Con-current Oral Abstract Presentations Session I

Biomimesis in Drug Delivery I: Scaffolds & Implants (General Session)

Biomimetic Nano-fibrous Scaffold for Multiple Factor Delivery

P. X. Ma, G. Wei; University of Michigan, Ann Arbor, MI.

The effect of soluble peptide sequences on neurite extension in three-dimensional collagen gels

M. J. Blewitt, R. K. Willits; Saint Louis University, St. Louis, MO.
Student Award for Outstanding Research - Undergraduate

Rationally Identified Affinity Peptides for Local Delivery of Nerve Growth Factor

P. J. Johnson, S. M. Willerth, D. J. Maxwell, S. Parsons, S. E. Sakiyama-Elbert; Washington University in St. Louis, St. Louis, MO.

Creating a glial scar-free implant-CNS interface by blocking chondroitin sulfate proteoglycan biosynthesis

N. Zhang, X. Wen; Clemson University, Charleston, SC.

A Multifaceted Approach to Post Operative Adhesion Prevention

J. T. Corbett¹, W. S. W. Shalaby², J. M. Lindsey, III¹, M. Shalaby², S. W. Shalaby¹; ¹Poly-Med, Inc., Anderson, SC, ²Lehigh Valley Hospital, Allentown, PA.

Fibronectin Conjugated TGF-Beta 1 via a PEG Linker: Bioactivity of the Surface-Bound Conjugate

C. T. Drinnan¹, J. M. Hart², L. J. Suggs¹; ¹University of Texas at Austin, Austin, TX, ²Boston Scientific, Plymouth, MN.

Cell Response to Micro/nanopatterned Biomaterials I (General Session)

Nanoscale Poly(L-Lactic Acid) Surface Texture Influences Fibroblast Response

K. R. Milner, C. A. Siedlecki; Pennsylvania State University, Milton S Hershey Medical Center, Hershey, PA.

Endothelial tubulogenesis on surface-patterned PEG hydrogels

J. J. Moon¹, B. A. Nsiah², M. S. Hahn³, J. L. West¹; ¹Rice University, Houston, TX, ²Iowa State, Ames, IA, ³Texas A&M, College Station, TX.

Extracellular Matrix Proteins Regulate Heart Valve Calcification

K. M. Reed, K. J. Rodriguez, K. S. Masters; University of Wisconsin, Madison, WI.

Fibronectin Behaviour and Cellular Response to Nanostructured Surfaces

M. S. Lord¹, B. G. Cousins², P. J. Doherty², J. M. Whitelock¹, A. Simmons¹, R. L. Williams², B. K. Milthorpe¹; ¹The University of New South Wales, Sydney, AUSTRALIA, ²The University of Liverpool, Liverpool, UNITED KINGDOM.

A Comparative Analysis of Neurite Development in PC12 Cells Cultured on Nanopillars and Nanopores

G. Zhang, F. Haq; University of Georgia, Athens, GA.

Platelet adhesion and activation on nanotextured polyurethane

K. R. Milner, H. Yamanaka, K. A. V. Zubris, S. Z. Jones, A. J. Snyder, C. A. Siedlecki; Pennsylvania State University, Milton S Hershey Medical Center, Hershey, PA.

Stem Cells: Source, Culture and Application Symposium I

Developing Human Embryonic Stem Cell for Use in Cell and Tissue Therapies

S. Stice; Univ of Georgia, Athens, GA.

Hepatodifferentiation Of Cadherin Expressing Embryonic Stem Cells Within A Microengineered Organotypic Model

R. Hughey¹, A. Dasgupta¹, N. Rajaei¹, M. Toner², L. Larue³, P. V. Moghe¹; ¹Rutgers University, Piscataway, NJ, ²Harvard Medical School, Massachusetts General Hospital, Boston, MA, ³Institut Curie, Orsay Cedex, FRANCE.

Synergistic Acceleration of Stem Cell Mediated Heart Valve Tissue Formation by Cyclic Flexure and Laminar Flow

G. C. Engelmayr, Jr.¹, V. L. Sales², J. E. Mayer, Jr.², M. S. Sacks¹; ¹University of Pittsburgh, Pittsburgh, PA, ²Children's Hospital Boston, Harvard Medical School, Boston, MA.

Surface-Aminated Electrospun Poly(ethersulfone) Fibers Enhances Ex Vivo Expansion of Human Umbilical Cord Blood Hematopoietic Progenitor (CD34+) Cells

K. N. Chua¹, C. Chai², X. S. Jiang², K. W. Leong³, S. Ramakrishna¹, H. Q. Mao³; ¹National University of Singapore, Singapore, SINGAPORE, ²Division of Johns Hopkins in Singapore Limited, Singapore, SINGAPORE, ³Johns Hopkins University, Baltimore, MD.

Engineering the Homogeneity of Embryonic Stem Cell Microenvironments to Direct Cellular Differentiation

R. L. Carpenedo, C. Y. Sargent, J. Kent, T. C. McDevitt; Georgia Institute of Technology / Emory University, Atlanta, GA.

Urological Tissue Engineering and Biomaterials (General Session)

Head-To-Head Comparison of Histologic and Functional Properties of Rat Bladders Augmented With Blood Vessel Matrix Versus Small Intestine Submucosa

G. E. Amiel, R. N. Yu, T. Shu, T. Shu, H. Lai, A. Gilbert, D. Kakiashvili, N. A. Salas, W. Jian, G. T. Somogyi, S. P. Lerner; Baylor College of Medicine, Houston, TX.

Fascial Tissue Reconstruction Using Acellular Collagen Matrix

D. Eberli, J. Yoo, A. Atala; Wake Forest University School of Medicine, Winston Salem, NC.

The Effects Of DNA Extracts From Urological Tissue Matrices

P. Vandevord, A. Singla, B. Krishnamurthy; Wayne state university, Detroit, MI.

Development of a Decellularised Bladder Matrix for Functional Tissue Engineering

F. Bolland¹, S. Korossis², E. Ingham², J. Fisher², J. Kearney³, J. Southgate¹; ¹University of York, York, UNITED KINGDOM, ²Leeds University, Leeds, UNITED KINGDOM, ³National Blood Service, Liverpool, UNITED KINGDOM.

Macrophage and Encapsulation Effects to Glucose Recovery through Implanted Microdialysis Probes

X. Mou¹, M. Lennartz², D. Loegering², J. A. Stenken¹; ¹Rensselaer Polytechnic Institute, Troy, NY, ²Albany Medical College, Albany, NY.

Development of a Collagenase-Sensitive, Flexible Scaffold for Engineering of Urological and Other Soft Tissues

J. Guan, J. Huard, W. Wagner; Univeristy of Pittsburgh, Pittsburgh, PA.

Con-current Oral Abstract Presentations Session II

Biodegradable Hydrogels for Tissue Engineering I (General Session)

Interpenetrating Networks Containing Gelatin Modified with PEGylated RGD and Soluble KGF: Synthesis, Characterization, Application in in vivo Critical Dermal Wound

H. Waldeck, A. S. Gustafson, M. Toth, K. Williams, W. J. Kao; University of Wisconsin - Madison, Madison, WI.

Novel Macromers for the Fabrication of Injectable, Calcium-Binding Hydrogels

M. C. Hacker, B. B. Ma, J. D. Kretlow, A. G. Mikos; Rice University, Houston, TX.

In-situ Crosslinked Scaffolds of Elastin-like Polypeptide Block Copolymer for Tissue Repair

D. Lim, D. L. Nettles, L. A. Setton, A. Chilkoti; Duke University, Durham, NC.

Characterization of DNA Release from Composites of Oligo(poly(ethylene glycol) fumarate) and Cationized Gelatin Microspheres In Vitro

H. Yang¹, E. Jerkins¹, K. Tanahashi¹, M. A. Barry², Y. Tabata³, A. G. Mikos¹; ¹Rice University, Houston, TX, ²Baylor College of Medicine, Houston, TX, ³Kyoto University, Kyoto, JAPAN.

Photopolymerizable Elastomers for Tissue Engineering Application Based on Poly(ethylene glycol) and Diacid Monomers

J. Kim, L. Lu, B. L. Currier, M. J. Yaszemski; Mayo Clinic, Rochester, MN.

Biodegradable Hydrogels based on PEGylated Proteins for Tissue Engineering Applications

D. Seliktar, M. Gonen-Wadmany, D. Dikovsky, K. Shapira, O. Sarig-Nadir; Technion, Haifa, ISRAEL.

Tunable Hydrogel System for the Development of Tissue Engineered Vascular Grafts

M. K. McHale, M. S. Hahn, J. Whittier, J. L. West; Rice University, Houston, TX.

A Novel Whole Organ Bioscaffold with an Intact Vascular Network for Tissue Engineering and Regenerative Medicine Applications

P. Baptista, M. Saddiqui, A. Atala, S. Soker; Wake Forest University School of Medicine, Winston Salem, NC.

Bionanotechnology: the Future of Biomaterials Symposium I

Towards Multifunctional Nanoparticle-Based Therapeutics

S. N. Bhatia; MIT, Cambridge, MA.

Photothermal Cancer Therapy Using Immunotargeted Nanoshells

A. R. Lowery, A. M. Gobin, E. S. Day, K. Y. Shah, N. J. Halas, J. L. West; Rice University, Houston, TX.

Nano-imprint Lithography for the Fabrication of Injectable Stimuli-Responsive Drug Delivery Devices

L. C. Glangchai, L. Shi, K. Roy; University of Texas at Austin, Austin, TX.

Tuning the Bioactive and Mechanical Properties of Self-assembled Nanofiber Networks for Synthetic ECM Mimics

H-W. Jun, V. Yuwono, S. Paramonov, H. Dong, J. Hartgerink; Rice University, Houston, TX.

Nanophase Hydroxyapatite Coated Metals for Orthopedic Applications: An in vitro and in vivo Study

T. J. Webster; Purdue University, West Lafayette, IN.

Nanoscale Dendritic Clusters of RGD Peptides

H. Yang¹, W. Kao²; ¹Virginia Commonwealth University, Richmond, VA, ²University of Wisconsin-Madison, Madison, WI.

Fabrication of Polymeric Replicas of Cell Surfaces with Nanoscale Resolution

J. M. Bruder, N. C. Monu, D. Hoffman-Kim; Brown University, Providence, RI.

New Concepts and Challenges for the Delivery of Therapeutic Nucleic Acids Symposium

Response of Human Embryonic and Adult Mesenchymal Stem Cells to Nanotopography

K. Leong, Duke University, Durham, NC

Surface-functionalized Polymer Microparticles for Combinatorial Delivery of Nucleic Acid Vaccines against Cancer

S. Pai Kasturi¹, K. Thomson¹, H. Qin², L. V. Kwak², K. Roy¹; ¹University of Texas at Austin, Austin, TX, ²University of Texas M. D. Anderson Cancer Center, Houston, TX.

The Use of pH-sensitive Poly(propylacrylic acid) Polymers to Enhance the Delivery of Antigens for Therapeutic Vaccination

S. Flanary, J. R. Kirkham, P. S. Stayton, A. S. Hoffman; University of Washington, Seattle, WA.

High Throughput Fabrication of Double Emulsion-Based Microparticles

S. R. Little; University of Pittsburgh, Pittsburgh, PA.

PEG-b-PPA/DNA Micelles for Liver-Targeted Gene Delivery

X. Jiang, H. Dai, K. Leong, H-Q. Mao; Johns Hopkins University, Baltimore, MD.

Development and Evaluation of “Smart” Polymer-Nucleic Acid Complexes

M. E. H. El-Sayed, E. M. Bulger, A. S. Hoffman, P. S. Stayton; University of Washington, Seattle, WA.

Delivery of Cyclodextrin-based Polyplexes from Solid Surfaces

I-K. Park, H. A. von Recum, S. Jiang, S. H. Pun; University of Washington, Seattle, WA.

Organic/Inorganic Hybrid Biomaterials Symposium I

Characterization of chitosan / nanocrystalline hydroxyapatite composite scaffolds for bone tissue engineering

B. M. Chesnutt¹, Y. Yuan¹, S. Oh², Y. Yang², A. M. Viano³, J. L. Ong², W. O. Haggard¹, J. D. Bumgardner¹; ¹University of Memphis, Memphis, TN, ²University of TN-Memphis, Memphis, TN, ³Rhodes College, Memphis, TN.

PLAGA/Nanocrystal Hydroxyapatite Composite Scaffolds for Bioreactor Based Bone Tissue Engineering

Q. Lv, C. T. Laurencin; University of Virginia, Charlottesville, VA.

Uniform Three-Dimensional Biomineralization of Protein Incorportated Mineral Layer on Porous Polymer Scaffolds

S. Segvich; University of Michigan, Ann Arbor, MI.

Biocompatibility of PCL-HA Hybrid with Bone Marrow Derived Osteogenetic and Vasculogenetic Cells

H. Yu, P. H. Wooley, S-Y. Yang; Wayne State University, Detroit, MI.

Angiogenic and Osteoinductive Hydrogels for Bone Regeneration

J. Patterson, R. Siew, S. W. Herring, P. S. Stayton; University of Washington, Seattle, WA.

Polycaprolactone Tissue Scaffolds Based on Computed Tomography for Temporo-Mandibular Joint Reconstruction

S. Das, S. J. Hollister, H. Chung, C. M. Flanagan, M. H. Smith, S. E. Feinberg; University of Michigan, Ann Arbor, MI.

Bio-hybrid Composite Scaffolds for Bone Tissue Regeneration

S. Lee, J-W. Lee, G. Lim, A. Atala, J. Yoo; Wake Forest University School of Medicine, Winston Salem, NC.

Synthesis and Characterization of a Biomimetic Calcium-Deficient Hydroxyapatite - Hydrogel Composite

S. A. Hutchens¹, R. S. Benson¹, B. R. Evans², H. M. O'Neill², C. J. Rawn²; ¹University of Tennessee, Knoxville, TN, ²Oak Ridge National Laboratory, Oak Ridge, TN.

Surface Modification and Characterization of Biomaterials I (General Session)

Surface Modification of Porous Scaffolds with Cell Adhesive Peptides for Tissue Engineering Applications

P. Blit, Y-H. A. Shen, M. J. Ernsting, J. P. Santerre; University of Toronto, Toronto, ON, CANADA.

Surface Engineering of Chronic Neural Implants for Enhanced Neuro-integration

W. He, R. V. Bellamkonda; Georgia Institute of Technology, Atlanta, GA.

Protein resistant silicones by graft polymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) via surface-initiated atom transfer radical polymerization (ATRP)

J. Guo, W. Feng, J. L. Brash, S. Zhu, H. D. Sheardown; McMaster University, Hamilton, ON, CANADA.

Controlling and Probing Protein Orientation / Conformation for Biomaterial Applications

M. Bernards; University of Washington, Seattle, WA.

Bioactive Surface Gradients to Control Cell Adhesion

N. D. Gallant, M. L. Becker, E. J. Amis; NIST, Gaithersburg, MD.

Sweet Surfaces: Carbohydrate Microarrays and Tools for Glycomics.

D. M. Ratner; Boston Medical Center, Boston, MA.

Superlow Fouling Poly(Sulfobetaine) Surfaces

Y. Chang, Z. Zhang, S. Chen, S. Jiang; University of Washington, Seattle, WA.

Characterization of Surface Microphase Structure of Poly(urethane urea) Biomaterials by Nanoscale Indentation with AFM

L-C. XU¹, P. Soman¹, A. Agnihotri¹, J. Runt², C. A. Siedlecki¹; ¹Pennsylvania State University College of Medicine, Hershey, PA, ²Pennsylvania State University Dept of Materials Science and Engineering, State College, PA.

Con-current Oral Abstract Presentations Session III

Bionanotechnology: The Future of Biomaterials Symposium II

Integration of OCT Imaging and Photothermal Cancer Therapy Using Near Infrared Absorbing Gold Nanoshells

A. M. Gobin, M-H. Lee, R. Drezek, N. Halas, J. West; Rice University, Houston, TX.

Modulation of Intracellular Ceramide using Polymeric Nanoparticles to Overcome Multidrug Resistance in Tumor Cells

L. E. van Vlerken¹, D. Shenoy¹, Z. Duan², M. V. Seiden², S. Mehta³, M. M. Amiji¹; ¹Northeastern University, Boston, MA, ²Massachusetts General Hospital, Boston, MA, ³Roger Williams Medical Center, Providence, RI.

Design and Characterization of a Polyethylene Glycol - Peptide Conjugate for In vitro Gene Delivery

N. M. Moore, T. R. Barbour, S. E. Sakiyama-Elbert; Washington University St. Louis, St. Louis, MO.

Nitric Oxide-Releasing Dendrimers for Targeted NO Therapy

L. J. Taite, J. L. West; Rice University, Houston, TX.

Polyketal Nanoparticles: A pH-Sensitive Biodegradable Drug Delivery Vehicle

M. J. Heffernan¹, R. H. Pierce², N. Murthy¹; ¹Georgia Institute of Technology, Atlanta, GA, ²University of Rochester, Rochester, NY.

Nanostructural control of the release of opioids prevents their abuse

M. Ni; University of Pennsylvania, Philadelphia, PA.

Temperature-sensitive Hydrogels with SiO2-Au Nanoshells for Controlled Protein Delivery

M. Bikram, A. M. Gobin, R. E. Whitmire, S. R. Sershen, J. L. West; Rice University, Houston, TX.

Gd@(Carbon Nanostructures) as Nanoprobes for Cellular Magnetic Resonance Imaging

B. Sitharaman¹, L. A. Tran¹, R. D. Bolskar², S. D. Flamm³, R. Muthupillai⁴, A. G. Mikos¹, L. J. Wilson¹; ¹Rice University, Houston, TX, ²TDA Research Inc, Wheatridge, CO, ³Baylor College of Medicine, Houston, TX, ⁴Philips Medical System, Cleveland, OH.

Fibrin Sealant and its Application in Tissue Engineering (General Session)

Bone Tissue Engineering Using Collagen Gel, Fibrin Sealant, and Stem Cells Derived From Postnatal Skeletal Muscle

A. Usas, A. Ho, G. M. Cooper, A. Olshanski, H. Peng, J. Huard; University of Pittsburgh, Pittsburgh, PA.

Incorporation of fibronectin domains into fibrin matrices for stem cell delivery

M. Martino; EPFL, Lausanne, SWITZERLAND.

Fabrication and Characterization of Sphere-templated Fibrin Scaffolding

M. P. Linnes, B. D. Ratner, C. M. Giachelli; University of Washington, Seattle, WA.

Scaffold Composition, Rather Than Delivered Growth Factor, Dramatically Altered The Chick Chorioallantoic Membrane Blood Vessel Response to Fibrin-based Constructs

J. D. Smith, M. E. Melhem, G. W. Fisher, A. S. Waggoner, P. G. Campbell; Carnegie Mellon University, Pittsburgh, PA.

Extracellular Matrix Engineering: Presentation of therapeutic motifs on fibrin matrices through molecular modification of fibrinogen

T. H. Barker¹, M. Martino¹, L. Yang¹, S. T. Lord², P. Frey¹, J. A. Hubbell¹; ¹Swiss Federal Institute of Technology - Lausanne, Lausanne, SWITZERLAND, ²University of North Carolina at Chapel Hill, Chapel Hill, NC.

The Use of Platelet Rich Plasma in Total Knee Arthroplasty: A Controlled Clinical Evaluation

W. S. Pietrzak¹, W. J. Berghoff², R. D. Rhodes³; ¹Biomet, Warsaw, IN, ²Orthopaedics Northeast, Fort Wayne, IN, ³Fort Wayne Medical Education Program, Fort Wayne, IN.

Rate-Dependent Mechanical Properties of Fibrin Biomaterial Scaffolds

E. G. Freeman¹, B. Tawil², M. C. Shaw¹; ¹California Lutheran University, Thousand Oaks, CA, ²Baxter Healthcare, Thousand Oaks, CA.

Hemostatic Potential of Platelet-Rich and Platelet-Poor Plasma Utilizing a Partial Thickness Skin Wound Model

W. S. Pietrzak¹, Y. H. An², Q. K. Kang², K. L. Ehrens², H. A. Demos²; ¹Biomet, Warsaw, IN, ²Medical University of South Carolina, Charleston, SC.

Ophthalmic Drug Delivery (General Session)

Effect of Zwitterion Concentration on the Biocompatibility of Perfluoropolyether Implants

T. C. Hughes¹, G. Y. N. Chan¹, M. D. M. Evans², G. Johnson², W. S. Knower¹, G. McFarland², K. M. McLean¹, X. Nguyen¹, D. F. Sweeney³, J. Wilkie¹, R. Xie³; ¹CSIRO, Clayton, AUSTRALIA, ²CSIRO, North Ryde, AUSTRALIA, ³Vision CRC, Kensington, AUSTRALIA.

In situ curable accommodating implant

T. C. Hughes¹, D. Denham², L. Donovan³, V. Fernandez², J. L. Jeffery¹, F. Manns², B. Mannor³, X. T. T. Nguyen¹, J-M. Parel², J. Watling¹, J. S. Wilkie¹, A. Ho³; ¹CSIRO, Victoria, AUSTRALIA, ²University of Miami, Miami, FL, ³Vision CRC, Sydney, AUSTRALIA.

Hydrogel nanoparticles for targeting retinal tissue

L. Tang, L. Zou; University of Texas at Arlington, Arlington, TX.

A BIOMIMETIC APPROACH OF RECOGNITIVE CONTACT LENSES FOR TAILORED LOADING AND RELEASE OF ANTIHISTAMINES TO TREAT ALLERGIC RHINOCONJUNCTIVITIS

S. Venkatesh, S. P. Sizemore, J. Zhang, M. E. Byrne; Auburn University, Auburn, AL.

A Programmable Device for Long-Term Transscleral Drug Delivery

M. J. Mescher¹, C. E. Dube¹, J. O. Fiering¹, D. L. Fyler¹, E. S. Kim¹, M. Hansberry¹, J. T. Borenstein¹, J. J. Bernstein¹, E. Gragoudas², J. Miller²; ¹Draper Laboratory, Cambridge, MA, ²Massachusetts Eye and Ear Infirmary, Boston, MA.

