ. of Virginia, Charlottesville, VA, ²Univ. of Connecticut, Farmington, CT, ³Pennsylvania State Univ., University Park, PA.

Effect of resorbable calcium-alkali-orthophosphate bone substitute cements on osteogenesis after implantation in the rabbit femur

C. Knabe¹, G. Berger², R. Gildenhaar³, A. Houshmand¹, C. Mueller-Mai⁴, A. Bednarek¹, C. Koch¹, D. Joern⁵, M. Stiller¹;

¹Charite Univ. Med. Ctr., Berlin, GERMANY, ²Federal Inst. for Materials Res. and Testing, Berlin, Berlin, GERMANY, ³Federal Inst. for Materials Res. and Testing, Berlin, GERMANY, ⁴Univ. of Bochum, Berlin, GERMANY, ⁵Federal Inst. for Materials Res. and Testing, Berli, Berlin, GERMANY.

The Essential Role of Sphingosine 1-Phosphate/S1P(3) Receptor in Enhanced Neovascularization and Mechanical Integrity of Massive Allografts: Pharmacological Manipulation to Improve Graft Incorporation

C. S. Huang, C. E. Petrie Aronin, S. J. Shin, Q. Cui, S. Jones-Quaidoo, E. A. Botchwey;

Univ. of Virginia, Charlottesville, VA.

Bone regeneration using collagen scaffolds loaded with different types of donor cells

M. Wei¹, X. Yu¹, L. Wang², F. Peng¹, X. Jiang², J. Huang², Z. Xia¹, D. Rowe²;

¹Univ. of Connecticut, Storrs, CT, ²Univ. of Connecticut Hlth.Ctr., Farmington, CT.

Local Lovastatin Injection Enhances Bone Regeneration Using Biodegradable Polyurethane Scaffolds

A. E. Hafeman, T. Yoshii, J. S. Nyman, J. M. Esparza, G. R. Mundy, G. E. Gutierrez, S. A. Guelcher;

Vanderbilt Univ., Nashville, TN.

Hydrogel microspheres increase cell survival and increase new bone volume in a gene therapy bone formation model.

R. M. R. Olabisi¹, Z. Lazard², M. Hall³, E. Sevick³, A. R. Davis², E. A. Davis², J. L. West¹;

¹Rice Univ., Houston, TX, ²Baylor Coll. of Med., Houston, TX, ³The Univ. of Texas Hlth.Sci. Ctr., Houston, TX.

Unidirectional bioactive glass (13-93) scaffolds with controllable pore size for repair of load-bearing bones

X. Liu, M. N. Rahaman, Q. Fu;

Missouri Univ. of Sci. and Technology, Rolla, MO.

Injectable Allograft Bone/Polymer Composite Bone Void Filler with Recombinant Human Bone Morphogenetic Protein

J. Dumas¹, K. Zienkiewicz¹, P. Baer², S. Guelcher¹;

¹Vanderbilt Univ., Nashville, TN, ²US Army Inst. of Surgical Res., San Antonio, TN.

Natural-based Polymeric Biomaterials and Composites

Keratose Biomaterial as a Carrier Matrix of BMP2 and Stem Cells for Bone Regeneration

R. C. de Guzman¹, T. Teli¹, S. L. Ray¹, M. D. Ellenburg¹, J. M. Saul¹, T. L. Smith², M. E. Van Dyke¹;

¹Wake Forest Inst. for Regenerative Med., Winston-Salem, NC, ²Dept. of Orthopaedic Surgery, Wake Forest Univ. Hlth.Sci., Winston-Salem, NC.

A novel polysaccharide for biomedical applications: a bottom up approach to establish ulvan as a biomaterial

A. Alves, R. A. Sousa, R. L. Reis;

3 B's Res. Group, Dept. of Polymer Engineering, Univ. of Minho, Caldas das Taipas, Guimarães, PORTUGAL.

New chitosan/Bioglass® composite membranes for guided tissue regeneration

J. F. Mano;

Univ. of Minho, Guimarães, PORTUGAL.

Keratin biomaterials promote sustained release and bioactivity of therapeutic agents

J. M. Saul, M. D. Ellenburg, R. C. de Guzman, M. E. Van Dyke;

Wake Forest Univ. Hlth.Sci., Winston-Salem, NC.

Ionic Strength Controls Fibrin Gel Mechanical Properties for Enhanced Osteogenesis

H. E. Davis, S. L. Miller, J. K. Leach;

Univ. of California, Davis, Davis, CA.

Composite Hydrogel-Hydroxyapatite Scaffold for Regeneration of Cartilage-Bone Interface

N. T. Khanarian, R. Burga, N. Haney, V. C. Mow, H. H. Lu;

Columbia Univ., New York, NY.

Injectable Chitosan-Collagen Composite Hydrogels for Tissue Engineering Applications

L. Wang, J. P. Stegemann;

Univ. of Michigan, Ann Arbor, MI.

Addition of Chitosan to Novel Mechanically Adjustable Thermoresponsive Hydrogel Blends to Enhance Neural Adhesion and Neurite Extension

J. Zuidema, E. Minner, R. J. Gilbert;

Michigan Technological Univ., Houghton, MI.

Stem Cell-Biomaterial Interactions (Symposia)

Stem Cell and Polymeric Materials Interactions: Cell Delivery and Cell Homing

J. Mao;

Columbia Univ., New York, NY.

The Evaluation of Neural Differentiation of Human Neural Stem/Progenitor Cells on Piezoelectric Scaffolds

Y-S. Lee, G. Collins, T. Livingston Arinzeh;

New Jersey Inst. of Technology, Newark, NJ.