Nanomechanical and Nanotribological Properties of Contact Lenses - Effect of Hydration and Temperature

M. E. Dickinson; Hysitron Inc., Minneapolis, MN.

Surface Modification and Characterization of Biomaterials II (General Session)

Poly(ethylene glycol)-crosslinked microgel coatings reduce macrophage adhesion to biomaterials

A. A. Walls, N. Singh, B. Blackburn, L. A. Lyon, A. J. García; Georgia Institute of Technology, Atlanta, GA.

Strong Resistance of Phosphorylcholine and Oligo(phosphorylcholine) Self-Assembled Monolayers to Protein Adsorption: Insights into Nonfouling Properties of Zwitterionic Materials

S. Chen; University of Washington, Seattle, WA.

Protein Resistance of Polyurethane Film Grafted with Poly(oligo(ethylene glycol) methacrylate) via Atom Transfer Radical Polymerization

W. Feng, S. Zhu, H. Sheardown, J. L. Brash; McMaster University, Hamilton, ON, CANADA.

Biomimetic silicone elastomer surfaces via dextran immobilization

J. Guo, M. Marshall, M. A. Brook, H. D. Sheardown; McMaster University, Hamilton, ON, CANADA.

3-D Visualization of Paclitaxel in Polymer Films by Coherent Anti-Stokes Raman Scattering Microscopy

E. Kang, I. Kwon, H. Wang, J-X. Cheng, K. Park; Purdue University, West Lafayette, IN.

Oxidative and In-Vitro Stability of Alkanethiol Self Assembled Monolayers (SAMs) on 316L Stainless Steel

A. Mahapatro¹, D. M. Johnson¹, D. N. Patel², M. D. Feldman², A. A. Ayon¹, C. M. Agrawal¹; ¹University of Texas at San Antonio, San Antonio, TX, ²University of Texas Health Science Center at San Antonio, San Antonio, TX.

Surface Modification of a Perfluorinated Ionomer Using a Glow Discharge Deposition Method to Control Protein Adsorption and Fibroblast Inflammatory Response

T. I. Valdes¹, W. Ciridon², B. D. Ratner², J. D. Bryers²; ¹University of Connecticut Health Center, Farmington, CT, ²University of Washington, Seattle, WA.

Covalent Grafting of Fibronectin on Plasma-Treated PTFE: Influence of the Conjugation Strategy on Fibronectin Biological Activity

K. Vallières, É. Petitclerc, G. Laroche; Laval University, CHUQ, Québec, PQ, CANADA.

Synthetic Orthopaedic Materials

Titanium Electrochemistry in the Presence of the Inflammatory Species H2O2

N. Chandrasekaran, Z. Bai, J. L. Gilbert; Syracuse University, Syracuse, NY.

Studies on the Formation of Biomimetic Apatite Layers on 3D-Printed Biodegradable Polymeric Scaffolds: Effect of Different Dynamic Coating Routes

A. L. Oliveira, S. A. Costa, R. A. Sousa, R. L. Reis; University of Minho, Braga, PORTUGAL.

Significant Reduction of the Mechanical Strength of the Plasma Sprayed HA Coatings Soaked in Bovine Serum

W. Tong, P. Li; DePuy Orthopaedics, Warsaw, IN.

100

Comparisons Between Regenerated Synovial Fluid and Bovine Calf Serum Under 1H Nuclear Magnetic Resonance (NMR) Spectroscopy

J. WEBB¹, J. G. BOWSHER², M. M. GROOTVELD³, J. C. SHELTON¹; ¹UNIVERSITY OF LONDON, LONDON, UNITED KINGDOM, ²LOMA LINDA UNIVERSITY, LOMA LINDA, CA, ³SOUTH BANK UNIVERSITY, LONDON, UNITED KINGDOM.

101

Sequentially Enhanced Polyethylene In 10 Million Cycle And Knee Simulation Study

R. Tsukamoto¹, I. C. Clarke¹, H. Shoji¹, M. Ogino², K. Yamada³, G. Pezzotti³; ¹Loma Linda University, Loma Linda, CA, ²Tsukamoto Orthopaedic Hospital, Tokyo, JAPAN, ³Kyoto Institute of Technology, Kyoto, JAPAN.

102

Static fracture J-R resistance of ultra high molecular weight polyethylene using a single specimen normalization method

R. Varadarajan, E. K. Dapp, C. M. Rimnac; Case Western Reserve University, Cleveland, OH.

103

Triggering the Phase Transformation of Zirconia Balls In Vivo and In Vitro

S. S. Brown¹, D. D. Green¹, G. Pezzotti², I. C. Clarke¹; ¹Orthopaedic Research Center, Loma Linda, CA, ²Kyoto Institute of Technology, Kyoto, JAPAN.

104

There is a linear relationship among disc height, intradiscal pressure anD implant volume for nucleus pulposus augmentation

M. Cannella¹, A. Orana¹, A. Arthur², M. Marcolongo¹; ¹Drexel university, Philadelphia, PA, ²Synthes Spine, West Chester, PA.

Con-current Oral Abstract Presentations Session IV

Innovative Techniques in Biomaterials Education (General Session)

105

OUT ON A LIMB: TEACHING BIOMATERIALS TO NON-BIO-ENGINEERS Biomaterials as a Design Course in a Traditional Mechanical Engineering Department

T. Topoleski; UMBC, Baltimore, MD.

106

Academic job search: Perspectives from a recent applicant

A. Khademhosseini, Harvard-MIT, Cambridge, MA

107 A Multidisciplinary Biomedical Product Development Course Incorporating Entrepreneurial Thinking

Lisa Friis, University of Kansas, Mechanical Engineering, Lawrence, KS

Stem Cells: Source, Culture and Application Symposium II

111

A Digital Micro-Mirror Device (DMD)-based Stereolithography System for the Microfabrication of Complex, Spatially-Patterned Tissue Engineering Scaffolds

G. Mapili, Y. Lu, G. Suhali, S. Chen, K. Roy; The University of Texas at Austin, Austin, TX.
Student Award for Outstanding Research - PhD Candidate

112

Heparinized Collagen Loaded with Stromal-Derived Factor 1alpha Increases Hematopoietic Stem Cell Adherence

B. Siebum; University of Twente, Enschede, THE NETHERLANDS.

113

Matrix Elasticity is sensed with Non-Muscle Myosin II and Directs Stem Cell Lineage Specification

A. J. Engler, S. Sen, H. L. Sweeney, D. E. Discher; University of Pennsylvania, Philadelphia, PA.

114

Amplification of Osteogenic Cells from Human Embryonic Stem Cells

J. M. Karp, L. S. Ferreira, A. Khademhosseini, A. H. Kwon, J. Yeh, O. C. Farokhzad, R. Langer; MIT, Cambridge, MA.

115

Mimicking cell-cell interactions at the biomaterial-cell interface for control of stem cell differentiation

B. L. Beckstead, D. M. Santosa, C. M. Giachelli; University of Washington, Seattle, WA.

116

Thermally responsive chitosan as an injectable matrix for therapeutic delivery of mesenchymal stem cells

J. M. Dang, S. Chew, K. W. Leong; Johns Hopkins University, Baltimore, MD.

Cell Response to Micro/nanopatterned Biomaterials II (General Session)

117

Directing Cell Migration with Engineered Two-Dimensional Concentration Gradients of Fibroblast Growth Factor-2

E. D. Miller, G. W. Fisher, K. Li, L. E. Weiss, L. M. Walker, T. Kanade, P. G. Campbell; Carnegie Mellon University, Pittsburgh, PA.

118

Cell Function Inducible Micropattern Surface for Maintenance of Undifferentiated Embryonic Stem Cells

T. Konno, K. Ishihara; School of Engineering, The University of Tokyo, Tokyo, JAPAN.

119

Cell Survival Responses Regulated through Controlled Nanoscale Presentation of EGFR and Integrin Ligands

E. T. Dimalanta, M. L. Ufret, L. B. Richardson, III, N. A. Marcantonio, B. D. Cosgrove, I. Taniguchi, W. Kuhlman, A. M. Mayes, L. G. Griffith; Massachusetts Institute of Technology, Cambridge, MA.

120

Aligned Biodegradable Polymer Nano/Micro Filaments for Guided Neurite Extension

H. Shen, Y-t. Kim, S. Kumar, R. Bellamkonda; Georgia Institute of Technology, Atlanta, GA.

121

Biological Characterization of Molecularly Imprinted Polysiloxane Scaffolds

K. Lee, R. Itharaju, D. A. Puleo; Center for Biomedical Engineering, University of Kentucky, Lexington, KY.

122

The Dimension of nano-grooves modulates the adhesion of osteoblast-like cells, MG-63, on silicon surfaces

W-B. Tsai¹, J-Y. Yang², Y-C. Ting¹; ¹National Taiwan University, Taipei, TAIWAN REPUBLIC OF CHINA, ²National Nano Device laboratories, Hsinchu, TAIWAN REPUBLIC OF CHINA.

Biodegradable Hydrogels for Tissue Engineering II (General Session)

123

Rapid Peripheral Nerve Regeneration Using Self-Assembled Human Hair Keratin Scaffolds in a Mouse Model

P. Sierpinski, J. Garrett, J. Ma, J. Burnell, S. Lee, T. Smith, A. Atala, M. Van Dyke; Wake Forest University School of Medicine, Winston Salem, NC.

124

In vitro and In vivo Characterization of Human Articular and Rat Growth Plate Chondrocytes Microencapsulated in Alginate using High Electrostatic Potential Technology

R. C. Kinney, A. G. Bailey, Z. Schwartz, B. D. Boyan; Georgia Institute of Technology, Atlanta, GA.

125

Application of Colloidal Gas Aphron Foaming Techniques to Alginate: Creation of a Novel Tissue Scaffold

E. E. Johnson, N. Meznarich, B. Ratner; University of Washington, Seattle, WA.

126

Controlled Release of Bioactive Doxorubicin from Microspheres Embedded within Gelatin Scaffolds

A. J. DeFail, H. Edington, W-C. C. Lee, F. J. Cartieri, K. G. Marra; University of Pittsburgh, Pittsburgh, PA.

127

Controlling the Degradation Rate of PEGylated Fibrin Gels for Cell Delivery

S. F. Collins¹, G. Zhang², J. Zhang², L. J. Suggs¹; ¹University of Texas at Austin, Austin, TX, ²University of Minnesota, Minneapolis, MN.

128

Effect of Hydrogel Porosity on Marrow Stromal Cell Phenotypic Expression

M. Dadsetan, S. Rajagopalan, T. E. Hefferan, L. Lu, M. J. Yaszemski; Mayo Clinic, Rochester, MN.

Advances in Biomaterials Science: What's in the Future of Biomaterials…Addrerssing Biological Problems Again!

129

The Marriage of Biomaterials and Biological Science: A Required Alliance

J. W. Burns; Genzyme Corporation, Waltham, MA.

130

Design and Application of "Smart" Polymers for Separations, Diagnostics and Drug Delivery

A. S. Hoffman, P. S. Stayton; University of Washington, Seattle, WA.

131

Tissue Engineering in Orthopaedic Surgery: Understanding the Clinical Parameters

S. Goodman; Stanford University, Stanford, CA.

Con-current Oral Abstract Presentations Session V

Biomimesis in Drug Delivery II: Targeted & Micro/Nano-Scale Carriers (General Session)

135

Antisenseoligo nucleotide delivery using polymer vesicles

Y. Kim, M. Tewari, S. Sen, D. E. Discher; University of Pennsylvania, Philadelphia, PA.

136

Cross-Linked Micelles for Vaccine Delivery

M. J. Heffernan¹, J. Hao¹, M. Kwissa², B. Pulendran², N. Murthy¹; ¹Georgia Institute of Technology, Atlanta, GA, ²Emory University, Atlanta, GA.

137

Targeting Efficiency Optimization of RGD-Modified Liposomes to Activated Platelets

G. G. Huang, Sr.¹, A. Sen Gupta, Sr.¹, K. Kottke-Marchant², R. E. Marchant, Sr.¹; ¹Case Western Reserve University, Cleveland, OH, ²Cleveland Clinic Foundation, Cleveland, OH.

138

Development and Characterization of Novel Targeted Lipid-Polymer Microcapsules

W. J. Duncanson¹, K. Oum², M. A. Wheatley², J. Y. Wong¹; ¹Boston University, Boston, MA, ²Drexel University, Philadelphia, PA.

139

Development of a Multi-functional Red Blood Cell Analog

T. T. Thula, R. Tran-Son-Tay, C. Batich; University of Florida, Gainesville, FL.

140

Synthetic Filamentous Phages for Anti-Cancer Drug Delivery

Y. Geng; University of Pennsylvania, Philadelphia, PA.

141

Modulation of Tumor Cytotoxicity and Targeting Selectivity of Nanocarriers via a Dual Ligand Targeting Approach

J. M. Saul¹, A. V. Annapragada², R. V. Bellamkonda¹; ¹Georgia Institute of Technology/Emory University, Atlanta, GA, ²University of Texas Medical Center, Houston, TX.

142

Absorbable Gel-forming Controlled Release Paclitaxel Formulation for Retarding Tumor Cell Growth

W. S. W. Shalaby¹, P. L. Tate², J. M. Lindsey, III², S. W. Shalaby²; ¹Lehigh Valley Hospital, Allentown, PA, ²Poly-Med, Inc., Anderson, SC.

Bionanotechnology: the Future of Biomaterials Symposium III

143

Fabrication of Dual-Functional Electrospun Nanofiber Scaffolds for Liver Tissue Engineering

K. N. Chua¹, Y. N. Tang², P. C. Lee², K. W. Leong³, S. Ramakrishna¹, H. Q. Mao³; ¹National University of Singapore, Singapore, SINGAPORE, ²Division of Johns Hopkins in Singapore Limited, Singapore, SINGAPORE, ³Johns Hopkins University, Baltimore, MD.

144

A Visual and Quantitative Analysis of Collagen Self-Assembly Under Microfluidic Hydrodynamic Flow

J. B. Leach¹, S. Koester², T. Pfohl², J. Y. Wong³; ¹University of Maryland, Baltimore County, Baltimore, MD, ²Max Planck Institute for Dynamics and Self-Organization, Goettingen, GERMANY, ³Boston University, Boston, MA.

145

Protein Adsorption and Crystal Structure of Poly(l-lactic acid)Nano Fibers

P. Wang, P. X. Ma; University of Michigan, ann arbor, MI.

146

Bone regeneration on nano-fibrous reverse solid freeform fabricated poly(L-lactic acid) scaffolds

L. A. Smith, V. J. Chen, P. X. Ma; University of Michigan, Ann Arbor, MI.

147

Identifying the SPARC binding sites on collagen I and procollagen I by atomic force microscopy

H. Wang¹, B. Ratner¹, H. Sage², S. Jiang¹; ¹University of Washington, Seattle, WA, ²Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, WA.

148

In Vitro Evaluation of Osteoblast and Fibroblast Response to Nano-phase Fillers

M. E. Clark¹, D. F. Farrar², C. Engel¹, P. J. C. Felstead¹, D. M. Walter¹, G. S. Walker¹, C. A. Scotchford¹, D. M. Grant¹; ¹University of Nottingham, Nottingham, UNITED KINGDOM, ²Smith and Nephew GRC, York, UNITED KINGDOM.

149

Hybrid Fibrous Scaffolds from a Synthetic Elastomer and Urinary Bladder Matrix

J. J. Stankus, D. O. Freytes, J. Guan, S. F. Badylak, W. R. Wagner; University of Pittsburgh, Pittsburgh, PA.

150

Stem Cell Impregnated Carbon Nanofibers/Nanotubes for Treating Neurological Disorders: An in vivo Study

J. Lee¹, J. Kim¹, D. Khang², T. J. Webster²; ¹Yonsei University, Seoul, REPUBLIC OF KOREA, ²Purdue University, West Lafayette, IN.

Dental and Orthopaedic Implant Coatings and Materials: Characterization, In vitro, In vivo and Clinical assessments

151

Effect of Surfactants on Physicochemical Properties of Amorphous Calcium Phosphate Filled Composites

J. M. Antonucci¹, D. Skrtic²; ¹National Institute of Standards and Technology, Gaithersburg, MD, ²Paffenbarger Research Center; American Dental Association Foundation, Gaithersburg, MD.

153

Biodegradable, Antibiotic Coatings for Orthopaedic and Dental/Craniofacial Implants

P. A. Norowski, Jr.¹, S. P. Noel¹, H. S. Courtney², Y. L. Yuan¹, K. Richelsoph¹, W. O. Haggard¹, J. L. Ong², J. D. Bumgardner¹; ¹University of Memphis, Memphis, TN, ²University of Tennessee-Health Sciences Center, Memphis, TN.

154

Microencapsulated TGFβ1 Released from Hollow Titanium Implants Enhances In Vivo Bone Ingrowth

P. A. Clark, E. K. Moioli, A. Lopez, J. J. Mao; University of Illinois at Chicago, Chicago, IL.

155

Rate and strength of osseointegration of oxidized and machined, turned implants in rabbit bone for 3 and 6 weeks

Y-T. Sul¹, Y. Jeong², C. Johansson³, T. Albrektsson¹; ¹Dept. of Biomaterials, Gothenburg University, Gothenburg, SWEDEN, ²Korea Institute of Machinery and Materials, Changwon, REPUBLIC OF KOREA, ³Department of Medical Technology, Orebro University, Orebro, SWEDEN.

156

Clinical Evaluation of a Laser Microtextured Surface on a Dental Implant

G. E. Pecora¹, J. L. Ricci², R. Guarnieri¹, R. Ceccarelli¹, H. Alexander³; ¹Group for Implant Research, Rome, ITALY, ²New York University, New York, NY, ³Orthogen Corporation, Springfield, NJ.

157

Evaluation of the Tissue Response to a Knee Hemiarthroplasty

L. C. Jones¹, M. Tucci², M. W. Hungerford¹; ¹Johns Hopkins University, Baltimore, MD, ²University of Mississippi, Jackson, MS.

158

Cure Monitoring of Hydrosilation-curable Silicones by Fluorescence Spectroscopy

F. W. Wang; National Institute of Standards and Technology, Gaithersburg, MD.

Mechanobiology of Skin and Bone (General Session)

159

A Novel Mitral Valvuloplasty Model for Heterograft Biomaterial In-vivo Assessment

M. S. Sacks¹, R. Gorman², J. H. Gorman, III², R. J. Levy²; ¹University of Pittsburgh, Pittsburgh, PA, ²University of Pennsylvania, Philadelphia, PA.

160

Ectopic Bone Formation from Hydrogel Carriers Loaded with BMP-transduced Cells

M. Bikram¹, C. Fouletier-Dilling², J. A. Shafer², J. A. Hipp², A. R. Davis², E. A. Olmsted-Davis², J. L. West¹; ¹Rice University, Houston, TX, ²Baylor College of Medicine, Houston, TX.

161

TIMP-3 is Differentially Regulated in Response to Mechanical Microenvironment in Cells Growing in Tissue Engineering Scaffolds

C. Klapperich, R. Wu; Boston University, Boston, MA..

162

Mechano-Active Cartilage Tissue Engineering: Effects of Biomechanical Conditioning

Y. Jung¹, S. Kim¹, S-H. Kim¹, Y. Kim², J. Xie³, T. Matsuda³, B. Min⁴; ¹Korea Institute of Science and Technology, Seoul, REPUBLIC OF KOREA, ²Gwangju Institute of Science and Technology, Gwangju, REPUBLIC OF KOREA, ³Kyushu University, Fukuoka, JAPAN, ⁴Seoul National University, Seoul, REPUBLIC OF KOREA.

163

Micromechanics of Electrospun Poly Ester Urethane Urea Scaffolds

T. Courtney, J. Liao, M. Sacks, J. Stankus, J. Guan, W. Wagner; University of Pittsburgh, Pittsburgh, PA.

164

Structure-Function Micromechanics of Fibrin Biomaterial Scaffolds

A. A. Corrin¹, B. Tawil², M. C. Shaw¹; ¹California Lutheran University, Thousand Oaks, CA, ²Baxter Healthcare, Thousand Oaks, CA.

165

Evaluation of “AFT” Bone Void Filler in a Sheep Vertebral Bone Defect

T. Fujishiro; The Cleveland Clinic Foundation, Cleveland, OH.

166

Effect of Tricalcium Phosphate Incorporation in Polycaprolactone Scaffolds for Bone Tissue Engineering

J. W. Wright¹, C. Boehm², K. Kumagai², L. G. Griffith¹, G. F. Muschler²; ¹Massachusetts Institute of Technology, Cambridge, MA, ²The Cleveland Clinic Foundation, Cleveland, OH.

Advances in Biomaterials Science: What have we learned from our mistakes?

167

Protein and Cellular Interactions with Biomaterials: Perspectives for Nanotechnology and Tissue Engineering

J. M. Anderson; Case Western Reserve University, Cleveland, OH.

168

Nanostructured Surface Modification and Coatings for Orthopaedic and Dental Implants

J. E. Lemons; University of Alabama at Birmingham, Birmingham, AL.

169

The "Theta Surface" for Biocompatibility: Minimizing Protein Denaturation

R. E. Baier; University at Buffalo, Buffalo, NY.

170

Engineered Biomaterials via Molecular (Nanoscale) Surface Modifications

B. D. Ratner; University of Washington, Seattle, WA.

Modeling Bioresponse to Biomaterials Symposium I

171

Rational Computer-Aided Design of Biomaterials

W. J. Welsh¹, V. Kholodovych¹, D. Knight², J. Kohn²; ¹UMDNJ, Piscataway, NJ, ²Rutgers University, Piscataway, NJ.

172

Molecular Modeling of Cell Adhesion Peptide Adsorption on Hydroxyapatite

S. Segvich; University of Michigan, Ann Arbor, MI.

173

Thermodynamic Perspectives on the Design of Protein Adsorption Resistant Surfaces

R. A. Latour; Clemson University, Clemson, SC.

174

Molecular Dynamics Simulations of Protein Interactions with Hydrophobic Surface

Y. Sun, F. Wang, R. A. Latour; Clemson University, Clemson, SC.

175

Molecular Simulations of Non-fouling SAM Surfaces

J. C. Hower; University of Washington, Seattle, WA.

176

Prediction of Fibrinogen Adsorption for the Library of Novel Biodegradable Polymers: Combined Molecular Dynamics and Surrogate Modeling Approach

A. V. Gubskaya; Rutgers University, The State University of New Jersey, Piscataway, NJ.

177

Molecular Modeling the Water Uptake of Biomaterials

V. Kholodovych¹, W. J. Welsh¹, R. Thakur², B. Michniak², J. Kohn²; ¹University of Medicine & Dentistry of New Jersey (UMDNJ)- Robert Wood Johnson Medical School, Piscataway, NJ, ²Rutgers, The State University of NJ, New Brunswick, NJ.

Con-current Oral Abstract Presentations Session VI

Biodegradable Hydrogels for Tissue Engineering III (General Session)

178

Laser Scanning Lithography and Soft Lithography of Micropatterned Cell-adhesive Self-assembled Monolayers

J. S. Miller¹, M. I. BÃ©thencourt², M. Hahn¹, T. Lee², J. L. West¹; ¹Rice University, Houston, TX, ²University of Houston, Houston, TX.

179

Stimulus-Responsive Degradation of Biocompatible Polypeptide Hydrogel for Tissue Engineering

M. Matsusaki, H. Yoshida, M. Akashi; Osaka University, Suita, JAPAN.

180

Dextran Hydrogel Used as a Phospholipid Delivery System for Viscosupplementation

D. Weinbrenner, J-A. Burdick, G. Lickfield, C. L. Simpson, M. LaBerge; Clemson University, Clemson, SC.

181

Tannic Acid Crosslinked Collagens and Potential for Breast Tissue Engineering

C. A. Parzel, K. J. L. Burg; Clemson University, Clemson, SC.

182

Development of Injectable Thermogelling Chitosan-Inorganic Phosphate Solution for Biomedical Applications

L. S. Nair¹, T. Starnes¹, C. Bijoux², C. T. Laurencin¹; ¹University of Vriginia, Charlottesville, VA, ²City College of New York, New York, NY.

183

DNA Delivery in Hyaluronic Acid Hydrogels

J. A. Wieland; Northwestern University, Evanston, IL.

184

Protein Interactions with Biological Matrices: A Fluorescence Correlation Spectroscopy Investigation

N. Washburn, J. A. J. Fitzpatrick; Carnegie Mellon University, Pittsburgh, PA.

185

The Development of Collagen Hydrogel Infused-Polymeric Scaffolds for Creating Vascularised Tissues In Vitro

H. C. H. Ko¹, S. Lim², J. Cooper-White², B. K. Milthorpe¹, L. Poole-Warren¹, C. D. McFarland¹; ¹University of New South Wales, Sydney, AUSTRALIA, ²University of Queensland, Brisbane, AUSTRALIA.

Biomimesis in Drug Delivery III: Intelligent and Responsive Gels (General Session)

186

Environmentally Sensitive Polymer Matrices

A. Panitch, B. L. Seal; Arizona State University, Tempe, AZ.

187

Hydrogels for Protease-Responsive Chemotherapy

J. R. Tauro, R. A. Gemeinhart; University of Illinois, Chicago, IL.

188

The Release of VEGF from Heparinized Collagen Matrices is controlled by Proteinase Induced Matrix Degradation

G. C. M. Steffens¹, C. Yao¹, M. Roderfeld², T. Rath², E. Roeb², J. Bernhagen¹; ¹RWTH University Aachen, Aachen, GERMANY, ²Justus-Liebig University, Giessen, GERMANY.

189

Integration of Thermally Responsive Nanosphere Hydrogels with Gold Nanoparticles for Intelligent Therapeutic Applications

D. E. Owens, III, N. A. Peppas; University of Texas at Austin, Austin, TX.

191

A Biomimetic Approach Towards The Formation Of Therapeutic Contact Lenses

S. Venkatesh, S. P. Sizemore, J. Zhang, M. E. Byrne; Auburn University, Auburn, AL.

192

Photopolymerizable Hydrogels made from Poly(ethylene glycol) and Albumin for Drug Delivery: Drug Binding and Release Properties

L. Oss-Ronen, D. Seliktar; Technion, Haifa, ISRAEL.

193

Topically applied S-nitrosoglutathione-containing hydrogel for transdermal nitric oxide release

A. B. Seabra¹, A. Fitzpatrick², R. Weller², Z. Lacza³, M. G. de Oliveira¹; ¹Instituto de Química - Universidade Estadual de Campinas, Campinas, BRAZIL, ²Dermatology Department, University of Edinburgh, Edinburgh, UNITED KINGDOM, ³Department of Human Physiology and Clinical Experimental Research, Faculty of Medicine, Semmelweis University, Budapest, HUNGARY.

Cellular Signal Transduction Symposium

194

Signaling downstream of S1P, VEGF, shear stress and platelet poor plasma

D. L. Elbert, S. K. Hughes, B. K. Wacker, M. M. Kaneda; Washington University, St. Louis, MO.

195

Macrophage expression of phospholipase A2 is altered by polycarbonate-urethane surfaces

D. M. Dinnes¹, J. P. Santerre², R. S. Labow¹; ¹University of Ottawa Heart Institute, Ottawa, ON, CANADA, ²Faculty of Dentistry, Institute for Biomaterials and Biomedical Engineering, University of Toronto, Ottawa, ON, CANADA.

196

Enhancement of Osteoblast Proliferation by Bioactive Glass is Accompanied by Selective Modulation of c-Jun, MAPK, and Integrin Gene Expression

A. Y. Au, R. Y. Au, T. K. Al-Talib, B. Eves, C. G. Frondoza; Nutramax Laboratories, Inc., Edgewood, MD.

197

Mixed Integrin-Specific Surfaces Synergistically Modulate Signal Transduction and Cell Proliferation

C. D. Reyes, T. A. Petrie, A. J. Garcia; Georgia Institute of Technology, Atlanta, GA.

198

Triethylene glycol derived from composite resins modulates the expression of genes associated with biofilm formation and other virulence factors in Streptococcus mutans

P. Khalichi, J. Singh, D. G. Cvitkovitch, J. P. Santerre; University of Toronto, Toronto, ON, CANADA.

199

Differential Macrophage Activation Due to Biomaterial Topography Requires the B2-Integrin Signaling Pathway

A. M. B. Collie, P. C. S. Bota, P. S. Stayton; University of Washington, Seattle, WA.

200

LC/MS identification of adherent U937 intracellular signaling proteins mediated by various surface adsorbed peptides and phosphorylation inhibitor AG18

S. T. Zuckerman, W. J. Kao; University of Wisconsin-Madison, Madison, WI.

201

Colocalization of Cell Adhesion Proteins in 3D Rapid Prototyped Tissue Engineering Scaffolds

T. Dutta Roy¹, J. J. Stone², W. Sun³, E. H. Cho⁴, S. J. Lockett⁴, F. W. Wang¹, L. A. Henderson¹; ¹National Institute of Standards and Technology, Gaithersburg, MD, ²North Dakota State University, Fargo, ND, ³Drexel University, Philadelphia, PA, ⁴National Cancer Institute, Frederick, MD.

Modeling Bioresponse to Biomaterials Symposium II

202

Design and Fabrication of Biomorphic Tissue Engineering Scaffolds using Trigonometric Templates

S. Rajagopalan, L. Lu, R. Robb, M. Yaszemski; Mayo Clinic College of Medicine, Rochester, MN.

203

Design and Fabrication of Durotaxic Tissue Engineering Scaffolds

S. Rajagopalan, L. Lichun, R. Robb, M. Yaszemski; Mayo Clinic College of Medicine, Rochester, MN.

204

Withdrawn

205

Effect of Scaffold Architecture on Diffusion of Oxygen in Tissue Engineered Constructs

T. S. Karande¹, J. Mahadevan², N. A. Peppas², W. Sun³, D. D. Dean¹, C. Agrawal¹; ¹The University of Texas Health Science Center at San Antonio, San Antonio, TX, ²The University of Texas at Austin, Austin, TX, ³Drexel University, Philadelphia, PA.

206

Mean Pore Size and Compressive Strain Effects on the Permeability of Collagen-GAG Scaffolds: Cellular Solids Modeling and Experimental Results

B. A. Harley¹, F. J. O'Brien², M. A. Waller³, P. J. Prendergast³, I. V. Yannas¹, L. J. Gibson¹; ¹Massachusetts Institute of Technology, Cambridge, MA, ²Royal College of Surgeons in Ireland, Dublin, IRELAND, ³Trinity College, Dublin, IRELAND.

207

Polyermization Fronts, Mechanical Constraint and Shrinkage-Induced Residual Stresses in Bone Cement: A one-dimensional thermal-kinetics-viscoelastic model of in-situ polymerization

J. L. Gilbert; Syracuse University, Syracuse, NY.

208

Prediction of Biodegration and Drug Release from a Biodegradable Stent

S. Prabhu, S. Hossainy, D. Gale; Guidant Corporation, Santa Clara, CA.

209

Analysis of Microvacsular Endothelial Cell Morphology During Migration on Haptotactic Fibronectin Gradients

J. T. Smith, J. T. Elkin, T. B. Kepler, W. M. Reichert; Duke University, Durham, NC.

Organic/Inorganic Hybrid Biomaterials Symposium II

210

Chitosan-Glycerophosphate hydrogel imparts injectability and thermosensitivity to calcium phosphate composite for bone repair

A. Chenite; Biosyntech Canada Inc., Laval, PQ, CANADA.

211

Development of a new CaHPO4 (Monetite) self-setting cement

T. R. Desai, S. B. Bhaduri, C. A. Tas; Clemson University, Clemson, SC

212

Performance of Degradable Long-Fibre Composites for Craniofacial Bone Repair in a Calvarial Defect Model

C. A. Scotchford¹, S. M. Shahtaheri¹, C. D. Rudd¹, S. E. Fisher², C. Efeoglu², A. S. High²; ¹University of Nottingham, Nottingham, UNITED KINGDOM, ²University of Leeds, Leeds, UNITED KINGDOM.

213

The Micromechanical Effects of Bone Cement Polymerization on Sheep Femur Cortical Bone

J. H. Kang, J. L. Gilbert; Syracuse University, Syracuse, NY.

214

Evaluation of Novel Injectable Hydrogels

J. Vernengo¹, G. Fussell², A. Lowman¹; ¹Drexel University, Philadelphia, PA, ²Synthes Spine, West Chester, PA.

215

A Tunable Hydroxyapatite Formation in Agarose Hydrogel as Biomineral Functions

J. Watanabe, M. Kashii, M. Hirao, K. Oka, K. Sugamoto, H. Yoshikawa, M. Akashi; Osaka University, Suita, JAPAN.

216

Effects of Salicylic Acid-Derived Poly(Anhydride-Esters) Bone Graft Barrier on Inflammation

M. Reynolds¹, M. Aichelmann-Riedy¹, A. Prudencio², K. Woodward¹, K. E. Uhrich²; ¹University of Maryland Dental School, Baltimore, MD, ²Rutgers University, Piscataway, NJ.

217

Fabrication of Novel Calcium Phosphate-Reinforced Polylactic Acid Continuous-Yarn Composites

M. Wei¹, C. Kothapalli¹, J. R. Olson², M. T. Shaw¹; ¹University of Connecticut, Storrs, CT, ²Teleflex Medical, Coventry, CT.

Orthopedic Bearing Surfaces

218

Protein degradation and chemical modification of bovine serum in small and large diameter metal-on-metal hip wear episodes

J. Webb¹, J. G. Bowsher², M. M. Grootveld³, J. C. Shelton¹; ¹University of London, London, United Kingdom, ²Loma Linda University Medical Center, Loma Linda, Ca, ³South Bank University, London, United Kingdom.

219

The Relationship of Metal-On-Metal Wear and Metal Ion Release in the Serum Lubricant

Y-S. Liao, M. Hanes; DePuy Orthopaedics, Inc., Warsaw, IN.

220

MULTI-LAB EVALUATION OF HIP SIMULATOR TEST CONDITIONS ON RELATIVE WEAR RATES OF CROSSLINKED POLYETHYLENES

D. E. McNulty¹, S. Swope¹, Y-S. Liao¹, H. McKellop², F-W. Shen³, A. Galvin⁴, J. Fisher⁴; ¹DePuy Othopaedics, Warsaw, IN, ²Orthopaedic Hospital, Los Angeles, CA, ³Los Angeles Orthopaedic Hospital, Los Angeles, CA, ⁴University of Leeds, Leeds, UNITED KINGDOM.

221

EFFECT OF TRABECULAR METAL THIRD BODY PARTICLES ON WEAR OF UHMWPE

L. L. Borgstede, O. O. Popoola, C. R. Blanchard, T. S. Johnson; Zimmer Inc., Warsaw, IN.

222

UHMWPE Fluid Absorption And Off-Gassing Following Supercritical CO2 Sterilization

J. D. DesJardins, J. Hemmer, M. Drews, M. LaBerge; Clemson University, Clemson, SC.

223

EFFECT OF MULTIPLE ACTIVITIES ON WEAR OF UHMWPE IN CRUCIATE-RETAINING (CR) KNEES

T. S. Johnson, O. O. Popoola, A. Y. Patil; Zimmer Inc., Warsaw, IN.

224

Effect of Femoral Head Size, Material, Surface Roughness And Serum Concentration On The Wear Of 5 Mrad Crosslinked- Remelted UHMWPE Acetabular Cups

H. McKellop¹, Y-S. Liao², F-W. Shen¹, W. McGarry¹; ¹Orthopaedic Hospital, Los Angeles, CA, ²DePuy Orthopaedics, Warsaw, IN.

225

TRIBOLOGICAL CHARACTERISTICS OF A NEW HIGH FLEXION GUIDED MOTION TKA DESIGN

A. Parikh¹, V. Good¹, M. Ries²; ¹Smith & Nephew, Inc., Memphis, TN, ²UCSF Medical Center, Dept. of Orthopaedics, San Francisco, CA.

POSTERS

Biodegradable Hydrogels for Tissue Engineering

230

Neocartilage Formation by Auricular Chondrocytes in Photopolymerizable HA Networks

C. Chung¹, J. Mesa², M. A. Randolph², J. A. Burdick¹; ¹University of Pennsylvania, Philadelphia, PA, ²Massachusetts General Hospital, Boston, MA.

231

Synthesis and Characterization of HA-grafted Thermo-reversible Chitosan Hydrogel for Cartilage and Meniscus Tissue Engineering

T-H. Cheng, J-P. Chen; Chang Gung University, Taoyuan, TAIWAN REPUBLIC OF CHINA.

232

Quality and Extent of Nerve Regeneration through Chitosan Nerve Guides

M. Patel, P. Vandevord, L. Mayton, H. Matthew, S. P. DeSilva, P. H. Wooley; Wayne State University, Detroit, MI.

233

Hydrogels that Mimic the Viscoelastic Behavior of the Nucleus Pulposus Under Dynamic Torsional Loading

R. A. Bader, W. E. Rochefort; Oregon State University, Corvallis, OR.

234

Degradation and Mechanical Characteristics of Photopolymerized PEGDA Hydrogels as Tissue Engineering Scaffold

X. Xin, C. Gaydos, J. Mao; University of Illinois at Chicago, Chicago, IL.

235

Modified collagen with DOPA as a tissue repair matrix

J. Zhang; University of Pittsburgh, Pittsburgh, PA.

237

Primary macrophage gelatinase A and B expression on interpenetrating networks containing gelatin modified with PEGylated RGD

A. S. Gustafson, Q. Gao, W. J. Kao; University of Wisconsin-Madison, Madison, WI.

238

Recoverable Polymer Hydrogel Composed of Novel Phospholipid Polymer for 3D-Tissue Culture

K. Ishihara, T. Konno; The University of Tokyo, Tokyo, JAPAN.

239

Enzymatic Surface Erosion of Poly(trimethylene carbonate) Films Studied by Atomic Force Microscopy

Z. Zhang¹, S. Zou², G. J. Vancso², D. W. Grijpma¹, J. Feijen¹; ¹Institute for Biomedical Technology (BMTI) and Department of Polymer Chemistry and Biomaterials, Enschede, THE NETHERLANDS, ²Materials Science and Technology of Polymers, MESA+ Institute for Nanotechnology, University of Twente, Enschede, THE NETHERLANDS.

240

In vitro Degradation of NovoSorb™ Polyurethanes Designed for Orthopaedic Applications

R. Adhikari, L. Tatai, M. RTA, T. Moore, S. Houshyar, L. Hanu, M. Wickramaratna, D. Menzies, P. Johnston, I. Griffiths, P. Gunatillake; PolyNovo Biomaterials Pty Ltd, Clayton South, AUSTRALIA.

241

In-Situ Biodegradable Hydrogels Based on Poly(ethylene glycol)-Polylactide Star Block Copolymers

Z. Zhong, C. Hiemstra, P. J. Dijkstra, J. Feijen; University of Twente, Enschede, THE NETHERLANDS.

242

Biphasic Mechanical Properties of Poly(vinyl alcohol) Hydrogels for Cartilaginous Tissue Replacement

H. Yao¹, Z. Schwartz¹, S. J. Kennedy², B. D. Boyan¹; ¹Georgia Institute of Technology, Atlanta, GA, ²Orhonics, Inc., Atlanta, GA.

243

Influence of Cross-linker Chemistry on Hydrogel Properties for DNA Delivery

S. A. Bencherif, J. A. Sheehan, L. M. Walker, J. O. Hollinger, N. R. Washburn; Carnegie Mellon University, Pittsburgh, PA.

244

Design Of Bone, Cartilage And Osteochondral Tissue Engineering Chitosan-Based Produced By A Particle Aggregation Methodology

P. Malafaya; 3B's Research Group-Biomaterials, Biodegradables and Biomimetics, Braga, PORTUGAL.

245

Novel Biocompatible Adhesives from Plant Derived Monomers

C. Klapperich¹, R. P. Wool², L. Zhu², L. Bonnaillie²; ¹Boston University, Boston, MA, ²University of Delaware, Newark, DE.

246

Study of GDNF Release From Chitosan Scaffolds

R. A. Gawade, P. J. VandeVord; Wayne State University, Detroit, MI.

247

In Vivo Stability and Encapsulation of Subcutaneously Implanted Alginate Disks

E. A. Nunamaker, E. K. Purcell, D. R. Kipke; University of Michigan, Ann Arbor, MI.

248

Composition-Property Relationships of Chitosan-Egg Phosphatidylcholine Films For Use in Drug Delivery

J. Grant; University of Toronto, Toronto, ON, CANADA.

249

Semi-degradable Multifunctional Hydrogel Constructs for the Repair of Cartilage Defects

K. L. Spiller¹, S. Maher², D. Charlton², A. Lowman¹; ¹Drexel University, Philadelphia, PA, ²Hospital for Special Surgery, New York, NY.

250

Transition Behavior of Hydrogels Consisting of Enantiomeric Block Copolymers of Polylactides (PLLA or PDLA) and Poly(ethylene glycol) (PEG)

T. Fujiwara¹, J. Nakano², Y. Kimura², T. Yamaoka³; ¹Boise State University, Boise, ID, ²Kyoto Institute of Technology, Kyoto, JAPAN, ³National Cardiovascular Center Research Institute, Osaka, JAPAN.

251

Deconstructing the Mechanism behind Poly(vinyl alcohol) - Amino Acid Hydrogel Formation

Z. Tatum, E. E. Johnson, B. D. Ratner; University of Washington, Seattle, WA.

252

Host Cell Infiltration to Implanted Vascular Grafts Made of Collagen Fibers in Porcine Model

T. Fujisato¹, N. Sasayama², K. Minatoya¹, K. Yoshida¹, S. Funamoto¹, A. Kishida³, A. Shirasu², T. Nakatani¹, H. Takano², H. Hattori²; ¹National Cardiovascular Center, Suita, JAPAN, ²Nipro Corporation, Kusatsu, JAPAN, ³Tokyo Medical and Dental University, Tokyo, JAPAN.

253

Amphiphilic Diblock Copolymer based on PPDO and PEG: Synthesis, Characterization, and Micellization

R. KC¹, S. Bhattarai¹, S. Aryal¹, D. Lee², H. Kim²; ¹Dept. of Bionanosystem Eng., Chonbuk National University, Jeonju, REPUBLIC OF KOREA, ²Dept. of Textile Eng., Chonbuk National University, Jeonju, REPUBLIC OF KOREA.

254

Preparation of biodegradable porous hydrogels cross-linked with polyphosphates

C. Wachiralarpphaithoon, Y. Iwasaki, K. Akiyoshi; Tokyo Medical and Dental University, Tokyo, JAPAN.

255

New Alginate Self-gelling Technology for Tissue Engineering

J. Melvik, J. Bjørnstad, M. Dornish; NovaMatrix/FMC Biopolymer, Oslo, NORWAY.

256

Thermosensitive, Biodegradable, and Cell Adhesive Pluronic Hydrogels for Tissue Engineering

D. Han¹, S. Cha¹, K-D. Ahn¹, J-M. Kim², K. Park³; ¹Korea Institute of Science and Technology, Seoul 130-650, REPUBLIC OF KOREA, ²Hanyang University, Seoul 133-791, REPUBLIC OF KOREA, ³Ajou University, Kyungki 443-749, REPUBLIC OF KOREA.

257

The effects of functionalized self-assembling peptide scaffolds on osteoblast proliferation and differentiation

A. Horii, F. Gelain, S. Zhang; MIT, Cambridge, MA.

258

Structural and Physicochemical Characterisation of an Enzymatically Cross-linked Collagen Scaffold

Y. Garcia; National Centre for Biomedical Engineering Science, NUI Galway, Galway, IRELAND.

259

In Vitro Development and Characterization of a Cortical Neural Stem Cell-Seeded Alginate Scaffold

E. K. Purcell, D. R. Kipke; University of Michigan, Ann Arbor, MI.

260

Three Dimensional Constructs Composed from Extracellular Matrix Particles

J. E. Valentin, S. F. Badylak; University of Pittsburgh, Pittsburgh, PA.

261

Natural collagen scaffolds for blood vessel engineering

S. Yazdani, J. Berry, A. Atala, S. Soker; Wake Forest University School of Medicine, Winston Salem, NC.

262

Fabrication of tissue-engineered blood vessel using electrospinning

J. Liu, S. Lee, S. Soker, G. Lim, A. Atala, J. Stitzel; Wake Forest University School of Medicine, Winston Salem, NC.

263

Anisotropic Hydrogels for Peripheral Nerve Regeneration Across Long Nerve Gaps

M. Dodla, R. V. Bellamkonda; Georgia Institute of Technology, Atlanta, GA.
Student Award for Outstanding Research - PhD Candidate

264

In vitro biocompatibility and biodegradation of poly(esterurethane urea) scaffolds

A. Srinivasan¹, K. Gallagher², S. McBride¹, S. Khetan³, S. Guelcher⁴, J. O. Hollinger¹; ¹Carnegie Mellon University, Pittsburgh, PA, ²Duquesne University, Pittsburgh, PA, ³Johns Hopkins, Baltimore, MD, ⁴Vanderbilt Univeristy, Nashville, TN.