Mechanical Stimulation Induced Fibroblastic Differentiation of hMSCs on Nanofiber Scaffolds

S. D. Subramony, B. R. Dargis, M. Castillo, E. Azeloglu, M. S. Tracey, H. H. Lu;

Columbia Univ., New York, NY.

Tissue-Specific Extracellular Matrix Derived Coatings Promote Differentiation of Muscle Progenitor and Human Stem Cell Derived Cardiomyocytes In Vitro

J. A. DeQuach, V. Mezzano, A. Miglani, S. Lange, G. M. Keller, F. Sheikh, K. L. Christman;

Univ. of California, San Diego, La Jolla, CA.

Elastin-Based Biomaterials for Embryonic Stem Cell-Derived Cardiomyocyte Applications

D. Sengupta, S. Heilshorn, E. Chiao, B. Leonard;

Stanford Univ., Stanford, CA.

A Novel, Calcium Phosphate Electrospun Composite Promotes the Osteogenic Differentiation of Stem Cells

A. Patlolla, T. Arinzeh;

New Jersey Inst. of Technology, Newark, NJ.

Scaffold-Directed Stem Cell Behavior: The Effect of Polymer Ceramic Composites on Bone Repair

Y. Khan¹, E. K. Cushnie², C. T. Laurencin¹;

¹Univ. of Connecticut Hlth.Ctr., Farmington, CT, ²Univ. of Virginia, Charlottesville, VA.

The Effect of Crosslinking Density and Pore Geometry of Poly(propylene fumarate)/Diethyl Fumarate Composite Scaffolds on Osteogenic Signal Expression of Rat Bone Marrow Stromal Cells

K. Kim¹, A. Lu¹, R. Breithaupt¹, D. Dean², A. G. Mikos³, J. P. Fisher¹;

¹Univ. of Maryland, Coll. Park, College Park, MD, ²Case Western Reserve Univ., Cleveland, OH, ³Rice Univeristy, Houston, TX.

Surface Modification and the Biological Response I (Symposia)

A new coating for medical implants: Polyzene^®-F

M. Grunze;

Univ.t Heidelberg, Heidelberg, GERMANY.

Analysis of macrophage activation on polymerized lipid bilayers

J. M. Page¹, B. A. Heitz², J. J. Joubert², S. S. Saavedra², W. He¹;

¹Univ. of Tennessee, Knoxville, TN, ²Univ. of Arizona, Tuscon, AZ.

Cell Surface Engineering for Control of Cell Adhesion

D. P. Cross, S-Y. Choh, C. Wang;

Univ. of Minnesota, Minneapolis, MN.

Osteoblast Responses on Nanocrystalline Diamond Modified by Hydrogen, Oxygen and Ammonium Plasmas

L. Yang, B. W. Sheldon, T. J. Webster;

Brown Univ., Providence, RI.

Inhibition of Noggin Increases Osteoblast Maturation on Microstructured Titanium Surfaces

R. Olivares-Navarrete¹, S. Hyzy¹, G. Dunn¹, Q. Pan¹, M. Dard², C. Appert², B. D. Boyan¹, Z. Schwartz¹;

¹Georgia Inst. of Technology, Atlanta, GA, ²Inst. Straumann, Basel, SWITZERLAND.

Using Molecular Beacon Probes to Image β1 Integrin Expression in Live Osteoblast-Like Cells

C. Hermann, M. Myers, F. Lennon, R. Olivares-Navarette, W. Rhee, Z. Schwartz, G. Bao, B. D. Boyan;

Georgia Inst. of Technology, Atlanta, GA.

Chick Chorioallantoic Membrane Assay for Evaluation of Fibrous Encapsulation of Decorin-Coated Implants

M. L. Sylvester, B. D. Ratner;

Univ. of Washington, Seattle, WA.

Targeted Drug Delivery / Polymer Conjugates (Symposia)

EXPANSILE NANOPARTICLES: SYNTHESIS, CHARACTERIZATION, AND IN VIVO EFFICACY

M. Grinstaff;

Boston Univ., Boston, MA.

Site-Specific, Stoichiometric Protein-Polymer Conjugates by In situ Atom Transfer Radical Polymerization

W. Gao, A. Chilkoti;

Duke Univ., Durham, NC.

Advanced Nanoparticle Drug Delivery System Targeting Staphylococcus aureus within Osteoblasts

B. Jiang, Sr., H. Li, Sr., B. Li, Sr.;

Dept. of Orthopaedics, Sch. of Med., West Virginia Univ., Morgantown, WV.

Target Specific Intracellular Delivery of siRNA Using Hyaluronic Acid - Reducible PEI Conjugate

K. Park, M. Lee, S. Hahn;

POSTECH, Pohang, KOREA, REPUBLIC OF.

Sustained Delivery of GDNF for Improved Peripheral Nerve Regeneration in a Sciatic Nerve Injury

K. G. Marra, L. E. Kokai, A. M. Ghaznavi;

Univ. of Pittsburgh, Pittsburgh, PA.

Low Molecular Weight Hyaluronic Acid-Methotrexate Conjugates for Targeted Drug Delivery in the Treatment of Rheumatoid Arthritis

N. Zhang, K. L. Wagoner, R. A. Bader;

Syracuse Univ., Syracuse, NY.

Identification of Fibrin-Specific Binding Motifs for Development of Fibrin-Targeted Therapeutics

S. E. Stabenfeldt, W. E. Brown, T. H. Barker;

Georgia Inst. of Technology, Atlanta, GA.