265

Starch-PolyCaprolactone Fiber Based Scaffolds Are Suitable For Cartilage Tissue Engineering Approaches

J. T. Oliveira; 3B's Research Group-Biomaterials, Biodegradables and Biomimetics, Braga, PORTUGAL.

266

L-tyrosine based Polyurethanes: Potential material for tissue engineering

D. Sarkar, J-C. Yang, S. T. Lopina; The University of Akron, Akron, OH.

267

Novel pH-responsive hydrogels based on chemically modified Arabic Gum polysaccharide

E. C. Muniz, Sr.; Universidade Estadual de Maringá, Maringá, BRAZIL.

268

Mechanical properties and in vivo performance of light-cured hydrogel/ABM/P-15 grafting materials

K. S. Walline¹, B. L. Atkinson²; ¹Dentsply Friadent CeraMed, Lakewood, CO, ²BioSet Inc., Rockville, MD.

269

Growth Factor Influence on Myoblastic Cells Attached to a Novel Polymer

E. E. Falco¹, J. S. Roth², J. P. Fisher¹; ¹University of Maryland, College Park, MD, ²University of Maryland Medical School, Baltimore, MD.

270

N-isopropylacrylamide-based Copolymer with Hydrolysis-dependent Lower Critical Solution Temperature as Injectable, Bioresorbable Gelling Materials for Controlled Drug Delivery

Z. Cui, B. Lee, B. L. Vernon; Arizona State University, Tempe, AZ.

271

Cell Colonization on Negatively Charged Polysaccharide Matrices

A. Ullm, J. Tillman, S. V. Madihally; Oklahoma State University, Stillwater, OK.

272

Injectable PEG-Genipin Hydrogels for Tissue Engineering

A. J. DeFail, A. I. Iddriss, K. G. Marra; University of Pittsburgh, Pittsburgh, PA.

273

Resistance of Self-interpenetrating Poly(Sulfobetaine methacrylate) Hydrogels to Fibrinogen Adsorption and Platelet Adhesion

Z. ZHANG; Unviersity of Washington, Seattle, WA.

274

A novel thermosensitive chitosan for the treatment of degenerative intervertebral disc

K. Park¹, J. Bae¹, Y. Lee², J. Shin², K. Park¹; ¹Ajou university, Suwon, REPUBLIC OF KOREA, ²Inje University, Gimhae, REPUBLIC OF KOREA.

275

Improved Mesenchymal Stem Cell Proliferation on Glycosaminoglycan Immobilized Chitosan - Effects of Membrane Thickness

B. E. Saygili, H. W. T. Matthew; Wayne State University, Detroit, MI.

276

One-step preparation of injectable hyaluronic acid based hydrogel at physiological condition

J. Kim¹, Y. Park¹, G. Tae², K. Lee¹, S. Hwang³, I. Kim³, I. Nho⁴, K. Sun¹; ¹Korea University, Korea Artificial Organ Center, Seoul, REPUBLIC OF KOREA, ²GIST, Gwang-ju, REPUBLIC OF KOREA, ³Seoul National University, Seoul, REPUBLIC OF KOREA, ⁴Seoul National University of Technology, Seoul, REPUBLIC OF KOREA.

277

In Vitro and In Vivo Degradation Behaviors of Acetylated Chitosan Porous Beads

D. Song¹, S. Oh¹, D. Lee-Yoon², E. Bae², J. Lee¹; ¹Hannam University, Daejeon, REPUBLIC OF KOREA, ²Regen Biotech, Inc., Seoul, REPUBLIC OF KOREA.

278

Optimizing Mechanical and Cell Adhesion Properties of Chitosans Through Simultaneous Manipulation of Molecular Weight and Crosslinking

R. Piparia, I. Robu, H. W. T. Matthew; Wayne State University, Detroit, MI.

279

Microhardness of Starch Based Biomaterials in Simulated Physiological Solutions as a Tool to Predict its Surface Stiffness When Implanted

N. Alves; University of Minho, Guimaraes, PORTUGAL.

280

Effects of UV Laser Parameters on Fabricating Three-Dimensional Poly(propylene fumarate) Scaffolds with Controlled Macropores Using Stereolithography

K-W. Lee, B. Fox, S. Wang, J. Gruetzmacher, L. Lu, M. Yaszemski; Mayo Clinic College of Medicine, Rochester, MN.

281

Fabrication of Permeable Tubular Structure from Chemically Modified Chitosan with Anticoagulant Activities for Small Blood Vessel Engineering

Y. Qiu¹, N. Zhang¹, Q. Kang², Y. An², X. Wen¹; ¹Clemson University, Charleston, SC, ²Medical University of South Carolina, Charleston, SC.

282

Di-biotin Functionalized Polymers via Atom Transfer Radical Polymerization and Click Chemistry

D. J. Siegwart, R. R. Gil, J. O. Hollinger, K. Matyjaszewski; Carnegie Mellon University, Pittsburgh, PA.

Biomimesis in Drug Delivery

283

Polymerization Kinetics of PEO-pNIPAAm Block Copolymers

W. G. Pitt, Y. Zeng; Brigham Young University, Provo, UT.

284

Controlled release of sphingosine 1-phosphate, a potent stimulator of endothelial cell migration

D. L. Elbert, B. K. Wacker, S. K. Hughes, M. M. Kaneda, E. A. Scott; Washington University, St. Louis, MO.

285

Magnetic Resonance Imaging of Osteoconductive Calcium Polyphosphate Drug Delivery Devices

J. M. Bray¹, S. D. Beyea²; ¹Dalhousie University, Halifax, NS, CANADA, ²Institute for Biodiagnostics (Atlantic) - NRC, Halifax, NS, CANADA.

286

Controlled Release of rhVEGF from Heparin-Functionalized Nanoparticles

G. Tae¹, Y-I. Chung¹, S. K. Kim², K-O. Cho², S. H. Yook³; ¹Gwangju Institute of Science and Technology, Gwangju, REPUBLIC OF KOREA, ²Chonnam National University, Gwangju, REPUBLIC OF KOREA, ³Hannam University, Daejon, REPUBLIC OF KOREA.

287

Management of the infected arthroplasty using antibiotic-loaded hydroxyapatite blocks combined with cement spacer

Y. Mochida, K. Ishii, N. Taki, N. Mitsugi, T. Saito; Yokohama City University, Yokohama, JAPAN.

288

Intermittent Exposure to Simvastatin Enhances Osteoblastic Activity

J. Jeon¹, M. V. Thomas², D. A. Puleo¹; ¹Univesity of Kentucky, Center for biomedical Engineering, Lexington, KY, ²Univesity of Kentucky, College of dentistry, Lexington, KY.

289

Stability of Disulfide-Linked Fetuin-Bisphosphonate Conjugates for Increased Mineral Affinity

S. Zhang, J. E. I. Wright, G. Bansal, H. Uludag; University of Alberta, Edmonton, AB, CANADA.

290

Cellular Response to Simvastatin Released from Calcium Sulfate

C. A. Martin¹, M. V. Thomas², D. A. Puleo¹; ¹University of Kentucky, Center for Biomedical Engineering, Lexington, KY, ²University of Kentucky, College of Dentristry, Lexington, KY.

291

Antibacterial sol-gel films on implant material with tailored controlled release properties

S. Radin¹, J. Parvizi², P. Ducheyne¹, I. Shapiro²; ¹University of Pennsylvania, Philadelphia, PA, ²Thomas Jefferson University, Philadelphia, PA.

292

Spatial Engineering of Soft Tissue Within Osseous Defect Using Microencapsulated Transforming Growth Factor-β3

E. K. Moioli, P. A. Clark, J. J. Mao; University of Illinois at Chicago, Chicago, IL.

293

Controlled Release of bFGF from Elastomeric Biodegradable Microporous Sheets

J. J. Stankus, J. Guan, K. Fujimoto, W. R. Wagner; University of Pittsburgh, Pittsburgh, PA.

294

In vivo targeting of dendritic cells in lymph nodes with poly(propylene sulfide) nanoparticles

S. T. Reddy; EPFL, Lausanne, SWITZERLAND.

295

Polymeric nanoparticles as cell-specific drug carriers

H. Maie, Y. Iwasaki, K. Akiyoshi; Tokyo Medical and Dental University, Tokyo, JAPAN.

296

Novel Sol-Gel Synthesis of Microspheres for the Control Delivery of Drugs

T. L. Chen, S. Radin, P. Ducheyne; University of Pennsylvania, Philadelphia, PA.

297

Cysteine Capped Gold Nanoparticles for DNA Delivery

S. Bhattarai¹, S. aryal¹, R. KC¹, H. Yi², P. Hwang³, H. Kim⁴; ¹Dept. of Bionanosystem Eng., Chonbuk National University, Jeonju, REPUBLIC OF KOREA, ²Dept. of Biochemistry, School of Dentistry, Chonbuk National University, Jeonju, REPUBLIC OF KOREA, ³Dept. of Pediatrics, School of Medicine, Chonbuk National University, Jeonju, REPUBLIC OF KOREA, ⁴Dept. of Textile Eng., Chonbuk National University, Jeonju, REPUBLIC OF KOREA.

298

Liposome-Hydroxyapatite Core-Shell Structure as Drug Carriers

Q. Xu, J. Czernuszka; University of Oxford, Oxford, UNITED KINGDOM.

299

Preparation of Protein-loaded Biodegradable Nanoparticles Based on Poly(γ-glutamic acid) Hydrophobic Derivatives and Their Potential Biomedical Applications

T. Akagi¹, S. Nakagawa², M. Baba³, M. Akashi¹; ¹Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, JAPAN, ²Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, JAPAN, ³Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, JAPAN.

300

Indomethacin Release Behavior from pH-and Thermo-responsive Alginate -Ca²+ Containing Poly(N-isopropylacrylamide) semi-IPN Beads

J. Shi; University of Minho, Guimarães, PORTUGAL.

301

Examination of a Polyacrylate Hydrogel System for Extended Cisplatin Delivery

X. Yan, R. A. Gemeinhart; University of Illinois at Chicago, Chicago, IL.

302

Degradable Calcium Polyphosphate Strategies For The Delivery of Therapeutic Agents

C. Petrone, M. Filiaggi; Dalhousie University, Halifax, NS, CANADA.

304

The effect of crosslinking of chitosan microspheres with genipin on protein release

Y. Yuan, B. M. Chesnutt, G. Utturkar, W. O. Haggard, Y. Yang, J. L. Ong, J. D. Bumgardner; The University of Memphis-University of Tennessee, Memphis, TN.

305

CONTROLLED RELEASE OF BUPIVACAINE FROM INJECTABLE HYDROGEL COMBINDED WITH MICROSPHERES: POTENTIAL USE FOR DISCOGENIC BACK PAIN CONTROL

J. Lee, T-H. Lim, J. B. Park; The University of Iowa, Iowa City, IA.

Bionanotechnology: The Future of Biomaterials Symposium

306

Nanosized Therapeutic Self Assembled Monolayers (T-SAMs) on 316L Stainless Steel

A. Mahapatro¹, D. M. Johnson¹, D. N. Patel², M. D. Feldman², A. Ayon¹, C. M. Agrawal¹; ¹University of Texas at San Antonio, San Antonio, TX, ²University of Texas Health Science Center at San Antonio, San Antonio, TX.

307

Drug Elution Using Therapeutic Self-Assembled Monolayers

G. Mani¹, D. M. Johnson¹, D. Marton², A. Mahapatro¹, M. Feldman², D. N. Patel², A. Ayon¹, C. M. Agrawal¹; ¹University of Texas at San Antonio, San Antonio, TX, ²University of Texas Health Science Center at San Antonio, San Antonio, TX.

308

Targeted Drug Delivery with Magnetic Nanoparticles

C. P. Sharma, W. Paul; Sree Chithra Tirunal Institute for Medical Science and Technology, Thiruvananthapuram, INDIA.

310

Cell Growth on Single Wall Carbon Nanotube Fibers

R. A. Dubin¹, G. C. Callegari², J. Kuppler², K. G. Kornev², S. Ruetsch², A. V. Neimark², J. Kohn³; ¹New Jersey Center for Biomaterials, Rutgers University, Piscataway, NJ, ²Center for Modeling and Characterization of Nanoporous Materials, TRI/Princeton University, Princeton, NJ, ³Rutgers University, Piscataway, NJ.

311

PLGA Nanospheres for Delivery of Chondroitinase ABC to the Glial Scar

A. Y. Au¹, P. Garma¹, D. J. Osterhout², D. J. Stelzner², J. M. Hasenwinkel¹; ¹Syracuse University, Syracuse, NY, ²SUNY Upstate Medical University, Syracuse, NY.

312

Nanostructured Biomaterials based on Carbon Nanotubes:Electroactive Support for Cells Regeneration

P. C. C. STEFANIA, Jr.; ECOLE POLYTECHNIQUE OF MONTREAL, MONTREAL, PQ, CANADA.

314

Drug Delivery Using Biodegradable Tyrosine-based Nanospheres

L. Sheihet, R. A. Dubin, D. Devore, J. Kohn; New Jersey Center for Biomaterials, Rutgers University, Piscataway, NJ.

315

Nano-stamped structures for bio-template and MRI applications

N. Farkas¹, R. Aryal¹, E. A. Evans¹, R. D. Ramsier¹, L. V. Ileva², S. T. Fricke², J. A. Dagata³; ¹The University of Akron, Akron, OH, ²Georgetown University, Washington, DC, ³National Institute of Standards and Technology, Gaithersburg, MD.

317

Zinc Phosphate-Insulin-Alginate particles for Oral Insulin Delivery: Feasibility Studies

C. P. Sharma, W. Paul; Sree Chithra Tirunal Institute for Medical Science and Technology, Thiruvananthapuram, INDIA.

318

Increased Osteoblast Adhesion on Nano-structured Anodized CoCrMo

C. Yao, E. Slamovich, T. Webster; Purdue University, West Lafayette, IN.

319

Synthesis and properties of crosslinked recombinant pro-resilin - an insect rubber-like biomaterial

C. M. Elvin¹, J. Werkmeister², J. Ramshaw², M. Kim¹, R. Lyons¹, T. Tebb²; ¹CSIRO Livestock Industries, Brisbane, AUSTRALIA, ²CSIRO Molecular and Health Technologies, Clayton, AUSTRALIA.

320

Utilization of Nanofibrous Polyester Materials as Drug/Protein Release Vehicles

M. D. Phaneuf¹, M. J. Bide², T. M. Phaneuf¹, P. J. Brown³; ¹BioSurfaces, Ashland, MA, ²University of Rhode Island, Kingston, RI, ³Clemson University, Clemson, SC.

321

Degradation Kinetics of Poly(lactide-co-glycolide) Mediated by Titania Nanoparticles

H. Liu, E. B. Slamovich, T. J. Webster; Purdue University, West Lafayette, IN.

322

Enhanced Fibronectin Adsorption on Carbon Nanotubes in Polycarbonate Urethane Composites Directs Osteoblast Adhesion

D. Khang¹, S. Durbin², T. Webster³; ¹Department of Physics, Purdue University, West Lafayette, IN, ²Department of Physcis, Purdue University, West Lafayette, IN, ³Weldon School of Biomedical Engineering and School of Materials Engineering, Purdue University, West Lafayette, IN.

323

Development of Core-Sheath Nanofibers for Soft Tissue Engineering via Co-axial Electrospinning

A. K. Moghe, B. S. Gupta, M. W. King; North Carolina State University, Raleigh, NC.

324

Surface Modification of Plaque-Targeting Nanoparticles Allows for Control of Cell Internalization

A. Mukherjee, J. Pillai, M. A. Ruegsegger; The Ohio State University, Columbus, OH.

325

Multimerizing Peptides Inspired by the Coiled Coil Domain of Fibrin for Constructing Self-Assembled Biomaterials

A. D. Gedra, A. Jain, E. K. Fox, J. H. Collier; University of Cincinnati, Cincinnati, OH.

326

Electrically Conductive Biopolymers Incorporating Carbon Nanotubes

R. A. MacDonald, J. P. Stegemann; Rensselaer Polytechnic Institute, Troy, NY.

327

Stability of Therapeutic Self-Assembled Monolayers During Drug Loading and In-vitro Drug Delivery

G. Mani¹, D. M. Johnson¹, D. Marton², A. Mahapatro¹, M. Feldman², D. N. Patel², A. Ayon¹, C. M. Agrawal¹; ¹University of Texas at San Antonio, San Antonio, TX, ²University of Texas Health Science Center at San Antonio, San Antonio, TX.

328

Tailoring Polymer Surface Nanostructure with Surface Modifying End Groups (SMEs): Using SMEs to Create Polymer Surfaces with Covalently Bonded Self-Assembled Monolayers

R. S. Ward, K. R. McCrea, Y. Tian, J. Parakka; The Polymer Technology Group, Inc., Berkeley, CA, CA.

329

Characterization of Nanoporous Titanium Dioxide Films for Biomedical Applications

A. A. Ayon; University of Texas at San Antonio, San Antonio, TX.

330

Interconnected Biodegradable Polymers in Sub-Micron Precision

R. J. Fasching, W. Ryu, F. Prinz; Stanford University, Stanford, CA.

331

Utilization of Nanoporous Titanium Dioxide Films on Drug-Eluting Stents

A. A. Ayon; University of Texas at San Antonio, San Antonio, TX.

332

Differences between Standard Methods Used to Characterize Particulate Implant Debris

N. J. Hallab, B. Mclachlan, A. Tarabishy, J. J. Jacobs; Rush University Medical Center, Chicago, IL.

334

Improved Nanodimensional Analysis by Morphological Models Generated from Atomic Force Microscope Images

Z. Liu, S. J. Eppell; Case Western Reserve University, Cleveland, OH.

335

Cysteine-containing Polypeptides Allow Control over Various Properties of Biodegradable Multilayer Nanofilms

D. T. Haynie, Y. Zhong; Louisiana Tech University, Ruston, LA.

336

Surface Modification of Nitinol Alloy by Novel Biocompatible Zwitterionic PEG for Peripheral Arterial Stents

D. Han¹, J. Kim¹, K-D. Ahn¹, J-M. Kim²; ¹Korea Institute of Science and Technology, Seoul 130-650, REPUBLIC OF KOREA, ²Hanyang University, Seoul 133-791, REPUBLIC OF KOREA.

337

Fibrous Scaffolds from Elastomeric Biodegradable PLCL for Cardiovascular Tissue Engineering

S. Chung¹, M. W. King¹, S. Kim²; ¹North Carolina State University, Raleigh, NC, ²Korea Institute of Science and Technology, Seoul, REPUBLIC OF KOREA.

338

Novel Electrospun Polycaprolactone Nanofibrous Scaffolds to use for Tissue Engineering

J. M. Gluck, G. Montero, M. W. King, J. P. Hinestroza; North Carolina State University, Raleigh, NC.

339

Biomimetic nanotechnology: conformational behavior of polypeptides

B. LI¹, J. Rozas², D. Haynie³; ¹WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE, MORGANTOWN, WV, ²University of Louisiana, Lafayette, LA, ³Louisiana Tech University, Ruston, LA.

340

A New Bone Tissue Engineering Scaffold for the Release of Biological Molecules

K. -. Jahed, A. El-Ghannam; University of Kentucky, Lexington, KY.

341

NOVEL NANOEMULSIONS FOR IMPROVED ORAL DELIVERY OF HYDROPHOBIC DRUGS

S. Tiwari, M. Amiji; Northeastern University, Boston, MA.

342

A comparative Second-Degree Burn Treatment Trial of Collagen Dressing vs. Silver Sulphadiazine Alone

S. Gunasekaran¹, M. Kwolek², A. Dhanikachalam³, R. P. Narayan⁴; ¹Encoll Corp., Fremont, CA, ²Cosmetic Dermatologist, Danville, CA, ³Head of Plastic Surgery, KMC Hospital, Chennai, INDIA, ⁴Head of Plastic Surgery, Sufdarjung Hospital, New Delhi, INDIA.

343

Ligands Designed for Targeting Nanoparticles Differentiate Normal and Atherosclerotic Tissue

J. Pillai, J. Shapiro, A. Mukherjee, S. C. Lee, M. A. Ruegsegger; The Ohio State University, Columbus, OH.

Cell Response to Micro/nanopatterned Biomaterials

344

Oriented and Interconnected Poly(L-lactic acid) Scaffolds for Guided Tissue Regeneration

S. Ghosh, J. F. Mano, J. C. Viana, R. L. Reis; University of Minho, Guimaraes, PORTUGAL.

345

Tetraglyme Plasma Treatment of Polyethylene Tubing Inhibits Platelet Activation: Flow Cytometry Studies

L. Cao, B. D. Ratner, T. A. Horbett; University of Washington, Seattle, WA.

346

Genomic and Morphological Analysis of Human Neuroblastoma Cell Growth in Three-Dimensional Matrices

C. M. Gourd, E. S. Deweerd, L. L. Livi, G. N. Li, D. Hoffman-Kim; Brown University, Providence, RI.

347

Progress in Processing and Evaluation of Hydroxyapatite Ultra-Thin Film Coatings for Coronary Stents

A. Rajtar¹, G. Kaluza², F. Clubb², M. Lien¹, D. Smith¹, D. Hakimi³, Q. Yang³, M. Tsui³, T. Troczynski³; ¹MIV Therapeteutics Inc, Vancouver, BC, CANADA, ²Texas Heart Institute, Houston, TX, ³University of British Columbia, Vancouver, BC, CANADA.

348

Macrophage Depletion Diminishes UHMWPE Particle- Induced Inflammatory Osteolysis in a Mouse Model

Y. Ding¹, X. Peng¹, B. Wu¹, P. H. Wooley¹, R. Schwendener², W. Ren, Sr.¹; ¹Department of Orthopedic Surgery, Detroit, MI, ²Division of Molecular Cell Biology, Paul Scherrer Institute, SWITZERLAND.

349

Sexual Dimorphism in Osteoblast Response to Surface Microstructure

G. Zhao¹, R. Olivares-Navarrete¹, A. Raines¹, M. A. Duran¹, M. Wieland², B. D. Boyan¹, Z. Schwartz¹; ¹Georgia Institute of Technology, Atlanta, GA, ²Institut Straumann AG, Basel, SWITZERLAND.

350

The Use of Alkanethiols and Circular Dichroism to Monitor Conformational Changes in Adsorbed Proteins

J. Marigliano, R. Latour, Jr., N. Vyavahare; Clemson University, Clemson, SC.

352

In Vivo Performance of Complex 3D Calcium Phosphate Cement Scaffolds

L. Jongpaiboonkit, S. J. Hollister, J. W. Halloran; University of Michigan, Ann Arbor, MI.

353

Quantifying Individual Cell Migration and Contraction Behavior in a Series of Well-Characterized Collagen-Glycosaminoglycan Scaffolds

B. A. Harley, H-D. Kim, M. H. Zaman, I. V. Yannas, L. J. Gibson; Massachusetts Institute of Technology, Cambridge, MA.

354

Excimer Laser Channel Creation in Polyethersulfone Hollow Fibers for Compartmentalized In Vitro Neuronal Culture Models

C. A. Brayfield, K. G. Marra, J. P. Leonard, W. R. Stauffer, X. T. Cui, J. C. Gerlach; University of Pittsburgh, Pittsburgh, PA.

355

Enhancement of Mineralization From Bone Marrow Cells on a Nano-Structured Titanium Surface

E. Hippensteel, X. Yang, S. Vass, P. Li; DePuy Orthopaedics, Warsaw, IN.

356

Rapid prototyping of micropatterned cells by liquid-crystal-display projection method

J. Kobayashi, K. Itoga, M. Yamato, A. Kikucho, T. Okano; Tokyo Women's Medical University, Tokyo, JAPAN.

357

Construction of 3-Dimensional Artificial Tissues by Layer-by-Layer Assembly Technique

Y. Nakahara¹, M. Matsusaki², M. Akashi²; ¹Institute of Biomedical Research and Innovation, Kobe, JAPAN, ²Osaka University, Suita, JAPAN.

358

Cell Morphogenesis and Organization on Electrospun Scaffolds is Guided by Varying Porosity and Fiber Diameter

C. A. Florek¹, P. A. Johnson¹, P. V. Moghe², J. Kohn¹; ¹New Jersey Center for Biomaterials, Rutgers University, Piscataway, NJ, ²Department of Biomedical Engineering, Rutgers University, Piscataway, NJ.

359

In Vivo Cytokine Sampling during the Foreign Body Response

X. Wang¹, D. Loegering², J. Stenken¹; ¹Rensselaer Polytechnic Institute, Troy, NY, ²Albany Medical College, Albany, NY.

360

Nanoporosity of PEOT/PBT Electrospun Scaffolds Enhances Cell Proliferation and Influences Cell Morphology

L. Moroni, R. Licht, J. R. de Wijn, C. A. van Blitterswijk; University of Twente, Utrecht, THE NETHERLANDS.

361

Co-Electrospun Nanofiber Fabrics of Polyester (PLCL) with Type I Collagen or Heparin

I. Kwon¹, T. Matsuda², K. Park¹; ¹Purdue University, West Lafayette, IN, ²Kyushu University, Fukuoka, JAPAN.

362

Identification and Initial Characterization of High Affinity Ligands Binding Specifically to Endothelial Progenitor Cells Using Phage Display Screening

A. N. Veleva¹, C. Patterson², S. Cooper³; ¹North Carolina State University, Raleigh, NC, ²University of Chapel Hill, Chapel Hill, NC, ³Ohio State University, Columbus, OH.

363

Neurite Outgrowth in Response to Micropatterned Molecular Cues and Three Dimensional Matrices

C. M. Gourd, V. J. Fong, D. Hoffman-Kim; Brown University, Providence, RI.

364

Resorption of Biomimetic Apatite by Osteoclasts Cultured From Bone Marrow Cells With and Without Vitamin D

E. Hippensteel, J. Longsworth, W. Tong, P. Li; DePuy Orthopaedics, Warsaw, IN.

365

Quantitative Effects of NGF Encapsulating PLGA Microsphere on Neurite Outgrowth at Single Cell Level

A. J. Sweeney¹, K. Burg¹, M. Kindy², G. Z. Bruce¹; ¹Clemson University, Clemson, SC, ²Medical University of South Carolina, Charleston, SC.

366

Evaluation of Microcarrier Formulations for Propagation of Osteoblasts and Chondrocytes

P. Phan¹, M. Grzanna¹, A. Polotsky¹, A. Shikani², D. S. Hungerford¹, C. G. Frondoza¹; ¹Johns Hopkins University, Dept of Othopaedic Surgery, Baltimore, MD, ²Johns Hopkins University, Dept of Otolaryngology, Baltimore, MD.

367

In Vitro Evaluation of Electrospun Nanofiber Conduits for Vascular Substitutes

S. Lee, J. Yoo, G. Lim, A. Atala, J. Stitzel; Wake Forest University School of Medicine, Winston Salem, NC.

368

The effect of substrate topography on the proliferation and morphology of chondrocytes

J. Nam, Y. Huang, M. Anghelina, S. Agarwal, J. Lannutti; The Ohio State University, Columbus, OH.

369

Micromolding of photocrosslinkable hyaluronic acid for cell encapsulation and entrapment

A. Khademhosseini¹, G. Eng², J. Yeh², J. Fukuda², J. Blumling III², J. Karp², R. Langer², J. Burdick³; ¹Harvard-MIT, Cambridge, MA, ²MIT, Cambridge, MA, ³University of Pennsylvania, Philadelphia, PA.

370

Mechanism of Bone Formation and Guided Tissue Growth at the Interface with Resorbable Bioactive Implant

A. El-Ghannam, C. Ning; University of Kentucky, Lexington, KY.

371

Histological and Immunohistochemical Study of Biopsies Sampled after Sinus Floor Augmentation Using Tricalcium Phosphate Particles with Varying Porosity

C. Knabe¹, C. Koch¹, A. Rack², M. Stiller¹; ¹Charite University Medical Center, Berlin, GERMANY, ²Helmholtz Research Center, Karlsruhe, GERMANY.

372

Electrospun Acrylic Terpolymer Nanofibers for Engineered Vascular Replacements

A. N. Veleva¹, J. Johnson², D. Heath², C. Patterson³, S. Cooper², J. Lannutti²; ¹North Carolina State University, Raleigh, NC, ²Ohio State University, Columbus, OH, ³University of Chapel Hill, Chappel Hill, NC.

374

In-Vivo evaluation of nano-coated calcium phosphate scaffolds for bone regeneration

S. Oh¹, N. Oh², H. Yoon¹, Y. Yang¹, M. Appleford¹, J. Bumgardner³, W. Haggard³, J. Ong¹; ¹University of Tennessee, Memphis, TN, ²Inha University, Incheon, REPUBLIC OF KOREA, ³University of Memphis, Memphis, TN.

375

Control of Cell-Matrix Interactions on Fibrin Bi-layers and Micro-Patterned Surfaces

H. Wang¹, B. Ratner¹, H. Sage², S. Jiang¹; ¹University of Washington, Seattle, WA, ²Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, WA.

376

Oriented Pore Scaffolds from an Elastase-Sensitive, Biodegradable Elastomer to Achieve Mechanical Anisotropy and Improved Cellularization

J. Guan, W. R. Wagner; Univeristy of Pittsburgh, Pittsburgh, PA.

377

Capillary Flow Networks in Collagen-Based Scaffolds for Microvascularized Tissue-Engineered Products

V. Janakiraman, B. L. Kienitz, H. Baskaran; Case Western Reserve University, Cleveland, OH.

378

Controlled chemical oxidation of titanium creates a nanotopography that enhances in vitro osteogenesis

A. Nanci¹, d. Paulo², A. Rosa², S. Zalzal¹, L. Richert¹, J-H. Yi¹, J. Wuest³, F. Rosei⁴; ¹Laboratoire de recherche sur les tissus calcifiés et les biomatériaux, Montreal, PQ, CANADA, ²University of Sao Paulo, Ribeirao Preto, BRAZIL, ³Université de Montréal, Montreal, PQ, CANADA, ⁴INRS-EMT, Varennnes, PQ, CANADA.

379

Porogen-induced Surface Modification of Nano-fibrous Poly(L-lactic acid) Scaffolds for Bone Tissue Engineering

X. Liu, Y. Won, P. X. Ma; University of Michigan, Ann Arbor, MI.

380

Effects of Nanoscale Pore Size and Microscale Particle Size on Diffusion of Proteinase K out of Sol-Gel Silica

W. Dong, W. Lin, Y. Lin, D. Elmatari, N. Contreras, S. Vo, M. Torres; Cal Poly Pomona, Pomona, CA.

381

Mechanisms of Enhanced Functions of Osteoblasts on Undoped and Yttrium-doped Nanocrystalline Hydroxyapatite

M. Sato¹, M. A. Sambito², A. Aslani², N. M. Kalkhoran², E. B. Slamovich¹, T. J. Webster¹; ¹Purdue University, West Lafayette, IN, ²Spire Biomedical, Inc., Bedford, MA.

382

Layer-by-Layer Assembled Titanium Dioxide Thin Films for Bone Tissue Engineering

S. M. Sriram; Louisiana Tech University, Ruston, LA.

383

AFM Investigation of Fibroblast-Fibroblast Interactions on Collagen Substrates

D. Dean¹, R. Gourdie², T. Borg³, L. Dooley¹, B. Z. Gao¹; ¹Clemson University, Clemson, SC, ²Medical University of South Carolina, Charleston, SC, ³University of South Carolina Medical School, Charleston, SC.

384

Manipulating protein structure and distribution on surfaces to control endothelial cell behavior

L. Liu¹, T. Chao¹, B. D. Ratner¹, H. Sage², S. Jiang¹; ¹University of Washington, Seattle, WA, ²Benaroya Research Institute at Virginia Mason, Seattle, WA.

385

Modulation of osteoblast-like cells, MG-63, on polyelectrolyte multilayer films

W-B. Tsai, S. Tan; National Taiwan University, Taipei, TAIWAN REPUBLIC OF CHINA.

386

The effect of combined hypergravity and microgrooved surface topography on the behavior of fibroblasts

W. Loesberg; Radboud University Nijmegen, Nijmegen, THE NETHERLANDS.

387

Quantitative Assessment of Continuous Infusion of Submicron-Sized Particles

S. G. Ortiz; Stanford Medical School, Stanford, CA.

388

Adsorption-Induced Changes in Protein Bioactivity Correlated with Adsorbed Protein Orientation and Conformation

K. Fears, R. A. Latour; Clemson University, Clemson, SC.

389

Hydrogels from chemically modified PVA with chondroitine sulfate: chemical characterization and biocompatibility

E. C. Muniz, Sr.; Universidade Estadual de Maringá, Maringá, BRAZIL.

390

Epithelial Cell Response to a Chemically Modified, Flexible Substrate, Presenting Nanoscale Topographic Features

T. J. Porri, K. Mallon, J. A. Dumesic, C. J. Murphy, P. F. Nealey; University of Wisconsin-Madison, Madison, WI.

391

Mineralization from Bone Marrow Cells on a Biomimetic Nano-crystalline Apatite Coating: An SEM Study

X. Yang, E. Hippensteel, P. Li; DePuy Orthopaedics, Inc, Warsaw, IN.

392

Generation of Laminin Micropatterns on Biocompatible Substrates Using Microscale Plasma-Initiated Patterning

B. Langowski, K. E. Uhrich; Rutgers University, Piscataway, NJ.

393

3D Multi-layered Micro-fabricated Tissue Scaffolds of Biodegradable Polymers

W. Ryu, S. Min, R. J. Fasching, F. B. Prinz; Stanford University, Stanford, CA.

394

U937 Macrophage Adhesion and TNF-α and IL-1β mRNA Expression on Gelatin-Based Interpenetrating Network (IPN) Grafted With PEGylated Fibronectin (FN)-Derived Peptides

Q. Gao¹, A. Gustafson¹, W. Kao²; ¹School of Pharmacy, University of Wisconsin-Madison, Madison, WI, ²School of Pharmacy, Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI.

395

Controlling Protein Adsorption and Bone Cells Response to PDLLA by a Gas Plasma Surface Treatment

C. M. Alves¹, Y. Yang², D. Carnes², J. Ong², V. Sylvia², D. Dean², R. Reis¹, C. Agrawal²; ¹3B's Research Group - University of Minho, Braga, PORTUGAL, ²Center for Clinical Bioengineering, UTHSCSA, San Antonio, TX.

Cellular Signal Transduction Symposium

397

Polycarbonate-based Polyurethanes Stimulate Reactive Oxygen Species Production in Macrophages

J. E. McBane¹, J. P. Santerre², R. S. Labow¹; ¹University of Ottawa Heart Institute, Ottawa, ON, CANADA, ²University Toronto, Toronto, ON, CANADA.

398

Effects of Local Infusion of Osteogenic Protein-1 on NSAID-Mediated Bone Formation in vivo

S. Goodman¹, E. Nelson¹, M. Chang¹, T. Ma¹, T. mawatari¹, K. J. Oh², M. Larsen¹, R. L. Smith¹; ¹Stanford University, Stanford, CA, ²Konkuk University, Seoul, REPUBLIC OF KOREA.

399

Studies on the signalling of oxidative stress induced by metallic corrosion products in human endothelial cells in vitro

K. Peters, R. Tsaryk, R. E. Unger, M. Fischer, C. Kirkpatrick; Institute of Pathology, Mainz, GERMANY.

400

Inhibitory effect of zinc ions in zinc-containing β-tricalcium phosphate on function of matured osteoclasts

Y. Yamada¹, A. Ito², H. Kojima², M. Sakane³, S. Miyakawa³, R. Z. LeGros⁴, T. Uemura²; ¹Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, JAPAN, ²AIST(National Institute of Advanced Industrial Science and Technology), Tsukuba Ibaraki, JAPAN, ³Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba Ibaraki, JAPAN, ⁴New York University, New York, NY.

401

Material surfaces affect the protein expression patterns of human macrophages: a proteomics approach

D. M. Dinnes¹, H. Marcal², S. M. Mahler³, J. P. Santerre⁴, R. S. Labow¹; ¹University of Ottawa Heart Institute, Ottawa, ON, CANADA, ²Graduate School of Biomedical Engineering, University of New South Wales, Sydney, AUSTRALIA, ³Bioengineering Centre, University of New South Wales, Sydney, AUSTRALIA, ⁴Faculty of Dentistry, Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, CANADA.

402

Effect of various surface adsorbed proteins and phosphorylation inhibitor AG18 upon intracellular signaling proteins in adherent U937 cells identified by LC/MS

S. T. Zuckerman, W. J. Kao; University of Wisconsin-Madison, Madison, WI.

403

Measuring the Biologic Reactivity of Implant Debris Using In Vitro Cellular Reactivity Correlated with In Vivo Serum Biomarkers

M. Caicedo, S. Anderson, A. Reddy, J. J. Jacobs, N. J. Hallab; Rush University Medical Center, Chicago, IL.

404

Effect of Surface Chemistry on Dendritic Cell Responses and Profile of Carbohydrates Associated with Adsorbed Proteins

S. Shankar¹, B. Keselowsky¹, R. Cornelius², J. Brash², A. Garcia¹, J. Babensee¹; ¹Georgia Institute of Technology, Atlanta, GA, ²McMaster University, Hamilton, ON, CANADA.

405

Promotion of neurite outgrowth on multi-molecular gradients by modulating downstream Rho pathways

E. S. Deweerd; Brown University, Providence, RI.

406

Measurement of Cytokines Collected from Lipopolysaccharide-Stimulated Monocytes

R. J. Schutte, D. Wang, W. Reichert; Duke University, Durham, NC.

407

Effects of Heparin on MC3T3-E1 Osteoblast-like Cell Behavior

T. Jiang, C. T. Laurencin; University of Virginia, Charlottesville, VA.

408

Effects of Simulated Microgravity on Human Osteoblast Behavior: A Proteomics Study

H. L. Nichols¹, N. Zhang¹, S. Holton², X. Wen¹; ¹Clemson University, Charleston, SC, ²University of South Carolina, Columbia, SC.

409

Fibronectin-mimetic Surfaces Directing α₅ß ₁ Integrin-Mediated Adhesion, Signaling, and Proliferation

T. A. Petrie, J. R. Capadona, A. J. Garcia; Georgia Institute of Technology, Atlanta, GA.

410

Effect of Changing Surface Hydrophobicity Alters Protein Expression and Cellular Dynamics

I. S. Miller¹, S. C. Penney¹, D. P. O'Connor¹, I. Lynch², K. Dawson², W. M. Gallagher¹; ¹UCD School of Biomolecular and Biomedical Science, Conway Insitiute of Biomolecular and Biomedical Research, Dublin, IRELAND, ²Centre for Colloid Science and Biomaterials, School of Chemistry and Chemical Biology, University College Dublin, Ireland, Dublin, IRELAND.

411

Influence of Smooth Muscle Cell Phenotype on Endothelial Cell Response to Biomaterial-Pretreated Leukocytes in an EC/SMC Co-Culture Model

S. Rose, J. Babensee; Georgia Institute of Technology, Atlanta, GA.

412

In Vitro Metal-Reactivity Is Associated With In Vivo Metal-Specific Antibodies (IgG) In Individuals with Metal Implants

M. S. Caicedo, A. Reddy, S. Anderson, J. J. Jacobs, N. J. Hallab; Rush University Medical Center, Chicago, IL.

413

Enhanced ECM regeneration in Mechano-active vascular tissue engineering

Y. KIM¹, J. LIM², S-H. KIM², S. KIM²; ¹Gwangju Inst Sci Tech (GIST), Gwangju, REPUBLIC OF KOREA, ²Korea Inst Sci Tech (KIST), Seoul, REPUBLIC OF KOREA.

414

Characterization of Single lumen and Multi-channel Poly(-capro-lactone-fumarate)(PCLF) for Experimental Nerve and Spinal Cord Repair

I. A. Onyeneho, G. C. W. de Ruiter, S. Wang, L. Lu, J. Gruetzmacher, R. J. Spinner, B. Currier, A. J. Windebank, M. J. Yaszemski; Mayo Clinic College of Medicine, Rochester, MN.

415

Adjuvant-like Activity of Silicone Breast Implants against Extracellular Matrix Molecules

R. C. de Guzman, P. H. Wooley, P. J. VandeVord; Wayne State University, Detroit, MI.

416

Biological reponse of calcium phosphate ceramics synthesized by using recycled eggshell

N. Oh¹, S. Song¹, J. Choi¹, S. Oh², S. Lee³, M. Lee⁴; ¹Inha University, Incheon, REPUBLIC OF KOREA, ²University of Tennessee, Memphis, TN, ³Mokpo National University, Mokpo, REPUBLIC OF KOREA, ⁴Korea Institute of Ceramic Eng.&Tech., Seoul, REPUBLIC OF KOREA.

417

Investigation of the Wound Healing Processes in the Region Adjacent to an Implanted Biosensor by Application of Electrical Impedance Spectroscopy

F. B. Karp¹, T. Valdes², K. Böhringer¹, B. Ratner¹; ¹University of Washington, Seattle, WA, ²University of Connecticut Health Center, Farmington, CT.

418

Poly(propylene fumarate)-co-Poly(ε-caprolactone) Tube for Guided Nerve Regeneration

S. Wang, G. C. W. de Ruiter, A. M. Knight, L. Lu, R. J. Spinner, B. L. Currier, A. J. Windebank, M. J. Yaszemski; Mayo Clinic, Rochester, MN.

419

Evaluation of biological tissue response of b-TCP bone substitute in high molecular sodium hyaluronate matrix in sheep for improved handling properties

Y. Bruderer¹, T. Stoll¹, P. Schupbach²; ¹Synthes, Oberdorf, SWITZERLAND, ²Peter Schüpbach GmbH, Mikroskopische Analysen, Horgen, SWITZERLAND.

420

Neurotoxicity Screening Test for Deep Brain Stimulation Leads

S. M. Hooper; Advanced Neuromodulation Systems, Inc., Plano, TX.

421

Peripheral Nerve Regeneration by a Novel Microporous PLGA/Pluronic Nerve Guide Conduit

S. Oh¹, J. Kim¹, S. Ghil², J. Yoon¹, K. Song³, B. Jeon³, I. Lee⁴, J. Lee¹; ¹Hannam University, Daejeon, REPUBLIC OF KOREA, ²Kyonggi University, Suwon, REPUBLIC OF KOREA, ³Chungnam National University Hospital, Daejeon, REPUBLIC OF KOREA, ⁴Catholic University Hospital, Daejeon, REPUBLIC OF KOREA.

Clinical Relevance of Stent Fractures, Cause, Effect, and Improved Designs

422

Biopolymer-Hydroxyapatite Matrix Composite Coatings for Stents

Q. Yang¹, M. Tsui¹, M. Lien², D. Smith², A. Rajtar², T. Troczynski¹; ¹The University of British Columbia, Vancouver, BC, CANADA, ²MIV Therapeteutics Inc, Vancouver, BC, CANADA.

423

Curcumin-loaded bioresorbable stents based on internally coiled helix designs

A. Dasnurkar; University of Texas Southwestern Medical School, Dallas, TX.

Fibrin Sealant and its Application in Tissue Engineering

424

Recombinant fibrinogen synthesis: transient transfection CHO cells in suspension

L. Yang; Laboratory for Regenerative Medicine and Pharmacobiology, Lausanne, SWITZERLAND.

425

Optimisation of a Fibrin Scaffold for Sustained Release of an Adenoviral Gene Vector

A. M. Breen¹, P. Strappe², T. H. Barker³, J. A. Hubbell³, T. O'Brien², A. S. Pandit¹; ¹National Centre for Biomedical Engineering and Science, Galway, IRELAND, ²Regenerative Medicine Institute, Galway, IRELAND, ³Ecole Polytechnique Federale de Lausanne, Lausanne, SWITZERLAND.

426

DNA Ligands for Integrating Biointeractive Materials

R. Mittal, N. R. Washburn, K. L. Robertson, B. A. Armitage; Carnegie Mellon University, Pittsburgh, PA.

427

Use of Radiochemically Sterilized, Absorbable Tissue Adhesive for Cat and Dog Lung Repair

S. W. Shalaby¹, D. Nickelson², M. A. Vaughn¹, T. Kennedy², P. L. Tate¹; ¹Poly-Med, Inc., Anderson, SC, ²Veterinary Products Laboratories, Phoenix, AZ.

428

Sustained Release of Transforming Growth Factor-Beta 1 from PEGylated Fibrin Gels

C. T. Drinnan¹, G. Zhang², J. Zhang², L. J. Suggs¹; ¹University of Texas at Austin, Austin, TX, ²University of Minnesota, Minneapolis, MN.

429

Plasminogen Free Fibrin Sealant

A. J. Gorman; Ethicon Inc, Somerville, NJ.

430

MAP Cell Binding Domain to Attach R28 Retinal Stem Cells to RCS Eyecups Over Time

M. P. Olivieri, M. I. Hurley, L. Trawally, R. Quarshie, C. Gurita; D'Youville College, Buffalo, NY.

432

Evaluation of Chitosan/β-TCP/Platelet-Rich Plasma Microspheres to Bone Repairing Materials

S-M. Kuo¹, T. Wang¹, L-C. Lin², S. Chang¹; ¹Department of Biomedical Engneering, Kaohsiung County, TAIWAN REPUBLIC OF CHINA, ²Orthopedic Department of Veteran General Hospital, Kaohsiung, TAIWAN REPUBLIC OF CHINA.

433

Use of Radiochemically Sterilized, Absorbable Tissue Adhesive for Rabbit Kidney Repair

P. L. Tate, B. L. Anneaux, M. A. Vaughn, S. W. Shalaby; Poly-Med, Inc., Anderson, SC.

Mechanobiology of Skin and Bone

434

Synthesis and Characterization of Injectable Bioreponsive Hydrogels for Soft Tissue Replacement

J. D. Thomas¹, M. Marcolongo¹, G. W. Fussell², A. M. Lowman¹; ¹Drexel University, Philadelphia, PA, ²Synthes-Spine, West Chester, PA.

435

Mechanical Properties of Cell Seeded Porous Hydroxyapatite Scaffolds

M. Appleford¹, S. Oh¹, Y. Yang¹, J. Bumgardner², W. Haggard², J. L. Ong¹; ¹University of Tennessee Health Science Center, Memphis, TN, ²University of Memphis, Memphis, TN.

436

Effect of Human Fibroblasts Over the Osteoblastic Activity of Human Osteoblastic-like Cells: Role for Cell-Cell Interactions

R. P. Pirraco, A. P. Marques, R. L. Reis; 3B's Research Group, Braga, PORTUGAL.

437

Cyclic mechanical strain regulates secretion of angiogenic cytokines

Y. Yung; Harvard University, Cambridge, MA.

438

EDC Crosslinking Increases Cultured Skin Substitute Stability and Strength

H. M. Powell, S. T. Boyce; Shriners Hospital for Children, Cincinnati, OH.

439

Y. Yuan¹, L. D. T. Topoleski¹, W. J. Mergner², L. Li³; ¹UMBC, Baltimore, MD, ²Univ. Maryland, Baltimore, Baltimore, MD, ³Office of the State Medical Examiner, Baltimore, MD.

440

The Effect of Surfactant Treatments on the Mechanical and Delamination Behavior of Human Stratum Corneum

K. Levi¹, K. S. Wu¹, K. P. Ananthapadmanabhan², R. H. Dauskardt¹; ¹Stanford University, Stanford, CA, ²Unilever Research and Development, Trumbull, CT.

441

Synthesis and Evaluation of Isopropyl Alcohol-Miscible Copolymers as Sprayable Skin Protective Barriers

J. M. Lindsey, III¹, M. Shalaby², S. W. Shalaby¹; ¹Poly-Med, Inc., Anderson, SC, ²Lehigh Valley Hospital, Allentown, PA.

442

Effect of Hyaluronic Acid Molecular Weight on the Rheology of Synovial Fluid Analogues

H. Fam, J. Lian, M. Kontopoulou, J. T. Bryant; Queen's University, Kingston, ON, CANADA.

443

Extracellular Matrix Molecules Enhance Allograft Skin Viability

K. L. Fitzpatrick¹, Y-I. Yang², K. R. Kirker¹, M. Massey³, J. Shelby¹; ¹Bacterin International, Inc., Belgrade, MT, ²School of Medicine, Inje University, Gae-Kum-dong, Pusan-Jin-gu, Pusan, REPUBLIC OF KOREA, ³Department of Surgery, University of Utah, Salt Lake City, UT.

444

Biodegradable polyurethane scaffolds for tissue engineering

S. Gogolewski¹, K. Gorna¹, E. Zaczynska², B. Zywicka³, A. Czarny²; ¹Polymer Research, AO Research Institute, Davos, SWITZERLAND, ²Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, POLAND, ³Institute of Experimental Surgery and Biomaterials Research, Medical University, Wroclaw, POLAND.

445

Lattice Architecture of the Cholecyst Derived Extracellular Matrix dictates an Integrative Tissue Response

A. Pandit, K. Burugapalli; National University of Ireland, Galway, Galway, IRELAND.

446

Development of Functional Nucleic Acid Aptamers for Inhibition of Cytokines Activity

S. Sun; Carnegie Mellon University, Pittsburgh, PA.

447

Influence of NaF and CaO Addition on Mechanical Properties of Tricalcium Phosphates

Z. M. Seeley; Washington State University, Pullman, WA.

448

The Potential for Reuse of Ilizarov Composite Half-Rings

A. Hahn, K. Golovin, A. S. Litsky; Ohio State Univeristy, Columbus, OH.

449

Mechanical properties of injectable calcium phosphate cement incorporated with PLGA microparticles

D. P. Link, J. van den Dolder, W. J. Jurgens, J. G. Wolke, J. A. Jansen; Radboud University Nijmegen, Nijmegen, THE NETHERLANDS.

450

Mechanical Properties upon Curing of Orthopaedic Composites

B. E. Carroll, T. D. Clineff, E. M. Erbe; Orthovita, Inc., Malvern, PA.

451

Bimodal porosity in bone scaffold materials: dual function of enhancing both biological function and fracture energy?

M. J. Baumann, I. O. Smith, E. D. Case; Michigan State University, East Lansing, MI.

452

Compartmentalized Bioreactor for Long-term Culture of Bone Cells

R. Dhurjati, E. Vogler; Penn State University, University Park, PA.

Modeling Bioresponse to Biomaterials

453

Rat Root Apical Bone Resorption Model: A New Aseptic Loosening Model

X. Peng, Jr., W. Ren, Sr., B. Wu, Jr., L. Mao, Jr., J. Hua, Sr., P. H. Wooley, Sr.; Wayne State University School of Medicine, Detroit, MI.

454

Bone Analog Development for Orthopaedic Device Evaluation

K. L. Calvert¹, L. A. Kirkpatrick², K. P. Trumble¹, T. J. Webster¹; ¹Purdue University, West Lafayette, IN, ²Zimmer, Inc., Warsaw, IN.

455

Comparison Between Force Field-Based Implicit Solvent Models and DFT/SCRF for Protein-Surface Interactions

Y. Sun, R. A. Latour; Clemson University, Clemson, SC.

456

Long Term Inlay Mobility In A Mobile Bearing Total Knee Replacement

M. Muenchinger¹, A. Franz², C. Reinschmidt¹; ¹Zimmer GmbH, Winterthur, SWITZERLAND, ²St. Marienkrankenhaus, Siegen, GERMANY.

457

Identifying In-Vivo Prosthetic Wear Debris Using Spectroscopic Techniques

M. W. Kovacik¹, J. D. Ehrman², E. T. Bender², N. Stojilovic², R. D. Ramsier²; ¹Summa Health System Hospitals, Akron, OH, ²The University of Akron, Akron, OH.

458

Molecular Modeling and Computational Study of Tyrosine-Derived Polyarylates

L. M. Valenzuela¹, A. Gubskaya², J. Kohn¹, D. Knight²; ¹New Jersey Center for Biomaterials, Rutgers University, Piscataway, NJ, ²Dept. of Mechanical & Aerospace Engineering, Rutgers University, Piscataway, NJ.

459

Molecular Simulation Study of Nanoscale Friction between Phosphocholine Self-Assembled Monolayer Surfaces Immersed in Aqueous Solution

Y. He; University of Washington, Seattle, WA.

460

The Biomaterials Store

D. Pulavarthi¹, D. Knight¹, J. Kohn²; ¹Rutgers-The State University of New Jersey, piscataway, NJ, ²Rutgers-The State University of New Jersey and NJ center for Biomaterials, piscataway, NJ.

461

Adaptive Umbrella Sampling Algorithm for the Calculation of Peptide/Surface Adsorption Free Energy

F. Wang, D. Y. Sun, S. J. Stuart, R. A. Latour, Jr.; Clemson University, Clemson, SC.

462

A Capacitive Immunosensor for Atrazine-Detection

C. Schröder¹, S. Braschoß¹, H. Schubert¹, U. Gross²; ¹TU Berlin, Berlin, GERMANY, ²Freie Universität Berlin, Berlin, GERMANY.

New Concepts and Challenges for the Delivery of Therapeutic Nucleic Acids Symposium

463

pH-Responsive Copolymers for Intracellular Drug Delivery

S. M. Henry, C. M. Pirie, M. E. H. El-Sayed, P. S. Stayton, A. S. Hoffman; University of Washington, Seattle, WA.

465

Biomaterial-Mediated Retroviral Gene Transfer Using Self-Assembled Monolayers

C. A. Gersbach, J. M. Le Doux, A. J. Garcia; Georgia Institute of Technology, Atlanta, GA.

466

Degradable PEG Nanogels for Cytosol-specific Release of Plasmid DNA

T. Park; KAIST, Daejeon, REPUBLIC OF KOREA.

467

PEGylated Nano-hybrid Adenovirus: Retargeting Adenovirus to Tumor Cells

T. Park; KAIST, Daejeon, REPUBLIC OF KOREA.

468

Nanoparticles for Hepatocyte-targeted Delivery

J. M. Bergen, H. A. von Recum, T. T. Goodman, A. P. Massey, S. H. Pun; University of Washington, Seattle, WA.

469

Relationship between the gene transfer efficacy and the facilitated disassembly of polyplexes composed of self-assembling amphiphilic polycations

T. Yamaoka¹, T. Kitagawa², K. Ishihara³, A. Mahara¹, A. Murakami², A. Kishida⁴; ¹National Cardiovascular Center Research Institute, Suita, JAPAN, ²Kyoto Institute of Technology, Kyoto, JAPAN, ³The University of Tokyo, Tokyo, JAPAN, ⁴Tokyo Medical and Dental University, Tokyo, JAPAN.

470

Freeze-drying Differentially Influcences the Transfection Efficiency of Polyethylenimine-DNA Condensates

L. Hahn; Harvard University, Cambridge, MA.

471

Major Histocomptability Complex (MHC) Class II-Directed Oligodeoxynucleotide Delivery in Dendritic Cells

J. R. Kovacs¹, Y. Zheng¹, L. Jia¹, E. S. Gawalt¹, H. Shen², W. S. Meng¹; ¹Duquesne University, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA.

472

Potential of Palmitic-Acid Modified Polyethylenimine (PEI) and Poly-L-Lysine (PLL) to Transfer Plasmid DNA into Bone Marrow Stromal Cells (BMSC)

H. Uludag¹, E. Tunis¹, V. Incani¹, C. Kucharski¹, B. Acan¹, A. Lavasanifar¹, Y. Li¹, A. Ghahary²; ¹University of Alberta, Edmonton, AB, CANADA, ²University of British Columbia, Vancouver, BC, CANADA.

473

Cell Binding and Cytotoxicity of Palmitic-Acid Modified Polyethylenimine (PEI) and Poly-L-lysine (PLL) on Bone Marrow Stromal Cells (BMSC)

V. Incani, C. Olson, E. Tunis, C. Kucharski, H. Uludag; University of Alberta, Edmonton, AB, CANADA.

474

Magnetic Nanobeads for the Delivery of Therapeautic Nucleic Acids to the Heart

W. Li; University of Rostock, Rostock, GERMANY.

Ophthalmic Drug Delivery

475

Dendrimer crosslinked collagen hydrogels modified with YIGSR peptide and their effects on cellular behaviors of human corneal epithelial cell line and nerve regeneration

D. Duan; McMaster University, Hamilton, ON, CANADA.

476

Quantification of doxorubicin concentration in rat tissues using polymeric micelles in ultrasonic-drug delivery

B. J. Staples, B. Roeder, W. G. Pitt; Brigham Young University, Provo, UT.

Organic/Inorganic Hybrid Biomaterials Symposium

477

Bioreactivity Responses to Bone Cement Are Dose Dependent

N. J. Hallab, S. Anderson, A. Reddy, M. Caicedo, J. J. Jacobs; Rush University Medical Center, Chicago, IL.

479

Bone induction by equine COLLOSS® E-filled titanium scaffolding material

X. Walboomers, M. E. L. Nienhuijs, M. A. W. Merkx, P. J. W. Stoelinga, J. A. Jansen; Radboud University Nijmegen Medical Center, Nijmegen, THE NETHERLANDS.

480

Preparation of hydroxyapatite/gelatine scaffolds crosslinke by Glutaraldehyde

m. kazemzadeh narbat; Materials and Energy Research Center, karaj, IRAN (ISLAMIC REPUBLIC OF).

481

The Effects Of Amino Acid Binders On Proliferation And Viability Of Fibroblast Cells

M. A. Tucci, H. A. Benghuzzi; University of Mississippi Medical Center, Jackson, MS.

482

Cytokine Expression after Endovascular Embolization of Experimental Aneurysms

G. M. Cruise¹, D. L. Elbert², J. C. Shum¹; ¹MicroVention, Inc., Aliso Viejo, CA, ²Washington University in St. Louis, St. Louis, MO.

483

Study on in vitro biocompatibility of PHBV/Wollastonite composites

J. Chang, H. Li, W. Zhai; Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, CHINA.

484

Structure/Property Relationships in Urethane Dimethacrylate-based ACP Composites

W. F. Regnault¹, T. B. Icenogle¹, J. M. Antonucci², D-W. Liu², D. Skrtic³; ¹Food and Drug Administration, Rockville, MD, ²National Institute of Standards and Technology, Gaithersburg, MD, ³American Dental Association Foundation, Gaithersburg, MD.

485

Interfacial Bonding and Mechanical Properties of Polyurethane Composites under Wet Conditions

S. Lyu, J. Schley, C. Hobot, R. Sparer; Medtronic Inc, Minneapolis, MN.

486

Enhanced Strength Retention of Bioresorbable Implants Sterilized by Ethylene Oxide (ETO)

A. J. McManus, R. C. Moser, R. B. Dabkowski, K. A. Thomas; MacroPore Biosurgery, San Diego, CA.

487

Bioresorbable Radiopaque Markers for Visualization of Resorbable Polymer Spinal Implants

K. A. Thomas; MacroPore Biosurgery, San Diego, CA.

488

Preparation of Biodegradable PHBV and Lignosulfonate Composite by Reactive Extrusion and Their Mechanical and Morphological Characterization

N. Durán, Sr.; Universidade Estadual de Campinas, Campinas, BRAZIL.

489

Osteoblast Response to Bioactive Borate Glass Surfaces for Titanium

R. F. Brown, T. King, L. Peddi, R. K. Brow; University of Missouri-Rolla, Rolla, MO.

490

Protein adsorption of sol-gel derived bioactive glasses/collagen composite scaffolds

J. Chang¹, W. Xia¹, J. Zhong²; ¹Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, CHINA, ²NovaBone Products, LLC, Alachua, FL.

491

In Situ Crosslinkable Bioresorbable Poly(Lactide Fumarate) Scaffolds for Guided Bone Regeneration

E. Jabbari; University of South Carolina, Columbia, SC.

492

Increase of cell adhesiveness on poly(ethylene terephthalate) fabric by coating of sintered hydroxyapatite nanocrystals

M. Masuda¹, M. Okada¹, S. Yasuda¹, H. Kadono¹, R. Tanaka², K. MIyatake³, T. Furuzono¹; ¹Department of Biomedical Engineering, National Cardiovascular Center Research Institute, Suita/city.Osaka, JAPAN, ²National Cardiovascular Center, Suita/city.Osaka, JAPAN, ³National Hospital Organization Osaka Minami Medical Center, Kawachinagano/city.Osaka, JAPAN.

493

Biocompatibility and Biodegradation of NovoSorb^TM Biodegradable Polyurethanes

P. A. Gunatillake¹, R. Adhikari¹, R. T. A. Mayadunne¹, S. Houshyar¹, L. Hanu¹, J. Field¹, M. McGee¹, M. McGee¹, J. Werkmeister², D. Menzis¹, T. Moore², I. Griffiths¹; ¹PolyNovo Biomaterials, Clayton South, AUSTRALIA, ²CSIRO Molecualr & Health Technologies, Clayton South, AUSTRALIA.

494

Biodegradable NovoSorb^TM Polymers: Structure/Property Relationships & In-vitro/In-vivo Degradation

R. T. A. Mayadunne¹, P. A. Gunatillake¹, R. Adhikari¹, I. M. Griffiths¹, J. R. Field², S. Houshyar¹, L. Hanu¹, D. Menzis¹, T. Moore¹, P. Johnston¹, L. Tatai¹, M. Wickramarathna¹; ¹PolyNovo Biomaterials Pty. Ltd., Clayton Sout MDC, Victoria, AUSTRALIA, ²Flinders University, Adelaide, AUSTRALIA.

495

COLLAGEN-HYDROXYAPATITE MEMBRANES FOR GUIDED BONE REGENERATION

J. H. Song¹, B. H. Yoon¹, S. H. Lee¹, I. K. Jun¹, H. E. Kim¹, H. W. Kim²; ¹Seoul National University, Seoul, REPUBLIC OF KOREA, ²Dankook University, Cheonan, REPUBLIC OF KOREA.

496

In Vitro Biodegradation of Fibroin Woven Scaffolds for Anterior Cruciate Ligament

A. Alessandrino¹, A. Boschi², M. Colombo¹, S. Fare¹, M. C. Tanzi¹, G. Freddi²; ¹Politecnico di Milano, Milan, ITALY, ²Silk Experimental Station, Milan, ITALY.

497

Copolymers from L-Lactide and PEG as Fast Resorbing Polymers with High Mechanical Strength

A. Enderle; Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, GERMANY.

498

Bone Matrix and Demineralized Bone Matrix Incorporated PLGA Matrices for Long-term Bone Repair and Bone Tissue Engineering

A. C. Jayasuriya; Medical University of Ohio at Toledo, Toledo, OH.

499

Effect of Porosity and Pore Size on Microstructures and Mechanical Properties of Poly-ε-Caprolactone (PCL)-Hydroxyapatite (HA) Composites

H. Yu, S-Y. Yang, H. W. Matthew, C. D. Huber, P. H. Wooley; Wayne State University, Detroit, MI.

500

Biostability of Materials for an Implanted Drug Delivery Device

S. Lipka, J. Maloney; MicroCHIPS, Inc., Bedford, MA.

502

Comparison of Glycosaminoglycan-Targeted Fixation Chemistries and their Effects on Bioprosthetic Heart Valve Cuspal Tissue

J. Mercuri, S. Shah, E. Pardue, J. Isenburg, D. Simionescu, N. Vyavahare; Clemson University, Clemson, SC.

503

Two Photon Induced Polymerization of Organic/Inorganic Hybrid Biomaterials For Microstructured Medical Devices

A. Doraiswamy¹, R. J. Narayan¹, A. Ovsianikov², R. Modi³, D. B. Chrisey³, B. Chichkov³; ¹University of North Carolina, Chapel Hill, NC, ²Laser Zentrum Hannover ev., Hannover, GERMANY, ³U. S. Naval Research Laboratory, Washington, DC.

504

Molecular Dynamics Simulations in Investigating the Liquid Crystalline Behavior Found in Biodegradable Polyarylates

A. V. Gubskaya; Rutgers University, The State University of New Jersey, Piscataway, NJ.

505

Development of Hybrid Nanofibrous Matrices for Bone Regeneration

H-W. Kim; Dankook University, Cheonan, REPUBLIC OF KOREA.

506

Bioactive Hybrid Microspheres for Bone Defect Filler

B-H. Yoon¹, H-W. Kim², J-H. Song¹, H-E. Kim¹; ¹Seoul National University, Seoul, REPUBLIC OF KOREA, ²Dankook University, Cheonan, REPUBLIC OF KOREA.

507

Production of Novel Ddense Composites of Hydroxyapatite-Bioglass by Hot-Pressing Technique

E-J. Lee, H-W. Kim, H-E. Kim; seoul national university, seoul, REPUBLIC OF KOREA.

508

Failure Tolerance of Preformed PFM Veneer Using Paste System

M-H. Lee¹, W-S. Seo¹, J-S. Han², D-H. Kim³, N-S. Oh⁴; ¹Korea Institute of Ceramic Engineering and Technology, Seoul, REPUBLIC OF KOREA, ²Seoul National University, Seoul, REPUBLIC OF KOREA, ³Che-Il Dental Laboratory, Seoul, REPUBLIC OF KOREA, ⁴Inha University, Incheon, REPUBLIC OF KOREA.

509

Effects of Temperature on In Vitro Degradation Behavior of a Poly(glycolide-co-L-lactide) Monofilament

M. Deng, D. Jamiolkowski, J. Zhou, G. Chen, Y. Xu, T. Barbolt; Ethicon, Inc., Somerville, NJ.

510

Mechanical Properties of a Fiber Loaded Calcium Phosphate Cement In Vitro

E. D. Jacobson, M. T. Fulmer, P. J. Leamy, P. W. Schaut, X. Liu; Synthes, West Chester, PA.

511

Wear Properties of a Pyrolytic Carbon Intervertebral Disc Replacement

N. Cheema¹, N. Hawkins², S. Salkeld¹, S. Cook³, K. Bailey²; ¹Fellowship of Orthopaedic Researchers, Metairie, LA, ²EBI, LP, Parsippany, NJ, ³Tulane University School of Medicine, New Orleans, LA.

512

Effect of Irradiation on the Tensile Properties of Injection Molded PVA Hydrogels

K. Liu, B. Thomas, K. Day, D. Yakimicki, J. Mason; Zimmer Holdings, Inc, Warsaw, IN.

513

Effect of Polymer Solution Viscosity on Injectability of Calcium Phosphate Cements

P. J. Leamy, M. T. Fulmer, M. Lehmicke; Synthes, West Chester, PA.

514

In-vitro Degradation and Cell Viability Analysis of a Biodegradable Polyesterurethane

J. A. Henry; National Centre for Biomedical Engineering Science, NUI Galway, Galway, IRELAND.

515

Investigation into the Influence of the Processing Environment on the Degree of Fibre Welding and Mesh Porosity

J. A. Henry; National Centre for Biomedical Engineering Science, NUI Galway, Galway, IRELAND.

516

Evaluation of in situ setting calcium phosphate cements as carrier materials for antibiotics

X. Liu, M. Fulmer; Synthes, West Chester, PA.

517

The effects of fiber length and loading on the handling and mechanical properties of a calcium phosphate material

E. D. Jacobson, P. J. Leamy, X. Liu, P. W. Schaut, D. Armbruster, M. T. Fulmer; Synthes, West Chester, PA.

518

Polyether Urethane With Covalently Attached Di-Tert-Butylphenol and Cholesterol Resists Oxidative Degradation

S. J. Stachelek¹, I. Alferiev¹, M. S. Sacks², R. J. Levy¹; ¹Children's Hospital of Philadelphia, Philadelphia, PA, ²University of Pittsburgh, Pittsburgh, PA.

519

Effect of Autologous Growth Factors on the Osteoinductive Properties of a DBM-based Bone Graft Substitute

K. E. Good, K. Sly, S. Lin; Exactech, Inc., Gainesville, FL.

520

Biosynthetic Hydrogels Promote 3-D Outgrowth and Dedifferentiation at the Edge of Articular Cartilage Explants in an in vitro Model

M. Livnat¹, Y. Tal¹, J. Boss², J. Bejar², D. Seliktar²; ¹Regentis Biomaterials Ltd., Haifa, ISRAEL, ²Technion, Haifa, ISRAEL.

521

Evaluation of Drug Release Profile for a Combination of Antibiotics in a Demineralized Bone Matrix Carrier

J. L. Simon, J. Manocchio, P. D'Antonio; EBI, LP, Parsippany, NJ.

522

A Collagen-Anorganic Bone Composite for Bone Repair: Part I. In Vitro Characterization Studies

S-T. Li; Collagen Matrix Inc., Franklin Lakes, NJ.

523

Packing Behavior of Calcium Phosphate Bone Graft Substitutes

T. D. Clineff, J. P. Murphy, J. G. Marx; Orthovita, Inc., Malvern, PA.

524

Addition of Minocycline and Rifampin to Calcium Sulfate Cement Slows Bulk Ceramic Resorption

J. L. Simon, J. Manocchio, P. D'Antonio; EBI, LP, Parsippany, NJ.

525

A Collagen-Anorganic Bone Composite for Bone Repair: Part II: In Vivo Study in a Rabbit Radius Defect Model

S-T. Li; Collagen Matrix Inc., Franklin Lakes, NJ.

526

In vivo results of a polylactide - ceramic composite in sheep at 3 years

W. R. Walsh¹, M. Borden², J. Hernandez²; ¹Uni New South Wales, Randwick, Sydney, NSW, AUSTRALIA, ²Interpore-Cross International, Irvine, CA.

527

Biomimetic Mineral Stability on 3D PLGA Scaffolds Immersed in Different Media

A. C. Jayasuriya; Medical University of Ohio at Toledo, Toledo, OH.

528

Influence of TiO₂ and Ag₂O Addition on Properties of Tricalcium Phosphates

Z. M. Seeley; Washington State University, Pullman, WA.

529

In vivo comparison of ACL reconstruction in the ovine model between a sterile allograft and autograft tendon

R. E. Olsen¹, A. M. York², C. W. Robinson¹, A. A. Zhukauskas², J. R. Bianchi²; ¹Frontier BioMedical Inc., Logan, UT, ²Regeneration Technologies Inc., Alachua, FL.

530

Crosslinking Characteristics and Shape Memory Effect of a Biodegradable Multiblock Copolymer Poly(propylene fumarate)-co-Poly(ε-caprolactone)

S. Wang, L. Lu, J. A. Gruetzmacher, K-w. Lee, B. L. Currier, M. J. Yaszesmki; Mayo Clinic, Rochester, MN.

531

In vivo Biocompatibility Assessment of a Pediatric Ventricular Assist Device

T. A. Snyder¹, C. Johnson, Jr.¹, J. Woolley¹, P. Wearden², A. Koert³, S. Richardson³, K. Dasse³, H. S. Borovetz¹, W. R. Wagner¹; ¹University of Pittsburgh, Pittsburgh, PA, ²Children's Hospital of Pittsburgh, Pittsburgh, PA, ³Levitronix, Waltham, MA.

532

Development and Characterization of a Self-Healing/Autonomic Acrylic Bone Cement

L. Jones, II¹, G. Lewis², P. Biggs¹; ¹Chicago State University, Chicago, IL, ²The University of Memphis, Memphis, TN.

533

Calcium Phosphate and Gypsum Composite Set with Hydroxypropyl Methylcellulose for Control of Degradation Rate

S. Kim; Yeungnam University, Gyeongbuk, REPUBLIC OF KOREA.

534

Nanocomposite of Poly(propylene fumarate) with Crosslinkable Hydroxyapatite

S. Wang, D. H. Kempen, L. Lu, J. A. Gruetzmacher, T. Hefferan, B. L. Currier, M. J. Yaszemski; Mayo Clinic, Rochester, MN.

535

Controllable Properties of Photocrosslinked Blends of Poly(propylene fumarate) and Poly(caprolactone fumarate)

S. Wang, D. H. Kempen, L. Lu, J. A. Gruetzmacher, B. L. Currier, M. J. Yaszemski; Mayo Clinic, Rochester, MN.

536

A Novel Percutaneous Device Realized the Prevention of Germ Infraction Made of a Nano-Scaled Hydroxyapatite Crystals/Polymer Composite

Y. Kogai¹, S. Yasuda¹, M. Okada², J. Tanaka³, T. Furuzono²; ¹Innovation Plaza Osaka, Japan Science and Technology Agancy, Izumi/city, Osaka, JAPAN, ²Department of Biomedical Engineering, National Cardiovascular Center Research Institute, Suita/city, Osaka, JAPAN, ³Independent Administrative Institution National Institute for Materials Science, Tsukuba/city, Ibaraki, JAPAN.

538

Characterization of Biodegradable Blends of PHBV/Tannin and PHBV/Lignin of sugarcane bagasse

N. Duran; Universidade Estadual de Campinas, Campinas, BRAZIL.

Orthopedic Bearing Surfaces

539

Detection of Vitamin E Radicals in Gamma-Irradiated α-T-UHMWPE

M. D. Ridley, M. S. Jahan; University of Memphis, Memphis, TN.

540

The Effect of Surface Finish on Micro Rotation and Frictional Torque of Taper-Locked Femoral Stems in Cemented Hip Joint Replacements

Z. Lu¹, H. McKellop¹, T. Schmalzried²; ¹Orthopaedic Hospital/UCLA, Los Angeles, CA, ²The Joint Replacement Institute, Los Angeles, CA.

541

A long-term Wear study of 28mm UHMWPE Hip liners against Silicon Nitride Versus Cobalt Chrome Femoral Heads

J. G. BOWSHER¹, T. K. DONALDSON¹, D. D. GREEN¹, R. LAKSHMINARAYANAN², A. KHANDKAR², I. C. CLARKE¹; ¹LOMA LINDA UNIVERSITY, LOMA LINDA, CA, ²AMEDICA, Salt lake city, UT.

542

No or Extremely Low Wear Debris from Cross-Linked Polyethylene Cups

H. G. Willert¹, I. Lang¹, L. Rabenseifner², R. Hilgers¹; ¹University of Goettingen, Goettingen, GERMANY, ²Department of Orthopaedics, General Hospital, Baden-Baden, GERMANY.

543

Debris from Combinations of Alumina Versus Alumina Matrix Composite: a Hip Simulator Model with Microseparation Test Mode

P. A. Williams, D. D. Green, N. L. Caffery, I. C. Clarke; Loma Linda University Medical Center, Loma Linda, CA.

544

Performance of Mechanically Enhanced Crosslinked Polyethylene Under Standard and Severe Wear Simulator Modes

J. G. BOWSHER, P. A. WILLIAMS, D. D. GREEN, I. C. CLARKE, T. K. DONALDSON; LOMA LINDA UNIVERSITY, LOMA LINDA, CA.

545

Thermally Stimulated Luminescence in Oxidized Gamma Sterilized Ultra High Molecular Weight Polyethylene

J. M. Gray, M. S. Jahan, M. Dunagan; The University of Memphis, Memphis, TN.

546

Effects of Protein Concentration in the Serum Lubricant on the Wear of Crosslinked, Thermally Treated UHMWPE

J. Chen, A. Alberts, Y-S. Liao; DePuy Orthopaedics, Inc., Warsaw, IN.

547

Retrieval Analysis of a Dislocating 38 mm Metal-on-Metal Hip Replacement

T. K. Donaldson, J. G. Bowsher, P. A. Williams, D. D. Green, I. C. Clarke; Loma Linda University, Loma Linda, CA.

548

Quantification of Total Knee Replacement Kinematics During UHMWPE Wear

J. A. Cammon, Sr.; Clemson University, Clemson, SC.

549

EFFECTS OF NEGATIVE CLEARANCE ON THE WEAR PERFORMANCE OF A MODERN METAL-ON-METAL IMPLANTS IN A HIP SIMULATION STUDY

Y-S. Liao, M. Hanes; DePuy Orthopaedics, Inc., Warsaw, IN.

550

Three Dimensional Laser Micrometry Analysis of Clinically Retrieved Acetabular Cups

J. Gaumer¹, J. Lannutti¹, J. Dyce¹, L. Nelson¹, P. Pavka¹, A. Kohm², V. Ravula¹, T. Dey¹, G. Li¹; ¹The Ohio State University, Columbus, OH, ²University of California Berkeley, Berkeley, CA.

551

Effects of Crosslinking on the Wear of Polyethylene after 5 Years Real Time Aging in Oxygen

K. R. St. John; University of Mississippi Medical Center, Jackson, MS.

552

Molded GUR1050 Resin Type Performance Versus ArCom 1900H In Knee Wear Simulation Study

R. Tsukamoto¹, M. Ogino², K. Yamada³, G. Pezzotti³, H. Shoji¹, I. C. Clarke¹; ¹Loma Linda University, Loma Linda, CA, ²Tsukamoto Orthopaedic Hospital, Tokyo, JAPAN, ³Kyoto Institute of Technology, Kyoto, JAPAN.

553

Wear Debris Morphology of Silicon-Nitride Generated from a Hip Simulator Model

P. A. Williams¹, A. Lakshminarayana², A. Khandkar², D. D. Green¹, I. C. Clarke¹; ¹Loma Linda University Medical Center, Loma Linda, CA, ²Amedica Corp, Salt Lake City, UT.

554

Raman Microspectroscopy of Polyethylene Structure, Strain & Oxidation Using New Glenoid Prostheses to Demonstrate Effects of Design and Manufacture

C. M. Jobe¹, G. Pezzotti², W. Phipatanakul¹; ¹Loma Linda University, Loma Linda, CA, ²Kyoto Institute of Technology, Kyoto, JAPAN.

555

Evaluation of Bio-mimic Collagen II/HA copolymer as scaffold for chondrocytes

S-J. Chang¹, T. Kuan¹, S. Kuo¹, Y. Wang², Y. Wang³; ¹I-Shou University, Kaohsiung County,, TAIWAN REPUBLIC OF CHINA, ²Yang MingUniversity, Taipei, TAIWAN REPUBLIC OF CHINA, ³Yang Ming University, Taipei, TAIWAN REPUBLIC OF CHINA.

556

Biological Evaluation of Poly(propylene fumarate)-co-Poly(ε-caprolactone) for Bone Tissue Engineering

S. Wang, D. H. Kempen, L. Lu, T. Hefferan, B. L. Currier, M. J. Yaszemski; Mayo Clinic, Rochester, MN.

557

Testing Parameters that Effect the Compressive Mechanical Behavior of the Intervertebral Disc

M. Cannella, M. Marcolongo; Drexel university, Philadelphia, PA.

558

Low-Grade Systemic Inflammation Increases Endothelial Superoxide Levels and Reduces Nitric Oxide Availability

C. H. Coyle, R. Kato, M. B. Chancellor, W. C. de Groat, F. de Miguel, N. Yoshimura; University of Pittsburgh, Pittsburgh, PA.

Stem Cells: Source, Culture and Application

559

Evaluating the Influence of Cell-Substratum Adhesivity on Human Mesenchymal Stem Cell Neural Differentiation

Y-S. Lee¹, J. Kohn², T. L. Arinzeh¹; ¹New Jersey Institute of Technology, Newark, NJ, ²Rutgers University and New Jersey Center for Biomaterials, Piscataway, NJ.

560

The Effects of Substrate on Muscle-Derived Stem Cell Differentiation

R. A. Long, J. Huard, M. B. Chancellor, M. S. Sacks; University of Pittsburgh, Pittsburgh, PA.

561

Maintaining Mixed Populations of Adult Stem Cells Enhances Osteogenic Potential

K. M. Esterly, J. J. Lee, G. Poynter, C. Parrish, J. A. Rowley, J. Hock, K. Goltry; Aastrom Biosciences, Inc., Ann Arbor, MI.

562

Osteogenic Differentiation of hMSC on Tyrosine Derived Polycarbonates

T. Briggs¹, T. Livingston Arinzeh¹, J. Kohn²; ¹New Jersey Institute of Technology, Newark, NJ, ²New Jersey Center for Biomaterials, Piscataway, NJ.

563

Development of an Acellular Stem Cell-Derived Biomaterial

R. Nair, T. C. McDevitt; Georgia Institute of Technology, Atlanta, GA.

565

Osteoprogenitor Cells Exposed to Polymethylmethacrylate Particles during the Proliferation Stage Are Susceptible to Irreversible Inhibition of Osteoblastic Differentiation

R. Chiu, T. Ma, R. L. Smith, S. B. Goodman; Stanford University School of Medicine, Stanford, CA.

566

Undifferentiated Marrow Stromal Cells Lose Their Osteogenic Capability After Exposure to Polymethylmethacrylate Particles in a Non-Osteogenic Environment

R. Chiu, T. Ma, R. L. Smith, S. B. Goodman; Stanford University School of Medicine, Stanford, CA.

567

Genomics-Guided Biomaterials Development

T. Xu, J. Hipp, G. Lim, J. Yoo, M. Van Dyke; Wake Forest University School of Medicine, Winston Salem, NC.

568

Osteogenic Differentiation of Human Mesenchymal Stem Cells in Injectable In situ Thermogelling Chitosan Solutions

L. S. Nair, T. Starnes, C. T. Laurencin; University of Vriginia, Charlottesville, VA.

569

Differentiation of Adipose-Derived Stem Cells on Bone Tissue Engineering Scaffolds

A. J. Wirtel, III¹, M. D. Kofron¹, X. Li¹, A. Mesfin², C. T. Laurencin¹; ¹University of Virginia, Charlottesville, VA, ²Drexel University, Philadelphia, PA.

570

Human Mesenchymal Stem Cell Response to Tethered Epidermal Growth Factor as a Surface Modification on Bone Implants

V. Fan; MIT, Cambridge, MA.

571

Differentiation of Human Mesenchymal Stem Cells on Biodegradable Polyurethane Membranes for Tissue Engineering

A. Chroscicka, Y. K. Tsui, M. Alini, S. Gogolewski; AO Research Institute, CH-7270 Davos, SWITZERLAND.

572

Fluorescent Activated Cell Sorting for the Characterization of Primary Rabbit Bone Marrow Fat Cell, Bone Marrow Stromal Cell, and Osteoblastic Cell Populations

M. D. Kofron¹, D. Lee², C. T. Laurencin¹; ¹University of Virginia, Charlottesville, VA, ²Drexel University, Philadelphia, PA.

573

Biophysical Regulation of Stem Cell Differentiation is Surface Dependent

B. D. Boyan¹, M. Duran¹, S. Safavynia¹, G. Barabino², B. J. Simon³, Z. Schwartz¹; ¹Georgia Institute of Technology, Atlanta, GA, ²Northeastern University, Boston, MA, ³EBI, LP, Parsippany, NJ.

574

Design and Qualification of a Novel Flex-Stretch-Flow Bioreactor for Engineering Heart Valve Tissues

G. C. Engelmayr, Jr.¹, L. Soletti¹, S. C. Vigmostad², S. G. Budilarto¹, W. J. Federspiel¹, K. B. Chandran², D. A. Vorp¹, M. S. Sacks¹; ¹University of Pittsburgh, Pittsburgh, PA, ²The University of Iowa, Iowa City, IA.

575

A Rapid Technique for the Isolation and Concentration of Stem Cells from Human Bone Marrow

M. Ponticiello; Interpore Cross Int'l, Irvine, CA.

576

In Vitro Optimization of Clinical Formulations of Adult Stem Cells with Matrices for Bone Regeneration

J. A. Rowley, K. Esterly, B. McEwen, B. Pavlic, K. Goltry, J. Hock; Aastrom Biosciences, Ann Arbor, MI.

577

Adipose-derived Stem Cell Attachment to Biomaterials

H. L. Prichard, W. Reichert, B. Klitzman; Duke Univeristy, Durham, NC.

578

Establishing procedures for using a goat model for studying autologous tissue engineering strategies for the repair of cartilage and bone defects

M. T. Rodrigues; University of Minho, Braga, PORTUGAL.

579

In Vitro and In Vivo Evaluation of Neural Stem Cells Seeded on Neural Probes

E. A. Charley, K. Lesk, W. R. Stauffer, G. T. Gobbel, X. Cui; University of Pittsburgh, Pittsburgh, PA.

580

The Effect of Varying the Architecture of Scaffolds on Mesenchymal Stem Cell Osteogenesis and Chondrogenesis

S. Shanmugasundaram¹, A. S Mautone², M. Jaffe¹, L. Rizio³, T. Livingston Arinzeh¹; ¹New Jersey Institute of Technology, Newark, NJ, ²University of Virginia, Richmond, VA, ³New Jersey Sports Medicine Institute, Verona, NJ.

581

Transfected neural precursor cultures exhibit dopaminergic properties when coated with porn/laminin

M. Timmer¹, K. Cesnulevicius¹, J. Grosskreutz¹, L. Just², J. Bufler¹, C. Grothe¹; ¹Hannover Medical School, Hannover, GERMANY, ²University of Tübingen, Tübingen, GERMANY.

582

Controlled Release Biomaterials for Directed Embryonic Stem Cell Differentiation

R. L. Carpenedo; Georgia Institute of Technology, Atlanta, GA.

583

Prefabrication of in vivo bone constructs following in vitro propagation of cultured bone marrow stromal cells on hydroxyapatite/tricalcium phosphate carpets

M. H. Mankani¹, S. A. Kuznetsov², P. Gehron Robey²; ¹UCSF, San Francisco, CA, ²NIDCR- NIH, Bethesda, MD.

584

Optimization of endothelial progenitor cells for pulmonary regeneration: Agarose cocooning for enhanced cell survival and targeted engraftment

M. L. Ormiston¹, G. Karoubi¹, J. Chan¹, D. J. Stewart², D. W. Courtman¹; ¹University of Toronto, Toronto, ON, CANADA, ²St. Michael's Hospital, Toronto, ON, CANADA.

585

Collagen Increases Surface Tissue Factor Activity in Baboon Endothelial Progenitor Cells

B. D. Markway, S. R. Hanson, M. T. Hinds; Oregon Health & Science University, Portland, OR.

586

Functional Polymeric Microcapsules for Neural Stem Cell Culture

S. H. Bakhru, T. W. Link, H. Song, H-Q. Mao; Johns Hopkins University, Baltimore, MD.

587

Adult-Derived Adipose Stem Cells for Bone Regeneration

Y-I. Yang¹, K. R. Kirker², M. Massey³, J. Shelby²; ¹School of Medicine, Inje University, Gae-Kum-dong, Pusan-Jin-gu, Pusan, REPUBLIC OF KOREA, ²Bacterin International, Inc., Belgrade, MT, ³Department of Surgery, University of Utah, Salt Lake City, UT.

588

Local Versus Systemic Delivery of Endothelial Progenitor Cells for a Tissue Scaffold

J. A. Jennings, J. W. McCullars, S. T. Moore, D. S. Feldman; University of Alabama at Birmingham, Birmingham, AL.

589

Notch Signaling Biomaterials for the Generation of T cells from Hematopoietic Stem Cells

S. Taqvi, L. A. Dixit, K. Roy; University of Texas at Austin, Austin, TX.

590

Effect of Scaffold Architecture and Culture Conditions on Hematopoietic Differentiation of Embryonic Stem Cells

S. Taqvi, L. A. Dixit, K. Roy; University of Texas at Austin, Austin, TX.

Surface Modification and Characterization of Biomaterials

591

Surface characterization and in vitro biocompatibility study of surface-sulfonated chitosan membrane

H-Y. Yeh, J-C. Lin; National Cheng Kung University, Tainan, TAIWAN REPUBLIC OF CHINA.

592

The Significance of Zeta Potential in Osteogenesis

J. J. Cooper¹, J. A. Hunt²; ¹Biocomposites Ltd, Staffordshire, UNITED KINGDOM, ²United Kingdom Centre for Tissue Engineering, Liverpool, UNITED KINGDOM.

593

Bioinspired PDMS Elastomer Possessing High Oxygen Permeability and Protein Adsorption Resistance

T. Goda, T. Konno, M. Takai, K. Ishihara; The University of Tokyo, Tokyo, JAPAN.

594

A Biocompatible Contact Lens to Prevent Non-Specific Protein Adsorption: Development of Novel Procedure to Modify Hydrogels with Phosphorylcholine

Y. SUDA¹, K. MAENO¹, K. MIYAZAWA¹, K. ISHIHARA²; ¹Shiseido Co., Ltd., Yokohama, JAPAN, ²The University of Tokyo, Tokyo, JAPAN.

595

Rapid Screening of Pyrolytic Carbon Leaflets and Fully Assembled Heart Valves for Blood Compatibility

B. Pederson¹, R. Nachreiner¹, K. Brandy², D. Cocking Johnson², G. H. R. Rao²; ¹ATS Medical, Minneapolis, MN, ²University of Minnesota, Minneapolis, MN.

596

Electrospray Coating: Optimization of Process Parameters for Biomedical Applications

S. G. Kumbar, S. Sethuramana, S. Bhattacharyya, C. T. Laurencin; University of Virginia, Chalottesville, VA.

597

Peptide fluorosurfactant polymer modification of ePTFE facilitates in vitro adhesion and growth of endothelial cells

C. C. Larsen¹, F. Kligman², R. E. Marchant¹, K. Kottke-Marchant²; ¹Case Western Reserve University, Cleveland, OH, ²Cleveland Clinic Foundation, Cleveland, OH.

598

Preparation of 3D Porous Collagen Scaffold around Implantable Biosensor for Improving Biocompatibility

Y. Ju; University of South Florida, Tampa, FL.

599

Synthesis of Novel Two-component Injectable Polyurethane Composites and Preliminary Assessment using Primary Human Osteoblasts

I. C. Bonzani; Imperial College, London, UNITED KINGDOM.

600

Fibrinogen Adsorption onyo 316L Stainless Steel: Voltage Effects

R. T. Gettens, J. L. Gilbert; Syracuse University, Syracuse, NY.

601

Exploring the Efficiency of a Surface-Tethered Hyaluronan Model for Testing Endothelial Cell Responses

S. Ibrahim, A. Ramamurthi; Clemson University, Charleston, SC.

602

Procoagulant Efficiency of Activated Hageman Factor (FXIIa) on Solid Substrates

K. Chatterjee¹, E. A. Vogler², C. A. Siedlecki¹; ¹Penn State College of Medicine, Hershey, PA, ²Penn State University, University Park, PA.

603

Interactions of the Platelet Integrin Receptor GPIIbIIIa with Surface-Adsorbed Fibrinogen

A. Agnihotri, C. A. Siedlecki; Penn State, Hershey, PA.

604

Modification of biomaterials with ephrins and Eph ligands for angiogenic applications

J. J. Moon, S. Lee, J. L. West; Rice University, Houston, TX.

605

von Willebrand's Factor Has a Major Role in Mediating Platelet Adhesion to Biomaterials at Higher Shear Rates

M. Zhang, Y. Wu, T. A. Horbett; University of Washington, Seattle, WA.

606

A functionally flexible, biomimetic scaffold for tissue repair

J. F. Alvarez-Barreto¹, S. Mullin¹, M. Shreve², P. DeAngelis², V. Sikavitsas¹; ¹University of Oklahoma, Norman, OK, ²University of Oklahoma Health Science Center, Oklahoma City, OK.

607

Histomorphometrical and clinical study of connective tissue around titanium dental implants with porous surface in a canine model

B. Zhao¹, I. Han¹, W. Bai², H. Feng², F-Z. Cui³, I-S. Lee¹; ¹Yonsei University, Seoul, REPUBLIC OF KOREA, ²Peking University, Beijing, CHINA, ³Tsinghua University, Beijing, CHINA.

608

CaP Coating of Polyurethane Foams for Bone Regeneration

S. Fare, C. De Marco, M. Moscatelli, M. C. Tanzi; Politecnico di Milano, Milan, ITALY.

609

Ectopic bone formation by microstructured synthetic materials through in vivo protein adsorption

H. Yuan¹, C. A. van Blitterswijk¹, K. de Groot¹, J. D. de Bruijn²; ¹University of Twente, Enschede, THE NETHERLANDS, ²Queen Mary University of London, London, UNITED KINGDOM.

611

Attachment of Osteoblasts to New Surface-Modified Substrates - A Preliminary Report

P. L. Tate¹, M. A. Hucks¹, S. Nagatomi¹, M. A. Vaughn¹, M. Shalaby², S. W. Shalaby¹; ¹Poly-Med, Inc., Anderson, SC, ²Lehigh Valley Hospital, Allentown, PA.

612

Mechanical Properties, Elution Profile and Antimicrobial Activity of a Silver-Coated Foam Dressing for Use with V.A.C.^® Therapy A. Ambrosio, J. Payne, C. Kauffman, D. Ginther; KCI, San Antonio, TX.

613

A high throughput method using electron microprobe analysis for quantification of protein adsorption

Z. Bai, M. J. Filiaggi, R. E. Mar, P. Stoffyn-Egli, J. R. Dahn; Dalhousie University, Halifax, NS, CANADA.

614

Molecular Detection of Proteins on Polymer Materials by Atomic Force Microscopy

P. Soman¹, Z. Rice², L-C. Xu¹, C. Siedlecki¹; ¹Pennsylvania State University, Hershey, PA, ²The University of Texas at Austin, Austin, TX.

615

Comparison of Mechanical and Structural Properties of Zirconia Femoral Head Implants in vitro and in vivo

S. A. Chowdhury¹, Y. K. Vohra¹, J. E. Lemons¹, M. Ueno², J. Ikeda²; ¹University of Alabama at Birmingham, Birmingham, AL, ²Japan Medical Materials Corporation (JMMC), Osaka, JAPAN.

616

The Synthesis and Characterization of Heparin-Doped Polypyrrole for Biomedical Applications

S. Meng, G. Shi, M. Rouabhia, Z. Zhang; Laval University, Québec, PQ, CANADA.

617

Immobilization of recombinant human activated protein C to poly (ethylene terephthalate) (Dacron): Creation of a novel anti-coagulant surface

S-Q. Wu¹, M. Phaneuf², F. LoGerfo¹; ¹Beth Israel Deaconess Medical Center, Boston, MA, ²BioSurfaces, Ashland, MA/Beth Israel Deaconess Medical Center, Boston, MA.

618

Development and Characterization of PLGA Impregnated Vascular Graft for Endovascular Abdominal Aortic Aneurysm (AAA) Repair

O. Moloye; University of Florida, Gainesville, FL.

619

Surface characterization of Polymeric Biomaterials processed by Reactive Ion Etching (RIE) plasma sterilization

T. A. Pinto, D. C. Oliveira, A. M. Oliveira, A. J. Moreira, M. R. Boscariol, J. M. F. Silva, N. Ordonez, R. D. Mansano; College of Pharmaceutical Sciences - University of São Paulo, São Paulo, BRAZIL.

620

Effect of Sterilization on the Activity of a Biomimetic Coating containing Polymer and Protein Components

W. Takeguchi¹, T. Kupumbati², J. Neff¹; ¹Allvivo Vascular, Inc, Lake Forest, CA, ²Medtronic Heart Valves, Santa Ana, CA.

621

Wet spinning and Characterization of Collagen Fibers Incorporating Hydroxyapatite in Mixed and Coated Form

S. N. Prakash, M. Jaffe, G. Collins, R. T. Dombrowski; New Jersey Institute of Technology, Newark, NJ.

622

Long-term and zero-order release of basic fibroblast growth factor from heparin-conjugated poly(L-lactide-co-glycolide) nanospheres and fibrin gel

O. Jeon, S-W. Kang, H-W. Lim, B-S. Kim; Hanyang University, Seoul, REPUBLIC OF KOREA.

623

Albumin Self-assembled Liposomes for Drug Delivery Applications

C. P. Sharma, K. Kaladhar; Sree Chithra Tirunal Institute for Medical Science and Technology, Thiruvananthapuram, INDIA.

624

Surface characteristics of surface-engineered titanium implants: surface chemistry, morphology, pore size configuration, oxide thickness, crystal structure and roughness

Y-T. Sul¹, E. Byon², B-S. Kang¹, A. Wennerberg¹; ¹Dept. of Biomaterials, Gothenburg University, Gothenburg, SWEDEN, ²Korea Institute of Machinery and Materials, Changwon, REPUBLIC OF KOREA.

625

Addition of Antibiotic Increases Fracture Toughness of PMMA Bone Cement

L. J. Pogula¹, M. W. Kovacik², D. A. Noe², M. J. Askew²; ¹The University of Akron, Akron, OH, ²Summa Health System Hospitals, Akron, OH.

626

Bioactivity of PTH(1-34) Immobilized by its N-Terminus

J. L. Sharon, D. A. Puleo; University of Kentucky, Lexington, KY.

627

The effects of degradation on the nanostructure surface in chitosan scaffolds

K. C. PATEL; WAYNE STATE UNIVERSITY, DETROIT, MI.

628

Carboxyl Functionalized Polypyrrole for Surface Modification in Tissue Engineering

J. D. Nickels, F. Serna, J-w. Lee, C. E. Schmidt; University of Texas at Austin, Austin, TX.

629

Efficacy, release profile, and degradation behaviour of PDLLA + Gentamicin Sulphate coating on Ti-6Al-7Nb alloy in PBS

A. Montali¹, O. Jahn¹, X. Liu²; ¹Synthes GmbH, Oberdorf, SWITZERLAND, ²Synthes, West Chester, PA.

630

New Technique for Evaluation of Retrieved Total Hip Arthroplasty

J. Gaumer¹, J. Lannutti¹, A. Kohm², P. Pavka¹, L. Pruitt², M. Reis³, V. Ravula¹, T. Dey¹, G. Li¹; ¹The Ohio State University, Columbus, OH, ²University of California Berkeley, Berkeley, CA, ³University of California San Francisco, San Francisco, CA.

631

Integrated Biological Coating (IBC) for Renal Dialysis Catheters

Y. Du; Spire Corporation, Bedford, MA.

632

Effect of Plate-Bone Contact on Stresses in Periarticular Locking Plates

M. A. Dharia, R. R. Kenyon, B. Durcholz, M. Keith, D. L. Levine, T. S. Johnson; Zimmer Inc., Warsaw, IN.

633

Tribological Evaluation of Nanostructured Diamond Coatings Against Ultra-High Molecular Weight Polyethylene

M. Hill, V. Konovalov, B. Etheridge, A. Stanishevsky, A. Catledge, J. Lemons, Y. Vohra, A. Eberhardt; University of Alabama at Birmingham, Birmingham, AL.

634

Study of the Formation of Self- Assembled Monolayers on Nitinol

R. Quinones, E. S. Gawalt; Duquesne University, Pittsburgh, PA.

635

Strength of Fibronectin Adsorption to Polymer Materials

C. C. Anamelechi, W. M. Reichert; Duke University, Durham, NC.

637

Biomechanical and Functional Comparisons of Bioprosthetic Heart Valve Tissue Anti-Calcification Treatments

P. A. Schmidt; Edwards Lifesciences, Irvine, CA.

638

Control of Surface Density and Distribution of FGF2 for Neural Stem Cell Expansion

X. LIU; Johns Hopkins University, BALTIMORE, MD.

639

Fabrication of a poly(D,L-lactide-co-glycolide)/hydroxyapatite composite scaffold with enhanced osteoconductivity

S-S. Kim¹, S-J. Gwak², K-M. Ahn¹, M. Park², J-H. Lee¹, C. Choi¹, B-S. Kim²; ¹Seoul National University, Seoul, REPUBLIC OF KOREA, ²Hanyang university, Seoul, REPUBLIC OF KOREA.

641

Effect of functional end groups of silane self-assembled monolayer surfaces on apatite formation, fibronectin adsorption and osteoblast cell function

G. K. Toworfe¹, R. J. Composto¹, C. S. Adams, IV², I. M. Shapiro², P. Ducheyne¹; ¹University of Pennsylvania, Philadelphia, PA, ²Thomas Jefferson University, Philadelphia, PA.

643

Structure and Mechanical Properties of Hydroxyapatite Nanoparticle Compacts

A. Stanishevsky, S. Chowdhury, P. Chinoda; University of Alabama at Birmingham, Birmingham, AL.

644

Atmospheric Plasma-Grafted Thermally Responsive Coatings for Cell-Sheet Engineering

M. G. McCord, X. Wang, S. A. Barcio, J. R. Gentry, N. A. Monteiro-Riviere; NC State University, Raleigh, NC.

645

Effect of modified stainless steel 316L substrates on 3T3 fibroblast cell attachment

A. Raman, E. S. Gawalt; Duquesne University, Pittsburgh, PA.

646

Carbonyldiimidazole Immobilization of an Extracellular Matrix Protein Mixture onto poly(HEMA) and Decellularized Esophageal Tissue

C. A. Barnes; University of Washington, Seattle, WA.

647

Controlled Immobilization of Bioactive Peptides via the N-Terminus

J. L. Sharon, D. A. Puleo; University of Kentucky, Lexington, KY.

648

The use of low and high viscosity cement in hip resurfacing arthroplasty: an In-vitro study

R. Howald¹, U. Kesteris², M. Wittwer³, R. Klabunde¹, J. Krevolin¹; ¹Zimmer Corporate Research, Winterthur, SWITZERLAND, ²University Hospital, Lund, SWEDEN, ³ETH, Zurich, SWITZERLAND.

649

Retrospective Study on Long Term Storage Effects on UHMWPE in an Inert Environment

A. S. Rufner, R. A. Gsell, H. E. Brinkerhuff, M. E. Hawkins; Zimmer, Inc., Warsaw, IN.

650

Clot lysis on lysine-coated peripheral stents preadsorbed with tPA

W. G. McClung¹, D. E. Babcock², W. Ebeling², J. A. Chinn², J. L. Brash¹; ¹McMaster University, Hamilton, ON, CANADA, ²SurModics, Inc., Eden Prairie, MN.

651

Osteoblast Response to Surface Microtopography is Modulated by Caveolin-1

B. F. Bell, Jr.¹, N. Majdi¹, H. Jo², M. Wieland³, Z. Schwartz¹, B. D. Boyan¹; ¹Georgia Institute of Technology, Atlanta, GA, ²Emory University Medical School, Atlanta, GA, ³Institut Straumann AG, Basel, SWITZERLAND.

652

Morphology and size distribution of polyethylene debris generated during multiple activity knee wear testing

O. O. Popoola, T. S. Johnson, S. S. Bhambri; Zimmer Inc., Warsaw, IN.

653

Plasma Fibronectin Modulates Foreign Body Response to Biomaterials

B. G. Keselowsky¹, K. E. Burns², C. C. Tate², M. C. LaPlaca², J. E. Babensee², A. J. Garcia²; ¹University of Florida, Gainesville, FL, ²Georgia Institute of Technology, Atlanta, GA.

654

Serum Proteins Limit the Kinetics of Surface Reactions in Novel Porous Bioactive Nanocomposites

G. GUPTA, A. El-Ghannam; UNIVERSITY OF KENTUCKY, LEXINGTON, KY.

655

Reduction of Pseudomonas Aeruginosa Biofilms In Vitro and Attenuation of Foreign Body Response In Vivo by Salicylic Acid-Derived Poly(Anhydride-Esters)

J. Bryers¹, R. Jarvis², J. Lebo², A. Prudencio³, T. Kyriakides⁴, K. E. Uhrich³; ¹University of Washington, Seattle, WA, ²University of Connecticut Health Center, Farmington, CT, ³Rutgers University, Piscataway, NJ, ⁴Yale University, New Haven, CT.

656

Towards Inert Implant Metal Oxide Surfaces

E. S. Gawalt, A. Raman, R. Quinones, K. Papariella; Duquesne University, Pittsburgh, PA.

657

Influence of Surface Modification on Anti-bacterial Activity of Chitosan Membranes

A. Sarasam, S. V. Madihally; Oklahoma State University, Stillwater, OK.

658

Endothelialization of Peptide-treated ePTFE Vascular Grafts in a Circulatory Bioreactor

C. LI; INCUBE, INC., MENLO PARK, CA.

659

Novel Matrix Metalloproteinase-Inhibiting Polymers for the Treatment of Chronic Skin Wounds

G. A. Skarja¹, R. K. Ho¹, M. H. May¹, M. V. Sefton²; ¹Rimon Therapeutics Ltd., Toronto, ON, CANADA, ²University of Toronto, Toronto, ON, CANADA.

660

Biologically active surfaces using chemical vapor deposition polymerization

H-Y. Chen, H. Nandivada, Y. Elkasabi, J. Lahann; University of Michigan, Ann Arbor, MI.

661

Smooth Muscle Cell Response to a Library of Poly(DTE Carbonate) Co-Polymers

P. A. Johnson; Rutgers University, Piscataway, NJ.

662

Spontaneous enrichment of phosphorylcholine groups on polyolefin surface with perfluoroalkylated lipids additives

Y. Iwasaki, K. Akiyoshi; Tokyo Medical and Dental University, Tokyo, JAPAN.

663

What surface properties determine significant differences of bone response to oxidized Mg-incorporated, TiUnite and Osseotite implants?

Y-T. Sul¹, C. Johansson², T. Albrektsson¹; ¹Dept. of Biomaterials, Gothenburg University, Gothenburg, SWEDEN, ²Dept. of Medical Technology, Orebro University, Orebro, SWEDEN.

664

Bone Regeneration with Calcium Sulfate/Poly (l lactic acid) Composites

S. S. Mamidwar¹, M. Weiner², A. Yampolsky³, J. L. Ricci², H. Alexander¹; ¹Orthogen Corporation, Springfield, NJ, ²New York University College of Dentistry, New York, NY, ³New York University College of Dentistry, Piscataway, NJ.

665

Plasma Surface Modification of Chitosan Membranes and Its Effect on Cell Adhesion and Proliferation

S. S. Silva, S. M. Luna, M. E. Gomes, J. Benesch, J. F. Mano, R. L. Reis; University of Minho, Braga, PORTUGAL.

666

Cell Adhesion Peptide Modified Silicone Rubber: Potential for Use in Blood Contacting Applications

A. S. Mikhail, K. S. Jones, H. Sheardown; McMaster University, Hamilton, ON, CANADA.

667

Effect on Osteoblast Responses of the Self-Assembly and Cross-linking of Collagen Immobilized on Titanium

H-W. Kim; Dankook University, Cheonan, REPUBLIC OF KOREA.

668

Optimization of Trans-Vinylene Index Measurements for Orthopaedic UHMWPE

C. A. Doyle; Zimmer Inc., Warsaw, IN.

669

Mechanical Testing of Reverse Shoulder Prosthesis Stability

N. Gronau¹, M. L. Mroczkowski², S. Boss¹; ¹Zimmer Corporate Research, Winterthur, SWITZERLAND, ²Zimmer Corporate Research, Warsaw, IN.

Synthetic Orthopaedic Materials

670

In Vitro and In Vivo Evaluation of a Slower Resorbing Calcium Sulfate Cement

J. McCanless¹, J. Moseley¹, R. Urban², T. Turner², D. Hall², M. Carroll¹; ¹Wright Medical Technology, Inc., Arlington, TN, ²Rush University Medical Center, Chicago, IL.

671

Temperature Effect on Biomimetic Ca-P Coating Formation

H. Qu, M. Wei; University of Connecticut, Storrs, CT.

672

Water-based fabrication and biological evaluation of calcite coatings on stainless steel

Y. Liu¹, W. Chen¹, Y. Yang¹, J. Ong¹, J. Bumgardner², W. Haggard²; ¹UT Health Science Center, Memphis, TN, ²UM, Memphis, TN.

673

Fabrication of nanoscale titania coating and their osteoblast responses

Y. Yang¹, N. Oh¹, Y. Liu¹, M. Appleford¹, W. Chen¹, S. Oh¹, W. Haggard², J. Bumgardner², J. Ong¹; ¹University of Tennessee Health Science Center, Memphis, TN, ²University of Memphis, Memphis, TN.

674

in vitro Study of HA and CMP Grit-Blasted and Acid Etched of Ti Surface

S. Kim; Yeungnam University, Gyeongbuk, REPUBLIC OF KOREA.

675

Allergic Patient Response to Low-Nickel Epidermal Contact

J. A. Disegi¹, J. Rakoski², B. Jessberger², E. Vocks², J. Ring²; ¹Synthes Technical Center, West Chester, PA, ²Technical University of Munich, Munich, GERMANY.

676

Probing Multiscale Cell-Biomaterial Interactions via Confocal/Multiphoton Imaging and X-ray micro-Tomography

M. Treiser, P. Johnson, R. Dubin, A. Rege, J. Kohn, P. V. Moghe, D. Denhardt; Rutgers University, Piscataway, NJ.

Urological Tissue Engineering and Biomaterials

677

Bioengineered Urethral Augmentation: Preliminary Results

D. J. Haworth, D. W. Chew, N. Yoshimura, M. Chancellor, D. A. Vorp; University of Pittsburgh, Pittsburgh, PA.

678

Mechanical and Structural Characteristics of Cholecyst-derived Extracellular Matrix

J. Coburn; National University of Ireland, Galway, Galway, IRELAND.

679

Porcine Urinary Bladder Matrix Derived Gel for Tissue Engineering Applications

D. O. Freytes, A. S. Lee, S. F. Badylak; University of Pittsburgh, Pittsburgh, PA.

680

Nano-Dimensional Bladder Tissue Replacement Constructs: An In Vivo Study

T. J. Webster; Purdue University, West Lafayette, IN.

681

Biomechanical properties of the prolapsed anterior vaginal wall in post-menopausal women

R. C. Eberhart; University of Texas Southwestern Medical School, Dallas, TX.

682

Development of a Biologically Stable Urethane-Silicone Copolymer Gel

A. D. Padsalgikar; AorTech Biomaterials, Mulgrave, Victoria, AUSTRALIA.

683

TEM quantification of changes in collagen distribution in the anterior vaginal wall of post-menopausal women undergoing cystocele repair

R. C. Eberhart; University of Texas Southwestern Medical School, Dallas, TX.

684

Characterization of Acellular Porcine Aortic Matrix for Urologic Reconstructive Surgery

R. N. Yu¹, M. K. McHale², T. Shu¹, P. Jian¹, A. Gilbert¹, W. Jian¹, S. P. Lerner¹, J. L. West², G. E. Amiel¹; ¹Baylor College og Medicine, Houston, TX, ²Rice University, Houston, TX.

685

Calcium Phosphates Formation On Bioactive Glasses In HEPES Solutions

K. Zhang¹, L. F. Francis²; ¹Zimmer Inc., Warsaw, IN, ²University of Minnesota, Mineapolis, MN